Micro-Electrodes Implanted in a Human Nerve
|Principal Investigator: DouglasHutchinson|
|Keywords: Hand , Micro-Electrodes , Amputation , Spinal Cord Injury , Peripheral Nerve Injury||Department: Orthopedic Surgery|
|IRB Number: 00055621||Co Investigator:|
|Specialty: Anesthesiology, Surgery, General|
We will investigate basic physiology of human peripheral nerves and muscle leads using high-count microelectrode arrays implanted into peripheral nerves and muscle of patients with limb amputations or peripheral nerve injury.
We will also concurrently investigate the use of intramuscular leads into residual forearm muscle to control external device. This will give us a direct comparison between two proposed methods of motor control: 1: Intraneural electrodes which is the new technique and 2: EMG which is currently used in a cruder transcutaneous method with this version allowing more specific inputs relating directly to hand function and placed intramuscularly.
We plan to enroll a maximum of twelve patients for this study. Patients will be selected amongst those with amputations or undergoing an elective amputation, with peripheral nerve injury, or chronic pain patients who are candidates for nerve or spinal stimulator. Patients must be at least 18 years of age and less than 65 years of age. The risks and benefits will be explained to the patients and families prior to obtaining consent.
Exclusion criteria include incarceration, pregnancy, inability to consent, and psychiatric comorbidity. Additionally, medical conditions that significantly increase the risk of adverse effects of general anesthesia will bar inclusion. Patients who are pregnant will be excluded from this study due to the risks posed by multiple rounds of anesthetic administration. Therefore, a pregnancy test will be given to all potentially fertile females.