Principal Investigator: Glen Morrell
Keywords: Magnetic Resonance Imaging , Sodium Breast Imaging , Breast Cancer Screening Department: Radiology Clinical
IRB Number: 00056812 Co Investigator: Matthew Stein
Specialty: Radiology, Radiology
Sub Specialties: Women's Imaging, Magnetic Resonance Imaging – MRI
Recruitment Status: Enrolling by invitation

Contact Information

Nousheen Alasti
nousheen.alasti@hsc.utah.edu
(801)585-6142

Simple Summary

1.Demonstrate the feasibility of breast sodium MRI as a component of breast MRI examination.2.Test the hypothesis that tissue sodium quantification with MRI can be used to classify breast lesions as benign or malignant

Inclusion Criteria

Patients will be enrolled who are scheduled to undergo breast biopsy based on abnormal x-ray mammogram or ultrasound.  Recruitment will be performed by Dr. Laurie Fajardo, Dr. Phoebe Freer, Dr. Nicole Winkler, and Dr. Matthew Morgan, breast imagers in the Radiology Department at the University of Utah.  Subjects will be recruited in the Breast Cancer Center located in the Huntsman Cancer Hospital  at the University of Utah at the time of x-ray mammogram or breast ultrasound.  In past studies (e.g. (12)) this patient population has proven to be extremely altruistic in their willingness to participate in trials that they perceive may benefit future breast cancer patients.   In the one-year period of 2016, 566 stereotactic and ultrasound guided breast biopsies were performed in our department. We believe recruitment of 60-100 patients in the study period is an acheivable goal.  To facilitate patient recruitment, MRI scan time slots may be reserved immediately before biopsy appointments so that patients may easily participate in the research MRI immediately before their breast biopsy procedure.

 

Inclusion Criteria for Control Group Cohort:

  • Healthy Volunteers 18 years and older,
  • Able to give consent

Inclusion Criteria for Study Group Subjects:

  • Healthy volunteers 18 years and older,
  • Patients referred for biopsy of suspicious lesions seen on mammogram, ultrasound, or MRI
  • Able to give consent.

Exclusion Criteria

 Exclusion criteria include age under 18 years, history of diabetes or renal insufficiency with estimated glomerular filtration rate (GFR) less than 30 mL/min/1.73m2, breast implants, and routine exclusion criteria for MRI outlined on the MRI safety screening form (i.e. metal in the orbits, cardiac pacemaker, cochlear implant, stents or other prosthetic devices which have not been tested for MRI compatibility).

Exclusion from receiving contrast will not be an exclusion from study participation. Participants can decline contrast injection and this will not be considered a protocol deviation.

Participant Reimbursement

Up to $100 per participant