GAS - Registry

Principal Investigator: ErinClark
Keywords: Puerperal Group A Streptococcal Sepsis Department: Maternal-Fetal Medicine
IRB Number: 00026335 Co Investigator: ErinClark
Specialty: OB/Gyn, General
Sub Specialties: Women's Health

Contact Information


Brief Summary

Cases of puerperal GAS sepsis occurring in the state of Utah between 1991 and 2006 have recently been reviewed.12, 13 41 cases of puerperal GAS sepsis were identified in two tertiary care centers in Utah from 1991-2006. Identification of cases, although rare, is important from several perspectives, including identification of possible nosocomial infections. It also allows for a better understanding of case characteristics, risk factors, and effective preventative and treatment measures. Prospective identification of cases would result in more proficient case identification and would also allow for bacterial virulence factors, maternal immunologic factors, and maternal histories to be obtained in a more effective and accurate manner.

We aim to create a prospective case registry for cases of puerperal GAS sepsis at University/LDS Hospital and Intermountain Medical Center. The registry will contain patient medical and obstetrical histories, detailed information regarding the hospitalization for puerperal GAS sepsis, microbiologic information on bacterial virulence factors, and information on maternal immunologic factors.

Data from IRB #19445 ("Puerperal Group A Streptococcal Sepsis: A Descriptive Case Series") (41 participants) will also be combined with this study. This data will provide more data for analysis related to puerperal Group A Strep.

Inclusion Criteria

Any femailes (13 years or older) identified as having puerperal GAS infection will be eligible for enrollment. A puerperal GAS infection will be defined as positive GAS cultures from the endometrium, vagina, wound, blood, urine, or other body fluid in a patient with clinical evidence of infection in the puerperium.

Participants from IRB #19445 ("Puerperal Group A Streptococcal Sepsis: A Descriptive Case Series").

Exclusion Criteria