The purpose of this study is to perform central pathology review and EBV testing on patient samples in order to verify eligibility for a clinical trial. The clinical trial will assess the safety and toxicity associated with administering allogeneic human leukocyte antigen (HLA) matched donor derived latent membrane protein (LMP) specific-cytotoxic T cell lymphocytes (CTLs) in children, adolescents and young adults (CAYA) with Epstein barr virus (EBV)-associated refractory/relapsed Hodgkin Lymphoma (HL) following reduced intensity conditioning (RIC) and allogeneic hematopoietic stem cell transplantation (HSCT). This trial will be run by the Childhood, Adolescent and Young Adult (CAYA) Lymphoma Cell Therapy Consortium (LCTC). Enrollment of patients at the University of Utah will be covered under a separate IRB protocol (0062028, P.I. Michael Pulsipher MD).
This protocol only involves review of diagnostic biopsy tissues collected at participating institutions as a part of patient care. Additional studies may be performed on the tissues as needed to confirm the diagnosis, but no additional patient procedures are involved.
1. Determine elibility for the LCTC CTL therapy clinical trial by performing central pathology review of diagnostic specimens to confirm the diagnosis of Hodgkin lymphoma.
2. Determine elibility for the LCTC CTL therapy clinical trial by performing EBV studies on diagnostic pathology materials submitted for central pathology review.