Environment and Genes

Principal Investigator: Meghan Candee
Keywords: Multiple Sclerosis , MS , Sclerosis , Pediatric , Neurology Department: Pediatric Neurology
IRB Number: 00071459 Co Investigator:  
Specialty: Pediatric Neurology, Neurology
Sub Specialties: Multiple Sclerosis
Recruitment Status: Recruiting

Contact Information

JoAnn Narus
joann.narus@hsc.utah.edu
801-585-7497

Brief Summary

 

This study has the following hypotheses:

Hypothesis 1. Genes reported to increase MS susceptibility in adults also increase susceptibility in children.

Hypothesis 2. EBV and HSV-1, but not cytomegalovirus (CMV), varicella zoster virus (VZV), HSV-2, or Human Herpes virus (HHV)-6 infections increase MS risk in children.

Hypothesis 3. Vitamin D deficiency increases MS risk in children.

Hypothesis 4. Fetal and/or second-hand exposure to cigarette smoking increases MS risk in children.

Hypothesis 5. Several genetic and environmental risk factors contribute together to increased MS susceptibility.

 

This project has the following Specific Aims/Objectives:

Specific Aim 1. To determine whether genes known to increase MS susceptibility in adults also increase susceptibility in children.

Specific Aim 2. To determine whether remote infections with EBV, and other common viruses increase susceptibility to pediatric-onset MS.

Specific Aim 3. To determine whether vitamin D insufficiency increases the risk of developing pediatric-onset MS.

Specific Aim 4. To determine whether exposure to cigarette smoking increases the risk of developing pediatric-onset MS.

Specific Aim 5. To study predictive models for susceptibility to pediatric-onset MS. 

 

Inclusion Criteria

Children are eligible for this study as cases if:

          • They have MS or clinically isolated syndrome (CIS):

  • –  MS: As defined by the 2010 McDonald criteria for diagnosis of MS (Polman 2010),

  • –  CIS: A first demyelinating event indicating high risk for MS (i.e., one clinical event involving the spinal cord, the optic nerve, the brainstem or cerebellum, or occasionally the hemispheres) and at least 2 silent T2 bright areas on a brain or spinal cord MRI (at least one must be in the brain); AND

    They are three years of age or older; AND
    Disease onset occurred before 18 years of age. 

Control Inclusion Criteria: 21 years of age or younger, 3 years of age or older

For purposes of completing the environmental assessment portion of the study, parents can be biological parents, step-parents, foster parents, adoptive parents or parental figures of the participating subject.  The assessment has the option of "don't know" for every question in the event that the individual providing responses does not know the answer or chooses not to respond to certain questions or is not permitted to provide the information for any reason.

 

Exclusion Criteria

 

Patients are not eligible for study participation if:

  • Disease onset occurred more than 4 years prior to the opportunity to enroll; OR

  • They have had an organ transplant; OR

  • They are known to have neuromyelitis optica (NMO). Children are not eligible to participate as pediatric controls if:

  • They are two years of age or younger; OR

  • They are 22 years of age or older; OR

  • They are known to have MS or another demyelinating disease (for ex- ample, neuromyelitis optica or acute disseminated encephalomyelitis); OR

  • They have a biological family member who has been enrolled as a control; OR

  • They have an immediate, biological family member (parent/sibling) who has been diagnosed with MS; OR

  • They have an autoimmune disorder (except asthma or eczema); OR

  • They have had an organ transplant; OR

  • They have a chronic neurological condition with major disability (this does not include, for example, migraine, controlled seizures, and mild learning disabilities such as ADD or ADHD).