|Principal Investigator: Scott Mcnally|
|Keywords: Vessel MRI , Carotid Artery , Plaque inflammation||Department: Radiology Clinical|
|IRB Number: 00074088||Co Investigator: Dennis Parker|
|Sub Specialties: Magnetic Resonance Imaging – MRI|
|Recruitment Status: Recruiting|
We hypothesize that carotid plaque inflammation is associated with local and systemic inflammatory pathways, and these may serve as future treatment targets. We also hypothesize that carotid plaque inflammation markers are elevated in recent ipsilateral ischemic stroke.
Exclusion Criteria. We will exclude patients with a gadolinium contrast allergy, eGFR<30 ml/min/1.73 m2. If the patient has an eGFR<30, they may still receive a noncontrast examination for the evaluation of MRI markers of plaque inflammation on noncontrast MRI, including intraplaque hemorrhage. Patients with other contraindications to MRI (e.g. orbital shrapnel, pacemaker) will be excluded from the study. Exclusions will be made on the basis of safety and study goals only, without restriction in regard to gender, race, age, and socioeconomic status. Noncarotid stroke sources will not be excluded but instead will be recorded as confounders.
Up to $150 per participant