Principal Investigator: Eun-Kee  Jeong
Keywords: Spine imaging , MS , MRI Department: Radiology Research
IRB Number: 00076312 Co Investigator: John  Rose
Specialty: Radiology
Sub Specialties: Magnetic Resonance Imaging – MRI
Recruitment Status: Recruiting

Contact Information

Nousheen Alasti

Simple Summary

Aim 1. Validate if LoHi-B diffusion imaging accurately measures ICF/ECF in cervical spinal cord (CSC). Aim 2: Statistically quantify the variance in ICF, ECF, and BPF of normal volunteers and establish a normative database in the cervical spinal cord. Aim 3: Test whether ICF/ECF/BPF measured LoHi-B DWI provides increased diagnostic values about MS lesions in the CSC.

Inclusion Criteria

MS patients:

(1) Clinically definite relapsing/remitting or secondary progressive multiple sclerosis or CIS with presentation as acute partial transverse myelitis of the cervical cord,
(2) subject willing to have one or more MRI scans performed with gadolinium injection,
(3) EDSS score between 1 to 6.5, inclusive,
(4) on no therapy, or treatment with interferon or glatiramer acetate or dimehtlyl fumarate may be included.

Healthy volunteer:

Age and gender-matched normal subjects will also be recruited from the local population.

For all subjects, there will be an age range or 18-60 with no preference on sex or race, as long as the subject would tolerate the examination for an hour, and written informed consent will be collected prior to any testing under this protocol.

Exclusion Criteria

Candidates will be excluded from study entry if any of the following exclusion criteria exist
at the time of enrollment:
(1) Diagnosis of primary progressive MS defined as a gradual progression of disability from the onset without relapses,
(2) Concurrent, clinically significant (as determined by the investigator) cardiac, immunologic, pulmonary, neurological, renal, and/or other major diseases,
(3) If prior treatment was received, the subject must have been off of immunosuppressive treatment or IVIG for the required period prior to enrollment, 
(4) Unwillingness or inability to comply with the requirements of this protocol including the presence of any condition (physical, mental, or social) that is likely to affect the subject's returning for follow-up visits on schedule,
(5) History of adverse side effects with gadolinium or allergy to gadolinium.
(6) Pregnant women
(7) Individuals with pacemakers or magnetic metal implants or metal objects in their body such as shrapnel or metal in the eye.
(8) Patients with impaired kidney functions (unless the investigators want those patients to undergo the MRI without contrast).

Participant Reimbursement