Principal Investigator: Kevin Duff
Keywords: Memory , Cognitive Training , Mild Cognitive Impairment Department: Neurology
IRB Number: 00076422
Specialty: Neurology, Neurology
Sub Specialties: Dementia,
Recruitment Status: Recruiting

Contact Information

Kevin Duff

Simple Summary

The purpose of the study is to test the effectiveness of a computerized cognitive (thinking) training program on improving thinking and memory in patients with mild cognitive impairment. We also hope to learn how short term changes in thinking abilities can be related to improvement in thinking abilities after the cognitive training program

Inclusion Criteria


  1. Classified as Mild Cognitive Impairment (i.e., subjective memory complaints, objective memory deficits, largely intact cognition otherwise, no significant functional impairments), through a clinical diagnosis or a total score of >= 20 and immediate and delayed recall scores of < = 8 on the Modified Telephone Interview for Cognitive Status
  2. 65 years of age or older
  3. Availability of a collateral source (e.g. spouse, adult child, caregiver) who will be able to comment on the cognitive abilities and daily functioning of the subject
  4. Access to a computer with audio device like speakers or headphones and the internet. This access could be at home, work, community center, or public library.
  5. Adequate vision, hearing, and motor abilities to participate in training. 

Additional inclusion criteria for Optional Sub-Study:

  1. Medicare beneficiary
  2. Able to tolerate [18F] Flutemetamol-PET/CT scan, to be determined by imaging staff

Exclusion Criteria

  1. History of major neurological illness (e.g. stroke, head injury with loss of consciousness of >30 minutes) or other neurological disorder or systemic illness that would likely affect cognition (e.g., seizure disorder, demyelinating disorder, etc.)
  2. Current or past major psychiatric illness (e.g., schizophrenia, bipolar disorders) that would likely affect cognition
  3. History of substance abuse.
  4. Current use of antipsychotic or anticonvulsant medications.
  5. Currently residing in a nursing home or other skilled nursing facility.
  6. Current depression as identified by a score of >=15 on the 30-item Geriatric Depression Scale. 

Additional exclusion criteria for Optional Sub-Study:

  1. Evidence of stroke or mass lesion on CT or MRI scan
  2. History of radiation therapy to the brain
  3. Known allergic or hypersensitivity reactions to previously administered radiopharmaceuticals.
  4. Requirement for monitored anesthesia for imaging studies.
  5. Severe claustrophobia
  6. Currently pregnant

Participant Reimbursement

You will be compensated for your time, up to a total of $120 for completion of the study. You will receive $40 for the first two visits, $40 for the third visit, and $40 for the final visit.Payment will be given at three points during the study via a University of Utah check in the mail.