Principal Investigator: Michelle Schober
Keywords: TBI , Shunt , ADAPT , Traumatic Brain Injury Department: Pediatric Administration
IRB Number: 00081782
Specialty: Pediatric Neurosurgery
Sub Specialties:
Recruitment Status: Recruiting

Contact Information

Samuel Sorenson

Brief Summary

Primary Objectives

Evaluate the association of 6 aspects of pediatric TBI care with outcomes


Aim 1a: Determine the effect of CSF diversion strategies (continuous drainage, intermittent drainage and none) on outcome.

Aim 1b: Determine the effect of hyperosmolar therapies (hypertonic saline, mannitol) on outcome.

Aim 2: Compare the effectiveness of strategies that mitigate specific secondary insults on outcome.

Aim 3: Compare the effectiveness of strategies that provide metabolic support on outcome.

Inclusion Criteria


  • Admission to the PICU for treatment of severe traumatic brain injury
  • Placement of an ICP monitor
  • GCS ≤ 8 after resuscitation

          Age 0 - < 18 years (<216 months)

Exclusion Criteria

  • Pregnancy
  • ICP monitor placed at another hospital prior to study hospital