Principal Investigator: David Shprecher
Keywords: Parkinson's Disease , Colonoscopy , Alpha-synuclein , Dementia with Lewy bodies , Movement Disorder Department: Neurology
IRB Number: 00038453 Co Investigator:  
Specialty: Neurology, Neurology
Sub Specialties: Movement Disorders, Sleep Disorders
Recruitment Status: Recruiting

Contact Information

Anna Hartvigsen

Brief Summary

This study is designed to determine if it is possible to identify abnormal alpha-synuclein aggregates characteristic of the histopathology of a given neurodegenerative disease using colon biopsies obtained during a routine, medically indicated, colonoscopy. A total of 70 subjects with medical indication for colonoscopy will be recruited (20 Parkinson disease patients, 5 atypical parkinsonism, 10 with unexplained GI symptoms, and 35 normal controls. During the procedure, 4 colon biopsies will be obtained and reviewed for presence of abnormal alpha synuclein pathology.

Inclusion Criteria

All subjects and controls will be at least 30 years of age. Controls will be age-matched within +/- three years. A diagnosis of probable PD, Parkinsonian disorder, or no disorder will be confirmed by the PI. If confirmation can not be made by review of clinic or referring physician records, a full assessment will be made by the PI, either through a new clinical consultation or a study visit and examination by the PI. For subjects with medically unexplained constipation or diarrhea, this assessment will be determined by the referring physician.

Exclusion Criteria

Subjects with GI complaints will be excluded if they have any known neurodegenerative or other movement disorder. Subjects will be excluded from participating as controls if they have any history of a neurodegenerative or other movement disorder, exam evidence of parkinsonism (tremor, bradykinesia, or rigidity) or admit to chronic diarrhea or constipation. Absence of parkinsonism will be confirmed with a screening exam by the PI. Chronic constipation will be defined as having less than 1 bowel movement per day.