Principal Investigator: Christopher Peters
Keywords: Total Knee Arthroplasty , Arthrofibrosis , Manipulation Under Anesthesia , Outcomes Department: Orthopedic Surgery Operations
IRB Number: 00092327 Co Investigator: Chris Pelt
Specialty: Orthopaedic Surgery
Sub Specialties: Adult Reconstruction
Recruitment Status: Recruiting

Contact Information

Brenna Blackburn

Brief Summary

The purpose of this study is to determine the efficacy of manipulation under anesthesia (MUA), with and without perioperative oral celecoxib and intravenous (IV) corticosteroid.

Inclusion Criteria

1) Received Primary Total Knee Arthroplasty (TKA) for a diagnosis of osteoarthritis

2) Experience arthrofibrosis and are scheduled for manipulation under anesthesia within 6-10 weeks of primary TKA.


Exclusion Criteria

1) All primary TKA constructs will have constraint that is less than that of varus-valgus constraint (VVC). 

2) All VVC and hinged TKAs will be excluded. 

3) Intolerance to NSAIDs

2) Renal dysfunction

3) Age < 18 or > 90 years,  

4) Primary diagnosis of rheumatoid arthritis 

5) Patients with GFR <60 as the cut off for CKD (stage 3 CKD).  

6) Use of non-steroidal anti-inflammatory medications post-operatively, as well as during the first two weeks after manipulation under anesthesia will exclude patients from participation in this study. However, celecoxib (a non-steroidal anti-inflamatory medication) will be provided for those patients randomized to the experimental group, once daily for fourteen days following the manipulation under anesthesia. Aspirin, used routinely for DVT prophylaxis post-operatively, did not restrict patients from participation in this study.