|Principal Investigator: Stavros Drakos|
|Keywords: Heart Failure||Department: Cardiovascular Medicine|
|IRB Number: 00095106|
|Specialty: Cardiology, Cardiology|
|Sub Specialties: Heart Failure|
|Recruitment Status: Recruiting|
The purpose of this study is to facilitate potential reverse remodeling and myocardial recovery in end-stage heart failure patients supported with continuous-flow LVAD through applying a myocardial conditioning protocol.
The study will:
1) develop protocol for conditioning of myocardium (see study design section);
2) identify structural and functional changes (as assessed by standard echocardiography) resulting from the myocardial conditioning protocol;
3) evaluate the impact of this protocol on peripheral vascular function and sympathetic nervous system activity;
4) publish and disseminate results.
The objective is to condition/reload the myocardium to facilitate potential reverse remodeling and myocardial recovery as assessed by standard of care imaging tests that we regularly perform in these patients such as echocardiography.
A secondary aim is to evaluate peripheral vascular function and sympathetic nervous system activity as pump speed is chronically modulated and to track the time course of these measures after heart transplant.
- Either Gender
- ≥ 18 years of age
- Any ethnicity
- Diagnosed with heart failure undergoing LVAD implantation as a bridge to transplant (BTT)
- Enrolled in the Effects of Mechanical Unloading on Myocardial Function and Structure study (IRB 30622)
- Neither patient nor patient representative understands spoken English.
- Neither patient nor the patient’s personal representative is willing to give written consent for participation.
- Patients with heart failure related adverse events leading to hospitalization during the optimum unloading phase are excluded from participation in the controlled reloading phase.