Principal Investigator: Stavros Drakos
Keywords: Heart Failure Department: Cardiovascular Medicine
IRB Number: 00095106
Specialty: Cardiology, Cardiology
Sub Specialties: Heart Failure
Recruitment Status: Recruiting

Contact Information

John Kirk
john.kirk@hsc.utah.edu
801-585-2944

Brief Summary

Purpose

The purpose of this study is to facilitate potential reverse remodeling and myocardial recovery in end-stage heart failure patients supported with continuous-flow LVAD through applying a myocardial conditioning protocol.

The study will:

1) develop protocol for conditioning of myocardium (see study design section);

2) identify structural and functional changes (as assessed by standard echocardiography) resulting from the myocardial conditioning protocol;

3) evaluate the impact of this protocol on peripheral vascular function and sympathetic nervous system activity;

4) publish and disseminate results. 

Objective

The objective is to condition/reload the myocardium to facilitate potential reverse remodeling and myocardial recovery as assessed by standard of care imaging tests that we regularly perform in these patients such as echocardiography.

A secondary aim is to evaluate peripheral vascular function and sympathetic nervous system activity as pump speed is chronically modulated and to track the time course of these measures after heart transplant.

Inclusion Criteria

  1. Either Gender
  2. ≥ 18 years of age
  3. Any ethnicity
  4. Diagnosed with heart failure undergoing LVAD implantation as a bridge to transplant (BTT)
  5. Enrolled in the Effects of Mechanical Unloading on Myocardial Function and Structure study (IRB 30622)

 

Exclusion Criteria

  1. Neither patient nor patient representative understands spoken English.
  2. Neither patient nor the patient’s personal representative is willing to give written consent for participation.
  3. Patients with heart failure related adverse events leading to hospitalization during the optimum unloading phase are excluded from participation in the controlled reloading phase.