LIVE_HCM/LQTS

Principal Investigator: Omar Wever-Pinzon
Keywords: Hypertrophic Cardiomyopathy , HCM , HOCM Department: Div Of Cardiovascular Medicine
IRB Number: 00096080 Co Investigator:  
Specialty: Cardiology
Sub Specialties: Heart Failure
Recruitment Status: Recruiting

Contact Information

Jonathan Gutierrez
Jonathan.Gutierrez@utah.edu
8012133417

Brief Summary

Specific Aim 1: to compare the composite risk of death, cardiac arrest, ventricular arrhythmias, or syncope in patients with hypertrophic cardiomyopathy (HCM) or the Long QT Syndrome (LQTS) who are participating in moderate or vigorous exercise with sedentary patients.
 
Hypothesis: Among HCM patients (hypothesis 1a) and LQTS patients (1b) the risk of these endpoints will not be higher in those exercising moderately or vigorously than in the less active
 
Exploratory Aim 1: To determine what phenotypic, clinical, genotypic, and sports-related factors moderate the impact of exercise on this composite endpoint. This exploratory aim will be hypothesis-generating.
 
Specific Aim 2: To compare emotional and physical QOL in patients with HCM or LQTS who are participating in moderate or vigorous exercise with sedentary patients.
Hypothesis: Among HCM patients (hypothesis 2a) and LQTS patients (2b,) QOL will be greater in those patients exercising moderately or vigorously than in the less active
 
Exploratory Aim 2: To identify clinical and psychological variables which may moderate the impact of exercise on QOL. This exploratory aim will be hypothesis-generating.

Inclusion Criteria

Inclusion criteria:
HCM: Diagnosis by physician, with confirmation by study personnel of meeting criteria in
recent ACC/AHA guidelines for diagnosis and treatment of HCM (ref 12 below)
OR documented genotype if phenotype negative, IF other family members are phenotype
positive with same genotype. Patients must be able to independently answer age-appropriate
(child/adult) questionnaires for any reason.
LQTS: Diagnosis by physician, with confirmation by study personnel of meeting criteria in
recent HRS/EHRA/APHRS consensus statement on inherited primary arrhythmias (reference
23 below)OR documented genotypic diagnosis, regardless of phenotype. Patients must be
able to independently answer age-appropriate (child/adult) questionnaires for any reason.
 
 

Exclusion Criteria

Exclusion criteria:
Congestive heart failure predominantly Class III or IV
Comorbidities which would preclude ability to exercise (eg, wheelchair-bound, severe lung
disease)
Left ventricular hypertrophy or prolonged QT which occur as part of a multi-system
syndromic disorder