Principal Investigator: Laura Pace
Keywords: Ehler's-Danlos Syndrome , Dysautonomia , Permeability Department: Gastroenterology
IRB Number: 00100853
Specialty: Gastroenterology, Gastroenterology, Gastroenterology
Sub Specialties: Esophageal Diseases, GI Motility
Recruitment Status: Recruiting

Contact Information

Alyssa Mills

Brief Summary

Our purpose is to look at esophageal, stomach, and small intestinal permeability in a groups of Eosinophil Gastrointestinal Disorders and Dysautonomic Patients


1) To determine the permeability of the esophagus, stomach, and small bowel in patients with eosinophilic disease (with and without dysautonomia and/or Ehlers-Danlos Syndrome (EDS)) as compared to normals and patients with dysautonomia and/or EDS alone

2) To determine whether permeability decreases after therapy and to stratify improvement based upon therapeutic modality

3) To determine whether alteration of diet in patients will alter small bowel permeability regardless of whether they have overt small bowel involvement in disease.

4) To correlate clinical symptoms with permeability in each cohort

Inclusion Criteria

Participants will consist of 3 different groups

1. Eosinophilic gastroenteritis and esophagitis patients with a known history of >15 eos/HPF in the esophagus (n=35)

 - subset with dysautonomia symptoms and lab findings (n=10) - the rest (n=25) with eosinophilic esophagitis without dysautonomia symptoms

 - subsequently, eosinophilic patients who have controlled disease via dietary modification(n=20)

2. Dysautonomia and/or EDS patients without known eosinophilia patients (n=40)

3. Normal controls - without known GI disease or symptoms (n=15)

Exclusion Criteria


Comorbidities that preclude osmotic test for permeability (i.e. diabetes, severe heart disease, renal failure on daily diuretics or pulmonary hypertension)

Known compliance issues

Known contraindication to sucrose/lactose/mannitol administration