Principal Investigator: Ganeshsharma  Adluru
Keywords: MRI , Cardiac Artery disease Department: Radiology Research
IRB Number: 00100410 Co Investigator: Edward  DiBella
Specialty: Radiology, Radiology
Sub Specialties: Cardiac Imaging, Magnetic Resonance Imaging – MRI
Recruitment Status: Recruiting

Contact Information

Nousheen Alasti
nousheen.alasti@hsc.utah.edu
(801)585-6142

Simple Summary

To develop improved MRI acquisition and reconstruction methods and ensure that the tools we develop will be clinically relevant and characterized. Aim 1: To obtain significantly higher slice coverage than existing methods for ungated free-breathing cardiac perfusion and late gadolinium enhancement MRI by developing novel simultaneous multi-slice techniques. Aim 2: To compare the performance of the proposed ungated free breathing radial SMS MRI methods with existing gated MRI methods. Aim 3: To evaluate the accuracy of the proposed ungated free breathing radial SMS MRI protocol for ischemic burden estimation in CAD patients.

Detailed Description

The objectives should be stated in such a way that the reader can determine the appropriateness of the study design. If appropriate, state the specific hypotheses being tested and/or study aims. Use lay language.To develop improved MRI acquisition and reconstruction methods and ensure that the tools we develop will be clinically relevant and characterized. Aim 1: To obtain significantly higher slice coverage than existing methods for ungated free-breathing cardiac perfusion and late gadolinium enhancement MRI by developing novel simultaneous multi-slice techniques. Aim 2: To compare the performance of the proposed ungated free breathing radial SMS MRI methods with existing gated MRI methods. Aim 3: To evaluate the accuracy of the proposed ungated free breathing radial SMS MRI protocol forischemic burden estimation in CAD patients.

Inclusion Criteria

Characteristics of participants: 

  • 18 years and older
  • Healthy volunteers with no known history of coronary artery disease, or
  • Patient subjects will either have suspected or known CAD, or with a prior history of myocardial infarction (MI), or 
  • Clinically CAD positive SPECT imaging.

Group One: Control subjects (half with no known history of coronary artery disease and half with known or suspected coronary artery disease) will be enrolled to generate ground truth data for development and testing of radial SMS and image reconstruction methods.

Group Two: Patients with suspected CAD or with a prior history of myocardial infarction (MI) will be enrolled to compare the proposed ungated free breathing radial SMS MRI acquisition and reconstruction methods with standard gated MRI acquisitions.
 
Group Three: Patients with clinically positive SPECT imaging will be enrolled to evaluate the accuracy of new ungated free-breathing MRI methods in computing the ischemic burden as compared to the measures obtained from SPECT imaging.
 
Only participants who are able to provide consent will be included the study.

Exclusion Criteria

  • Can not provide informed consent,
  • Critically ill, on ventilators, unstable angina or with hypotension, asthmatics, and other medical conditions that safety may be at risk from undergoing an MRI examination
  • Claustrophobia.
  • Contraindication to MRI (pacemaker, metal implants, or certain types of heart valves)
  • Abnormal kidney function defined as eGFR < 30 mL/min/1.73 m2, 
  • Mentally disabled,
  • Pregnant women.

Any university student or staff member who directly reports to the PI or reports to someone who reports directly to the PI will be excluded from the study in order to avoid ethical concerns.

Participant Reimbursement

Up to $150 per participant