Principal Investigator: Sarah Morimoto
Keywords: Depression , Geriatric , Post-stroke , cognitive remediation Department: Adult Psychiatry
IRB Number: 00103167 Co Investigator: zKolby zLeonardi
Specialty: Psychiatry
Sub Specialties: Mood Disorders
Recruitment Status: Not yet recruiting

Contact Information

zKolby zLeonardi

Brief Summary

The primary objective of the study is to test the tolerability and effectiveness of the computerized cognitive remediation in geriatric depression (CCR-GD) protocol in elderly depressed patients and elderly controls. Secondarily, we will explore whether the proposed protocol improves both depressive and cognitive symptoms associated with late life depression more than a control condition.

This study is intended as a pilot study to serve to provide information and data that will be used to improve the intervention for future randomized controlled trials. Because this is a pilot study it is not adequately powered to test these hypotheses. 

Inclusion Criteria

Medicated Depressed Participants

Inclusion Criteria

1. Age: 55-89 years

2. Diagnosis: Major depression, unipolar (by DSM-IV criteria);

3. Severity of depression: MADRS >or =15 following at least 8-weeks of controlled antidepressant treatment.

4. No plans to change current antidepressant treatment.


Non-Medicated Depressed Participants Inclusion Criteria

1. Age: 60-89 years

2. Diagnosis: Major depression, unipolar (by DSM-IV criteria);

3. Severity of depression: MADRS >or =15

4. No antidepressant treatment within the current episode.




Control Participants Inclusion Criteria

1.55-89 years

Exclusion Criteria

Exclusion Criteria (Depressed)

1. Psychotic depression by DSM-IV, i.e., presence of delusions with a score higher than 2 (questionable delusion) rated by the Scale for Assessment of Positive Symptoms (SAPS) [47];

2. High suicide risk, i.e. intent or plan to attempt suicide in near future;

3. Presence of any Axis I psychiatric disorder (other than unipolar major depression) or substance abuse; Axis II diagnosis of antisocial personality (by SCID-P and DSM-IV);

4. History of psychiatric disorders other than unipolar major depression or generalized anxiety disorder (bipolar disorder, hypomania, and dysthymia are exclusion criteria);

5. Dementia: Mattis Dementia Rating Scale scores below 130 or diagnosis of dementia by DSM-IV; multiple sclerosis, history of head trauma or history of electroconvulsive therapy;

6. Amnestic Mild Cognitive Impairment (a-MCI), or Multiple Domain Mild Cognitive Impairment (md-MCI);

7. Acute or severe medical illness, i.e., delirium, metastatic cancer, decompensated cardiac, liver or kidney failure, major surgery, stroke or myocardial infarction during the three months prior to entry; or drugs known to cause depression, e.g., reserpine, alpha-methyl-dopa, steroids, sympathomimetics withdrawal; Presence of a neurological brain disease and/or history of electroconvulsive therapy;

8. Current involvement in psychotherapy;

9. Inability to perform any of the ADLs (MAI: ADL subscale) even with assistance, e.g. walking with a cane is not an exclusion criterion;

10. Inability to speak English;

11. Aphasia;

12. Corrected visual acuity < 20/70; Color blindness