Principal Investigator: Sarah Morimoto
Keywords: Depression , Geriatric , Post-stroke , cognitive remediation Department: Adult Psychiatry
IRB Number: 00103167 Co Investigator: zKolby zLeonardi
Specialty: Psychiatry
Sub Specialties: Mood Disorders
Recruitment Status: Not yet recruiting

Contact Information

zKolby zLeonardi
kolby.leonardi@hsc.utah.edu
801-829-7382

Brief Summary

The primary objective of the study is to test the tolerability and effectiveness of the computerized cognitive remediation in geriatric depression (CCR-GD) protocol in elderly depressed patients and elderly controls. Secondarily, we will explore whether the proposed protocol improves both depressive and cognitive symptoms associated with late life depression more than a control condition.

This study is intended as a pilot study to serve to provide information and data that will be used to improve the intervention for future randomized controlled trials. Because this is a pilot study it is not adequately powered to test these hypotheses. 

Inclusion Criteria

Medicated Depressed Participants

Inclusion Criteria

1. Age: 55-89 years

2. Diagnosis: Major depression, unipolar (by DSM-IV criteria);

3. Severity of depression: MADRS >or =15 following at least 8-weeks of controlled antidepressant treatment.

4. No plans to change current antidepressant treatment.

 

Non-Medicated Depressed Participants Inclusion Criteria

1. Age: 60-89 years

2. Diagnosis: Major depression, unipolar (by DSM-IV criteria);

3. Severity of depression: MADRS >or =15

4. No antidepressant treatment within the current episode.

 

 

 

Control Participants Inclusion Criteria

1.55-89 years

Exclusion Criteria

Exclusion Criteria (Depressed)

1. Psychotic depression by DSM-IV, i.e., presence of delusions with a score higher than 2 (questionable delusion) rated by the Scale for Assessment of Positive Symptoms (SAPS) [47];

2. High suicide risk, i.e. intent or plan to attempt suicide in near future;

3. Presence of any Axis I psychiatric disorder (other than unipolar major depression) or substance abuse; Axis II diagnosis of antisocial personality (by SCID-P and DSM-IV);

4. History of psychiatric disorders other than unipolar major depression or generalized anxiety disorder (bipolar disorder, hypomania, and dysthymia are exclusion criteria);

5. Dementia: Mattis Dementia Rating Scale scores below 130 or diagnosis of dementia by DSM-IV; multiple sclerosis, history of head trauma or history of electroconvulsive therapy;

6. Amnestic Mild Cognitive Impairment (a-MCI), or Multiple Domain Mild Cognitive Impairment (md-MCI);

7. Acute or severe medical illness, i.e., delirium, metastatic cancer, decompensated cardiac, liver or kidney failure, major surgery, stroke or myocardial infarction during the three months prior to entry; or drugs known to cause depression, e.g., reserpine, alpha-methyl-dopa, steroids, sympathomimetics withdrawal; Presence of a neurological brain disease and/or history of electroconvulsive therapy;

8. Current involvement in psychotherapy;

9. Inability to perform any of the ADLs (MAI: ADL subscale) even with assistance, e.g. walking with a cane is not an exclusion criterion;

10. Inability to speak English;

11. Aphasia;

12. Corrected visual acuity < 20/70; Color blindness