Principal Investigator: Jana Wold
Keywords: Ischemic Stroke , TIA , cPAP , OSA Department: Neurology
IRB Number: 00118579 Co Investigator: Adam  DeHavenon
Specialty: Sleep Medicine, Neurology
Sub Specialties: Stroke
Recruitment Status: Recruiting

Contact Information

Theodore Rock
theodore.rock@hsc.utah.edu
801-585-0541

Brief Summary

To test whether treatment of OSA with aCPAP after recent stroke or high-risk TIA prevents recurrent stroke, acute coronary syndrome, or death.

 

To test whether treatment of OSA with aCPAP after recent ischemic stroke improves recovery.

 

To determine whether aCPAP for OSA after recent stroke improves neurological recovery, improves cognitive function, or improves quality of life at 3 months.

Detailed Description

The primary goals of this study are to determine whether treatment of OSA with positive airway pressure starting shortly after acute ischemic stroke or high risk TIA (1) reduces recurrent stroke, acute coronary syndrome, and all-cause mortality 6 months after the event, and (2) improves stroke outcomes at 3 months in patients who experienced an ischemic stroke.

Inclusion Criteria

1.       Age ≥18

2.       TIA with ABCD2 ≥4 or ischemic stroke, within the prior 14 days.

Exclusion Criteria

1.       pre-event inability to perform all of own basic ADLs

2.       unable to obtain informed consent from subject or legally authorized representative

3.       incarcerated

4.       known pregnancy

5.       current mechanical ventilation (can enroll later if this resolves) or tracheostomy

6.       current use of positive airway pressure, or use within one month prior to stroke

7.       anatomical or dermatologic anomaly that makes use of CPAP interface unfeasible

8.       severe bullous lung disease

9.       history of prior spontaneous pneumothorax or current pneumothorax

10.     hypotension requiring current treatment with pressors (can enroll later if this resolves)

11.     other specific medical circumstances that conceivably, in the opinion of the site PI, could render the patient at risk of harm from use of CPAP

12.     massive epistaxis or previous history of massive epistaxis

13.     cranial surgery or head trauma within the past 6 months, with known or possible CSF leak or pneumocephalus

14.     recent hemicraniectomy or suboccipital craniectomy (i.e. those whose bone has not yet been replaced), or any other recent bone removal procedure for relief of intracranial pressure

15.     current receipt of oxygen supplementation via face mask