Principal Investigator: Scott Tadler
Keywords: EEG Department: Anesthesiology
IRB Number: 00124302
Specialty: Psychiatry
Sub Specialties:
Recruitment Status: Recruiting

Contact Information

Rebecca Jacobs
rebecca.jacobs@utah.edu
8018297382

Brief Summary

The research questions are: 1) How do ECT and ketamine affect patients' EEG characteristics around the time of treatment? and 2) Do any of these noted characteristics correlate with clinical outcomes?

Objectives


1)    Using EEG, characterize the neurophysiological effect of ketamine infusion and ECT treatment on patients with treatment resistant depression


a.    Characterize the immediate (first 60 minutes) post-treatment changes in EEG
b.    Characterize the within treatment effects
c.    Characterize the pretreatment effects


2)    Correlate EEG changes with behavioral, perceptual and cognitive responses

Currently collected as part of clinical practice:


a.    QIDS before each treatment 
b.    PROMIS
c.    CGI

Will collect for research purposes (only for ketamine treatments):

d.    Ketamine Experience Scale

e.    MEQ-30
 

Inclusion Criteria

Inclusion criteria:

1) DSM-5 Major Depressive Disorder or Bipolar Disorder

2) Current moderate to severe depressive episode with QIDS>10

3) Patients must be 18 years of age or older 

4) Patients must have the cognitive and decision making capacity to consent

5) Elected to undergo clinical treatment with ketamine infusions after consultation by and per the recommendation of a responsible Psychiatrist at the University Neuropsychiatric Institute (UNI) Treatment Resistant Mood Disorders (TRMD) Clinic

** Please note**

All clinical assessments and evaluation for suitability and treatment safety are done as part of normal clinical practice.  The only study related procedure will be to record and analyze the EEGs and to add the 2 specified questionnaires.

 

 

Exclusion Criteria

1) Allergy to adhesive or conducting materials (gel) of the frontal eeg electrode

2) Patient refusal or other clinical contraindication to treatment (based on clinical decisions that are not part of the study) .

**Please note** 

As specified above this study only involves recording and analyzing EEGs and two additional questionnaires. No treatment decisions will be made based on EEG information, additional questionnair responses and treating doctors will be blinded to these.