Principal Investigator: Kathryn Peterson
Keywords: Healthy volunteers , gastrointestinal mucosa Department: Gastroenterology
IRB Number: 00127286
Specialty: Gastroenterology, Gastroenterology
Sub Specialties: Endoscopy
Recruitment Status: Completed

Contact Information

Tiffany Tomkinson

Brief Summary

Aim:To define the normal cellular and protein milieu and involvement throughout the GI tract in participants without symptoms. 

We propose to recruit true normal participants for endoscopic evaluation. Participants will consent to upper endoscopy with biopsies of esophagus, stomach and small bowel for analysis and/or lower endoscopy with biopsies of the ileum, ascending colon, transverse colon, descending colon, sigmoid colon, and rectum.. This is the first study to specifically recruit only normal participants to evaluate. Other studies have been done with endoscopy in diseased states which are more likely to result in adverse outcomes.

Inclusion Criteria

Inclusion: Ages 18-70

Healthy volunteers:

Over 25% of healthy screening colons have polyps and there is no guarantee they are healthy and may over 50 will be taking NSAIDS and other medications that can affect the GI tract- additionally, this way we can capture a range of ages - not just those over  50 to adequately sample what normal colonic tissue does throughout age groups. Thus, we will need to enroll healthy controls and not screening colonoscopy patients. 

In our tissue bank, it is not common to get totally healthy people in screening... often they are on PPI etc...which can alter the findings This way we are much more selective and can make sure they qualify - and get some additional age ranges. 

25 for upper endoscopy and 25 for lower endoscopy 

Exclusion Criteria

No current GI complaints greater than once a month (i.e. diarrhea, reflux or heartburn, bloating)

Without current autoimmune or metabolic disease

Intolerance of sedation

Sleep apnea

NSAIDS or ASA consumption greater than once every 2 weeks

Current autoimmune disease or metabolic disease

Pregnant and breastfeeding females

Complaints of heartburn, dysphagia, abdominal pain, bloating (requiring medical evaluation), loose stool greater than 3 times a day more than once a month

Any complaints of dysphagia or blood in stool

History of surgery of the foregut or colon

Iron deficiency anemia

Any current condition or symptoms which are deemed risk factors for GI disease as determined by the primary investigator

Chronic use of medications thought to alter GI issues as determined by the primary investigator (i.e. alendronate, potassium, etc).

Bleeding diathesis or current use of blood thinners other than aspirin (but aspirin must be discontinued within 1 month of the procedure if taken via patient choice and not physician directed)

No employees will be enrolled if: 

     1. they are directly supervised by an investigator (PI or sub-I) of the research

     2. their direct supervisor reports to an investigator (PI or sub-I) of the research