|Principal Investigator: Brian Mickey|
|Keywords: MRI , Brain Scan , Healthy Comparison Participants||Department: Psychiatry|
|IRB Number: 00138372|
|Recruitment Status: Recruiting|
The Neural and Antidepressant Effects of Propofol (NAP) Study is evaluating propofol's impact on brain function in participants with treatment-resistant depression.
This NAP-HC companion study is a minimal-risk, observational study of healthy comparison (HC) subjects that has the following specific aims:
Aim 1: Quantify differences in neurochemistry and brain functional connectivity between depressed and HC groups.
Aim 2: Evaluate the reproducibility of brain functional measures acquired weeks apart.
Age 18-55 years
16-item Quick Inventory of Depressive Symptomatology (self-rated) < 6
Contraindication to MRI
Body mass index > 40 kg/m2
Daily use of psychotropic medication
Poorly controlled medical condition
Pregnant or breast feeding
Traumatic brain injury or significant neurologic signs (past year)
History of psychiatric disorder (lifetime)
Substance use disorder, moderate-to-severe (past 3 months)
Neurocognitive disorder (past year)
Incompetent to provide consent