Principal Investigator: Muharrem Baytunca
Keywords: schizophrenia , hypoxia , phosphorus magnetic resonance spectroscopy Department: Adult Psychiatry
IRB Number: 00138477 Co Investigator: Perry Renshaw
Specialty: Psychiatry
Sub Specialties:
Recruitment Status: Not yet recruiting

Contact Information

Muharrem Baytunca
burak.baytunca@hsc.utah.edu
8572008904

Brief Summary

The primary aim of this study is to evaluate and compare the mitochondrial functioning of schizophrenia patients and healthy controls (HC) by comparing cellular bioenergetics before and after hypoxic stress. We primarily hypothesized that schizophrenia patients will show impaired compensatory response compared to HC when hypoxic stress induced. This compensatory response will be assessed by the quantification of high energy phosphate molecules which will also enable us to indirectly investigate the CK forward rate.  The antioxidant defense mechanisms are required for the maintenance of balanced ROSs (reactive oxygen species) generated via oxidation/reduction (ox/redox) reactions, which is energy dependent. The second component is to evaluate the alteration in the oxidized and reduced oxidized forms of glutathione molecules in plasma at baseline and following hypoxia challenge. The third component of this study is to compare plasma polyamine levels, which are NMDA receptor modulators, of schizophrenia subjects vs healthy controls before and after hypoxia experiment.

Detailed Description

The primary aim of this study is to evaluate and compare the mitochondrial functioning of schizophrenia patients and healthy controls (HC) by comparing cellular bioenergetics before and after hypoxic stress. We primarily hypothesized that schizophrenia patients will show impaired compensatory response compared to HC when hypoxic stress induced. This compensatory response will be assessed by the quantification of high energy phosphate molecules which will also enable us to indirectly investigate the CK forward rate.  The antioxidant defense mechanisms are required for the maintenance of balanced ROSs (reactive oxygen species) generated via oxidation/reduction (ox/redox) reactions, which is energy dependent. The second component is to evaluate the alteration in the oxidized and reduced oxidized forms of glutathione molecules in plasma at baseline and following hypoxia challenge. The third component of this study is to compare plasma polyamine levels, which are NMDA receptor modulators, of schizophrenia subjects vs healthy controls before and after hypoxia experiment.

Inclusion Criteria

1- Chronic schizophrenia patients aged 18-65 years old

2- Lack of neurological deficits/disorders, clinically significant cardiovascular, pulmonary     disorders, alcohol and other substance use disorders

3- Lack of clinically significant intellectual disability

4- Being capable of providing valid informed consent

5 - Healthy counterparts in the same age group with similar gender balance will be included as the comparison group. Relevant interview scales PANNS, Young Mania Rating Scale [for schizoaffective patients] will be utilized to rule out mental disorders.

6- Lack of suicidal ideation, recent suicidal behavior or aborted suicide attempt in the past one month

Exclusion Criteria

1- Alcohol or substance use or a positive screen for drugs of abuse at the screening visit

2- History of known or suspected mental retardation

3- Contraindication to MRI scanning, e.g. ferrometallic implant

4- History of clinically significant claustrophobia

5- History of pulmonary disease, decompensated heart failure, seizure disorder, unstable medical conditions

6- Need of baseline oxygen treatment

7- Concurrent participation in another clinical study in which the subject has been exposed to an investigational or non-investigational drug

8- Presence of acute psychotic break, manic episode, suicide attempt within 1 month prior to study participation

9- Pregnant women and breastfeeding women will be excluded

10-Individuals who report directly to the investigators of this study or report to a supervisor who reports to the investigators of this project will not be enrolled in this study.

11- individuals displaying active suicidal ideation or who have had preparatory suicidal behavior or aborted suicide attempt in the past month

12- Individuals involuntarily held as a result of a psychiatric condition, or involuntarily confined for any reason, will be excluded from participation