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Linda S. Book

Linda S. Book, MD

Languages spoken: English

Clinical Locations

Eccles Primary Children's Outpatient Services Building

Salt Lake City
801-662-2940
  • Dr. Linda Book graduated from the University Of Cincinnati College Of Medicine, completed a pediatric residency at Cincinnati Children’s Medical Center and the University of Utah followed by fellowship training in Pediatric Gastroenterology at the University of Utah. She is a Professor of Pediatrics and is the former Chief of the Division of Pediatric Gastroenterology Hepatology and Nutrition at the University Of Utah College Of Medicine. She is the Director of the Pediatric Liver Transplant Program and Liver Center at Primary Children’s Medical Center. She has over 25 years’ experience compassionately caring for infants, children and adolescents with liver disease including those needing before and after liver transplant care. She is particularly proud to be part of the Primary Children’s Hospital liver transplant team, which has one of the best patient outcomes in the U.S. Dr.Book has worked extensively at the regional and national levels to prioritize organ allocation to children and in the development of living donor liver transplantation She is interested in quality improvement and care models for in and outpatient transplant care, and the transitioning of adolescents to adult transplant care.. Her current research interests are biliary atresia, cholestatic liver disease and pediatric liver transplantation. She received the American Academy of Pediatrics Utah Chapter Service to Children Award and the American Academy of Pediatrics Murray Davidson Award, which recognizes clinical, teaching and research excellence in pediatric gastroenterology. She is recognized in the Hall of Honor of the Cincinnati Children’s Hospital Medical Center. Dr. Book has held numerous national leadership positions in the American Academy of Pediatrics, Society of Pediatric Liver Transplantation and North American Society for Pediatric Gastroenterology Hepatology and Nutrition.

    Board Certification

    American Board of Pediatrics (Pediatrics)
    American Board of Pediatrics (Sub: Pediatric Gastroenterology)
    National Board of Medical Examiners
    Pediatric Transplant Hepatolgoy - Subspecialty
  • Dr. Linda Book graduated from the University Of Cincinnati College Of Medicine, completed a pediatric residency at Cincinnati Children’s Medical Center and the University of Utah followed by fellowship training in Pediatric Gastroenterology at the University of Utah. She is a Professor of Pediatrics and is the former Chief of the Division of Pediatric Gastroenterology Hepatology and Nutrition at the University Of Utah College Of Medicine. She is the Director of the Pediatric Liver Transplant Program and Liver Center at Primary Children’s Medical Center. She has over 25 years’ experience compassionately caring for infants, children and adolescents with liver disease including those needing before and after liver transplant care. She is particularly proud to be part of the Primary Children’s Hospital liver transplant team, which has one of the best patient outcomes in the U.S. Dr.Book has worked extensively at the regional and national levels to prioritize organ allocation to children and in the development of living donor liver transplantation She is interested in quality improvement and care models for in and outpatient transplant care, and the transitioning of adolescents to adult transplant care.. Her current research interests are biliary atresia, cholestatic liver disease and pediatric liver transplantation. She received the American Academy of Pediatrics Utah Chapter Service to Children Award and the American Academy of Pediatrics Murray Davidson Award, which recognizes clinical, teaching and research excellence in pediatric gastroenterology. She is recognized in the Hall of Honor of the Cincinnati Children’s Hospital Medical Center. Dr. Book has held numerous national leadership positions in the American Academy of Pediatrics, Society of Pediatric Liver Transplantation and North American Society for Pediatric Gastroenterology Hepatology and Nutrition.

    Board Certification and Academic Information

    Academic Departments Pediatrics -Primary
    Academic Divisions Gastroenterology
    Board Certification
    American Board of Pediatrics (Pediatrics)
    American Board of Pediatrics (Sub: Pediatric Gastroenterology)
    National Board of Medical Examiners
    Pediatric Transplant Hepatolgoy - Subspecialty

    Education history

    Fellowship Cystic Fibrosis - University of Utah School of Medicine Fellow
    Pediatric Gastroenterology Hepatology and Nutrition - University of Utah School of Medicine Fellow
    Residency Pediatrics - University of Utah School of Medicine Resident
    Pediatrics - Children's Hospital of Cincinnati Intern
    Professional Medical Medicine - University of Cincinnati M.D.
    Biology - Marietta College B.S.

    Selected Publications

    Journal Article

    1. Lopez-Verdugo F, Sanchez-Garcia J, Baraki S, Kastenberg ZJ, Sanchez-Garavito JE, Zendejas I, Alonso D, Jensen MK, Fujita S, Meyers RL, Book L, Rodriguez-Davalos MI (2023). Utilization of Segmental Grafts Is Associated With Higher Transplant Rates in Pediatric Patients. J Surg Res, 290, 28-35. (Read full article)
    2. Kastenberg ZJ, Deneau MR, OBrien EA, Huynh K, Book LS, Srivastava R, Jensen MK, Jaramillo CM, Guthery SL (2023). Fractionated Bilirubin Among 252 892 Utah Newborns with and Without Biliary Atresia: A 15-year Historical Birth Cohort Study. J Pediatr, 257, 113339. (Read full article)
    3. Blachman-Braun R, Lopez-Verdugo F, Alonso D, Book L, Feola GP, Rodriguez-Davalos MI (2019). Revision of meso-Rex bypass utilizing a collateral vein in a patient with portal steal phenomenon after liver transplant: A case report. Int J Surg Case Rep, 60, 230-233. (Read full article)
    4. Jackson WD, Book LS (2015). Nonalcoholic fatty liver disease and dyslipidemia: the beleagured hepatocyte. J Pediatr Gastroenterol Nutr, 60(3), 287. (Read full article)
    5. Elizabeth Parsons C, Nelson R, Book LS, Kyle Jensen M (2014). Renal replacement therapy in infants and children with hepatorenal syndrome awaiting liver transplantation: a case-control study. Liver Transpl, 20(12), 1468-74. (Read full article)
    6. Deneau M, Book LS, Guthery SL, Jensen MK (2014). Outcome after discontinuation of immunosuppression in children with autoimmune hepatitis: a population-based study. J Pediatr, 164(4), 714-719.e2. (Read full article)
    7. Deneau M, Jensen MK, Holmen J, Williams MS, Book LS, Guthery SL (2013). Primary sclerosing cholangitis, autoimmune hepatitis, and overlap in Utah children: epidemiology and natural history. Hepatology, 58(4), 1392-400. (Read full article)
    8. Deneau M, Jensen MK, Holmen J, Williams MS, Book LS, Guthery LS (2013). Primary Sclerosing Cholangitis, Autoimmune Hepatitis and Overlap in Utah Children: Epidemiology and natural History. Hepatology, 00(00).
    9. Rollins MD, Ward RM, Jackson WD, Mulroy CW, Sencer CP, Ying, J, Greene T, Book LS (2013). Effect of decreased parenteral soybean lipid emulsion on hepatic function in infants at risk for parenteral nutrition-associated liver disease: A pilot study. J Pediatr Surg, 48, 1348-1356.
    10. Kim RD, Book L, Haafiz A, Schwartz JJ, Sorensen JB, Gonzalez-Peralta RP (2011). Liver transplantation in a 7-month-old girl with Caroli's disease. J Pediatr Surg, 46(8), 1638-41. (Read full article)
    11. Martin SR, Alvarez F, Anand R, Song C, Yin W, SPLIT Research Group (2011). Outcomes in children who underwent transplantation for autoimmune hepatitis. Liver Transpl, 17(4), 393-401. (Read full article)
    12. Jaskowski TD, Donaldson MR, Hull CM, Wilson AR, Hill HR, Zone JJ, Book LS (2010). Novel screening assay performance in pediatric celiac disease and adult dermatitis herpetiformis. J Pediatr Gastroenterol Nutr, 51(1), 19-23. (Read full article)
    13. Rollins MD, Scaife ER, Jackson WD, Meyers RL, Mulroy CW, Book LS (2010). Elimination of soybean lipid emulsion in parenteral nutrition and supplementation with enteral fish oil improve cholestasis in infants with short bowel syndrome. Nutr Clin Pract, 25(2), 199-204. (Read full article)
    14. Ng VL, Fecteau A, Shepherd R, Magee J, Bucuvalas J, Alonso E, McDiarmid S, Cohen G, Anand R, Studies of Pediatric Liver Transplantation Research Group (2008). Outcomes of 5-year survivors of pediatric liver transplantation: report on 461 children from a north american multicenter registry. Pediatrics, 122(6), e1128-35. (Read full article)
    15. Donaldson MR, Book LS, Leiferman KM, Zone JJ, Neuhausen SL (2008). Strongly positive tissue transglutaminase antibodies are associated with Marsh 3 histopathology in adult and pediatric celiac disease. J Clin Gastroenterol, 42(3), 256-60. (Read full article)
    16. Donaldson MR, Firth SD, Wimpee H, Leiferman KM, Zone JJ, Horsley W, OGorman MA, Jackson WD, Neuhausen SL, Hull CM, Book LS (2007). Correlation of duodenal histology with tissue transglutaminase and endomysial antibody levels in pediatric celiac disease. Clin Gastroenterol Hepatol, 5(5), 567-73. (Read full article)
    17. Garner CP, Ding YC, Steele L, Book L, Leiferman K, Zone JJ, Neuhausen SL (2007). Genome-wide linkage analysis of 160 North American families with celiac disease. Genes Immun, 8(2), 108-14. (Read full article)
    18. Tsou VM, Baker R, Book L, Hammo AH, Soffer EF, Wang W, Comer GM (2006). Multicenter, randomized, double-blind study comparing 20 and 40 mg of pantoprazole for symptom relief in adolescents (12 to 16 years of age) with gastroesophageal reflux disease (GERD). Clin Pediatr (Phila), 45(8), 741-9. (Read full article)
    19. Donaldson M, Book L, Zone J, Neuhausen S (2006). Strongly Positive Tissue Transglutaminase Antibodies Are Associated With Marsh 3 Histopathology in Adult and Pediatric Disease. J Clin Gastroenterol.
    20. Meyers RL, Book LS, OGorman MA, White KW, Jaffe RB, Feola PG, Hedlund GL (2004). Percutaneous cholecysto-cholangiography in the diagnosis of obstructive jaundice in infants. J Pediatr Surg, 39(1), 16-8. (Read full article)
    21. Lowichik A, Book L (2003). Pediatric Celiac Disease: Clinicopathologic and Genetic Aspects. Pediatr Dev Pathol. (Read full article)
    22. Meyers RL, Book LS, OGorman MA, Jackson WD, Black RE, Johnson DG, Matlak ME (2003). High-dose steroids, ursodeoxycholic acid, and chronic intravenous antibiotics improve bile flow after Kasai procedure in infants with biliary atresia. J Pediatr Surg, 38(3), 406-11. (Read full article)
    23. Book L, Zone JJ, Neuhausen SL (2003). Prevalence of celiac disease among relatives of sib pairs with celiac disease in U.S. families. Am J Gastroenterol, 98(2), 377-81. (Read full article)
    24. Meyers R, Book L, OGorman M, Jackson D, Black R, Downey E, Johnson D, Matlak M, Scaife E (2003). High dose Steroids, Ursodeoxycholic Acid, and Chronic IV Antibiotics Improve Bile Flow after Kasai Procedure in Infants with Biliary Atresia. J Pediatr Surg, 38(3), 406-411.
    25. Book L, Lowichik A (2003). Pediatric Celiac disease in the 21st century. XXIV(9), 325-333.
    26. Neuhausen SL, Feolo M, Camp NJ, Farnham J, Book L, Zone JJ (2002). Genome-wide linkage analysis for celiac disease in North American families. Am J Med Genet, 111(1), 1-9. (Read full article)
    27. Book LS (2002). Diagnosing celiac disease in 2002: who, why, and how? Pediatrics, 109(5), 952-4. (Read full article)
    28. Book L, Hart A, Black J, Feolo M, Zone JJ, Neuhausen SL (2001). Prevalence and clinical characteristics of celiac disease in Downs syndrome in a US study. Am J Med Genet, 98(1), 70-4. (Read full article)
    29. Neuhausen SL, Feolo M, Farnham J, Book L, Zone JJ (2001). Linkage analysis of HLA and candidate genes for celiac disease in a North American family-based study. BMC Med Genet, 2(1), 12. (Read full article)
    30. Lewis C, Book L, Black J, Sawitzke A, Cannon-Albright L, Zone J, Neuhausen S (2000). Celiac disease and human leukocyte antigen genotype: accuracy of diagnosis in self-diagnosed individuals, dosage effect, and sibling risk. J Pediatr Gastroenterol Nutr, 31(1), 22-7. (Read full article)
    31. Bousvaros A, Leichtner AM, Book L, Shigeoka A, Bilodeau J, Semeao E, Ruchelli E, Mulberg AE (1996). Treatment of pediatric autoimmune enteropathy with tacrolimus (FK506). Gastroenterology, 111(1), 237-43. (Read full article)

    Review

    1. Lowichik A, Book L (2004). Pediatric celiac disease: clinicopathologic and genetic aspects. [Review]. Pediatr Dev Pathol, 6(6), 470-83. (Read full article)

    Book Chapter

    1. Book L (2002). Ascites and Peritonitis in Children. In L Osborne & T Witte (Eds.), Pediatrics for the Clinician. New York: Harcourt Press.
    2. Book L (2002). Viral Hepatitis and Cholecystitis in Children. In L Osborne & T Witte (Eds.), Pediatrics for the Clinician. New York : Harcourt Press.
    3. Book L (2002). Abdominal Pain in Children. In L Osborne & T Witte (Eds.), Pediatrics for the Clinician. New York : Harcourt Press.
    4. Book L (2002). Abdominal Distention in Children . In L Osborne & T Witte (Eds.), Pediatrics for the Clinician. New York: Harcourt Press.

    Case Report

    1. Martin T, Schwartz J, Demetris A, Comstock J, Lowichik A, Book L (2011). Plasmapheresis treatment of antibody-mediated rejection in an A2 donor to O pediatric liver transplant recipient. Pediatr Transplant, 15(1), E15-8. (Read full article)

    Abstract

    1. Neuhausen S, Book L, Black J, Feola G, Farnham J, Zone J (2000). Linkage Study of Eleven Candidate Genes with Association of 7P15-P14 in Celiac Disease in a U.S. Family-Based Study. Presented to the World Congress of Pediatric Gastroenterology and Nutrition: August 5th [Abstract]. J Pediatr Gastroenterol Nutr, 31(2), 1079.
    2. Gunasekaran T, Pan W, Torres-Pinedo R, Book L, Gremse D, Steffen R, Czinn S, Chiu Y, Pilmer B, Fitzgerald J (2000). Pharmacokinetics of Lansoprazole in Adolescent Patients with Gastroesophageal Reflux Disease (GERD). Presented at the American Gastroenterology Association: May 10th [Abstract]. Gastroenterology, 118(4), 5683.
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