Allie Harris Grossmann,
MD, PhD
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Languages Spoken: English
Labs: Website
Board Certification and Academic Information
| Academic Departments | Pathology
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Associate Professor Oncological Sciences - Adjunct Associate Professor |
| Academic Divisions | Anatomic Pathology |
| Board Certification | American Board of Pathology (Anatomic) American Board of Pathology (Sub: Molecular Genetic Pathology) |
Academic Locations
Board Certification and Academic Information
| Academic Departments | Pathology
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Associate Professor Oncological Sciences - Adjunct Associate Professor |
| Academic Divisions | Anatomic Pathology |
| Board Certification | American Board of Pathology (Anatomic) American Board of Pathology (Sub: Molecular Genetic Pathology) |
Education History
| Fellowship | University of Utah, Department of Pathology, ARUP Laboratories Molecular Genetic Pathology Clinical Fellow, 2013 |
| Research Fellow | University of Utah Molecular Medicine Program\ Research Fellow, 2012 |
| Residency | University of Utah, ARUP Laboratories Anatomic Pathology Resident, 2011 |
| Professional Medical | Oregon Health Sciences University Medicine, Cell and Developmental Biology M.D., Ph.D., 2007 |
| Undergraduate | College of Idaho Zoology B.S., 1993 |
Selected Publications - Journal Articles
Journal Article
- Sun Z, Zhao H, Fang D, Davis CT, Shi DS, Lei K, Rich BE, Winter JM, Guo L, Sorensen LK, Pryor RJ, Zhu N, Lu S, Dickey LL, Doty DJ, Tong Z, Thomas KR, Mueller AL, Grossmann AH, Zhang B, Lane TE, Fujinami RS, Odelberg SJ, Zhu W (2022). Neuroinflammatory disease disrupts the blood-CNS barrier via crosstalk between proinflammatory and endothelial-to-mesenchymal-transition signaling. Neuron, 110(19), 3106-3120.e7.
- Li J, Mulvihill TS, Li L, Barrott JJ, Nelson ML, Wagner L, Lock IC, Pozner A, Lambert SL, Ozenberger BB, Ward MB, Grossmann AH, Liu T, Banito A, Cairns BR, Jones KB (2021). A Role for SMARCB1 in Synovial Sarcomagenesis Reveals That SS18-SSX Induces Canonical BAF Destruction. Cancer Discov, 11(10), 2620-2637.
- Trivedi S, Grossmann AH, Jensen O, Cody MJ, Wahlig TA, Hayakawa Serpa P, Langelier C, Warren KJ, Yost CC, Leung DT (2021). Intestinal Infection Is Associated With Impaired Lung Innate Immunity to Secondary Respiratory Infection. Open Forum Infect Dis, 8(6), ofab237.
- Kircher DA, Trombetti KA, Silvis MR, Parkman GL, Fischer GM, Angel SN, Stehn CM, Strain SC, Grossmann AH, Duffy KL, Boucher KM, McMahon M, Davies MA, Mendoza MC, VanBrocklin MW, Holmen SL (2019). AKT1E17K Activates Focal Adhesion Kinase and Promotes Melanoma Brain Metastasis. Mol Cancer Res, 17(9), 1787-1800.
- Yoo JH, Brady SW, Acosta-Alvarez L, Rogers A, Peng J, Sorensen LK, Wolff RK, Mleynek T, Shin D, Rich CP, Kircher DA, Bild A, Odelberg SJ, Li DY, Holmen SL, Grossmann AH (2019). The Small GTPase ARF6 Activates PI3K in Melanoma to Induce a Prometastatic State. Cancer Res, 79(11), 2892-2908.
- Ekiz HA, Huffaker TB, Grossmann AH, Stephens WZ, Williams MA, Round JL, OConnell RM (2019). MicroRNA-155 coordinates the immunological landscape within murine melanoma and correlates with immunity in human cancers. JCI Insight, 4(6).
- Barrott JJ, Illum BE, Jin H, Hedberg ML, Wang Y, Grossmann A, Haldar M, Capecchi MR, Jones KB (2018). Paracrine osteoprotegerin and β-catenin stabilization support synovial sarcomagenesis in periosteal cells. J Clin Invest, 28(1), 207-18.
- Yang H, Kircher DA, Kim KH, Grossmann AH, VanBrocklin MW, Holmen SL, Robinson JP (2017). Activated MEK cooperates with Cdkn2a and Pten loss to promote the development and maintenance of melanoma. Oncogene, 36(27), 3842-3851.
- Yoo JH, Shi DS, Grossmann AH, Sorensen LK, Tong Z, Mleynek TM, Rogers A, Zhu W, Richards JR, Winter JM, Zhu J, Dunn C, Bajji A, Shenderovich M, Mueller AL, Woodman SE, Harbour JW, Thomas KR, Odelberg SJ, Ostanin K, Li DY (2016). ARF6 Is an Actionable Node that Orchestrates Oncogenic GNAQ Signaling in Uveal Melanoma. Cancer Cell, 29(6), 889-904.
- Cho JH, Robinson JP, Arave RA, Burnett WJ, Kircher DA, Chen G, Davies MA, Grossmann AH, VanBrocklin MW, McMahon M, Holmen SL (2015). AKT1 Activation Promotes Development of Melanoma Metastases. Cell Rep, 13(5), 898-905.
- Barrott JJ, Illum BE, Jin H, Zhu JF, Mosbruger T, Monument MJ, Smith-Fry K, Cable MG, Wang Y, Grossmann AH, Capecchi MR, Jones KB (2015). β-catenin stabilization enhances SS18-SSX2-driven synovial sarcomagenesis and blocks the mesenchymal to epithelial transition. Oncotarget, 6(26), 22758-66.
- Sant DW, Margraf RL, Stevenson DA, Grossmann AH, Viskochil DH, Hanson H, Everitt MD, Rios JJ, Elefteriou F, Hennessey T, Mao R (2015). Evaluation of somatic mutations in tibial pseudarthrosis samples in neurofibromatosis type 1. J Med Genet, 52(4), 256-61.
- Shin CH, Grossmann AH, Holmen SL, Robinson JP (2015). The BRAF kinase domain promotes the development of gliomas in vivo. Genes Cancer, 6(1-2), 9-18.
- Gibson CC, Zhu W, Davis CT, Bowman-Kirigin JA, Chan AC, Ling J, Walker AE, Goitre L, Delle Monache S, Retta SF, Shiu YT, Grossmann AH, Thomas KR, Donato AJ, Lesniewski LA, Whitehead KJ, Li DY (2015). Strategy for Identifying Repurposed Drugs for the Treatment of Cerebral Cavernous Malformation. Circulation, 131(3), 289-299.
- Chaturvedi A, Hoffman LM, Jensen CC, Lin YC, Grossmann AH, Randall RL, Lessnick SL, Welm AL, Beckerle MC (2014). Molecular dissection of the mechanism by which EWS/FLI expression compromises actin cytoskeletal integrity and cell adhesion in Ewing sarcoma. Mol Biol Cell, 25(18), 2695-709.
- Abel HJ, Al-Kateb H, Cottrell CE, Bredemeyer AJ, Pritchard CC, Grossmann AH, Wallander ML, Pfeifer JD, Lockwood CM, Duncavage EJ (2014). Detection of gene rearrangements in targeted clinical next-generation sequencing. J Mol Diagn, 16(4), 405-17.
- Goodwin ML, Huifeng J, Smith-Frye K, Zhu JF, Monument MJ, Grossmann A, Randall RL, Capecchi MR, Jones KB (2014). Modeling Alveolar Soft Part Sarcomagenesis in the Mouse: A Role for Lactate in the Tumor Microenvironment. Cancer Cell, 26(6), 851-62.
- Grossmann AH, Yoo JH, Clancy J, Sorensen LK, Sedgwick A, Tong Z, Ostanin K, Rogers A, Grossmann KF, Tripp SR, Thomas KR, DSouza-Schorey C, Odelberg SJ, Li DY (2013). The small GTPase ARF6 stimulates β-catenin transcriptional activity during WNT5A-mediated melanoma invasion and metastasis. Sci Signal, 6(265), ra14.
- Hall BJ, Grossmann AH, Webber NP, Ward RA, Tripp SR, Rosenthal HG, Florell SR, Randall RL, Cockerell CJ, Layfield LJ, Liu T (2013). Atypical intradermal smooth muscle neoplasms (formerly cutaneous leiomyosarcomas): case series, immunohistochemical profile and review of the literature. Appl Immunohistochem Mol Morphol, 21(2), 132-8.
- Zhu W, London NR, Gibson CC, Davis CT, Tong Z, Sorensen LK, Shi DS, Guo J, Smith MC, Grossmann AH, Thomas KR, Li DY (2012). Interleukin receptor activates a MYD88-ARNO-ARF6 cascade to disrupt vascular stability. Nature, 492(7428), 252-5.
- Grossmann AH, Layfield LJ, Randall RL (2012). Classification, molecular characterization, and the significance of pten alteration in leiomyosarcoma. Sarcoma, 2012, 380896.
- Chan AC, Drakos SG, Ruiz OE, Smith AC, Gibson CC, Ling J, Passi SF, Stratman AN, Sacharidou A, Revelo MP, Grossmann AH, Diakos NA, Davis GE, Metzstein MM, Whitehead KJ, Li DY (2011). Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice. J Clin Invest, 121(5), 1871-81.
- Grossmann AH, Kolibaba KS, Willis SG, Corbin AS, Langdon WS, Deininger MW, Druker BJ (2004). Catalytic domains of tyrosine kinases determine the phosphorylation sites within c-Cbl. FEBS Lett, 577(3), 555-62.
- Gurtu VE, Verma S, Grossmann AH, Liskay RM, Skarnes WC, Baker SM (2002). Maternal effect for DNA mismatch repair in the mouse. Genetics, 160(1), 271-7.
- Baker SM, Harris AC, Tsao JL, Flath TJ, Bronner CE, Gordon M, Shibata D, Liskay RM (1998). Enhanced intestinal adenomatous polyp formation in Pms2-/-;Min mice. Cancer Res, 58(6), 1087-9.
- Prolla TA, Baker SM, Harris AC, Tsao JL, Yao X, Bronner CE, Zheng B, Gordon M, Reneker J, Arnheim N, Shibata D, Bradley A, Liskay RM (1998). Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair. Nat Genet, 18(3), 276-9.
- Baker SM, Plug AW, Prolla TA, Bronner CE, Harris AC, Yao X, Christie DM, Monell C, Arnheim N, Bradley A, Ashley T, Liskay RM (1996). Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over. Nat Genet, 13(3), 336-42.
Review
- Grossmann AH, Zhao H, Jenkins N, Zhu W, Richards JR, Yoo JH, Winter JM, Rich B, Mleynek TM, Li DY, Odelberg SJ (12/21/2016). The small GTPase ARF6 regulates protein trafficking to control cellular function during development and in disease. [Review]. Small GTPases, 10(1), 1-12.
- Grossmann AH, Grossmann KF, Wallander ML (2012). Molecular testing in malignant melanoma. [Review]. Diagn Cytopathol, 40(6), 503-10.
- Grossmann AH, Samowitz WS (2011). Epidermal growth factor receptor pathway mutations and colorectal cancer therapy. [Review]. Arch Pathol Lab Med, 135(10), 1278-82.
Book Chapter
- Liu T, Narra KK, Stephenson PD, Grossmann AH, Downs-Kelly EP, Albertson D (04/04/2016). Pathology of Soft Tissue Tumors. In Raphael E. Pollock, R. Lor Randall, and Brian O’ Sullivan (Eds.), Sarcoma Oncology: A Multidisciplinary Approach. Shelton, CT: People's Medical Publishing House.
Case Report
- Monument MJ, Grossmann AH, Baker CC, Randall RL, Liu T, Albertson DJ (2015). Molecular Confirmation of Ewing Sarcoma in an 85-Year-Old Woman. Int J Surg Pathol, 23(6), 500-504.
- Anker CJ, Ribas A, Grossmann AH, Chen X, Narra KK, Akerley W, Andtbacka RH, Noyes RD, Shrieve DC, Grossmann KF (2013). Severe liver and skin toxicity after radiation and vemurafenib in metastatic melanoma. J Clin Oncol, 31(17), e283-7.
Editorial
- Grossmann AH, Samowitz W, Cohen M (2014). Dance Well: Partnering with reference laboratories for oncology testing. Arch Pathol Lab Med, 139(5), 585-586.