Jonathan Robert Genzen,
MD, PhD
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Languages Spoken: English
Dr. Genzen is an Associate Professor (Clinical) in the Department of Pathology at the University of Utah. He serves as Chief Operating Officer at ARUP Laboratories, where he is a Medical Director of the ARUP Automated Core Laboratory and Medical Director of the Farmington Health Center Clinical Laboratory. He is board certified in Clinical Pathology by the American Board of Pathology and is a Fellow of the American Society for Clinical Pathology. He is a member of the American Association for Clinical Chemistry and the Academy of Clinical Laboratory Physicians and Scientists.
Dr. Genzen received both his Ph.D. and M.D. from the University of Chicago. He completed his clinical pathology residency at Yale-New Haven Hospital / Yale University in the Department of Laboratory Medicine, where he also conducted his postdoctoral research fellowship. He then served as Assistant Professor in the Department of Pathology at Weill Cornell Medical College (WCMC) and Assistant Attending Pathologist at New York Presbyterian Hospital, where he was Medical Director of the Westchester Division clinical laboratory and Assistant Director of the WCMC core clinical laboratory. He joined the University of Utah in 2013.
Dr. Genzen’s clinical and research focus is on automated clinical chemistry and quality improvement through informatics.
Specialties
Board Certification and Academic Information
| Academic Departments | Pathology
-
Associate Professor (Clinical) |
| Academic Divisions | Clinical Pathology |
| Board Certification | American Board of Pathology (Clinical Path) |
Dr. Genzen is an Associate Professor (Clinical) in the Department of Pathology at the University of Utah. He serves as Chief Operating Officer at ARUP Laboratories, where he is a Medical Director of the ARUP Automated Core Laboratory and Medical Director of the Farmington Health Center Clinical Laboratory. He is board certified in Clinical Pathology by the American Board of Pathology and is a Fellow of the American Society for Clinical Pathology. He is a member of the American Association for Clinical Chemistry and the Academy of Clinical Laboratory Physicians and Scientists.
Dr. Genzen received both his Ph.D. and M.D. from the University of Chicago. He completed his clinical pathology residency at Yale-New Haven Hospital / Yale University in the Department of Laboratory Medicine, where he also conducted his postdoctoral research fellowship. He then served as Assistant Professor in the Department of Pathology at Weill Cornell Medical College (WCMC) and Assistant Attending Pathologist at New York Presbyterian Hospital, where he was Medical Director of the Westchester Division clinical laboratory and Assistant Director of the WCMC core clinical laboratory. He joined the University of Utah in 2013.
Dr. Genzen’s clinical and research focus is on automated clinical chemistry and quality improvement through informatics.
Academic Locations
Board Certification and Academic Information
| Academic Departments | Pathology
-
Associate Professor (Clinical) |
| Academic Divisions | Clinical Pathology |
| Board Certification | American Board of Pathology (Clinical Path) |
Education History
| Research Fellow | Yale University School of Medicine, Department of Laboratory Medicine Postdoctoral Research Fellow, 2009 |
| Residency | Yale-New Haven Hospital and VA Connecticut Healthcare System Clinical Pathology Resident, 2007 |
| Professional Medical | University of Chicago, Pritzker School of Medicine M.D., 2004 |
| Doctoral Training | University of Chicago, Committee on Neurobiology Ph.D., 2002 |
| Undergraduate | Northwestern University, College of Arts and Sciences Biological Sciences / Neurobiology Concentration & International Studies B.A., 1995 |
Selected Publications - Journal Articles
Journal Article
- Genzen JR, Nwosu A, Long T, Murphy H, Alter DN (2022). An International Survey of Glucose-6-Phosphate Dehydrogenase Laboratory Reporting Practices: Implications for Tafenoquine Eligibility Assessment. Arch Pathol Lab Med.
- Hunsaker JJH, Laulu SL, LaGrave D, Murphy W, Reichman HA, Snow TM, McMillin GA, Johnson-Davis KL, Genzen JR (2021). Tobacco and Cannabis Use During Pregnancy. Am J Clin Pathol, 157(1), 146-152.
- Nelson HA, Genzen JR, Delgado JC, Rudolf JW (2021). An Interference in an Automated HCO3- Assay Leads to an Unexpected IgG Monoclonal Gammopathy Diagnosis. J Appl Lab Med, 7, 622-625.
- Pandya V, Hunsaker JJH, Laulu SL, Genzen JR, Frank EL, Johnson LM, Rudolf JW (2021). Excessively low cholesterol and triglyceride levels in an apparently healthy patient. Clin Biochem, 96, 78-81.
- Haspel RL, Genzen JR, Wagner J, Fong K, Undergraduate Training in Genomics UTRIG Working Group, Wilcox RL (2021). Call for improvement in medical school training in genetics: results of a national survey. Genet Med, 23(6), 1151-1157.
- Patel MK, El-Khoury JM, Simundic EA, Farnsworth CW, Broell F, Genzen JR, Amukele TK (2020). Evolution of Blood Sample Transportation and Monitoring Technologies. Clin Chem, 67(6), 812-819.
- Rychert J, Couturier MR, Elgort M, Lozier BK, Laulu S, Genzen JR, Straseski JA, Delgado JC, Slev PR (2020). Evaluation of 3 SARS-CoV-2 IgG Antibody Assays and Correlation with Neutralizing Antibodies. J Appl Lab Med, 6(3), 614-624.
- Laulu SL, Turner DR, Zupan E, Genzen JR (2021). Pretreatment of Body Fluid Specimens Using Hyaluronidase and Ultracentrifugation. Lab Med, 52, 469-476.
- Calvaresi EC, Laulu SL, Snow TM, Allison TR, Genzen JR (2021). Plasma hemoglobin: A method comparison of six assays for hemoglobin and hemolysis index measurement. Int J Lab Hematol, 43, 1145-1153.
- Klutts JS, Genzen JR (2020). Disparities and Bias in Pathology and Laboratory Medicine. J Appl Lab Med, 6(1), 3-6.
- Jackson BR, Genzen JR (2020). The Lab Must Go On. Am J Clin Pathol, 155(1), 4-11.
- Smy L, De Biase I, Genzen JR, Yuzyuk T (2020). The nuclear magnetic resonance metabolic profile: Impact of fasting status. Clin Biochem, 87, 85-92.
- Naides SJ, Genzen JR, Abel G, Bashleben C, Ansari MQ (2020). Antinuclear Antibodies Testing Method Variability: A Survey of Participants in the College of American Pathologists' Proficiency Testing Program. J Rheumatol, 47(12), 1768-1773.
- Haspel RL, Genzen JR, Wagner J, Lockwood CM, Fong K, Training Residents in Genomics TRIG Working Group (2020). Integration of Genomic Medicine in Pathology Resident Training. Am J Clin Pathol, 154(6), 784-791.
- Calvaresi EC, Genzen JR (2020). Evaluating Percentage-Based Reporting of Glucose-6-Phosphate Dehydrogenase (G6PD) Enzymatic Activity. Am J Clin Pathol, 154(2), 248-254.
- Roundy CS, Lin DC, Klopping PJ, Ence AT, Krezel AC, Genzen JR (2019). Specimen Temperature Detection on a Clinical Laboratory Pre-Analytic Automation Track: Implications for Direct-from-Track Total Laboratory Automation (TLA) Systems. SLAS Technol, 25(3), 293-299.
- Rychert J, Delgado JC, Genzen JR (2020). Modification of In Vitro Diagnostic Devices: Leveling the Playing Field. Clin Chem, 66(6), 760-762.
- Lakshmipathi J, Gao Y, Hu C, Stuart D, Genzen J, Ramkumar N, Kohan DE (2020). Nephron-Specific Disruption of Polycystin-1 Induces Cyclooxygenase-2-Mediated Blood Pressure Reduction Independent of Cystogenesis. J Am Soc Nephrol, 31(6), 1243-1254.
- Peedin AR, Genzen JR, Karp JK (2019). Correlating Transfusion Medicine In-Service Examination Scores With Outcomes of the American Board of Pathology Transfusion Medicine Subspecialty Certifying Examination. Am J Clin Pathol, 153(4), 497-501.
- Brown K, Fenn JP, Fong K, Freeman V, Genzen J, Goodyear N, Lunz Houston M, Taff T, Tanabe P (2019). ASCP Board of Certification Survey of Medical Laboratory Science Education Programs. Lab Med, 50(4), e70-e74.
- Brown K, Parker Fenn J, Fong K, Freeman V, Genzen J, Goodyear N, Lunz Houston M, Taff T, Tanabe P (2019). ASCP Board of Certification Survey of Medical Laboratory Science Faculty. Lab Med, 50(4), e75-e81.
- Maharjan AS, Wyness SP, Ray JA, Willcox TL, Seiter JD, Genzen JR (2019). Detection and characterization of estradiol (E2) and unconjugated estriol (uE3) immunoassay interference due to anti-bovine alkaline phosphatase (ALP) antibodies. Pract Lab Med, 17, e00131.
- Hunsaker JJH, Wyness SP, Needham LL, Genzen JR (2019). Evaluation of L-index interference limits on Roche cobas c502 and c702 immunoturbidimetric assays using endogenously lipemic specimens and intralipid spiking. Clin Biochem, 70, 18-23.
- Genzen JR (2019). Regulation of Laboratory-Developed Tests. Am J Clin Pathol, 152(2), 122-131.
- Mohlman JS, Genzen JR, Weiss RL, Schmidt RL (2018). Reliability and Validity of Proposed Risk Stratification Methods for Laboratory Developed Tests. Lab Med, 50(2), 194-201.
- Needham LL, Smy L, Lee MA, Kunzler TM, Genzen JR (2018). Phlebotomy tube interference with nuclear magnetic resonance (NMR) lipoprotein subclass analysis. Clin Chim Acta, 488, 235-241.
- Genzen JR, Laulu SL, Wyness SP, Scholes KL, Signorelli HN, Greer RW (2018). Identifying and Eliminating Laboratory Contamination by Topical Testosterone Therapeutics. Clin Chem, 65(1), 67-73.
- Lu J, Genzen JR, Grenache DG (2018). Development of an enzymatic assay to measure lactate in perchloric acid-precipitated cerebrospinal fluid. Clin Chim Acta, 483, 142-144.
- Owen WE, Hunsaker JJH, Genzen JR (2018). Alpha-fetoprotein in pericardial, peritoneal, and pleural fluids: A body fluid matrix evaluation. Clin Biochem, 56, 109-112.
- Hunsaker JJH, Laulu SL, Wyness SP, Genzen JR (2018). Lipemic interference of ceruloplasmin assays - An evaluation of lipid removal methods. Clin Chim Acta, 480, 71-78.
- Genzen JR, Murray DL, Abel G, Meng QH, Baltaro RJ, Rhoads DD, Delgado JC, Souers RJ, Bashleben C, Keren DF, Ansari MQ (2017). Screening and Diagnosis of Monoclonal Gammopathies: An International Survey of Laboratory Practice. Arch Pathol Lab Med, 142(4), 507-515.
- Genzen JR, Burnham CD, Felder RA, Hawker CD, Lippi G, Peck Palmer OM (2017). Challenges and Opportunities in Implementing Total Laboratory Automation. Clin Chem, 64(2), 259-264.
- Lin DC, Genzen JR (2017). Concordance analysis of paired cancer antigen (CA) 15-3 and 27.29 testing. Breast Cancer Res Treat, 167(1), 269-276.
- Genzen JR, Mohlman JS, Lynch JL, Squires MW, Weiss RL (2017). Laboratory-Developed Tests: A Legislative and Regulatory Review. Clin Chem, 63(10), 1575-1584.
- Taylor JR, Thompson PJ, Genzen JR, Hickner J, Marques MB (2016). Opportunities to Enhance Laboratory Professionals' Role On the Diagnostic Team. Lab Med, 48(1), 97-103.
- Rhoads DD, Genzen JR, Bashleben CP, Faix JD, Ansari MQ (2016). Prevalence of Traditional and Reverse-Algorithm Syphilis Screening in Laboratory Practice: A Survey of Participants in the College of American Pathologists Syphilis Serology Proficiency Testing Program. Arch Pathol Lab Med, 141(1), 93-97.
- Hunsaker JJH, Wyness SP, Snow TM, Genzen JR (2016). Clinical performance evaluation of total protein measurement by digital refractometry and characterization of non-protein solute interferences. Pract Lab Med, 6, 14-24.
- Wyness SP, Hunsaker JJH, Snow TM, Genzen JR (2016). Evaluation and analytical validation of a handheld digital refractometer for urine specific gravity measurement. Pract Lab Med, 5, 65-74.
- Blanchard MG, Kittikulsuth W, Nair AV, de Baaij JH, Latta F, Genzen JR, Kohan DE, Bindels RJ, Hoenderop JG (2015). Regulation of Mg2+ Reabsorption and Transient Receptor Potential Melastatin Type 6 Activity by cAMP Signaling. J Am Soc Nephrol, 27(3), 804-13.
- Johnson-Davis KL, Sadler AJ, Genzen JR (2015). A Retrospective Analysis of Urine Drugs of Abuse Immunoassay True Positive Rates at a National Reference Laboratory. J Anal Toxicol, 40(2), 97-107.
- Genzen JR, Hunsaker JJ, Nelson LS, Faine BA, Krasowski MD (2015). N-acetylcysteine interference of Trinder-based assays. Clin Biochem, 49(1-2), 100-4.
- Krasowski MD, Savage J, Ehlers A, Maakestad J, Schmidt GA, Laulu S, Rasmussen NN, Strathmann FG, Genzen JR (2015). Ordering of the Serum Angiotensin-Converting Enzyme Test in Patients Receiving Angiotensin-Converting Enzyme Inhibitor Therapy: An Avoidable but Common Error. Chest, 148(6), 1447-1453.
- Signorelli H, Straseski JA, Genzen JR, Walker BS, Jackson BR, Schmidt RL (2015). Benchmarking to Identify Practice Variation in Test Ordering: A Potential Tool for Utilization Management. Lab Med, 46(4), 356-64.
- Owen WE, Thatcher ML, Crabtree KJ, Greer RW, Strathmann FG, Straseski JA, Genzen JR (2015). Body fluid matrix evaluation on a Roche cobas 8000 system. Clin Biochem, 48(13-14), 911-4.
- Scholes KL, Ence AT, Strathmann FG, Genzen JR (2015). Identification and characterization of EDTA test strip interfering substances using a digital color detector. Clin Lab, 61(7), 785-791.
- Owen WE, Caron JE, Genzen JR (2015). Liver function testing on the Abaxis Piccolo Xpress: Use in Ebola virus disease protocols. Clin Chim Acta, 446, 119-27.
- Scholes KL, Laulu SL, Ence AT, Logan HL, Parker RL, Strathmann FG, Genzen JR (2015). Evaluation of test strips for the rapid identification of ethylenediaminetetraacetic acid (EDTA) specimens. Lab Med, 46(2), 97-108.
- Schmidt RL, Kordy MA, Genzen JR, Straseski JA, Greene DN, Lehman CM (2014). A mathematical procedure to estimate the impact of a change in method on discordance or misclassification at a decision limit in laboratory method comparison studies. Clin Chim Acta, 440, 23-30.
- Laulu SL, Straseski JA, Schmidt RL, Genzen JR (2014). Thrombin-mediated degradation of parathyroid hormone in serum tubes. Clin Chim Acta, 437, 191-6.
- Kang H, Kerloch A, Rotival M, Xu X, Zhang Q, DSouza Z, Kim M, Scholz JC, Ko JH, Srivastava PK, Genzen JR, Cui W, Aitman TJ, Game L, Melvin JE, Hanidu A, Dimock J, Zheng J, Souza D, Behera AK, Nabozny G, Cook HT, Bassett JH, Williams GR, Li J, Vignery A, Petretto E, Behmoaras J (2014). Kcnn4 is a regulator of macrophage multinucleation in bone homeostasis and inflammatory disease. Cell Rep, 8(4), 1210-24.
- Genzen JR (2014). Hypercalcemic crisis due to vitamin D toxicity. Lab Med, 45(2), 147-50.
- Genzen JR, Gosselin JT, Wilson TC, Racila E, Krasowski MD (2013). Analysis of vitamin D status at two academic medical centers and a national reference laboratory: result patterns vary by age, gender, season, and patient location. BMC Endocr Disord, 13, 52.
- Genzen JR (2013). An Overview of United States Physician Training, Certification, and Career Pathways in Clinical Pathology (Laboratory Medicine). EJIFCC, 24(1), 21-9.
Book Chapter
- Block DR, Genzen JR (2020). Diagnostic body fluid testing. In Clarke W, Marzinke M (Eds.), Contemporary Practice in Clinical Chemistry (4th Edition). Cambridge, MA: Academic Press.
- Genzen JR, Hawker CD, Burnham CA, Wittwer CT (2020). Automation in the clinical laboratory. In Rifai N, Horvath AR, Wittwer CT (Eds.), Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics (7th Edition). St Louis: Elsevier.
- Hawker CD, Genzen JR (2018). Chapter 19. Automation in the clinical laboratory. In Rifai N, Horvath R, Wittwer C. (Eds.), Tietz Textbook of Clinical Chemistry and Molecular Diagnostics (6th Edition, p. 370). St. Louis, MO: Elsevier.
- Block DR, Genzen JR (2016). Diagnostic body fluid testing. In Clarke, W (Eds.), Contemporary Practice in Clinical Chemistry (3rd Edition). Washington, DC: AACC Press.
- Genzen JR (2016). Clinical protein and immunofixation electrophoresis. In Linden MA, McKenna RW (Eds.), Plasma Cell Neoplasms: A Morphologic, Cytogenetic, and Immunophenotypic Approach. Cham, Switzerland: Springer International Publishing.
- Genzen JR, Bordey A (2008). Ependymal cells and the neurogenic niche. In Bonfanti L (Ed.), Postnatal and Adult Neurogenesis. Research Signpost.
Editorial
Letter
- Willrich MAV, Long TA, Bashleben C, Fink SL, Rudolf JW, Peterson D, Wener MH, Baltaro RJ, Genzen JR, Ansari MQ, Rhoads DD, Linden MA (2020). Performance of perpendicular drop versus tangent skimming gating of M-protein in proficiency testing challenges. [Letter to the editor]. Clin Chem Lab Med, 59(1), e19-e22.
- McCarthy MW, Genzen JR, Wilkin TJ, Singh HK (2014). Use of a commercial HIV co-receptor tropism assay in clinical practice. [Letter to the editor]. AIDS Patient Care STDS, 29(2), 53-4.