John J. Ryan,
MD, MB, BCh, BAO
Languages Spoken: English
Dr. Ryan is an internationally renowned specialist in Cardiovascular Medicine and Pulmonary Hypertension. He is an Associate Professor in the Division of Cardiovascular Medicine at the University of Utah. Dr. Ryan is the Director of the University of Utah Pulmonary Hypertension Center. He also is the Medical Director of the Cardiovascular Medicine Unit and Liaison to the Chair for Advancement in the Department of Medicine. He is an author on the guidelines from the ACCP on the treatment of Pulmonary Hypertension. Dr. Ryan also is a Sports Cardiology Consultant for the United States Olympic Committee, the International Olympic Committee, the National Basketball Association, Major League Soccer, and the NCAA. Dr. Ryan is on the editorial boards of Circulation, Circulation: Cardiovascular Quality and Outcomes, Circulation: Heart Failure, The Canadian Journal of Cardiology, among others. Dr. Ryan has published over 130 research publications, including in leading medical journals such as The New England Journal of Medicine, Nature Medicine, The British Medical Journal, Circulation, CHEST, and The Journal of the American College of Cardiology.
Clinical Locations
801-585-7676
Fax: (801) 213-8156
Cardiovascular Center
801-585-7676
Fax: (801) 581-7735
Board Certification and Academic Information
| Academic Departments | Internal Medicine
-
Associate Professor (Clinical) Family & Preventive Medicine - Adjunct Associate Professor Orthopaedics - Adjunct Associate Professor Radiology and Imaging Sciences - Adjunct Associate Professor |
| Academic Divisions | Cardiovascular Medicine Clinical Radiology Family Medicine |
| Board Certification | American Board of Internal Medicine (Sub: Advanced Heart Failure & Transplant Cardiology) American Board of Internal Medicine (Sub: Cardiovascular Disease) Certification Board of Nuclear Cardiology National Board of Echocardiography (Special Competence in Adult Echocardiography) National Board of Physicians and Surgeons Royal College of Physicians in Ireland |
Patient Rating
The Patient Rating score is an average of all responses to care provider related questions on our nationally-recognized Press Ganey Patient Satisfaction Survey.
Responses are measured on a scale of 1 to 5 with 5 being the best score.
Likelihood of recommending care provider
4.9/ 5
Care provider's explanation of condition/problem
4.8/ 5
Care provider's effort to include me in decisions
4.8/ 5
Wait time at clinic
4.6/ 5
Care provider's concern for questions & worries
4.9/ 5
Patient Comments
Patient comments are gathered from our Press Ganey Patient Satisfaction Survery and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.
UofU Patient
November 07, 2022
University Hospital
I would recommend Dr. Ryan to anyone. He shows true concern for my health and demonstrates great expertise in his field.
UofU Patient
October 11, 2022
SUGAR HOUSE HEALTH CENTER
Grateful for thoroughness and answer to all my questions.
UofU Patient
August 22, 2022
UH HOSPITALS AND CLINICS
The diagnosis was shocking to hear but we appreciate being told what is wrong because obviously there is health issues.
UofU Patient
August 22, 2022
UH HOSPITALS AND CLINICS
Again, an XCLNT (excellent) Service (O_O)Kleenex: They are small and feel like a file.Please, bring the old ones back (*_*)
UofU Patient
July 21, 2022
UH HOSPITALS AND CLINICS
I was very impressed with Dr. Ryan and the care I was given.He was very professional and was very concerned about my health care needs. I would highly recommend him.
UofU Patient
June 09, 2022
UH HOSPITALS AND CLINICS
Overall the visit was very good. The bevy of people I saw were very competent and knowledgeable. I liked that my drugs were reviewed quite thoroughly so the doc coukd review and say no changes needed to be done. I didn't see the doc very much but I was there mainly to set up a lical cardiologist. He is also a pulmonologist and approved my additional appt with him. Overall. Quite pleased with appt and staff.
UofU Patient
May 12, 2022
UH HOSPITALS AND CLINICS
Excellent care throughout the experience
UofU Patient
May 07, 2022
UH HOSPITALS AND CLINICS
Dr. Ryan is one of the most (maybe THE most) caring doctors I've ever had.
UofU Patient
April 06, 2022
UH HOSPITALS AND CLINICS
They took the time to explain everything to me; even medications that I had been taking for years and didn't know much about were explained to me so that I finally knew what I was taking them for. I really appreciate that.
UofU Patient
April 06, 2022
UH HOSPITALS AND CLINICS
Dr. Ryan and his staff are the very best!!!
UofU Patient
April 01, 2022
UH HOSPITALS AND CLINICS
Again, an XCLNT (Excellent) Service (O)__(O) Highly Recommended (o)__(o)
UofU Patient
February 09, 2022
SUGAR HOUSE HEALTH CENTER
Dr. Ryan was very knowledgeable about my medical issues. He took the time needed to explain things.
UofU Patient
February 09, 2022
SUGAR HOUSE HEALTH CENTER
Appreciated the time Dr. Ryan spent with me despite the crush of Covid patients.
UofU Patient
December 05, 2021
SUGAR HOUSE HEALTH CENTER
Dr Ryan is always very personable, and we feel like he cares a lot about [NAME REMOVED] health issues.
UofU Patient
November 20, 2021
UH HOSPITALS AND CLINICS
Didn't have treatment options but discussed diagnosis in depth and what I can do about it
UofU Patient
October 29, 2021
SUGAR HOUSE HEALTH CENTER
First time to Dr Ryan. Him and his staff that assisted me were wonderful. All very calm and patient didn't acted rush and like hey were there for just me. Great experience especially when I was so nervous. Dr. Ryan was way more than I even expected. So happy to be here and have him as my doctor. Great all the was around.
UofU Patient
October 10, 2021
UH HOSPITALS AND CLINICS
John Ryan is a wonderful doc. He is efficient, yet listens and answers patient questions well. I better understand a condition that I've had for some time and until now wasn't aware of the why. We're very fortunate that he is here. He also seems to run his team of PA and MAs very well.
UofU Patient
October 03, 2021
UH HOSPITALS AND CLINICS
Was very direct about what needed to happen so I can get my diagnosis
UofU Patient
October 01, 2021
UH HOSPITALS AND CLINICS
Very professional
UofU Patient
September 30, 2021
UH HOSPITALS AND CLINICS
They were concerned for me helped me understand the procedure that they felt was needed for my health
UofU Patient
September 22, 2021
UH HOSPITALS AND CLINICS
I wish he would have contacted my primary care doctor and explained why I was taken off a medication she (primary care) had me taking it would have prevented a great deal of confusion and problems for me
UofU Patient
September 14, 2021
SUGAR HOUSE HEALTH CENTER
I believe that Dr. John Ryan is a "star" in his field, and the UofU should be very proud to have him.
UofU Patient
September 08, 2021
SUGAR HOUSE HEALTH CENTER
Dr. Ryan explained what he found from the test and added an addition inhaler stating he felt that I was possibly be off the oxygen during the day and only use it at night.
UofU Patient
August 29, 2021
SUGAR HOUSE HEALTH CENTER
Unsure of any risks or treatment
UofU Patient
August 22, 2021
SUGAR HOUSE HEALTH CENTER
Just like his staff, Dr. Ryan is both professional and friendly at the same time. He is also very intelligent and knowledgeable but explains things in a way that I can understand. And he is caring! I wish all doctors had this rare combination of traits he does. He is by far my favorite doctor I've ever had.
UofU Patient
July 24, 2021
SUGAR HOUSE HEALTH CENTER
Good
UofU Patient
July 12, 2021
SUGAR HOUSE HEALTH CENTER
Dr. John Ryan is excellent!
UofU Patient
June 28, 2021
UH HOSPITALS AND CLINICS
Physician provided me the answers to my questions and his approach was excellent.
UofU Patient
June 21, 2021
UH HOSPITALS AND CLINICS
again, an XCLNT Service (O_O)
Dr. Ryan is an internationally renowned specialist in Cardiovascular Medicine and Pulmonary Hypertension. He is an Associate Professor in the Division of Cardiovascular Medicine at the University of Utah. Dr. Ryan is the Director of the University of Utah Pulmonary Hypertension Center. He also is the Medical Director of the Cardiovascular Medicine Unit and Liaison to the Chair for Advancement in the Department of Medicine. He is an author on the guidelines from the ACCP on the treatment of Pulmonary Hypertension. Dr. Ryan also is a Sports Cardiology Consultant for the United States Olympic Committee, the International Olympic Committee, the National Basketball Association, Major League Soccer, and the NCAA. Dr. Ryan is on the editorial boards of Circulation, Circulation: Cardiovascular Quality and Outcomes, Circulation: Heart Failure, The Canadian Journal of Cardiology, among others. Dr. Ryan has published over 130 research publications, including in leading medical journals such as The New England Journal of Medicine, Nature Medicine, The British Medical Journal, Circulation, CHEST, and The Journal of the American College of Cardiology.
Academic Locations
School of Medicine
801-585-7676
(801) 581-7735
Research Statement
John J. Ryan MD, FACC, FAHA, is a cardiologist with extensive training and experience in research investigation and clinical patient care. He is an internationally renowned specialist in pulmonary hypertension and has an appointment in the Division of Cardiovascular Medicine at the University of Utah.
Dr. Ryan has won more than ten university awards in Ireland, Boston, Chicago and Utah. He received Ireland’s prestigious Ceannt Medal, for ranking first in Ireland’s National High School exit exam. He was also an acknowledged scholar at University College Cork and in 2004 received their Blayney Medal for graduating at the top of his class from the University College Cork, School of Medicine. He was also awarded the Stewart Medal from the National University of Ireland in 2004 for being among the highest-ranking medical graduates in Ireland.
After postgraduate training in Internal Medicine and General Surgery at Cork University Hospital in Cork, Ireland, he was moved to Boston University. Between 2005 and 2009 he trained in Boston in Internal Medicine, ultimately being selected as the Chief Resident for Boston University. In Boston, he received awards for humanism from Boston University and the Department of Medicine’s Faculty Teacher of the Year Award.
After Boston, Dr. Ryan moved to Chicago and completed a fellowship in Cardiovascular Medicine at the University of Chicago, where he served as Chief Cardiology Fellow. At the University of Chicago he was awarded Teaching Fellow of the Year from the Department of Medicine and was served on the Illinois-American College of Cardiology Board of Governors. After fellowship, he undertook advanced training in pulmonary hypertension. For his work in pulmonary hypertension he was awarded the Cournand and Comroe Young Investigator Award from the American Heart Association.
At the University of Utah, Dr. Ryan has continued to be involved in medical education, and has been awarded the Department of Family Medicine Outstanding Preceptor of the Year Award.
Dr. Ryan is on the editorial board of Circulation, Circulation: Cardiovascular Quality and Outcomes, Circulation: Heart Failure, The Canadian Journal of Cardiology, among others. Dr. Ryan’s research has been published in leading cardiovascular journals including Circulation, CHEST, The Journal of the American College of Cardiology, among others. Dr. Ryan is a writing member of the CHEST Pulmomary Arterial Hypertension guidelines.
Dr. Ryan is the director of the University of Utah Pulmonary Hypertension Center, which is the first accredited Pulmonary Hypertension Association Comprehensive Care Center in the Mountain West.
Dr Ryan is also Sports Cardiology Consultant for the United States Olympic Committee, the National Basketball Association, the Utah Jazz and the University of Utah Utes.
Dr. Ryan is board certified in Internal Medicine, Cardiovascular Medicine, Advanced Heart Failure and Transplant Cardiology, Echocardiography and Nuclear Cardiology.
Board Certification and Academic Information
| Academic Departments | Internal Medicine
-
Associate Professor (Clinical) Family & Preventive Medicine - Adjunct Associate Professor Orthopaedics - Adjunct Associate Professor Radiology and Imaging Sciences - Adjunct Associate Professor |
| Academic Divisions | Cardiovascular Medicine Clinical Radiology Family Medicine |
| Board Certification | American Board of Internal Medicine (Sub: Advanced Heart Failure & Transplant Cardiology) American Board of Internal Medicine (Sub: Cardiovascular Disease) Certification Board of Nuclear Cardiology National Board of Echocardiography (Special Competence in Adult Echocardiography) National Board of Physicians and Surgeons Royal College of Physicians in Ireland |
Education History
| Research Fellow | University of Chicago Medical Center Advanced Cardiovascular Research Fellow, 2013 |
| Fellowship | University of Chicago Medical Center Cardiovascular Fellow, 2012 |
| Fellowship | University of Chicago Cardiology Chief Fellow, 2011 |
| Chief Resident | Boston Medical Center Internal Medicine Chief Medical Resident, 2009 |
| Residency | Boston Medical Center Internal Medicine Resident, 2008 |
| Internship | Cork University Hospital Internal Medicine and General Surgery Intern, 2005 |
| Professional Medical | University College Cork, Ireland Medicine M.D., 2004 |
Selected Publications - Journal Articles
Journal Article
- Chang KY, Duval S, Badesch DB, Bull TM, Chakinala MM, De Marco T, Frantz RP, Hemnes A, Mathai SC, Rosenzweig EB, Ryan JJ, Thenappan T, PHAR Investigators (2022). Mortality in Pulmonary Arterial Hypertension in the Modern Era: Early Insights From the Pulmonary Hypertension Association Registry. J Am Heart Assoc, 11, e024969.
- Ratchford SM, Lee JF, Bunsawat K, Alpenglow JK, Zhao J, Ma CL, Ryan JJ, Khor LL, Wray DW (2022). The Impact of Obesity on the Regulation of Muscle Blood Flow during Exercise in Patients with Heart Failure with a Preserved Ejection Fraction. J Appl Physiol (1985), 132(5), 1240-1249.
- Minhas J, Narasimmal SP, M Bull T, Marco T, McConnell JW, Lammi MR, Thenappan T, P Feldman J, S Sager J, B Badesch D, Ryan JJ, C Grinnan D, Zwicke D, M Horn E, Elwing JM, Moss JE, Eggert M, Shlobin OA, P Frantz R, D Bartolome S, Mathai SC, Mazimba S, C Pugliese S, Al-Naamani N (2021). Health-related quality of life and hospitalizations in chronic thromboembolic pulmonary hypertension versus idiopathic pulmonary arterial hypertension: an analysis from the Pulmonary Hypertension Association Registry (PHAR). Pulm Circ, 11(4), 20458940211053196.
- Vahdatpour CA, Ryan JJ, Zimmerman JM, MacCormick SJ, Palevsky HI, Alnuaimat H, Ataya A (2021). Advanced airway management and respiratory care in decompensated pulmonary hypertension. Heart Fail Rev.
- DuBrock HM, Burger CD, Bartolome SD, Feldman JP, Ivy DD, Rosenzweig EB, Sager JS, Presberg KW, Mathai SC, Lammi MR, Klinger JR, Eggert M, De Marco T, Elwing JM, Badesch D, Bull TM, Cadaret LM, Ramani G, Thenappan T, Ford HJ, Al-Naamani N, Simon MA, Mazimba S, Runo JR, Chakinala M, Horn EM, Ryan JJ, Frantz RP, Krowka MJ (2021). Health disparities and treatment approaches in portopulmonary hypertension and idiopathic pulmonary arterial hypertension: an analysis of the Pulmonary Hypertension Association Registry. Pulm Circ, 11(3), 20458940211020913.
- Mayeux JD, Pan IZ, Dechand J, Jacobs JA, Jones TL, McKellar SH, Beck E, Hatton ND, Ryan JJ (2020). Management of Pulmonary Arterial Hypertension. Curr Cardiovasc Risk Rep, 15(1), 2.
- Lee JD, Burger CD, Delossantos GB, Grinnan D, Ralph DD, Rayner SG, Ryan JJ, Safdar Z, Ventetuolo CE, Zamanian RT, Leary PJ (2020). A Survey-based Estimate of COVID-19 Incidence and Outcomes among Patients with Pulmonary Arterial Hypertension or Chronic Thromboembolic Pulmonary Hypertension and Impact on the Process of Care. Ann Am Thorac Soc, 17(12), 1576-1582.
- Ratchford SM, Clifton HL, La Salle DT, Broxterman RM, Lee JF, Ryan JJ, Hopkins PN, Wright JB, Trinity JD, Richardson RS, Wray DW (2020). Cardiovascular responses to rhythmic handgrip exercise in heart failure with preserved ejection fraction. J Appl Physiol (1985), 129(6), 1267-1276.
- Fakhri S, Hannon K, Moulden K, Peterson R, Hountras P, Bull T, Maloney J, De Marco T, Ivy D, Thenappan T, Sager JS, Ryan JJ, Mazimba S, Hirsch R, Chakinala M, Shlobin O, Lammi M, Zwicke D, Robinson J, Benza RL, Klinger J, Grinnan D, Mathai S, Badesch D (2020). Residence at moderately high altitude and its relationship with WHO Group 1 pulmonary arterial hypertension symptom severity and clinical characteristics: the Pulmonary Hypertension Association Registry. Pulm Circ, 10(4), 2045894020964342.
- Zenger B, Swink JM, Turner JL, Bunch TJ, Ryan JJ, Shah RU, Turakhia MP, Piccini JP, Steinberg BA (2020). Social Media Influence Does Not Reflect Scholarly or Clinical Activity in Real Life. Circ Arrhythm Electrophysiol, 13(11), e008847.
- Wohlfahrt P, Stehlik J, Pan IZ, Ryan JJ (2020). Empowering People Living with Heart Failure. Heart Fail Clin, 16(4), 409-420.
- Ryan JJ, Melendres-Groves L, Zamanian RT, Oudiz RJ, Chakinala M, Rosenzweig EB, Gomberg-Maitland M (2020). Care of patients with pulmonary arterial hypertension during the coronavirus (COVID-19) pandemic. Pulm Circ, 10(2), 2045894020920153.
- Leary PJ, Jenny NS, Bluemke DA, Kawut SM, Kronmal RA, Lima JA, Maron BA, Ralph DD, Rayner SG, Ryan JJ, Steinberg ZL, Hinckley Stukovsky KD, Tedford RJ (2019). Endothelin-1, cardiac morphology, and heart failure: the MESA angiogenesis study. J Heart Lung Transplant, 39(1), 45-52.
- Shah AM, Cikes M, Prasad N, Li G, Getchevski S, Claggett B, Rizkala A, Lukashevich I, OMeara E, Ryan JJ, Shah SJ, Mullens W, Zile MR, Lam CSP, McMurray JJV, Solomon SD, PARAGON-HF Investigators (2019). Echocardiographic Features of Patients With Heart Failure and Preserved Left Ventricular Ejection Fraction. J Am Coll Cardiol, 74(23), 2858-2873.
- Ratchford SM, Clifton HL, Gifford JR, LaSalle DT, Thurston TS, Bunsawat K, Alpenglow JK, Richardson RS, Wright JB, Ryan JJ, Wray DW (2019). Impact of acute antioxidant administration on inflammation and vascular function in heart failure with preserved ejection fraction. Am J Physiol Regul Integr Comp Physiol, 317(5), R607-R614.
- Maron BA, Ryan JJ (2019). A Concerning Trend for Patients With Pulmonary Hypertension in the Era of Evidence-Based Medicine. Circulation, 139(16), 1861-1864.
- Klinger JR, Elliott CG, Levine DJ, Bossone E, Duvall L, Fagan K, Frantsve-Hawley J, Kawut SM, Ryan JJ, Rosenzweig EB, Sederstrom N, Steen VD, Badesch DB (2019). Therapy for Pulmonary Arterial Hypertension in Adults: Update of the CHEST Guideline and Expert Panel Report. Chest, 155(3), 565-586.
- Franco V, Ryan JJ, McLaughlin VV (2018). Pulmonary Hypertension in Women. Heart Fail Clin, 15(1), 137-145.
- Cirulis MM, Ryan JJ, Archer SL (2019). Pathophysiology, incidence, management, and consequences of cardiac arrhythmia in pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension. Pulm Circ, 9(1), 2045894019834890.
- Cirulis MM, Huston JH, Sardar P, Suksaranjit P, Wilson BD, Hatton ND, Liou TG, Ryan JJ (2018). Right-to-left ventricular end diastolic diameter ratio in severe sepsis and septic shock. J Crit Care, 48, 307-310.
- Agarwal S, Spiekerkoetter E, Austin ED, de Jesus Perez V, Dezfulian C, Maron BA, Ryan JJ, Starks MA, Yu PB, Bonnet S, Perman SM (2018). Career Development of Young Physician-Scientists in the Cardiovascular Sciences: Perspective and Advice From the Early Career Committee of the Cardiopulmonary, Critical Care, and Resuscitation Council of the American Heart Association. Circ Res, 122(10), 1330-1333.
- Ryan JJ, Waxman AB (2018). The Dyspnea Clinic. Circulation, 137(19), 1994-1996.
- Thenappan T, Ormiston ML, Ryan JJ, Archer SL (2018). Pulmonary arterial hypertension: pathogenesis and clinical management. BMJ, 360, j5492.
- Keefe AC, Hymas JC, Emerson LL, Ryan JJ (2017). An atypical presentation of cardiac tamponade and periorbital swelling in a patient with eosinophilic granulomatosis with polyangiitis: a case report. J Med Case Rep, 11(1), 271.
- Cruz L, Ryan JJ (2017). Nitric Oxide Signaling in Heart Failure With Preserved Ejection Fraction. JACC Basic Transl Sci, 2(3), 341-343.
- Ryan JJ (2016). Tyrosine Kinase Inhibitors in Pulmonary Vascular Disease. JACC Basic Transl Sci, 1(7), 684-686.
- Ryan JJ (2016). CD47-Blocking Antibodies and Atherosclerosis. JACC Basic Transl Sci, 1(5), 413-415.
- Ryan JJ, Suksaranjit P, Hatton N, Bull DA, Wilson BD (2015). Eisenmenger syndrome with unrepaired patent ductus arteriosus. Circulation, 131(16), e409-11.
- Harrison A, Hatton N, Ryan JJ (03/11/2015). The right ventricule under pressure: evaluating the adaptive and maladaptive changes in the right ventricle in pulmonary arterial hypertension using echocardiography. Pulm Circ, 5(1), 29-47.
- Ryan JJ, Butrous G, Maron BA (2014). The Heterogeneity of Clinical Practice Patterns among an International Cohort of Pulmonary Arterial Hypertension Experts. Pulm Circ.
- Ryan JJ, Archer SL (2014). The right ventricle in pulmonary arterial hypertension: disorders of metabolism, angiogenesis and adrenergic signaling in right ventricular failure. Circ Res, 115(1), 176-88.
- Tong C, Ahmad T, Brittain EL, Bunch TJ, Damp JB, Dardas T, Hijar A, Hill JA, Hilliard AA, Houser SR, Jahangir E, Kates AM, Kim D, Lindman BR, Ryan JJ, Rzeszut AK, Sivaram CA, Valente AM, Freeman AM (2014). Challenges Facing Early Career Academic Cardiologists. J Am Coll Cardiol.
- Harrison A, Wilson BD, Ryan JJ (2014). Exploring the Role of Aldosterone in Right Ventricular Function. Can J Cardiol, 30(2), 155-158.
- Piao L, Fang YH, Parikh K, Ryan JJ, Toth PT, Archer SL (2013). Cardiac glutaminolysis: a maladaptive cancer metabolism pathway in the right ventricle in pulmonary hypertension. J Mol Med (Berl), 91(10), 1185-97.
- Ryan JJ (2013). Chloroquine in pulmonary arterial hypertension: a new role for an old drug? Circ Cardiovasc Genet, 6(3), 310-1.
- Ryan JJ, Marsboom G, Fang YH, Toth PT, Morrow E, Luo N, Piao L, Hong Z, Ericson K, Zhang HJ, Han M, Haney CR, Chen CT, Sharp WW, Archer SL (2013). PGC1alpha-mediated mitofusin-2 deficiency in female rats and humans with pulmonary arterial hypertension. Am J Respir Crit Care Med, 187(8), 865-78.
- Kim GH, Ryan JJ, Archer SL (03/01/2013). Epigenetics in Cardiovascular Medicine (ahead of print). Antioxid Redox Signal.
- Piao L, Sidhu VK, Fang YH, Ryan JJ, Parikh KS, Hong Z, Toth PT, Morrow E, Kutty S, Lopaschuk GD, Archer SL (2013). FOXO1-mediated upregulation of pyruvate dehydrogenase kinase-4 (PDK4) decreases glucose oxidation and impairs right ventricular function in pulmonary hypertension: therapeutic benefits of dichloroacetate. J Mol Med (Berl), 91(3), 333-46.
- Hong Z, Kutty S, Toth PT, Marsboom G, Hammel JM, Chamberlain C, Ryan JJ, Zhang HJ, Sharp WW, Morrow E, Trivedi K, Weir EK, Archer SL (03/1/2013). Role of dynamin-related protein 1 (drp1)-mediated mitochondrial fission in oxygen sensing and constriction of the ductus arteriosus. Circ Res, 112(5), 802-15.
- Ryan JJ, Marsboom G, Fang YH, Toth PT, Morrow E, Luo N, Piao L, Hong Z, Zhang HJ, Haney C, Chen CT, Sharp W, Archer SL (02/28/2013). Mitofusion-2 deficiency promotes smooth muscle cell proliferation and mitofusin-2 gene therapy regresses experimental pulmonary arterial hypertension in females. Am J Respir Crit Care Med.
- Ryan JJ, Musunuru K, Prakash SK (2013). Top advances in functional genomics and translational biology for 2012. Circ Cardiovasc Genet, 6(1), 132-4.
- Ryan JJ, Marsboom G, Archer SL (2013). Rodent models of group 1 pulmonary hypertension. Handb Exp Pharmacol, 218, 105-49.
- Archer SL, Fang YH, Ryan JJ, Piao L (2013). Metabolism and bioenergetics in the right ventricle and pulmonary vasculature in pulmonary hypertension. Pulm Circ, 3(1), 144-52.
- Piao L, Fang YH, Parikh KS, Ryan JJ, DSouza KM, Theccanat T, Toth PT, Pogoriler J, Paul J, Blaxall BC, Akhter SA, Archer SL (12/01/2012). GRK2-mediated inhibition of adrenergic and dopaminergic signaling in right ventricular hypertrophy: therapeutic implications in pulmonary hypertension. Circulation, 126(24), 2859-69.
- Marsboom G, Toth PT, Ryan JJ, Hong Z, Wu X, Fang YH, Thenappan T, Piao L, Zhang HJ, Pogoriler J, Chen Y, Morrow E, Weir EK, Rehman J, Archer SL (2012). Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension. Circ Res, 110(11), 1484-97.
- Ryan JJ, Mehta R, Thiruvoipati T, Ward RP, Williams KA (2012). Stress-only imaging in patients with prior SPECT MPI: a simulation study. J Nucl Cardiol, 19(2), 311-8.
- Ryan JJ, Rich JD, Thiruvoipati T, Swamy R, Kim GH, Rich S (2012). Current practice for determining pulmonary capillary wedge pressure predisposes to serious errors in the classification of patients with pulmonary hypertension. Am Heart J, 163(4), 589-94.
- Marsboom G, Wietholt C, Haney CR, Toth PT, Ryan JJ, Morrow E, Thenappan T, Bache-Wiig P, Piao L, Paul J, Chen CT, Archer SL (2012). Lung (1)(8)F-fluorodeoxyglucose positron emission tomography for diagnosis and monitoring of pulmonary arterial hypertension. Am J Respir Crit Care Med, 185(6), 670-9.
- Ryan JJ, Thenappan T, Luo N, Ha T, Patel AR, Rich S, Archer SL (2012). The WHO classification of pulmonary hypertension: A case-based imaging compendium. Pulm Circ, 2(1), 107-21.
- Kim GH, Ryan JJ, Marsboom G, Archer SL (2011). Epigenetic mechanisms of pulmonary hypertension. Pulm Circ, 1(3), 347-56.
- Maree AO, Vangjeli C, Jneid H, Ryan J, Cox D, Cannon CP, Shields DC, Fitzgerald DJ (2010). G-protein beta3 subunit polymorphism and bleeding in the orbofiban in patients with unstable coronary syndromes-thrombolysis in myocardial infarction 16 trial. J Thromb Haemost, 8(5), 934-41.
- Shin JH, Pokharna HK, Williams KA, Mehta R, Ward RP (2009). SPECT myocardial perfusion imaging with prone-only acquisitions: correlation with coronary angiography. J Nucl Cardiol, 16(4), 590-6.
- Ryan AM, Ryan J, Wan-Ahmed M, Hardiman O, Farrell MA, McNamara B, Sweeney BJ (2009). Vacuolar leucoencephalopathy and pulvinar sign in association with coeliac disease.LID - 10.1136/bcr.08.2008.0650 [doi]LID - bcr08.2008.0650 [pii]. BMJ Case Rep, 2009.
- Ryan JJ, Ryan A, McGrath E (2004). Is Secondary Care Paediatrics Evidenced Based? An Evaluation in a County Hospital. 2/3, 3.
Review
- Jacobs JA, Jahangir E, Ryan JJ (2022). Differentiating pulmonary hypertension associated with protein kinase inhibitors. [Review]. Pulm Circ, 12(2), e12075.
- Alamri AK, Ma CL, Ryan JJ (2021). Left Heart Disease-Related Pulmonary Hypertension. [Review]. Cardiol Clin, 40(1), 69-76.
- Ryan J, Bloch K, Archer SL (2011). Rodent models of pulmonary hypertension: harmonisation with the world health organisation's categorisation of human PH. [Review]. Int J Clin Pract Suppl, (172), 15-34.
- Steiling K, Ryan J, Brody JS, Spira A (2008). The field of tissue injury in the lung and airway. [Review]. Cancer Prev Res (Phila), 1(6), 396-403.
Book Chapter
- Ryan JJ, Marsboom G, Archer S (2013). Pulmonary Hypertension: Animal Models. In Humbert M, Evgenov OV, Stasch JP (Eds.), Pharmacotherapy of Pulmonary Hypertension (Chapter 5).
- Archer SL, Ryan JJ, Rich S, Nathan S, Tsai K, Patel AR, Fang Yh, Piao L (2012). The Right Ventricle: Reemergence of the Forgotten Ventricle. In Joseph A. Hill and Eric N. Olson (Eds.), Muscle: Fundamental Biology and Mechanisms of Disease (CHAPTER 38).
- Archer SL, Ryan J (2011). Mitochondrial ROS and Redox State in Pulmonary Vascular O2 sensing. In Yuan JXJ, Garcia JGN , Hales CA, Stuart R, Archer SL, West JB (Eds.), Textbook of Pulmonary Vascular Disease (CHAPTER 19).
- Gomberg-Maitland M, Thenappan T, Ryan J, Cipriani N, Hussain A, Fedson S, Archer SL (2011). Cor Pulmonale. In Yuan JXJ, Garcia JGN , Hales CA, Stuart R, Archer SL, West JB (Eds.), Textbook of Pulmonary Vascular Disease (CHAPTER 97).
Case Report
- Ferrel MN, Ryan JJ, Han FT (2022). Acute myeloid leukemia causing acute thrombosis of the coronary arteries: a case report. J Med Case Rep, 16(1), 149.
- Ferrel MN, Iriana S, Raymond Thomason I, Ma CL, Tsarova K, Wilson BD, McKellar SH, Ryan JJ (2021). Constrictive pericarditis in the setting of repeated chest trauma in a mixed martial arts fighter. BMC Cardiovasc Disord, 21(1), 561.
- Pugh A, Tonna JE, Youngquist S, Ryan JJ, Brant-Zawadzki G (2020). Emergency department extracorporeal membrane oxygenation as a rescue therapy for ventricular tachycardia electrical storm: a case report. J Am Coll Emerg Physicians Open, 1(4), 371-374.
- Pan IZ, Carey JR, Jacobs JA, Dechand J, Sessions JJ, Sorensen T, Penn BA, Mayeux JD, Hatton ND, Ryan JJ (2020). Transitioning Between Prostanoid Therapies in Pulmonary Arterial Hypertension. Front Med (Lausanne), 7, 81.
- Kundu A, Sardar P, Sen P, Chatterjee S, Huston J, Nairooz R, Ryan JJ, Aronow WS (2015). Patient Taking A Novel Oral Anticoagulant Presents With Major GI Bleeding. J Atr Fibrillation, 8(3), 1218.
- Ryan JJ, Swamy RS, Shah AP (2011). Sudden cardiac death due to large coronary aneurysm successfully treated with a covered stent and ChromaFlo guidance. J Invasive Cardiol, 23(2), E22-5.
- Ryan AM, Ryan JJ, Wan-Ahmed M, Hardiman O, Farrell MA, McNamara B, Sweeney BJ (2007). Vacuolar leucoencephalopathy and pulvinar sign in association with coeliac disease. J Neurol Neurosurg Psychiatry, 78(1), 98-9.
Editorial
- Gilbertson EA, Hatton ND, Ryan JJ (2020). Point of care ultrasound: the next evolution of medical education. Ann Transl Med, 8(14), 846.
- Ferrel MN, Ryan JJ (2020). The Impact of COVID-19 on Medical Education. Cureus, 12(3), e7492.
- Beck EM, Hatton ND, Ryan JJ (2019). Novel techniques for advancing our understanding of pulmonary arterial hypertension. Eur Respir J, 53(5).
- Catino AB, Ryan JJ (2019). A Change in Focus. Circ Cardiovasc Imaging, 12(5), e009186.
- Cirulis MM, Ryan JJ (2018). Who's Who of Pulmonary Hypertension: Redefining Classification to Advance Precision Care. Circ Genom Precis Med, 11(4), e002116.
- Mathai SC, Ryan JJ (2018). The Growing Burden of Pulmonary Hypertension in the Modern Era: A Zebra No More? Circ Cardiovasc Qual Outcomes, 11(2), e004536.
- Hatton N, Ryan JJ (2014). The complicated question of anticoagulation in pulmonary arterial hypertension: time to get some simple answers. Can J Cardiol, 30(8), 850-2.
- Hatton N, Ryan JJ (2014). Sex differences in response to pulmonary arterial hypertension therapy: is what's good for the goose, good for the gander? Chest, 145(6), 1184-1186.
- Luo N, Ryan JJ (2013). Transitioning between endothelin receptor blockers: monitoring to ensure a smooth transition. Can J Cardiol, 29(6), 659-61.
- Thenappan T, Ryan JJ, Archer SL (2012). Evolving Epidemiology of Pulmonary Arterial Hypertension. Am. J. Respir. Crit. Care Med, 186, 707-709.
- Ryan JJ, Rich S, Archer SL (2011). Pulmonary endarterectomy surgery--a technically demanding cure for WHO Group IV Pulmonary Hypertension: requirements for centres of excellence and availability in Canada. Can J Cardiol, 27(6), 671-4.
- Ryan JJ, Rehman J, Archer SL (2011). Paracrine proliferative signaling by senescent cells in world health organization group 3 pulmonary hypertension: age corrupting youth? Circ Res, 109(5), 476-9.
Letter
- Lee JD, Burger CD, Rayner SG, Ryan JJ, Leary PJ (2021). Reply: COVID-19 Experience and Pulmonary Arterial Hypertension: Do Earlier Theses and New Data Still Match? [Letter to the editor]. Ann Am Thorac Soc, 18(6), 1081-1082.
- Jacobs JA, Ryan JJ (2020). Clinical uncertainty for the use of rivaroxaban in obesity. [Letter to the editor]. J Thromb Haemost, 19(3), 870-871.
- Bunsawat K, Ratchford SM, Alpenglow JK, Ryan JJ, Richardson RS, Wray DW (2020). Direct Assessment of Muscle Sympathetic Nerve Activity During Exercise in Heart Failure With Preserved Ejection Fraction: A Case Report. [Letter to the editor]. J Card Fail, 27(1), 114-116.
- Ryan JJ, Maron BA (2020). Vericiguat in Heart Failure with Reduced Ejection Fraction. [Letter to the editor]. N Engl J Med, 383(15), 1497.
- Klinger JR, Elliott G, Levine DJ, Bossone E, Duvall L, Fagan K, Frantsve-Hawley J, Kawut SM, Ryan JJ, Rosenzweig EB, Sederstrom N, Steen VD, Badesch DB (2019). Response. [Letter to the editor]. Chest, 156(1), 187-188.
- Cirulis MM, Liou TG, Ryan JJ (2018). RV/LV ratio in severe sepsis and septic shock: Response to Letter to the Editor. [Letter to the editor]. J Crit Care, 50, 311-312.
- Leary PJ, Hess E, Barn AE, Branch KR, Choudhary G, Hough CL, Maron BA, Ralph DD, Ryan JJ, Tedford RJ, Weiss NS, Zamanian RT, Lahm T (2018). H2 Receptor Antagonist Use and Mortality in Pulmonary Hypertension: Insight from the VA-CART Program. [Letter to the editor]. Am J Respir Crit Care Med, 197(12), 1638-1641.
- Ryan JJ, Kalscheur M, Dellefave L, McNally E, Archer SL (2012). A KCNE1 missense variant (V47I) causing exercise-induced long QT syndrome (Romano Ward). [Letter to the editor]. Int J Cardiol, 156(2), e33-5.
- Ryan AM, Ryan J, Wan-Ahmed M, Hardiman O, Farrell MA, McNamara B, Sweeney BJ (2007). Vacuolar leucoencephalopathy and pulvinar sign in association with coeliac disease. [Letter to the editor]. J Neurol Neurosurg Psychiatry, 78(1), 98-9.
Other
- Francisco MA, Lee JF, Barrett-OKeefe Z, Groot HJ, Ratchford SM, Bunsawat K, Alpenglow JK, Ryan JJ, Nativi JN, Richardson RS, Wray DW (2021). Locomotor Muscle Microvascular Dysfunction in Heart Failure With Preserved Ejection Fraction. Hypertension (78(6), pp. 1750-1759). United States.
- Nassif ME, Windsor SL, Borlaug BA, Kitzman DW, Shah SJ, Tang F, Khariton Y, Malik AO, Khumri T, Umpierrez G, Lamba S, Sharma K, Khan SS, Chandra L, Gordon RA, Ryan JJ, Chaudhry SP, Joseph SM, Chow CH, Kanwar MK, Pursley M, Siraj ES, Lewis GD, Clemson BS, Fong M, Kosiborod MN (2021). The SGLT2 inhibitor dapagliflozin in heart failure with preserved ejection fraction: a multicenter randomized trial. Nat Med (27(11), pp. 1954-1960). United States.
- Ryan JJ (2004). Author of several hundred columns for the 'weekly column' of Ireland's leading medical newspapers. Medicine Weekly and Irish Medical Times.
Video/Film/CD/Web/Podcast
- Ryan JJ (2012). Digital Business Strategy [Web]. American College of Cardiology.
- Ryan JJ (2012). Usability Project, Fellows-In-Training representative. [Web]. CardioSource.
Global Impact
Education History
| Internship | Cork University Hospital Internal Medicine and General Surgery Intern |
| Professional Medical | University College Cork, Ireland Medicine M.D. |
Presentations
| Moderator, American Heart Association Annual Meeting 2012 | Global |
| University College Cork, Medical Alumni Conference, Cork, Ireland. | Global |
| Pulmonary Hypertension post Atrial Fibrilation Ablation, Western AFib Conference, Park City, Utah. USA | Global |
News Articles
Department News
The Scope & Other Podcasts
- Why Women Experience Heart Attack Symptoms Differently Than Men
- More Than a Metaphor – Broken Hearts Are Real
- The Super Bowl and Heart Attacks, is it Really a Thing?
- Seven Questions for a Cardiologist
- Smoking e-Cigarettes Can Cause Heart Attacks
- Always Out of Breath When Exercising? You Might Have Dyspnea
- What is CTEPH and How Do I Know If I Should Get Checked?
- Caring for your heart