Laith F. Al-Rabadi,
MD
Languages Spoken: English
Dr. Al-Rabadi finished his undergraduate and medical training at Jordan University of Science and Technology in 2007. Afterwards, he joined Edelman lab at Harvard-MIT Division of Health Sciences and Technology to study endothelial dysfunction in uremic milieu. Dr. Al-Rabdi finished his Internal Medicine training at University of Iowa in 2013 then moved on to begin nephrology training at Boston University-Boston Medical Center. He had the privilege to work with Dr. David Salant and developed special interest in Glomerular diseases. Dr. Al-Rabadi was also actively involved in teaching students and residents.
His clinical interests include different aspects of nephrology particularly glomerular diseases, transplant, and peritoneal dialysis. He is involved in several clinical research projects and literature reviews.
He established a unique collaboration with Dr. Laurence Beck at Boston Medical Center to initiate innovative projects related to membranous nephropathy (MN) pathogenesis with the goal of developing clinical and translational research and enhancing University of Utah role as a destination site for MN. Dr. Beck is a world-renowned expert and an authority in MN and published extensively on the pathogenesis and biomarkers in MN. He also established a collaboration with Dr. Bernstein and from Moran Eye Center to perform clinical studies related to Alport syndrome (AS). He has been working closely with Dr. Gregory who, along with Dr. Atkins, has collected samples, clinical information and pedigrees of 130 families with X- linked AS. They also identified over 30 families with probable autosomal recessive AS based on patterns of inheritance. He evaluates many patients with AS at the kidney and the transplant clinic.
He is motivated and committed to advance the field of glomerular diseases and Alport syndrome at the university of Utah
Clinical Locations
Transplant and Specialty Clinic
801-585-6320
Fax: (801) 581-5727
Kidney and Liver Clinic
801-585-6320
Fax: (801) 581-7627
Board Certification and Academic Information
| Academic Departments | Internal Medicine
-
Associate Professor (Clinical) |
| Academic Divisions | Nephrology |
| Board Certification | American Board of Internal Medicine American Board of Internal Medicine (Sub: Nephrology) |
Patient Rating
The Patient Rating score is an average of all responses to care provider related questions on our nationally-recognized Press Ganey Patient Satisfaction Survey.
Responses are measured on a scale of 1 to 5 with 5 being the best score.
Likelihood of recommending care provider
4.8/ 5
Care provider's explanation of condition/problem
4.8/ 5
Care provider's effort to include me in decisions
4.8/ 5
Wait time at clinic
4.6/ 5
Care provider's concern for questions & worries
4.9/ 5
Patient Comments
Patient comments are gathered from our Press Ganey Patient Satisfaction Survery and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.
UofU Patient
February 19, 2022
UH HOSPITALS AND CLINICS
Great experience
UofU Patient
February 18, 2022
UH HOSPITALS AND CLINICS
Very personable
UofU Patient
February 08, 2022
UH HOSPITALS AND CLINICS
Routine visit.
UofU Patient
February 04, 2022
UH HOSPITALS AND CLINICS
I just can't enough good things abt dr Al Rabidi. He is an amazing and compassionate physician.
UofU Patient
January 31, 2022
UH HOSPITALS AND CLINICS
My Drs has been great. I have not met a doctor that doesn't care. All the Drs I've seen so far have been so caring and helpful. I owe them so much more than my life. I know they care and love each patient. A Dr who has empathy towards their patients is a good Dr. One that takes their time to help you and make sure you're going to be taken care of. I couldn't ask for better Drs. Thank you all! Please give them raises so they can continue to work as my Drs for many years to come!
UofU Patient
January 27, 2022
UH HOSPITALS AND CLINICS
Excellent as always
UofU Patient
January 19, 2022
UH HOSPITALS AND CLINICS
The doctors and all of the staff are always great with answering questions and making sure I understand all options for treatment.
UofU Patient
December 10, 2021
UH HOSPITALS AND CLINICS
I love Dr al Rabadi. He's the best
UofU Patient
October 22, 2021
UH HOSPITALS AND CLINICS
Interview seem rushed. Under the circumstances of Covid-19 and the pressure put on medical personal, the rushed interview is understandable.
UofU Patient
October 08, 2021
UH HOSPITALS AND CLINICS
Exceptional attention and care Quick but complete and reassuring
UofU Patient
October 02, 2021
UH HOSPITALS AND CLINICS
Dr. Was a bit rushed because of another unscheduled patient, but still managed to be very attentive.
UofU Patient
September 16, 2021
UH HOSPITALS AND CLINICS
Dr. Was very sweet with my mother.
UofU Patient
July 18, 2021
UH HOSPITALS AND CLINICS
Excellent, thoughtful, and considerate interaction with me and my wife. Very nice experience.
UofU Patient
June 08, 2021
UH HOSPITALS AND CLINICS
Good
UofU Patient
May 16, 2021
UH HOSPITALS AND CLINICS
superb experience
UofU Patient
May 03, 2021
UH HOSPITALS AND CLINICS
Very optimistic, encouraging, positive attitude and concerned about my health.
UofU Patient
March 04, 2021
UH HOSPITALS AND CLINICS
listened to my concerns and advocated foe me to go home to my own space for healing
UofU Patient
December 26, 2020
UH HOSPITALS AND CLINICS
The best I ever experienced
UofU Patient
November 28, 2020
UH HOSPITALS AND CLINICS
Dr Al-Rabadi is one of the best doctors
UofU Patient
August 27, 2020
UH HOSPITALS AND CLINICS
DR LAITH SPENT A LONG TIME WITH US, EXPLAINING HIS CONCERNS, LISTENING TO OUR CONCERNS, EXPLAINING RECOMENDATIONS AND FOLLOW UP REQUIREMENTS FOR MARGI...
UofU Patient
August 22, 2020
UH HOSPITALS AND CLINICS
Basically very brief in-person visit to review results of lab work and check blood pressure.
UofU Patient
August 10, 2020
UH HOSPITALS AND CLINICS
He is always awesome! He is so cheerful, and he makes you feel that he really does care.
UofU Patient
July 22, 2020
UH HOSPITALS AND CLINICS
VERY GOOD
Dr. Al-Rabadi finished his undergraduate and medical training at Jordan University of Science and Technology in 2007. Afterwards, he joined Edelman lab at Harvard-MIT Division of Health Sciences and Technology to study endothelial dysfunction in uremic milieu. Dr. Al-Rabdi finished his Internal Medicine training at University of Iowa in 2013 then moved on to begin nephrology training at Boston University-Boston Medical Center. He had the privilege to work with Dr. David Salant and developed special interest in Glomerular diseases. Dr. Al-Rabadi was also actively involved in teaching students and residents.
His clinical interests include different aspects of nephrology particularly glomerular diseases, transplant, and peritoneal dialysis. He is involved in several clinical research projects and literature reviews.
He established a unique collaboration with Dr. Laurence Beck at Boston Medical Center to initiate innovative projects related to membranous nephropathy (MN) pathogenesis with the goal of developing clinical and translational research and enhancing University of Utah role as a destination site for MN. Dr. Beck is a world-renowned expert and an authority in MN and published extensively on the pathogenesis and biomarkers in MN. He also established a collaboration with Dr. Bernstein and from Moran Eye Center to perform clinical studies related to Alport syndrome (AS). He has been working closely with Dr. Gregory who, along with Dr. Atkins, has collected samples, clinical information and pedigrees of 130 families with X- linked AS. They also identified over 30 families with probable autosomal recessive AS based on patterns of inheritance. He evaluates many patients with AS at the kidney and the transplant clinic.
He is motivated and committed to advance the field of glomerular diseases and Alport syndrome at the university of Utah
Academic Locations
Research Statement
A major focus is examining the role of collecting duct-derived endothelin in regulating systemic blood pressure and renal sodium and water excretion. We pioneered cell-specific gene targeting in the kidney using the Cre-loxP system and have used this technique to knockout components of the endothelin system selectively in principal cells of the collecting duct. Collecting duct endothelin-1 knockout mice are hypertensive and have impaired ability to excrete a sodium or water load. Knockout of collecting duct endothelin receptors revealed an important autocrine system for control of blood pressure and sodium excretion in health and in hypertension. We are now investigating how the renal endothelin system is regulated, using whole animal transgenic, cell culture and molecular biologic techniques.
We investigate the role of specific adenylyl cyclase isoforms in mediating the renal actions of vasopressin. These studies involve cell-specific knockout of adenylyl cyclases followed by whole animal and cell and molecular biologic characterization of the phenotype.
Our laboratory also studies the role of the intrarenal renin-angiotensin system in the control of system blood pressure and urinary Na excretion. These studies include development of mouse models over- and under-expressing components of the renin-angiotensin in specific renal cell types.
Finally, we are examining how cilia and polycystins regulate blood pressure and renal function in health and disease. These findings are related to alterations in nitric oxide, endothelin and purinergic signaling.
Board Certification and Academic Information
| Academic Departments | Internal Medicine
-
Associate Professor (Clinical) |
| Academic Divisions | Nephrology |
| Board Certification | American Board of Internal Medicine American Board of Internal Medicine (Sub: Nephrology) |
Research Interests
- Glomerular Diseases
- Uremia
Education History
| Fellowship | Boston Medical Center, Boston University Nephrology Fellow, 2015 |
| Residency | University of Iowa Hospitals and Clinics Internal Medicine Resident, 2013 |
| Internship | University of Iowa Hospitals and Clinics Internal Medicine Intern, 2011 |
| Internship | King Abdullah University Hospital General Surgery Intern, 2009 |
| Internship | Ministry of Health General Medicine Transitional Internship, 2008 |
| Professional Medical | Jordan University of Science and Technology Medicine M.B.B.S., 2007 |
Selected Publications - Journal Articles
Journal Article
- Al-Hijazeen MA, Al-Rawashdeh MS, Al-Rabadi GJ (2021). Cooked broiler meat quality affected by different Mediterranean medicinal plants in the diet. Anim Biosci, 35(2), 290-298.
- Tiffany N Caza1, Laith F Al-Rabadi2 and Laurence H Beck Jr (2021). How Times Have Changed! A Cornucopia of Antigens for Membranous Nephropathy . Front Immunol.
- Al Rabadi LS, Cook MM, Kaempf AJ, Saraceni MM, Savin MA, Mitri ZI (2021). Ado-trastuzumab for the treatment of metastatic HER2-positive breast cancer in patients previously treated with Pertuzumab. BMC Cancer, 21(1), 1150.
- Savige J, Storey H, Watson E, Hertz JM, Deltas C, Renieri A, Mari F, Hilbert P, Plevova P, Byers P, Cerkauskaite A, Gregory M, Cerkauskiene R, Ljubanovic DG, Becherucci F, Errichiello C, Massella L, Aiello V, Lennon R, Hopkinson L, Koziell A, Lungu A, Rothe HM, Hoefele J, Zacchia M, Martic TN, Gupta A, van Eerde A, Gear S, Landini S, Palazzo V, Al-Rabadi L, Claes K, Corveleyn A, Van Hoof E, van Geel M, Williams M, Ashton E, Belge H, Ars E, Bierzynska A, Gangemi C, Lipska-Zitkiewicz BS (2021). Consensus statement on standards and guidelines for the molecular diagnostics of Alport syndrome: refining the ACMG criteria. Eur J Hum Genet, 29(8), 1186-1197.
- Al-Rabadi LF, Caza T, Trivin-Avillach C, Rodan AR, Andeen N, Hayashi N, Williams B, Revelo MP, Clayton F, Abraham J, Lin E, Liou W, Zou CJ, Ramkumar N, Cummins T, Wilkey DW, Kawalit I, Herzog C, Storey A, Edmondson R, Sjoberg R, Yang T, Chien J, Merchant M, Arthur J, Klein J, Larsen C, Beck LH Jr (2021). Serine Protease HTRA1 as a Novel Target Antigen in Primary Membranous Nephropathy. J Am Soc Nephrol.
- Al-Rabadi LF, Caza T, Trivin-Avillach C, Rodan AR, Andeen N, Hayashi N, Williams B, Revelo MP, Clayton F, Abraham J, Lin E, Liou W, Zou CJ, Ramkumar N, Cummins T, Wilkey DW, Kawalit I, Herzog C, Storey A, Edmondson R, Sjoberg R, Yang T, Chien J, Merchant M, Arthur J, Klein J, Larsen C, Beck LH Jr (2021). Serine Protease HTRA1 as a Novel Target Antigen in Primary Membranous Nephropathy. J Am Soc Nephrol.
- Cook MM, Al Rabadi L, Kaempf AJ, Saraceni MM, Savin MA, Mitri ZI (2020). Everolimus Plus Exemestane Treatment in Patients with Metastatic Hormone Receptor-Positive Breast Cancer Previously Treated with CDK4/6 Inhibitor Therapy. Oncologist, 26(2), 101-106.
- Alrabadi N, Haddad R, Albustami I, Al-Faouri I, Obeidat N, Al-Ghazo M, Al-Rabadi D, Khassawneh A (2020). The lockdown may contribute to the COVID-19 cases in developing countries, different perspectives on the curfew act, a report from Jordan. Ann Med Surg (Lond), 61, 41-43.
- Alrabadi N, Al-Rabadi GJ, Maraqa R, Sarayrah H, Alzoubi KH, Alqudah M, Al-Udatt DG (2020). Androgen effect on body weight and behaviour of male and female rats: novel insight on the clinical value. Andrologia, 52(10), e13730.
- Al Rabadi L, LeBlanc M, Bucy T, Ellis LM, Hershman DL, Meyskens FL Jr, Taylor L, Blanke CD (2019). Trends in Medical Aid in Dying in Oregon and Washington. JAMA Netw Open, 2(8), e198648.
- Khalighi MA, Al-Rabadi L, Chalasani M, Smith M, Kakani S, Revelo MP, Meehan SM (2018). Staphylococcal Infection-Related Glomerulonephritis With Cryoglobulinemic Features. Kidney Int Rep, 3(5), 1128-1134.
- Al-Rabadi L, Box T, Singhania G, Al-Marji C, Agarwal A, Hall I, Gordon CE, Tran H (2018). Rationale for treatment of hepatitis C virus infection in end-stage renal disease patients who are not kidney transplant candidates. Hemodial Int, 22 Suppl 1, S45-S52.
- Al-Rabadi GJ, Al-Rawashdeh MS, Al-Hijazeen MA, Al-Omari HY (2018). Effects of Sucrose-based High-lysine Diet on Blood Chemistry, Growth Performance, and Gastrointestinal Morphology of Broiler Chickens During the Growing Stage. J Poult Sci, 55(4), 263-268.
- Al-Rabadi L, Quillen K, Shashar M, Al Marji C, Jaberi A, Chitalia V, Henderson J, Salant D, Beck LH (2017). Concurrent Presentation of Thrombotic Thrombocytopenic Purpura and Membranous Nephropathy. Kidney Int Rep.
- Shivanna S, Kolandaivelu K, Shashar M, Belghasim M, Al-Rabadi L, Balcells M, Zhang A, Weinberg J, Francis J, Pollastri MP, Edelman ER, Sherr DH, Chitalia VC (2016). The Aryl Hydrocarbon Receptor is a Critical Regulator of Tissue Factor Stability and an Antithrombotic Target in Uremia. J Am Soc Nephrol, 27(1), 189-201.
- Al-Rabadi L, Francis JM, Henderson J, Ghai S (2015). Proliferative glomerulonephritis with monoclonal immunoglobulin in renal allografts. Clin Kidney J, 8(6), 722-8.
- Chitalia VC, Murikipudi S, Indolfi L, Rabadi L, Valdez R, Franses JW, Edelman ER (2011). Matrix-embedded endothelial cells are protected from the uremic milieu. Nephrol Dial Transplant, 26(12), 3858-65.
Review
- Caza T, Wijewardena C, Al-Rabadi L, Perl A (2022). Cell type-specific mechanistic target of rapamycin-dependent distortion of autophagy pathways in lupus nephritis. [Review]. Transl Res.
- Caza TN, Al-Rabadi LF, Beck LH Jr (2021). How Times Have Changed! A Cornucopia of Antigens for Membranous Nephropathy. [Review]. Front Immunol, 12, 800242.
Book Chapter
- Al-Rabadi L (2019). Renal and Metabolic Disorders Related to Alcohol and Other Drug Use. In The ASAM Essentials of Addiction Medicine (3rd).
Case Report
- Bansal S, Singhania N, Nukala CM, Singh AK, Al-Rabadi L (2021). Histoplasma stomatitis unveiled: Not all opportunistic infections get better after initiation of antiretroviral therapy. Clin Case Rep, 9(3), 1466-1468.
- Singhania N, Singhania G, Al-Rabadi L (2020). Acquired Reactive Perforating Collagenosis. Clin Exp Nephrol, 24(11), 1086-1087.
- Singhania N, Al-Odat R, Singh AK, Al-Rabadi L (2020). Intestinal necrosis after co-administration of sodium polystyrene sulfonate and activated charcoal. Clin Case Rep, 8(4), 722-724.
- Al-Rabadi L, Quillen K, Shashar M, Al Marji C, Jaberi A, Chitalia V, Henderson J, Salant D, Beck LH Jr (2017). Concurrent Presentation of Thrombotic Thrombocytopenic Purpura and Membranous Nephropathy. Kidney Int Rep, 3(2), 476-481.
- Al-Rabadi L, Ayalon R, Bonegio RG, Ballard JE, Fujii AM, Henderson JM, Salant DJ, Beck LH Jr (2016). Pregnancy in a Patient With Primary Membranous Nephropathy and Circulating Anti-PLA2R Antibodies: A Case Report. Am J Kidney Dis, 67(5), 775-8.
- Aburizik A, Singh S, Al-Rabadi L, Blosser C (2014). Mistaken identity: normotensive scleroderma renal crisis.LID - 10.1136/bcr-2013-202566 [doi]LID - bcr2013202566 [pii]. BMJ Case Rep, 2014.
Abstract
- Al-Odat R, Al-Rabadi L (2014). Pseudo renal injury associated with Isopropyl alcohol [Abstract]. American Society of Nephrology, ASN's 2014 Abstract Supplement of JASN.
- Al-Odat R, Al-Rabadi L, Blosser C, Francis J (2014). Hypermagnesemia-induced hypothermia in a pregnant patient [Abstract]. ASN's 2014 Abstract Supplement of JASN.
- Al-Rabadi LF, Al-odat RT, Blosser CD (2012). Tacrolimus-Induced Thrombotic Microangiopathy Post Allogeneic Stem Cell Transplant [Abstract]. American Society of Nephrology, 23(Abstract Issue), PUB36, 902A.
- Erinle AO, Al-Rabadi LF, Sarker A, Gamilla-Crudo AK, Ishihara K, Beach R (2008). Seronegative Anti-GBM Disease; Clinical Dilemma in Management [Abstract]. American Society of Nephrology, PUB778, 19(Abstract Issue), 989A-990A.
Other
- Savige J, Lipska-Zietkiewicz BS, Watson E, Hertz JM, Deltas C, Mari F, Hilbert P, Plevova P, Byers P, Cerkauskaite A, Gregory M, Cerkauskiene R, Ljubanovic DG, Becherucci F, Errichiello C, Massella L, Aiello V, Lennon R, Hopkinson L, Koziell A, Lungu A, Rothe HM, Hoefele J, Zacchia M, Martic TN, Gupta A, van Eerde A, Gear S, Landini S, Palazzo V, Al-Rabadi L, Claes K, Corveleyn A, Van Hoof E, van Geel M, Williams M, Ashton E, Belge H, Ars E, Bierzynska A, Gangemi C, Renieri A, Storey H, Flinter F (2021). Guidelines for Genetic Testing and Management of Alport Syndrome. Clin J Am Soc Nephrol (17(1), pp. 143-154). United States.
- May RM, Cassol C, Hannoudi A, Larsen CP, Lerma EV, Haun RS, Braga JR, Hassen SI, Wilson J, VanBeek C, Vankalakunti M, Barnum L, Walker PD, Bourne TD, Messias NC, Ambruzs JM, Boils CL, Sharma SS, Cossey LN, Baxi PV, Palmer M, Zuckerman JE, Walavalkar V, Urisman A, Gallan AJ, Al-Rabadi LF, Rodby R, Luyckx V, Espino G, Santhana-Krishnan S, Alper B, Lam SG, Hannoudi GN, Matthew D, Belz M, Singer G, Kunaparaju S, Price D, Chawla S, Rondla C, Abdalla MA, Britton ML, Paul S, Ranjit U, Bichu P, Williamson SR, Sharma Y, Gaspert A, Grosse P, Meyer I, Vasudev B, El Kassem M, Velez JCQ, Caza TN (2021). A multi-center retrospective cohort study defines the spectrum of kidney pathology in Coronavirus 2019 Disease (COVID-19). Kidney Int (100(6), pp. 1303-1315). United States.
- Huang Z, Liu S, Tang A, Al-Rabadi L, Henkemeyer M, Mimche PN, Huang Y (2021). Key role for EphB2 receptor in kidney fibrosis. Clin Sci (Lond) (135(17), pp. 2127-2142). England.
- Lazaro-Guevara J, Fierro-Morales J, Wright AH, Gunville R, Simeone C, Frodsham SG, Pezzolesi MH, Zaffino CA, Al-Rabadi L, Ramkumar N, Pezzolesi MG (2021). Targeted Next-Generation Sequencing Identifies Pathogenic Variants in Diabetic Kidney Disease. Am J Nephrol (52(3), pp. 239-249). Switzerland.
Global Impact
Education History
| Internship | King Abdullah University Hospital General Surgery Intern |
| Internship | Ministry of Health General Medicine Transitional Internship |
| Professional Medical | Jordan University of Science and Technology Medicine M.B.B.S. |