Ben Shofty,
MD, PhD
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Languages Spoken: English, Hebrew, Spanish
Ben Shofty, MD/PhD is an Israeli-board certified functional neurosurgeon and a former Israeli national rugby player. He graduated from the Tel-Aviv University Faculty of Medicine, and received a PhD in systems neuroscience from the Israeli Institute of Technology. He completed his neurosurgical training at the Tel-Aviv Medical Center, followed by two years of combined research/clinical fellowship at Baylor College of Medicine. His practice will focus on neuromodulation for psychiatric disorders, surgical treatments for cancer pain, movement disorders and epilepsy. In his lab, he is investigating high-order cognition and network dependent functions such as creativity and mind wondering, as well as novel interventions for OCD, depression and PTSD. In addition, he is interested in advanced imaging and visual biopsies.
Specialties
Board Certification and Academic Information
| Academic Departments | Neurosurgery
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Assistant Professor |
| Board Certification | Board of Neurosurgery (Israel) Educational Commission for Foreign Medical Graduates |
Ben Shofty, MD/PhD is an Israeli-board certified functional neurosurgeon and a former Israeli national rugby player. He graduated from the Tel-Aviv University Faculty of Medicine, and received a PhD in systems neuroscience from the Israeli Institute of Technology. He completed his neurosurgical training at the Tel-Aviv Medical Center, followed by two years of combined research/clinical fellowship at Baylor College of Medicine. His practice will focus on neuromodulation for psychiatric disorders, surgical treatments for cancer pain, movement disorders and epilepsy. In his lab, he is investigating high-order cognition and network dependent functions such as creativity and mind wondering, as well as novel interventions for OCD, depression and PTSD. In addition, he is interested in advanced imaging and visual biopsies.
Academic Locations
Clinical Neurosciences Center
801-585-7575
Board Certification and Academic Information
| Academic Departments | Neurosurgery
-
Assistant Professor |
| Board Certification | Board of Neurosurgery (Israel) Educational Commission for Foreign Medical Graduates |
Education History
| Fellowship | Baylor College of Medicine Stereotactic and Functional Neurosurgery Fellow, 2022 |
| Residency | Tel Aviv University Sackler Faculty of Medicine Neurosurgery Chief Resident, 2020 |
| Residency | Tel Aviv University Sackler Faculty of Medicine Neurosurgery Resident, 2018 |
| Professional Medical | Technion - Israeli Institute of Technology Systems Neuroscience Ph.D., 2017 |
| Internship | Rambam Health Care Campus Rotating Intern, 2013 |
| Professional Medical | Tel Aviv University Sackler Faculty of Medicine Medicine M.D., 2012 |
| Professional Medical | Tel Aviv University Sackler Faculty of Medicine Medical Science (Pre-Med) B.Med.Sci., 2008 |
Selected Publications - Journal Articles
Journal Article
- Jalon I, Berger A, Shofty B, Goldway N, Artzi M, Gurevitch G, Hochberg U, Tellem R, Hendler T, Gonen T, Strauss I (2022). Lesions to both somatic and affective pain pathways lead to decreased salience network connectivity. Brain.
- Giridharan N, Katlowitz KA, Anand A, Gadot R, Najera RA, Shofty B, Snyder R, Larrinaga C, Prablek M, Karas PJ, Viswanathan A, Sheth SA (2022). Robot-Assisted Deep Brain Stimulation: High Accuracy and Streamlined Workflow. Oper Neurosurg (Hagerstown), 23(3), 254-260.
- Gadot R, Vanegas Arroyave N, Dang H, Anand A, Najera RA, Taneff LY, Bellows S, Tarakad A, Jankovic J, Horn A, Shofty B, Viswanathan A, Sheth SA (2022). Association of clinical outcomes and connectivity in awake versus asleep deep brain stimulation for Parkinson disease. J Neurosurg, 1-12.
- Das A, Myers J, Mathura R, Shofty B, Metzger BA, Bijanki K, Wu C, Jacobs J, Sheth SA (2022). Spontaneous neuronal oscillations in the human insula are hierarchically organized traveling waves. Elife, 11.
- Anand A, Magnotti JF, Smith DN, Gadot R, Najera RA, Hegazy MIR, Gavvala JR, Shofty B, Sheth SA (2022). Predictive value of magnetoencephalography in guiding the intracranial implant strategy for intractable epilepsy. J Neurosurg, 1-11.
- Shofty B, Gonen T, Bergmann E, Mayseless N, Korn A, Shamay-Tsoory S, Grossman R, Jalon I, Kahn I, Ram Z (2022). The default network is causally linked to creative thinking. Mol Psychiatry, 27(3), 1848-1854.
- Haim O, Abramov S, Shofty B, Fanizzi C, DiMeco F, Avisdris N, Ram Z, Artzi M, Grossman R (2022). Predicting EGFR mutation status by a deep learning approach in patients with non-small cell lung cancer brain metastases. J Neurooncol, 157(1), 63-69.
- Shofty B, Bergman L, Berger A, Aizenstein O, Ben-Valid S, Gurovich D, Tankus A, Attias M, Fahoum F, Strauss I (2021). Adopting MR-guided stereotactic laser ablations for epileptic lesions: initial clinical experience and lessons learned. Acta Neurochir (Wien), 163(10), 2797-2803.
- Shimony N, Popovits N, Shofty B, Abergel A, Ram Z, Grossman R (2021). Endoscopic transsphenoidal surgery reduces the need for re-operation compared to the microscopic approach in pituitary macroadenomas. Eur J Surg Oncol, 47(6), 1352-1356.
- Roth J, Jonas Kimchi T, Shofty B, Agur A, Ben-Sira L, Constantini S (2021). The Role of 3D Reconstruction of the Skull in Patients with Suspected Shunt Malfunction. Pediatr Neurosurg, 56(2), 110-115.
- Grossman R, Haim O, Abramov S, Shofty B, Artzi M (2021). Differentiating Small-Cell Lung Cancer From Non-Small-Cell Lung Cancer Brain Metastases Based on MRI Using Efficientnet and Transfer Learning Approach. Technol Cancer Res Treat, 20, 15330338211004919.
- Karas PJ, Giridharan N, Treiber JM, Prablek MA, Khan AB, Shofty B, Krishnan V, Chu J, Van Ness PC, Maheshwari A, Haneef Z, Gavvala JR, Sheth SA (2020). Accuracy and Workflow Improvements for Responsive Neurostimulation Hippocampal Depth Electrode Placement Using Robotic Stereotaxy. Front Neurol, 11, 590825.
- Shofty B, Haim O, Costa M, Kashanian A, Shtrozberg S, Ram Z, Grossman R (2020). Impact of repeated operations for progressive low-grade gliomas. Eur J Surg Oncol, 46(12), 2331-2337.
- Sapir Y, Korn A, Bitan-Talmor Y, Vendrov I, Berger A, Shofty B, Zegerman A, Strauss I (2020). Intraoperative Neurophysiology for Optimization of Percutaneous Spinothalamic Cordotomy for Intractable Cancer Pain. Oper Neurosurg (Hagerstown), 19(6), E566-E572.
- Artzi M, Gershov S, Ben-Sira L, Roth J, Kozyrev D, Shofty B, Gazit T, Halag-Milo T, Constantini S, Ben Bashat D (2020). Automatic segmentation, classification, and follow-up of optic pathway gliomas using deep learning and fuzzy c-means clustering based on MRI. Med Phys, 47(11), 5693-5701.
- Asleh J, Shofty B, Cohen N, Kavushansky A, Lpez-Jurez A, Constantini S, Ratner N, Kahn I (2020). Brain-wide structural and functional disruption in mice with oligodendrocyte-specific NF1 deletion is rescued by inhibition of nitric oxide synthase. Proc Natl Acad Sci U S A, 117(36), 22506-22513.
- Shofty B, Artzi M, Shtrozberg S, Fanizzi C, DiMeco F, Haim O, Peleg Hason S, Ram Z, Bashat DB, Grossman R (2020). Virtual biopsy using MRI radiomics for prediction of BRAF status in melanoma brain metastasis. Sci Rep, 10(1), 6623.
- Shofty B, Mauda-Havakuk M, Ben-Sira L, Bokstein F, Lidar Z, Salame K, Korn A, Constantini S (2019). Surgical Management of "Kissing" Spinal Plexiform Neurofibromas in Neurofibromatosis Type 1 Patients. World Neurosurg, 134, e1143-e1147.
- Shofty B, Richetta C, Haim O, Kashanian A, Gurevich A, Grossman R (2019). 5-ALA-assisted stereotactic brain tumor biopsy improve diagnostic yield. Eur J Surg Oncol, 45(12), 2375-2378.
- Shofty B, Bergmann E, Zur G, Asleh J, Bosak N, Kavushansky A, Castellanos FX, Ben-Sira L, Packer RJ, Vezina GL, Constantini S, Acosta MT, Kahn I (2019). Autism-associated Nf1 deficiency disrupts corticocortical and corticostriatal functional connectivity in human and mouse. Neurobiol Dis, 130, 104479.
- Richetta C, Shofty B, Gurevich A, Grossman R (2019). Valve Failure in Ventriculoperitoneal Shunts of Neuro-Oncologic Patients: A Historical Cohort Study. World Neurosurg, 128, e329-e333.
- van Baarsen K, Roth J, Serova N, Packer RJ, Shofty B, Thomale UW, Cinalli G, Toledano H, Michowiz S, Constantini S (2017). Optic pathway-hypothalamic glioma hemorrhage: a series of 9 patients and review of the literature. J Neurosurg, 129(6), 1407-1415.
- Shofty B, Artzi M, Ben Bashat D, Liberman G, Haim O, Kashanian A, Bokstein F, Blumenthal DT, Ram Z, Shahar T (2017). MRI radiomics analysis of molecular alterations in low-grade gliomas. Int J Comput Assist Radiol Surg, 13(4), 563-571.
- Barzilai O, Ben Moshe S, Sitt R, Sela G, Shofty B, Ram Z (2018). Improvement in cognitive function after surgery for low-grade glioma. J Neurosurg, 1-9.
- Gonen L, Nov E, Shimony N, Shofty B, Margalit N (2017). Sphenoorbital meningioma: surgical series and design of an intraoperative management algorithm. Neurosurg Rev, 41(1), 291-301.
- Shofty B, Ben-Sira L, Kesler A, Jallo G, Groves ML, Iyer RR, Lassaletta A, Tabori U, Bouffet E, Thomale UW, Herniz Driever P, Constantini S, Isolated Optic Nerve Abnormalities IONA Collaboration (2017). Isolated optic nerve gliomas: a multicenter historical cohort study. J Neurosurg Pediatr, 20(6), 549-555.
- Mauda-Havakuk M, Shofty B, Ben-Shachar S, Ben-Sira L, Constantini S, Bokstein F (2017). Spinal and Paraspinal Plexiform Neurofibromas in Patients with Neurofibromatosis Type 1: A Novel Scoring System for Radiological-Clinical Correlation. AJNR Am J Neuroradiol, 38(10), 1869-1875.
- Shimony N, Shofty B, Harosh CB, Sitt R, Ram Z, Grossman R (2016). Surgical Resection of Cerebral Metastases Leads to Faster Resolution of Peritumoral Edema than Stereotactic Radiosurgery: A Volumetric Analysis. Ann Surg Oncol, 24(5), 1392-1398.
- Shimony N, Shofty B, Ram Z, Grossman R (2016). Perioperative Risk Assessment of Patients with Gliomatosis Cerebri. World Neurosurg, 98, 334-338.
- Shimony N, Gonen L, Shofty B, Abergel A, Fliss DM, Margalit N (2016). Surgical resection of skull-base chordomas: experience in case selection for surgical approach according to anatomical compartments and review of the literature. Acta Neurochir (Wien).
- Neuberger A, Shofty B, Bishop B, Naffaa ME, Binawi T, Babich T, Rappaport ZH, Zaaroor M, Sviri G, Yahav D, Paul M (2016). Risk factors associated with death or neurological deterioration among patients with Gram-negative postneurosurgical meningitis. Clin Microbiol Infect, 22(6), 573.e1-4.
- Shofty B, Neuberger A, Naffaa ME, Binawi T, Babitch T, Rappaport ZH, Zaaroor M, Sviri G, Paul M (2015). Intrathecal or intraventricular therapy for post-neurosurgical Gram-negative meningitis: matched cohort study. Clin Microbiol Infect, 22(1), 66-70.
- Shofty B, Mauda-Havakuk M, Weizman L, Constantini S, Ben-Bashat D, Dvir R, Pratt LT, Joskowicz L, Kesler A, Yalon M, Ravid L, Ben-Sira L (2015). The effect of chemotherapy on optic pathway gliomas and their sub-components: A volumetric MR analysis study. Pediatr Blood Cancer, 62(8), 1353-9.
- Pratt L, Helfer D, Weizman L, Shofty B, Constantini S, Joskowicz L, Ben Bashat D, Ben-Sira L (2015). Tumor burden evaluation in NF1 patients with plexiform neurofibromas in daily clinical practice. Acta Neurochir (Wien), 157(5), 855-61.
- Weizman L, Helfer D, Ben Bashat D, Pratt LT, Joskowicz L, Constantini S, Shofty B, Ben Sira L (2013). PNist: interactive volumetric measurements of plexiform neurofibromas in MRI scans. Int J Comput Assist Radiol Surg, 9(4), 683-93.
- Ram ST, Neuberger A, Thapa LJ, Vir Singh RP, Shofty B, Schwartz E (2014). Japanese encephalitis among patients with acute encephalitic syndrome admitted to a tertiary hospital in Chitwan, Nepal--a prospective observational study. PLoS One, 9(6), e99999.
- Weizman L, Sira LB, Joskowicz L, Rubin DL, Yeom KW, Constantini S, Shofty B, Bashat DB (2014). Semiautomatic segmentation and follow-up of multicomponent low-grade tumors in longitudinal brain MRI studies. Med Phys, 41(5), 052303.
- Shofty B, Constantini S, Bokstein F, Ram Z, Ben-Sira L, Freedman S, Vainer G, Kesler A (2013). Optic pathway gliomas in adults. Neurosurgery, 74(3), 273-9; discussion 279-80.
- Shofty B, Ben-Sira L, Constantini S, Freedman S, Kesler A (2011). Optic nerve sheath diameter on MR imaging: establishment of norms and comparison of pediatric patients with idiopathic intracranial hypertension with healthy controls. AJNR Am J Neuroradiol, 33(2), 366-9.
- Weizman L, Ben Sira L, Joskowicz L, Constantini S, Precel R, Shofty B, Ben Bashat D (2011). Automatic segmentation, internal classification, and follow-up of optic pathway gliomas in MRI. Med Image Anal, 16(1), 177-88.
- Weizman L, Ben-Sira L, Joskowicz L, Aizenstein O, Shofty B, Constantini S, Ben-Bashat D (2013). Prediction of brain MR scans in longitudinal tumor follow-up studies. 15(Pt 2), 179-87.
- Shofty B, Ben-Sira L, Freedman S, Yalon M, Dvir R, Weintraub M, Toledano H, Constantini S, Kesler A (2011). Visual outcome following chemotherapy for progressive optic pathway gliomas. Pediatr Blood Cancer, 57(3), 481-5.
- Shofty B, Weizman L, Joskowicz L, Constantini S, Kesler A, Ben-Bashat D, Yalon M, Dvir R, Freedman S, Roth J, Ben-Sira L (2011). MRI internal segmentation of optic pathway gliomas: clinical implementation of a novel algorithm. Childs Nerv Syst, 27(8), 1265-72.
- Shofty B, Gadot R, Viswanathan A, Provenza NR, Storch EA, McKay SA, Meyers MS, Hertz AG, Avendano-Ortega M, Goodman WK, Sheth SA (In press). Intraoperative valence testing to adjudicate between ventral capsule/ventral striatum and bed nucleus of the stria terminalis target selection in deep brain stimulation for obsessive-compulsive disorder. (Epub ahead of print) J Neurosurg.
Review
- Gadot R, Najera R, Hirani S, Anand A, Storch E, Goodman WK, Shofty B, Sheth SA (2022). Efficacy of deep brain stimulation for treatment-resistant obsessive-compulsive disorder: systematic review and meta-analysis. [Review]. J Neurol Neurosurg Psychiatry.
- Najera RA, Gregory ST, Shofty B, Anand A, Gadot R, Youngerman BE, Storch EA, Goodman WK, Sheth SA (2022). Cost-effectiveness analysis of radiosurgical capsulotomy versus treatment as usual for treatment-resistant obsessive-compulsive disorder. [Review]. J Neurosurg, 1-11.
- Allam AK, Larkin Michael MB, Shofty B, Viswanathan A (2022). Ablation Procedures. [Review]. Neurosurg Clin N Am, 33(3), 339-344.
- Gadot R, Korst G, Shofty B, Gavvala JR, Sheth SA (2022). Thalamic stereoelectroencephalography in epilepsy surgery: a scoping literature review. [Review]. J Neurosurg, 1-16.
- Shofty B, Ben Sira L, Constantini S (2020). Neurofibromatosis 1-associated optic pathway gliomas. [Review]. Childs Nerv Syst, 36(10), 2351-2361.
- Shofty B, Barzilai O, Khashan M, Lidar Z, Constantini S (2020). Spinal manifestations of Neurofibromatosis type 1. [Review]. Childs Nerv Syst, 36(10), 2401-2408.
- Shimony N, Gonen L, Shofty B, Abergel A, Fliss DM, Margalit N (2016). Surgical resection of skull-base chordomas: experience in case selection for surgical approach according to anatomical compartments and review of the literature. [Review]. Acta Neurochir (Wien), 159(10), 1835-1845.
- Hussein K, Bitterman R, Shofty B, Paul M, Neuberger A (2017). Management of post-neurosurgical meningitis: narrative review. [Review]. Clin Microbiol Infect, 23(9), 621-628.
- Shofty B, Constantini S, Ben-Shachar S (2015). Advances in Molecular Diagnosis of Neurofibromatosis Type 1. [Review]. Semin Pediatr Neurol, 22(4), 234-9.
- Shofty B, Ben-Sira L, Kesler A, Constantini S (2014). Optic pathway gliomas. [Review]. Adv Tech Stand Neurosurg, 42, 123-46.
- Shofty B, Constantini S, Freedman S, Ben-Sira L, Kesler A (2011). [Optic pathway gliomas--current position and future directions]. [Review]. Harefuah, 149(11), 721-5, 748.
- Shofty B, Gadot R, Provenza N, Storch EA, Goomand WK, Sheth SA (In press). Neurosurgical Approaches for Treatment-Resistant Obsessive-Compulsive Disorder. [Review]. Psychiatr Clin North Am.
Book Chapter
- Shofty B, Ben-Sira L, Toledano-Alhadef H, Bokstein F, Constantini S (2018). Neurofibromatosis type I. In Jallo GI, Kothbauer K, Recinos VMR (Eds.), Handbook of Pediatric Neurosurgery. Thieme.
- Shofty B, Barzilai O, Lidar Z, Hwang E, Constantini S (2017). Pediatric Intradural Spinal Cord Tumors. In Swaiman KF, Ashwal S, Ferriero DM, Schor NF, Finkel RS, Gropman AL, Pearl PL, Shevell M (Eds.), Swaiman’s Pediatric Neurology: Principles and Practice (6th Edition). Elsevier.
- Shofty B, Ben-Sira L, Kesler A, Constantini S (2014). Optic Pathway Gliomas. In Albright AL, Pollack IF, Adelson PD (Eds.), Principles and Practice of Pediatric Neurosurgery (3rd Edition). Thieme.
- Shofty B, Ben-Sira L, Kesler A, Constantini S (2013). Optic Pathway Gliomas. In Pickard JD, Rocco C, Dolenc VV, Fahlbusch R, Lobo Antunes J, Sindou M, Tribolet N, Tulleken CAF, Vapalahti M (Eds.), Advances and Technical Standards in Neurosurgery ((NEUROSURGERY, volume 29)). Springer.
- Shofty B, Korn A, Lidar Z, Constantini S (2012). Intradural Spinal Cord Tumors. In Packer RJ, Schiff D (Eds.), Neurology in Practice: Neuro-Oncology (1st Edition). Wiley-Blackwell.
Commentary
Case Report
- Anand A, Gavvala JR, Mathura R, Najera RA, Gadot R, Shofty B, Sheth SA (2022). Elimination of anxiety after laser interstitial thermal ablation of the dominant cingulate gyrus for epilepsy. Surg Neurol Int, 13, 178.
- Gadot R, Shofty B, Najera RA, Anand A, Banks G, Khan AB, LoPresti MA, Vanegas Arroyave N, Sheth SA (2021). Case Report: Dual Target Deep Brain Stimulation With Externalized Programming for Post-traumatic Complex Movement Disorder. Front Neurosci, 15, 774073.
- Shofty B, Roth J, Ben-Sira L, Brotchi J, Korn A, Constantini S (2012). Massive hematomyelia following intramedullary spinal cord tumor surgery. Acta Neurochir (Wien), 154(4), 751-2.
Video/Film/CD/Web/Podcast
- Shofty B, Mathura RK, Provenza NR, Vogt GS, Storch EA, Goodman WK, Sheth SA (2021). DBS for Severe, treatment resistant obsessive-compulsive disorder [Web]. CNS Nexus. Available: https://www.cns.org/nexus/case/detail/dbs-severe- treatment-resistant-obsessive-compulsiv.