Robin Mark Shaw
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Robin Mark Shaw, MD, PhD

  • Dr. Robin Shaw is the Nora Eccles Harrison Presidential Endowed Chair and Professor of Medicine at the University of Utah School of Medicine. He is also Director of the Nora Eccles Harrison Cardiovascular Research and Training Institute. Dr. Shaw's clinical interests include advanced heart failure and cardiac arrhythmias. His research interests involve the cell biology of heart muscle cells, with a particular focus on the movement of cardiac ion channels and the mechanisms of heart failure progression. Dr. Shaw's research team has identified new cardiac proteins and are developing a novel gene therapy for treating advanced heart failure.

    Dr. Shaw earned his M.D. and Ph.D. degrees at Case Western Reserve University in 1997 and 1999. He completed Internal Medicine and Cardiology Fellowship training at the University of California, San Francisco. He remained at the University of California San Francisco as an Assistant and then tenured Associate Professor and Investigator at its Cardiovascular Research Institute. In 2013 he moved to Los Angeles as Professor of Medicine at UCLA and the Wasserman Foundation Endowed Chair in Cardiology at Cedars-Sinai Smidt Heart Institute. Dr. Shaw was recruited to the University of Utah in 2019 with a primary responsibility to serve as Director of the CVRTI.

    Specialties

    Board Certification

    American Board of Internal Medicine (Sub: Cardiovascular Disease)

  • Dr. Robin Shaw is the Nora Eccles Harrison Presidential Endowed Chair and Professor of Medicine at the University of Utah School of Medicine. He is also Director of the Nora Eccles Harrison Cardiovascular Research and Training Institute. Dr. Shaw's clinical interests include advanced heart failure and cardiac arrhythmias. His research interests involve the cell biology of heart muscle cells, with a particular focus on the movement of cardiac ion channels and the mechanisms of heart failure progression. Dr. Shaw's research team has identified new cardiac proteins and are developing a novel gene therapy for treating advanced heart failure.

    Dr. Shaw earned his M.D. and Ph.D. degrees at Case Western Reserve University in 1997 and 1999. He completed Internal Medicine and Cardiology Fellowship training at the University of California, San Francisco. He remained at the University of California San Francisco as an Assistant and then tenured Associate Professor and Investigator at its Cardiovascular Research Institute. In 2013 he moved to Los Angeles as Professor of Medicine at UCLA and the Wasserman Foundation Endowed Chair in Cardiology at Cedars-Sinai Smidt Heart Institute. Dr. Shaw was recruited to the University of Utah in 2019 with a primary responsibility to serve as Director of the CVRTI.

    Board Certification and Academic Information

    Academic Departments Internal Medicine -Professor
    Academic Divisions Cardiovascular Medicine
    Board Certification
    American Board of Internal Medicine (Sub: Cardiovascular Disease)

    Selected Publications

    Journal Article

    1. Valdez SE, Taylor LA, Selzman CH, Drakos SG, Shaw RM, Palatinus JA (2025). Left Ventricular Unloading With Assist Device Implantation Increases GJA1-20k Expression in Patients With Arrhythmogenic Cardiomyopathy. Circ Heart Fail, 18(5), e012174. (Read full publication)
    2. Baum R, Nguyen VD, Maalouf M, Shimura D, Waghalter M, Srapyan S, Jin Q, Kuzmanovich L, Gaffney AT, Bell BR, Xiao S, Palatinus JA, Klber AG, Grintsevich EE, Hong T, Shaw RM (2024). A truncated isoform of Connexin43 caps actin to organize forward delivery of full-length Connexin43. J Cell Biol, 224(3). (Read full publication)
    3. Jin Q, Lee KY, Selimi Z, Shimura D, Wang E, Zimmerman JF, Shaw RM, Kucera JP, Parker KK, Saffitz JE, Kleber AG (2023). Determinants of electrical propagation and propagation block in Arrhythmogenic Cardiomyopathy. J Mol Cell Cardiol, 186, 71-80. (Read full publication)
    4. Khan MS, Smego D, Ishidoya Y, Hirahara AM, Offei E, Ruiz Castillo MS, Gharbia O, Li H, Palatinus JA, Krueger L, Hong T, Hoareau GL, Ranjan R, Selzman CH, Shaw RM, Dosdall DJ (2023). A canine model of chronic ischemic heart failure. Am J Physiol Heart Circ Physiol, 324(6), H751-H761. (Read full publication)
    5. Hogen T, Li J, Balmaceda P, Ha T, Brown GW, Shaw RM, Hong T (2023). Echocardiography Recording in Awake Miniature Pigs. J Vis Exp, (195). (Read full publication)
    6. Palatinus JA, Valdez S, Taylor L, Whisenant C, Selzman CH, Drakos SG, Ranjan R, Hong T, Saffitz JE, Shaw RM (2023). GJA1-20k Rescues Cx43 Localization and Arrhythmias in Arrhythmogenic Cardiomyopathy. Circ Res, 132(6), 744-746. (Read full publication)
    7. Shimura D, Nuebel E, Baum R, Valdez SE, Xiao S, Warren JS, Palatinus JA, Hong T, Rutter J, Shaw RM (2021). Protective mitochondrial fission induced by stress-responsive protein GJA1-20k. Elife, 10. (Read full publication)
    8. Xiao S, Shimura D, Baum R, Hernandez DM, Agvanian S, Nagaoka Y, Katsumata M, Lampe PD, Kleber AG, Hong T, Shaw RM (2019). Auxiliary trafficking subunit GJA1-20k protects connexin-43 from degradation and limits ventricular arrhythmias. J Clin Invest, 130(9), 4858-4870. (Read full publication)
    9. Li J, Agvanian S, Zhou K, Shaw RM, Hong T (2020). Exogenous Cardiac Bridging Integrator 1 Benefits Mouse Hearts With Pre-existing Pressure Overload-Induced Heart Failure. Front Physiol, 11, 708. (Read full publication)
    10. Hitzeman TC, Xie Y, Zadikany RH, Nikolova AP, Baum R, Caldaruse AM, Agvanian S, Melmed GY, McGovern DPB, Geft DR, Chang DH, Moriguchi JD, Hage A, Azarbal B, Czer LS, Kittleson MM, Patel JK, Wu AHB, Kobashigawa JA, Hamilton M, Hong T, Shaw RM (2020). cBIN1 Score (CS) Identifies Ambulatory HFrEF Patients and Predicts Cardiovascular Events. Front Physiol, 11, 503. (Read full publication)
    11. Liu Y, Zhou K, Li J, Agvanian S, Caldaruse AM, Shaw S, Hitzeman TC, Shaw RM, Hong T (2020). In Mice Subjected to Chronic Stress, Exogenous cBIN1 Preserves Calcium-Handling Machinery and Cardiac Function. JACC Basic Transl Sci, 5(6), 561-578. (Read full publication)
    12. Shaw RM, Saffitz JE (2021). A role for connexin-43 in Duchenne muscular dystrophy cardiomyopathy. J Clin Invest, 130(4), 1608-1610. (Read full publication)
    13. Epifantseva I, Xiao S, Baum RE, Klber AG, Hong T, Shaw RM (2020). An Alternatively Translated Connexin 43 Isoform, GJA1-11k, Localizes to the Nucleus and Can Inhibit Cell Cycle Progression. Biomolecules, 10(3). (Read full publication)
    14. Shaw RM (2019). Correlating Cardiac Origin Neurohormonal Stress Levels With Heart Failure Outcomes. JAMA Cardiol, 5(3), 326-327. (Read full publication)
    15. Nikolova AP, Hitzeman TC, Baum R, Caldaruse AM, Agvanian S, Xie Y, Geft DR, Chang DH, Moriguchi JD, Hage A, Azarbal B, Czer LS, Kittleson MM, Patel JK, Wu AHB, Kobashigawa JA, Hamilton M, Hong T, Shaw RM (2018). Association of a Novel Diagnostic Biomarker, the Plasma Cardiac Bridging Integrator 1 Score, With Heart Failure With Preserved Ejection Fraction and Cardiovascular Hospitalization. JAMA Cardiol, 3(12), 1206-1210. (Read full publication)
    16. Basheer WA, Fu Y, Shimura D, Xiao S, Agvanian S, Hernandez DM, Hitzeman TC, Hong T, Shaw RM (2018). Stress response protein GJA1-20k promotes mitochondrial biogenesis, metabolic quiescence, and cardioprotection against ischemia/reperfusion injury. JCI Insight, 3(20). (Read full publication)
    17. Epifantseva I, Shaw RM (2017). Intracellular trafficking pathways of Cx43 gap junction channels. Biochim Biophys Acta Biomembr, 1860(1), 40-47. (Read full publication)
    18. Fu Y, Zhang SS, Xiao S, Basheer WA, Baum R, Epifantseva I, Hong T, Shaw RM (2017). Cx43 Isoform GJA1-20k Promotes Microtubule Dependent Mitochondrial Transport. Front Physiol, 8, 905. (Read full publication)
    19. Basheer WA, Xiao S, Epifantseva I, Fu Y, Kleber AG, Hong T, Shaw RM (2017). GJA1-20k Arranges Actin to Guide Cx43 Delivery to Cardiac Intercalated Discs. Circ Res, 121(9), 1069-1080. (Read full publication)
    20. Xu B, Fu Y, Liu Y, Agvanian S, Wirka RC, Baum R, Zhou K, Shaw RM, Hong T (2017). The ESCRT-III pathway facilitates cardiomyocyte release of cBIN1-containing microparticles. PLoS Biol, 15(8), e2002354. (Read full publication)
    21. Hong T, Shaw RM (2016). Cardiac T-Tubule Microanatomy and Function. Physiol Rev, 97(1), 227-252. (Read full publication)
    22. Levitan BM, Manning JR, Withers CN, Smith JD, Shaw RM, Andres DA, Sorrell VL, Satin J (2016). Rad-deletion Phenocopies Tonic Sympathetic Stimulation of the Heart. J Cardiovasc Transl Res, 9(5-6), 432-444. (Read full publication)
    23. Basheer W, Shaw R (2015). The "tail" of Connexin43: An unexpected journey from alternative translation to trafficking. Biochim Biophys Acta, 1863(7 Pt B), 1848-56. (Read full publication)
    24. Basheer WA, Shaw RM (2015). Connexin 43 and CaV1.2 Ion Channel Trafficking in Healthy and Diseased Myocardium. Circ Arrhythm Electrophysiol, 9(6), e001357. (Read full publication)
    25. Xiao S, Shaw RM (2014). Cardiomyocyte protein trafficking: Relevance to heart disease and opportunities for therapeutic intervention. Trends Cardiovasc Med, 25(5), 379-89. (Read full publication)
    26. Chen-Izu Y, Shaw RM, Pitt GS, Yarov-Yarovoy V, Sack JT, Abriel H, Aldrich RW, Belardinelli L, Cannell MB, Catterall WA, Chazin WJ, Chiamvimonvat N, Deschenes I, Grandi E, Hund TJ, Izu LT, Maier LS, Maltsev VA, Marionneau C, Mohler PJ, Rajamani S, Rasmusson RL, Sobie EA, Clancy CE, Bers DM (2014). Na+ channel function, regulation, structure, trafficking and sequestration. J Physiol, 593(6), 1347-60. (Read full publication)
    27. Shaw RM (2014). Desmosomal hotspots, microtubule delivery, and cardiac arrhythmogenesis. Dev Cell, 31(2), 139-40. (Read full publication)
    28. Smyth JW, Zhang SS, Sanchez JM, Lamouille S, Vogan JM, Hesketh GG, Hong T, Tomaselli GF, Shaw RM (2014). A 14-3-3 mode-1 binding motif initiates gap junction internalization during acute cardiac ischemia. Traffic, 15(6), 684-99. (Read full publication)
    29. Hong T, Yang H, Zhang SS, Cho HC, Kalashnikova M, Sun B, Zhang H, Bhargava A, Grabe M, Olgin J, Gorelik J, Marbn E, Jan LY, Shaw RM (2014). Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia. Nat Med, 20(6), 624-32. (Read full publication)
    30. Zhang SS, Hong S, Klber AG, Lee LP, Shaw RM (2014). A micropatterning approach for imaging dynamic Cx43 trafficking to cell-cell borders. FEBS Lett, 588(8), 1439-45. (Read full publication)
    31. Schumacher-Bass SM, Vesely ED, Zhang L, Ryland KE, McEwen DP, Chan PJ, Frasier CR, McIntyre JC, Shaw RM, Martens JR (2014). Role for myosin-V motor proteins in the selective delivery of Kv channel isoforms to the membrane surface of cardiac myocytes. Circ Res, 114(6), 982-92. (Read full publication)
    32. Zhang SS, Shaw RM (2014). Trafficking highways to the intercalated disc: new insights unlocking the specificity of connexin 43 localization. Cell Commun Adhes, 21(1), 43-54. (Read full publication)
    33. Samson SC, Ferrer T, Jou CJ, Sachse FB, Shankaran SS, Shaw RM, Chi NC, Tristani-Firouzi M, Yost HJ (2013). 3-OST-7 regulates BMP-dependent cardiac contraction. PLoS Biol, 11(12), e1001727. (Read full publication)
    34. Smyth JW, Shaw RM (2013). Autoregulation of connexin43 gap junction formation by internally translated isoforms. Cell Rep, 5(3), 611-8. (Read full publication)
    35. Shaw RM, Colecraft HM (2013). L-type calcium channel targeting and local signalling in cardiac myocytes. Cardiovasc Res, 98(2), 177-86. (Read full publication)
    36. Gao D, Zhang L, Dhillon R, Hong TT, Shaw RM, Zhu J (2013). Dynasore protects mitochondria and improves cardiac lusitropy in Langendorff perfused mouse heart. PLoS One, 8(4), e60967. (Read full publication)
    37. Zhang SS, Shaw RM (2012). Multilayered regulation of cardiac ion channels. Biochim Biophys Acta, 1833(4), 876-85. (Read full publication)
    38. Cogswell R, McGlothlin D, Kobashigawa E, Shaw R, De Marco T (2012). Performance of the REVEAL model in WHO Group 2 to 5 pulmonary hypertension: application beyond pulmonary arterial hypertension. J Heart Lung Transplant, 32(3), 293-8. (Read full publication)
    39. Cogswell R, Kobashigawa E, McGlothlin D, Shaw R, De Marco T (2012). Validation of the Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension Disease Management (REVEAL) pulmonary hypertension prediction model in a unique population and utility in the prediction of long-term survival. J Heart Lung Transplant, 31(11), 1165-70. (Read full publication)
    40. Hong TT, Cogswell R, James CA, Kang G, Pullinger CR, Malloy MJ, Kane JP, Wojciak J, Calkins H, Scheinman MM, Tseng ZH, Ganz P, De Marco T, Judge DP, Shaw RM (2012). Plasma BIN1 correlates with heart failure and predicts arrhythmia in patients with arrhythmogenic right ventricular cardiomyopathy. Heart Rhythm, 9(6), 961-7. (Read full publication)
    41. Hong TT, Smyth JW, Chu KY, Vogan JM, Fong TS, Jensen BC, Fang K, Halushka MK, Russell SD, Colecraft H, Hoopes CW, Ocorr K, Chi NC, Shaw RM (2011). BIN1 is reduced and Cav1.2 trafficking is impaired in human failing cardiomyocytes. Heart Rhythm, 9(5), 812-20. (Read full publication)
    42. Smyth JW, Vogan JM, Buch PJ, Zhang SS, Fong TS, Hong TT, Shaw RM (2012). Actin cytoskeleton rest stops regulate anterograde traffic of connexin 43 vesicles to the plasma membrane. Circ Res, 110(7), 978-89. (Read full publication)
    43. Smyth JW, Shaw RM (2011). The gap junction life cycle. Heart Rhythm, 9(1), 151-3. (Read full publication)
    44. Smyth JW, Shaw RM (2012). Visualizing cardiac ion channel trafficking pathways. Methods Enzymol, 505, 187-202. (Read full publication)
    45. Zhang SS, Kim KH, Rosen A, Smyth JW, Sakuma R, Delgado-Olgun P, Davis M, Chi NC, Puviindran V, Gaborit N, Sukonnik T, Wylie JN, Brand-Arzamendi K, Farman GP, Kim J, Rose RA, Marsden PA, Zhu Y, Zhou YQ, Miquerol L, Henkelman RM, Stainier DY, Shaw RM, Hui CC, Bruneau BG, Backx PH (2011). Iroquois homeobox gene 3 establishes fast conduction in the cardiac His-Purkinje network. Proc Natl Acad Sci U S A, 108(33), 13576-81. (Read full publication)
    46. Smyth JW, Shaw RM (2010). Forward trafficking of ion channels: what the clinician needs to know. Heart Rhythm, 7(8), 1135-40. (Read full publication)
    47. Shaw RM, Rudy Y (2009). Cardiac muscle is not a uniform syncytium. Biophys J, 98(12), 3102-3; discussion 3104-5. (Read full publication)
    48. Hong TT, Smyth JW, Gao D, Chu KY, Vogan JM, Fong TS, Jensen BC, Colecraft HM, Shaw RM (2010). BIN1 localizes the L-type calcium channel to cardiac T-tubules. PLoS Biol, 8(2), e1000312. (Read full publication)
    49. Smyth JW, Hong TT, Gao D, Vogan JM, Jensen BC, Fong TS, Simpson PC, Stainier DY, Chi NC, Shaw RM (2009). Limited forward trafficking of connexin 43 reduces cell-cell coupling in stressed human and mouse myocardium. J Clin Invest, 120(1), 266-79. (Read full publication)
    50. Ieda M, Tsuchihashi T, Ivey KN, Ross RS, Hong TT, Shaw RM, Srivastava D (2008). Cardiac fibroblasts regulate myocardial proliferation through beta1 integrin signaling. Dev Cell, 16(2), 233-44. (Read full publication)
    51. Smyth JW, Shaw RM (2008). Visualizing ion channel dynamics at the plasma membrane. Heart Rhythm, 5(6 Suppl), S7-11. (Read full publication)
    52. Chi NC, Shaw RM, Jungblut B, Huisken J, Ferrer T, Arnaout R, Scott I, Beis D, Xiao T, Baier H, Jan LY, Tristani-Firouzi M, Stainier DY (2007). Genetic and physiologic dissection of the vertebrate cardiac conduction system. PLoS Biol, 6(5), e109. (Read full publication)
    53. Saxena A, Fish JE, White MD, Yu S, Smyth JW, Shaw RM, DiMaio JM, Srivastava D (2008). Stromal cell-derived factor-1alpha is cardioprotective after myocardial infarction. Circulation, 117(17), 2224-31. (Read full publication)
    54. Chi NC, Shaw RM, De Val S, Kang G, Jan LY, Black BL, Stainier DY (2008). Foxn4 directly regulates tbx2b expression and atrioventricular canal formation. Genes Dev, 22(6), 734-9. (Read full publication)
    55. Shaw RM, Fay AJ, Puthenveedu MA, von Zastrow M, Jan YN, Jan LY (2006). Microtubule plus-end-tracking proteins target gap junctions directly from the cell interior to adherens junctions. Cell, 128(3), 547-60. (Read full publication)
    56. Ionescu-Zanetti C, Shaw RM, Seo J, Jan YN, Jan LY, Lee LP (2005). Mammalian electrophysiology on a microfluidic platform. Proc Natl Acad Sci U S A, 102(26), 9112-7. (Read full publication)
    57. Viswanathan PC, Shaw RM, Rudy Y (1999). Effects of IKr and IKs heterogeneity on action potential duration and its rate dependence: a simulation study. Circulation, 99(18), 2466-74. (Read full publication)
    58. Shaw RM, Rudy Y (1997). Ionic mechanisms of propagation in cardiac tissue. Roles of the sodium and L-type calcium currents during reduced excitability and decreased gap junction coupling. Circ Res, 81(5), 727-41. (Read full publication)
    59. Shaw RM, Rudy Y (1997). Electrophysiologic effects of acute myocardial ischemia: a theoretical study of altered cell excitability and action potential duration. Cardiovasc Res, 35(2), 256-72. (Read full publication)
    60. Shaw RM, Rudy Y (1997). Electrophysiologic effects of acute myocardial ischemia. A mechanistic investigation of action potential conduction and conduction failure. Circ Res, 80(1), 124-38. (Read full publication)
    61. Rudy Y, Shaw RM (1997). Cardiac excitation: an interactive process of ion channels and gap junctions. Adv Exp Med Biol, 430, 269-79. (Read full publication)
    62. Shaw RM, Rudy Y (1995). The vulnerable window for unidirectional block in cardiac tissue: characterization and dependence on membrane excitability and intercellular coupling. J Cardiovasc Electrophysiol, 6(2), 115-31. (Read full publication)
    63. Clarke LP, Cullom SJ, Shaw R, Reece C, Penney BC, King MA, Silbiger M (1992). Bremsstrahlung imaging using the gamma camera: factors affecting attenuation. J Nucl Med, 33(1), 161-6. (Read full publication)

    Review

    1. Maalouf M, Gaffney AT, Bell BR, Shaw RM (2024). Exploring the Potent Roles of an Internally Translated Truncated Connexin-43 Isoform. [Review]. Biology (Basel), 13(12). (Read full publication)
    2. Whisenant CC, Shaw RM (2022). Internal translation of Gja1 (Connexin43) to produce GJA1-20k: Implications for arrhythmia and ischemic-preconditioning. [Review]. Front Physiol, 13, 1058954. (Read full publication)
    3. Shimura D, Shaw RM (2022). GJA1-20k and Mitochondrial Dynamics. [Review]. Front Physiol, 13, 867358. (Read full publication)

    Editorial

    1. Hong T, Shaw RM (2018). Editorial commentary: Extracellular vesicles in cardiovascular diagnosis and therapy. Trends Cardiovasc Med, 29(6), 324-325. (Read full publication)
    2. Shaw RM, Nikolova AP (2018). The Clinical Course of a Genetic Dilated Cardiomyopathy: Letting the Cat Out of the BAG3. J Am Coll Cardiol, 72(20), 2482-2484. (Read full publication)
    3. Nikolova AP, Shaw RM (2018). Editorial commentary: Are cytokines ready for prime time? Insights from markers and trials. Trends Cardiovasc Med, 28(6), 380-381. (Read full publication)
    4. Shaw RM, Nikolova AP (2017). A Surprising Noncanonical Role for Calcineurin in Pressure-Induced Cardiac Hypertrophy. J Am Coll Cardiol, 71(6), 668-669. (Read full publication)
    5. Fu Y, Shaw RM (2017). CASAAV Technology to Examine Regulators of Heart Failure: Cause or Effect. Circ Res, 120(12), 1846-1848. (Read full publication)
    6. Fu Y, Xiao S, Hong T, Shaw RM (2015). Cytoskeleton regulation of ion channels. Circulation, 131(8), 689-91. (Read full publication)
    7. Shaw RM (2012). Reduced sodium channels in human ARVC. Heart Rhythm, 10(3), 420-1. (Read full publication)

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