Robin Mark Shaw
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Robin Mark Shaw, MD, PhD

Dr. Robin Shaw is the Nora Eccles Harrison Presidential Endowed Chair and Professor of Medicine at the University of Utah School of Medicine. He is also Director of the Nora Eccles Harrison Cardiovascular Research and Training Institute. Dr. Shaw's clinical interests include advanced heart failure and cardiac arrhythmias. His research interests involve the cell biology of heart muscle cells, with a particular focus on the movement of cardiac ion channels and the mechanisms of heart failure progression. Dr. Shaw's research team has identified new cardiac proteins and are developing a novel gene therapy for treating advanced heart failure.

Dr. Shaw earned his M.D. and Ph.D. degrees at Case Western Reserve University in 1997 and 1999. He completed Internal Medicine and Cardiology Fellowship training at the University of California, San Francisco. He remained at the University of California San Francisco as an Assistant and then tenured Associate Professor and Investigator at its Cardiovascular Research Institute. In 2013 he moved to Los Angeles as Professor of Medicine at UCLA and the Wasserman Foundation Endowed Chair in Cardiology at Cedars-Sinai Smidt Heart Institute. Dr. Shaw was recruited to the University of Utah in 2019 with a primary responsibility to serve as Director of the CVRTI.

Specialties

Board Certification

American Board of Internal Medicine (Sub: Cardiovascular Disease)

Dr. Robin Shaw is the Nora Eccles Harrison Presidential Endowed Chair and Professor of Medicine at the University of Utah School of Medicine. He is also Director of the Nora Eccles Harrison Cardiovascular Research and Training Institute. Dr. Shaw's clinical interests include advanced heart failure and cardiac arrhythmias. His research interests involve the cell biology of heart muscle cells, with a particular focus on the movement of cardiac ion channels and the mechanisms of heart failure progression. Dr. Shaw's research team has identified new cardiac proteins and are developing a novel gene therapy for treating advanced heart failure.

Dr. Shaw earned his M.D. and Ph.D. degrees at Case Western Reserve University in 1997 and 1999. He completed Internal Medicine and Cardiology Fellowship training at the University of California, San Francisco. He remained at the University of California San Francisco as an Assistant and then tenured Associate Professor and Investigator at its Cardiovascular Research Institute. In 2013 he moved to Los Angeles as Professor of Medicine at UCLA and the Wasserman Foundation Endowed Chair in Cardiology at Cedars-Sinai Smidt Heart Institute. Dr. Shaw was recruited to the University of Utah in 2019 with a primary responsibility to serve as Director of the CVRTI.

Board Certification and Academic Information

Academic Departments Internal Medicine -Professor
Academic Divisions Cardiovascular Medicine
Board Certification
American Board of Internal Medicine (Sub: Cardiovascular Disease)

Selected Publications

Journal Article

  1. Rudy Y, Shaw RM (1997). Cardiac excitation: an interactive process of ion channels and gap junctions. Adv Exp Med Biol, 430, 269-79.
  2. Cogswell R, Kobashigawa E, McGlothlin D, Shaw R, De Marco T (2012). Validation of the Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension Disease Management (REVEAL) pulmonary hypertension prediction model in a unique population and utility in the prediction of long-term survival. J Heart Lung Transplant, 31(11), 1165-70.
  3. Cogswell R, McGlothlin D, Kobashigawa E, Shaw R, De Marco T (2013). Performance of the REVEAL model in WHO Group 2 to 5 pulmonary hypertension: application beyond pulmonary arterial hypertension. J Heart Lung Transplant, 32(3), 293-8.
  4. Zhang SS, Shaw RM (2013). Multilayered regulation of cardiac ion channels. Biochim Biophys Acta, 1833(4), 876-85.
  5. Basheer W, Shaw R (2016). The "tail" of Connexin43: An unexpected journey from alternative translation to trafficking. Biochim Biophys Acta, 1863(7 Pt B), 1848-56.
  6. Shaw RM, Rudy Y (2010). Cardiac muscle is not a uniform syncytium. Biophys J, 98(12), 3102-3; discussion 3104-5.
  7. Shaw RM, Rudy Y (1995). The vulnerable window for unidirectional block in cardiac tissue: characterization and dependence on membrane excitability and intercellular coupling. J Cardiovasc Electrophysiol, 6(2), 115-31.
  8. Shaw RM, Rudy Y (1997). Electrophysiologic effects of acute myocardial ischemia: a theoretical study of altered cell excitability and action potential duration. Cardiovasc Res, 35(2), 256-72.
  9. Shaw RM, Colecraft HM (2013). L-type calcium channel targeting and local signalling in cardiac myocytes. Cardiovasc Res, 98(2), 177-86.
  10. Shaw RM, Fay AJ, Puthenveedu MA, von Zastrow M, Jan YN, Jan LY (2007). Microtubule plus-end-tracking proteins target gap junctions directly from the cell interior to adherens junctions. Cell, 128(3), 547-60.
  11. Shaw RM, Rudy Y (1997). Electrophysiologic effects of acute myocardial ischemia. A mechanistic investigation of action potential conduction and conduction failure. Circ Res, 80(1), 124-38.
  12. Shaw RM, Rudy Y (1997). Ionic mechanisms of propagation in cardiac tissue. Roles of the sodium and L-type calcium currents during reduced excitability and decreased gap junction coupling. Circ Res, 81(5), 727-41.
  13. Smyth JW, Vogan JM, Buch PJ, Zhang SS, Fong TS, Hong TT, Shaw RM (2012). Actin cytoskeleton rest stops regulate anterograde traffic of connexin 43 vesicles to the plasma membrane. Circ Res, 110(7), 978-89.
  14. Schumacher-Bass SM, Vesely ED, Zhang L, Ryland KE, McEwen DP, Chan PJ, Frasier CR, McIntyre JC, Shaw RM, Martens JR (2014). Role for myosin-V motor proteins in the selective delivery of Kv channel isoforms to the membrane surface of cardiac myocytes. Circ Res, 114(6), 982-92.
  15. Basheer WA, Xiao S, Epifantseva I, Fu Y, Kleber AG, Hong T, Shaw RM (2017). GJA1-20k Arranges Actin to Guide Cx43 Delivery to Cardiac Intercalated Discs. Circ Res, 121(9), 1069-1080.
  16. Viswanathan PC, Shaw RM, Rudy (1999). Effects of IKr and IKs heterogeneity on action potential duration and its rate dependence: a simulation study. Circulation, 99(18), 2466-74.
  17. Saxena A, Fish JE, White MD, Yu S, Smyth JW, Shaw RM, DiMaio JM, Srivastava (2008). Stromal cell-derived factor-1alpha is cardioprotective after myocardial infarction. Circulation, 117(17), 2224-31.
  18. Zhang SS, Hong S, Kléber AG, Lee LP, Shaw R (2014). A micropatterning approach for imaging dynamic Cx43 trafficking to cell-cell borders. FEBS letters, 588(8), 1439-45.
  19. Chi NC, Shaw RM, De Val S, Kang G, Jan LY, Black BL, Stainier D (2008). Foxn4 directly regulates tbx2b expression and atrioventricular canal formation. Genes & development, 22(6), 734-9.
  20. Smyth JW, Hong TT, Gao D, Vogan JM, Jensen BC, Fong TS, Simpson PC, Stainier DY, Chi NC, Shaw R (2010). Limited forward trafficking of connexin 43 reduces cell-cell coupling in stressed human and mouse myocardium. The Journal of clinical investigation, 120(1), 266-79.
  21. Xiao S, Shimura D, Baum R, Hernandez DM, Agvanian S, Nagaoka Y, Katsumata M, Lampe PD, Kleber AG, Hong T, Shaw R (2020). Auxiliary trafficking subunit GJA1-20k protects connexin-43 from degradation and limits ventricular arrhythmias. The Journal of clinical investigation, 130(9), 4858-4870.
  22. Shaw RM, Saffitz J (2020). A role for connexin-43 in Duchenne muscular dystrophy cardiomyopathy. The Journal of clinical investigation, 130(4), 1608-1610.
  23. Clarke LP, Cullom SJ, Shaw R, Reece C, Penney BC, King MA, Silbiger (1992). Bremsstrahlung imaging using the gamma camera: factors affecting attenuation. Journal of nuclear medicine, 33(1), 161-6.
  24. Chen-Izu Y, Shaw RM, Pitt GS, Yarov-Yarovoy V, Sack JT, Abriel H, Aldrich RW, Belardinelli L, Cannell MB, Catterall WA, Chazin WJ, Chiamvimonvat N, Deschenes I, Grandi E, Hund TJ, Izu LT, Maier LS, Maltsev VA, Marionneau C, Mohler PJ, Rajamani S, Rasmusson RL, Sobie EA, Clancy CE, Bers D (2015). Na+ channel function, regulation, structure, trafficking and sequestration. The Journal of physiology, 593(6), 1347-60.
  25. Smyth JW, Shaw R (2012). Visualizing cardiac ion channel trafficking pathways. Methods in enzymology, 505, 187-202.
  26. Hong T, Shaw R (2017). Cardiac T-Tubule Microanatomy and Function. Physiological reviews, 97(1), 227-252.
  27. Ionescu-Zanetti C, Shaw RM, Seo J, Jan YN, Jan LY, Lee L (2005). Mammalian electrophysiology on a microfluidic platform. Proceedings of the National Academy of Sciences of the United States of America, 102(26), 9112-7.
  28. Zhang SS, Kim KH, Rosen A, Smyth JW, Sakuma R, Delgado-Olguín P, Davis M, Chi NC, Puviindran V, Gaborit N, Sukonnik T, Wylie JN, Brand-Arzamendi K, Farman GP, Kim J, Rose RA, Marsden PA, Zhu Y, Zhou YQ, Miquerol L, Henkelman RM, Stainier DY, Shaw RM, Hui CC, Bruneau BG, Backx P (2011). Iroquois homeobox gene 3 establishes fast conduction in the cardiac His-Purkinje network. Proceedings of the National Academy of Sciences of the United States of America, 108(33), 13576-81.
  29. Hong T, Yang H, Zhang SS, Cho HC, Kalashnikova M, Sun B, Zhang H, Bhargava A, Grabe M, Olgin J, Gorelik J, Marbán E, Jan LY, Shaw R (2014). Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia. Nature medicine, 20(6), 624-32.
  30. Xiao S, Shaw R (2015). Cardiomyocyte protein trafficking: Relevance to heart disease and opportunities for therapeutic intervention. Trends in cardiovascular medicine, 25(5), 379-89.
  31. Smyth JW, Zhang SS, Sanchez JM, Lamouille S, Vogan JM, Hesketh GG, Hong T, Tomaselli GF, Shaw R (2014). A 14-3-3 mode-1 binding motif initiates gap junction internalization during acute cardiac ischemia. Traffic (Copenhagen, Denmark), 15(6), 684-99.
  32. Ieda M, Tsuchihashi T, Ivey KN, Ross RS, Hong TT, Shaw RM, Srivastava (2009). Cardiac fibroblasts regulate myocardial proliferation through beta1 integrin signaling. Developmental cell, 16(2), 233-44.
  33. Shaw R (2014). Desmosomal hotspots, microtubule delivery, and cardiac arrhythmogenesis. Developmental cell, 31(2), 139-40.
  34. Zhang SS, Shaw R (2014). Trafficking highways to the intercalated disc: new insights unlocking the specificity of connexin 43 localization. Cell communication & adhesion, 21(1), 43-54.
  35. Chi NC, Shaw RM, Jungblut B, Huisken J, Ferrer T, Arnaout R, Scott I, Beis D, Xiao T, Baier H, Jan LY, Tristani-Firouzi M, Stainier D (2008). Genetic and physiologic dissection of the vertebrate cardiac conduction system. PLoS biology, 6(5), e109.
  36. Hong TT, Smyth JW, Gao D, Chu KY, Vogan JM, Fong TS, Jensen BC, Colecraft HM, Shaw R (2010). BIN1 localizes the L-type calcium channel to cardiac T-tubules. PLoS biology, 8(2), e1000312.
  37. Samson SC, Ferrer T, Jou CJ, Sachse FB, Shankaran SS, Shaw RM, Chi NC, Tristani-Firouzi M, Yost H (2013). 3-OST-7 regulates BMP-dependent cardiac contraction. PLoS biology, 11(12), e1001727.
  38. Xu B, Fu Y, Liu Y, Agvanian S, Wirka RC, Baum R, Zhou K, Shaw RM, Hong (2017). The ESCRT-III pathway facilitates cardiomyocyte release of cBIN1-containing microparticles. PLoS biology, 15(8), e2002354.
  39. Smyth JW, Shaw R (2008). Visualizing ion channel dynamics at the plasma membrane. Heart rhythm, 5(6 Suppl), S7-11.
  40. Hong TT, Smyth JW, Chu KY, Vogan JM, Fong TS, Jensen BC, Fang K, Halushka MK, Russell SD, Colecraft H, Hoopes CW, Ocorr K, Chi NC, Shaw R (2012). BIN1 is reduced and Cav1.2 trafficking is impaired in human failing cardiomyocytes. Heart rhythm, 9(5), 812-20.
  41. Hong TT, Cogswell R, James CA, Kang G, Pullinger CR, Malloy MJ, Kane JP, Wojciak J, Calkins H, Scheinman MM, Tseng ZH, Ganz P, De Marco T, Judge DP, Shaw R (2012). Plasma BIN1 correlates with heart failure and predicts arrhythmia in patients with arrhythmogenic right ventricular cardiomyopathy. Heart rhythm, 9(6), 961-7.
  42. Smyth JW, Shaw R (2010). Forward trafficking of ion channels: what the clinician needs to know. Heart rhythm, 7(8), 1135-40.
  43. Smyth JW, Shaw R (2012). The gap junction life cycle. Heart rhythm, 9(1), 151-3.
  44. Gao D, Zhang L, Dhillon R, Hong TT, Shaw RM, Zhu (2013). Dynasore protects mitochondria and improves cardiac lusitropy in Langendorff perfused mouse heart. PloS one, 8(4), e60967.
  45. Basheer WA, Shaw R (2016). Connexin 43 and CaV1.2 Ion Channel Trafficking in Healthy and Diseased Myocardium. Circulation. Arrhythmia and electrophysiology, 9(6), e001357.
  46. Levitan BM, Manning JR, Withers CN, Smith JD, Shaw RM, Andres DA, Sorrell VL, Satin (2016). Rad-deletion Phenocopies Tonic Sympathetic Stimulation of the Heart. Journal of cardiovascular translational research, 9(5-6), 432-444.
  47. Fu Y, Zhang SS, Xiao S, Basheer WA, Baum R, Epifantseva I, Hong T, Shaw R (2017). Cx43 Isoform GJA1-20k Promotes Microtubule Dependent Mitochondrial Transport. Frontiers in physiology, 8, 905.
  48. Hitzeman TC, Xie Y, Zadikany RH, Nikolova AP, Baum R, Caldaruse AM, Agvanian S, Melmed GY, McGovern DPB, Geft DR, Chang DH, Moriguchi JD, Hage A, Azarbal B, Czer LS, Kittleson MM, Patel JK, Wu AHB, Kobashigawa JA, Hamilton M, Hong T, Shaw R (2020). cBIN1 Score (CS) Identifies Ambulatory HFrEF Patients and Predicts Cardiovascular Events. Frontiers in physiology, 11, 503.
  49. Li J, Agvanian S, Zhou K, Shaw RM, Hong (2020). Exogenous Cardiac Bridging Integrator 1 Benefits Mouse Hearts With Pre-existing Pressure Overload-Induced Heart Failure. Frontiers in physiology, 11, 708.
  50. Smyth JW, Shaw R (2013). Autoregulation of connexin43 gap junction formation by internally translated isoforms. Cell reports, 5(3), 611-8.
  51. Epifantseva I, Xiao S, Baum RE, Kléber AG, Hong T, Shaw R (2020). An Alternatively Translated Connexin 43 Isoform, GJA1-11k, Localizes to the Nucleus and Can Inhibit Cell Cycle Progression. Biomolecules, 10(3),
  52. Nikolova AP, Hitzeman TC, Baum R, Caldaruse AM, Agvanian S, Xie Y, Geft DR, Chang DH, Moriguchi JD, Hage A, Azarbal B, Czer LS, Kittleson MM, Patel JK, Wu AHB, Kobashigawa JA, Hamilton M, Hong T, Shaw R (2018). Association of a Novel Diagnostic Biomarker, the Plasma Cardiac Bridging Integrator 1 Score, With Heart Failure With Preserved Ejection Fraction and Cardiovascular Hospitalization. JAMA cardiology, 3(12), 1206-1210.
  53. Shaw R (2020). Correlating Cardiac Origin Neurohormonal Stress Levels With Heart Failure Outcomes. JAMA cardiology, 5(3), 326-327.
  54. Basheer WA, Fu Y, Shimura D, Xiao S, Agvanian S, Hernandez DM, Hitzeman TC, Hong T, Shaw R (2018). Stress response protein GJA1-20k promotes mitochondrial biogenesis, metabolic quiescence, and cardioprotection against ischemia/reperfusion injury. JCI insight, 3(20),
  55. Liu Y, Zhou K, Li J, Agvanian S, Caldaruse AM, Shaw S, Hitzeman TC, Shaw RM, Hong (2020). In Mice Subjected to Chronic Stress, Exogenous cBIN1 Preserves Calcium-Handling Machinery and Cardiac Function. JACC. Basic to translational science, 5(6), 561-578.
  56. Epifantseva I, Shaw R (2018). Intracellular trafficking pathways of Cx43 gap junction channels. Biochimica et biophysica acta. Biomembranes, 1860(1), 40-47.
  57. Valdez SE, Taylor LA, Selzman CH, Drakos SG, Shaw RM, Palatinus J (2025). Left Ventricular Unloading With Assist Device Implantation Increases GJA1-20k Expression in Patients With Arrhythmogenic Cardiomyopathy. Circulation. Heart failure, 18(5), e012174.
  58. Baum R, Nguyen VD, Maalouf M, Shimura D, Waghalter M, Srapyan S, Jin Q, Kuzmanovich L, Gaffney AT, Bell BR, Xiao S, Palatinus JA, Kléber AG, Grintsevich EE, Hong T, Shaw R (2025). A truncated isoform of Connexin43 caps actin to organize forward delivery of full-length Connexin43. The Journal of cell biology, 224(3),
  59. Jin Q, Lee KY, Selimi Z, Shimura D, Wang E, Zimmerman JF, Shaw RM, Kucera JP, Parker KK, Saffitz JE, Kleber A (2024). Determinants of electrical propagation and propagation block in Arrhythmogenic Cardiomyopathy. Journal of molecular and cellular cardiology, 186, 71-80.
  60. Khan MS, Smego D, Ishidoya Y, Hirahara AM, Offei E, Ruiz Castillo MS, Gharbia O, Li H, Palatinus JA, Krueger L, Hong T, Hoareau GL, Ranjan R, Selzman CH, Shaw RM, Dosdall D (2023). A canine model of chronic ischemic heart failure. American journal of physiology. Heart and circulatory physiology, 324(6), H751-H761.
  61. Hogen T, Li J, Balmaceda P, Ha T, Brown GW, Shaw RM, Hong (2023). Echocardiography Recording in Awake Miniature Pigs. Journal of visualized experiments, (195),
  62. Palatinus JA, Valdez S, Taylor L, Whisenant C, Selzman CH, Drakos SG, Ranjan R, Hong T, Saffitz JE, Shaw R (2023). GJA1-20k Rescues Cx43 Localization and Arrhythmias in Arrhythmogenic Cardiomyopathy. Circulation research, 132(6), 744-746.
  63. Shimura D, Nuebel E, Baum R, Valdez SE, Xiao S, Warren JS, Palatinus JA, Hong T, Rutter J, Shaw R (2021). Protective mitochondrial fission induced by stress-responsive protein GJA1-20k. eLife, 10,

Review

  1. Maalouf M, Gaffney AT, Bell BR, Shaw R (2024). Exploring the Potent Roles of an Internally Translated Truncated Connexin-43 Isoform. Biology, 13(12),
  2. Whisenant CC, Shaw R (2022). Internal translation of Gja1 (Connexin43) to produce GJA1-20k: Implications for arrhythmia and ischemic-preconditioning. Frontiers in physiology, 13, 1058954.
  3. Shimura D, Shaw R (2022). GJA1-20k and Mitochondrial Dynamics. Frontiers in physiology, 13, 867358.

Editorial

  1. Fu Y, Shaw RM (2017). CASAAV Technology to Examine Regulators of Heart Failure: Cause or Effect. Circ Res, 120(12), 1846-1848.
  2. Fu Y, Xiao S, Hong T, Shaw R (2015). Cytoskeleton regulation of ion channels. Circulation, 131(8), 689-91.
  3. Shaw RM, Nikolova A (2018). A Surprising Noncanonical Role for Calcineurin in Pressure-Induced Cardiac Hypertrophy. Journal of the American College of Cardiology, 71(6), 668-669.
  4. Shaw RM, Nikolova A (2018). The Clinical Course of a Genetic Dilated Cardiomyopathy: Letting the Cat Out of the BAG3. Journal of the American College of Cardiology, 72(20), 2482-2484.
  5. Nikolova AP, Shaw R (2018). Editorial commentary: Are cytokines ready for prime time? Insights from markers and trials. Trends in cardiovascular medicine, 28(6), 380-381.
  6. Hong T, Shaw R (2019). Editorial commentary: Extracellular vesicles in cardiovascular diagnosis and therapy. Trends in cardiovascular medicine, 29(6), 324-325.
  7. Shaw R (2013). Reduced sodium channels in human ARVC. Heart rhythm, 10(3), 420-1.

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