Apr 13, 2022 10:00 AM

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The press release below was prepared by the Pancreatic Cancer Action Network. View the original here

The Pancreatic Cancer Action Network (PanCAN), a leading nonprofit in the fight against pancreatic cancer, has announced the latest updates to its innovative adaptive clinical trial, Precision PromiseSM, including the addition of an investigational treatment from global healthcare company, Novartis, as well as the opening of five additional sites across the country.

PanCan Precision Promise Map
PanCAN has announced the addition of five new sites to the already fifteen active sites where pancreatic cancer patients will be able to access its Precision Promise adaptive clinical trial.

Pancreatic cancer is the world's toughest cancer with an overall five-year survival rate of just 11 percent. It is currently the third leading cause of cancer-related death in the U.S., underscoring the urgent need for new treatment options and research discoveries in this space. PanCAN's Precision Promise, which launched in 2020, is working to revolutionize the clinical development paradigm for this disease by enabling a faster, more efficient, and patient-centric approach to developing new treatment options and improving outcomes for pancreatic cancer patients.

PanCAN's novel clinical trial tests the efficacy of investigational pancreatic cancer therapies – including this new drug combination from Novartis – more efficiently by requiring fewer patients to understand if a potential new therapy is working. Through Precision Promise, Novartis will be testing canakinumab (IL-1 beta inhibitor) and spartalizumab (PD-1 inhibitor) in combination with nab-paclitaxel and gemcitabine. This new therapeutic combination will be made available to patients through Precision Promise as each clinical trial site fully activates the new protocol. Interested patients should inquire with their physicians regarding availability at their local site.

"The adaptive nature of Precision Promise allows us to regularly bring on innovative investigational therapies to study against the current standard of care and we are thrilled to be bringing an investigational treatment option from Novartis into the fold," said Julie Fleshman, JD, MBA, president and CEO of PanCAN.

In addition to bringing Novartis' investigational treatment into the study, PanCAN has announced the addition of five new sites to the already fifteen active sites where pancreatic cancer patients will be able to access the trial. The new sites designated include:

  • Harold C. Simmons Comprehensive Cancer Center (Dallas, Texas)
  • Huntsman Cancer Institute at the University of Utah (Salt Lake City, Utah)
  • Mayo Clinic Cancer Center (Rochester, Minn.)
  • Sylvester Comprehensive Cancer Center (Miami, Fla.)
  • University of Michigan Rogel Cancer Center (Ann Arbor, Mich.)

Following the activation of these additional five institutions, PanCAN expects to also add 10 more sites by early 2023, bringing Precision Promise to a total of 30 top cancer centers nationwide and doubling the footprint of the trial. A full list of institutions that are currently open and actively enrolling patients can be found at pancan.org/precisionpromise/locations. This list is updated as new sites are activated.

"Pancreatic cancer patients deserve better treatment options," said Fleshman, "We're hopeful that by expanding access of Precision Promise to more diverse populations and thirty total sites by early 2023, we'll be able to deliver results that will improve patient outcomes in the future."

When selecting the new sites for its Precision Promise clinical trial, PanCAN evaluated institutions with not only strong pancreatic cancer programs, but also institutions in different geographic regions that serve a diverse patient population in order to expand access of the trial to typically underserved communities.

"The Pancreatic Cancer Action Network’s Precision Promise adaptive clinical trial platform provides new treatment options for metastatic pancreatic cancer patients here at Huntsman Cancer Institute,” says Susan Sharry, Huntsman Cancer Institute phase I clinical research program manager. “There are multiple sub-protocols conducted simultaneously for initial and subsequent patient treatment options. Our site collaborates with other pancreatic cancer researchers and clinicians across the nation. We offer both supportive care and biomarker research. Both play an important role in the care and treatment of our pancreatic cancer patients at Huntsman Cancer Institute."

For more information about Precision Promise and PanCAN's commitment to research in its urgent mission to save lives, visit pancan.org or follow PanCAN on TwitterInstagram and Facebook.

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About the Pancreatic Cancer Action Network

The Pancreatic Cancer Action Network (PanCAN) leads the way in accelerating critical progress for pancreatic cancer patients. PanCAN takes bold action by funding life-saving research, providing personalized patient services and creating a community of supporters and volunteers who will stop at nothing to create a world in which all pancreatic cancer patients will thrive.

Media Contact

Public Relations – Huntsman Cancer Institute
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About Huntsman Cancer Institute at the University of Utah

Huntsman Cancer Institute (HCI) at the University of Utah is the official cancer center of Utah and the only National Cancer Institute (NCI)-Designated Comprehensive Cancer Center in the Mountain West. The campus includes a state-of-the-art cancer specialty hospital, and two buildings dedicated to cancer research. HCI provides patient care, cancer screening, and education at community clinics and affiliate hospitals throughout the Mountain West. HCI is consistently recognized among the best cancer hospitals in the country by U.S. News and World Report. The region’s first proton therapy center opened in 2021 and a major hospital expansion is underway. HCI is committed to creating a diverse and inclusive environment for staff, students, patients, and communities. Advancing cancer research discoveries and treatments to meet the needs of patients who live far away from a major medical center is a unique focus. More genes for inherited cancers have been discovered at HCI than at any other cancer center, including genes responsible for breast, ovarian, colon, head and neck cancers, and melanoma. HCI was founded by Jon M. and Karen Huntsman.

Cancer touches all of us.

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