Cell Response and Regulation

CRR Membership Directory

cell response and regulation research programCell Response and Regulation (CRR) program conducts basic research on the fundamental cellular mechanisms that are deregulated in cancer cells. This discovery science provides new insight into cancer pathways and potential biomarkers.

The CRR program brings together scientists with shared research interests in three main thematic areas:

  • Mechanisms underlying cell turnover, including cell division, checkpoints, cell death, and stem cells, as well as their dysregulation in cancer in order to identify and characterize cancer targets.
  • Aberrant signaling in cancer and mechanisms of drug resistance, including signaling molecules and pathways relevant to drug resistance and cancer treatment.
  • Mechanisms and pathways mediating cell adhesion, motility, and metastasis, including developing an understanding of how cancer cells acquire the capability to reach distant sites and grow in those environments, which is critical for eventual therapeutic or preventative targeting.

Program Reports

2015 report

CRR Program Newsletters

CRR 2016 Winter Newsletter
CRR 2015 Summer Newsletter

Previous newsletters are available upon request.
Please email vanessa.tuckett@hci.utah.edu.

Program achievements include an improved understanding of the machinery that executes cell division, elucidation of signaling pathways involved in epithelial homeostasis and migration, and identification of a new biomarker for breast cancer, a critical mediator of drug resistance in myeloma, and factors that drive brain tumor and melanoma metastasis. A major asset of the CRR Program is the development of robust high-fidelity preclinical models of cancer. Basic CRR Program discoveries are leading to early phase clinical trials in breast cancer and melanoma and have impacted a chemoprevention trial in colon cancer.

The CRR Program led by Katharine Ullman, PhD, and draws its members from many academic units on campus, providing a forum for interdepartmental communication among individuals who share a common interest in understanding the cellular basis of cancer. The CRR Program stimulates scientific exchange and promotes cancer-focused transdisciplinary research by capitalizing on opportunities to link the diverse expertise in techniques and model systems in synergistic projects. This extends across Cancer Center Programs and is further promoted by the interface with disease-oriented teams.

The Cell Response and Regulation Program received $9.8 million in total research support from the National Institutes of Health, the American Cancer Society, the National Science Foundation, and other funding agencies in 2013, with 34% coming from the National Cancer Institute. Cancer-focused articles published between 2009-2013 total 212, of which 37% are inter-programmatic and 18% are intra-programmatic publications.

Sheri Holmen, PhD

Alana Welm, PhD

Jody Rosenblatt Alana Welm

CRR Membership Directory 


Name E-mail Research Interests Website
Beckerle, MaryMary Beckerle e-mail Cell adhesion; cell migration; Ewing's sarcoma website
Christian, JanJan Christian e-mail Cellular mechanisms that regulate the activity of Wnts and bone morphogenetic proteins
Edgar, Brucebruce-edgar.jpg e-mail Regulation of cell growth and cell cycle progression. Epithelial damage responses. Signal transduction as a regulator of proliferation. Edgar Lab
Evason, KimberleyKimberley Evason e-mail Investigating mechanism of HCC initiation and progression and identifying potential treatments for HCC, using a combination of approaches including human tissue, cultured human cells, and zebrafish models.
Factor, RachelRachel Factor e-mail
Breast cancer pathology
Fults, DanielDaniel Fults e-mail
Defective signaling in medulloblastoma and metastasis
Grossman, DouglasDoug Grossman e-mail Apoptotic mechanisms underlying skin cancer development, with a focus on the apoptosis and cell cycle regulator, Survivin; oxidative stress in melanoma website
Grossmann, AllieAllie Grossmann e-mail Mechanisms of cancer disease progression. Identification and development of therapeutic interventions.
Holmen, SheriSheri Holmen e-mail To identify and validate novel molecular targets for cancer therapy. website
Kadrmas, JulieJulie Kadrmas e-mail Cell adhesion, cell migration, Ewing sarcoma
Kramer, JessicaJessica Kramer e-mail Developing chemical tools to study the glycocalyx (cell surface glycoproteins and glycolipids), which is strikingly altered in cancer
Lim, CarolCarol Lim e-mail Targeting apoptotic mechanisms in cancer cells
Mendoza, Michellemichelle-mendoza.jpg e-mail Biochemical signaling mechanisms that control the cytoskeletal changes of cell motility
Moos, PhilipPhilip Moos e-mail Redox dysregulation in cancer; selenoprotein function in cancer.
Murtaugh, CharlesCharles Murtaugh e-mail Pancreatic development and cancer
Myers, BenjaminBenjamin Myers e-mail Mechanistic studies of cell-cell communication in vertebrate development and physiology, as well as how pathway dysregulation can give rise to cancer and other diseases
O'Hare, ThomasThomas OHare e-mail
Target discovery and inhibitor development for chronic and acute leukemias; mechanism-based targeting of leukemic cells, including leukemia stem cells; design, validation and coordination of function-first profiling for new therapeutic target in leukemia
Oliver, TrudyTrudy Oliver e-mail Mouse models of lung cancer; chemotherapeutic resistance; p53 regulation website
Roh-Johnson, Minnaroh-johnson-minna.jpg Cell signaling in the tumor microenvironment and regulation of metastasis, in animal and in vitro systems
Rosenblatt, JodyJody Rosenblatt e-mail
Mechanisms and regulation of cell death and division; novel mechanisms for initiating tumor cell metastasis.
Round, JuneJune Round e-mail
How the microbiota influences the immune response.
Spike, Benjaminbenjamin-spike.jpg e-mail Mechanisms of cellular plasticity and heterogeneity in complex tissues that govern individual stem cells and cancer cells in multicellular systems. Spike Lab
Stanfield, GillianGillian Stanfield e-mail Cell polarity; cell migration, and the role of proteases in cancer
Stewart, RodneyRodney Stewart e-mail
Cell survival and migration during embryogenesis and cancer
Sundquist, WesleyWesley Sundquist e-mail Membrane trafficking; cytokinesis website
Katharine UllmanUllman, Katharine e-mail Cell division, biomarkers and tumor suppressors in breast cancer. website
VanBrocklin, MatthewMatthew VanBrocklin e-mail
Identifying novel molecular targets that can be developed for therapeutic intervention strategies.
Welm, AlanaAlana Welm e-mail Tumor inflammation and cancer, particularly breast cancer website
Welm, BryanBryan Welm e-mail Breast cancer stem cells, cancer drug screening
Williams, MatthewMatthew Williams e-mail Understanding of the cellular and molecular signals that regulate the differentiation and cell fate decisions of activated T cells in vivo
Zangle, Thomasthomas-zangle.jpg e-mail Developing technologies to quantify cancer cell response to therapy using optical measurements of cell mass.
Zimmerman, GuyGuy Zimmerman e-mail Cell adhesion and inflammation, thrombosis in cancer.