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The Chandrasekharan Lab focus is to understand the regulation and functions of histone and non-histone protein modifications during transcription, replication, recombination, and repair. Our current interest is to uncover the molecular mechanisms involved in the crosstalk between histone H2B ubiquitination and histone H3 lysine-4 & lysine-79 methylation.

Enzymes and regulatory factors involved in this evolutionarily conserved trans-histone crosstalk play important roles in normal development and in cancer-related processes. We use yeast and mammalian model systems, and employ both classical and modern, biochemical, biophysical, genetic and genomics-based approaches to understand various aspects of epigenetics and chromatin biology.