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Investigational Drug Studies

At the PRR, we house a centralized resource for animal models along with expertise in experimental design and technical skills. We ensure all studies are designed with reproducibility and compliance with local and federal regulatory agencies. Our typical investigational drug study includes:

  • Tolerability studies for new compounds to determine the appropriate drug concentration for mouse treatment.

  • Tumor transplantation in an orthotopic or subcutaneous site.
    • Transplantation sites include mammary fat pad and intra-tibial; ask about additional orthotopic sites.
    • When appropriate, transplantation includes Matrigel or hormone pellets.
  • Tumor growth measurements and dosing of compound and vehicle control.
    • Dosing routes include: oral gavage, subcutaneous, intra-peritoneal, intra-venous, intra-tumoral, and by food or drinking water.
    • Tumors and body weight are measured twice weekly either by caliper or bioluminescence.
  • Necropsy to harvest tumor tissue and metastatic organs for histology and RNA/DNA analysis.
    • Collected based on experimental design.
    • Includes flash freezing and paraffin embedded tissue.

We have PDX tumor models available, or we can utilize cell lines or transgenic mice. We can help in consultation and executing all aspects of your in vivo experiments, providing you with necropsy tissue, survival curves, and growth data, everything you need to generate a figure for publication in a paper or grant.