This content was originally produced for audio. Certain elements such as tone, sound effects, and music, may not fully capture the intended experience in textual representation. Therefore, the following transcription has been modified for clarity. We recognize not everyone can access the audio podcast. However, for those who can, we encourage subscribing and listening to the original content for a more engaging and immersive experience.
All thoughts and opinions expressed by hosts and guests are their own and do not necessarily reflect the views held by the institutions with which they are affiliated.
What Can Cause Hyperarousability?
Interviewer: It's normal to jump at a really loud, unfamiliar sound. But when you get startled at the tiniest noise, that might not be so normal. We'll discover what's normal and what's not with being jumpy. That's coming up next, on The Scope.
We're talking today with Kirtly Parker Jones, who is an expert on all things women. Dr. Jones, my mother, has developed this jumpy scare anxiety, and I'm not even sure what it is. Everything makes her jumpy. Talking to her when her back is facing me makes her jumpy. Thunder makes her jumpy. Loud noise on the TV makes her jumpy. I don't feel that's normal.
Stress and Cortisol
Dr. Jones: Doesn't sound like it's normal for her, and it doesn't sound like it's very pleasant for her. And her getting startled is startling you, so there it's probably not okay. Let's talk about arousability. There's some very interesting research now looking into arousability or hyperarousability. We have some data that looks at women who are extremely anxious, very stressed during their pregnancy, and who have very high serum cortisol levels during their pregnancy.
Cortisol is the level we make when we're stressed. When their babies were born, their babies had high levels of cortisol and they were more hyperarousable. Little startle noises made them jumpy; these are the babies. So this is something where the baby is born with a trait of being arousable and being hyperalert based on the experience in utero.
Caffeine, Sleep Loss, and Other Everyday Triggers
But there are other conditions that can lead to a hyperarousable state. First of all, the most predictable is caffeine. We are now the caffeine nation, and I see young people consuming very high levels of caffeine. When you drink coffee or caffeine-like drinks all the time, people are hyperexcitable. They jump at smaller things, they're hyperirritable, their brain is irritable, meaning the same loud noises that don't bother other people seem to bother them. So loud noises, bright lights, the brain is irritable when it's hypercaffeinated. And often it's a little underslept. So that can make the brain hyperirritable.
Overactive Thyroid
People who are hyperthyroid. So when your engine is just running too fast, it can make you hyperirritable. You jump or become startled at smaller things. You can't calm yourself as well. So that can be one of the signs of hyperthyroidism.
Post-Traumatic Stress Syndrome
I think more importantly for me, is that I see more and more women who have really a form of PTSD, which is Post-traumatic Stress Syndrome. It's been a lot in the newspaper with respect to our soldiers. Men and women coming back from overseas because of very loud noises, they saw horrible things, they were traumatized, and now their brains are on high alert all the time. Little things make them jump. That's the hallmark of PTSD. People don't sleep. They wake up with nightmares, loud noises make them duck and cover, and they're very irritable.
Well, this can happen outside the battlefield as well. Women who've been sexually abused, women who've had a traumatic episode on the street, a near-death experience in a car accident. Maybe even a very scary medical episode where they were afraid for their life, and they were in the emergency room. Something really scary had happened, and now they can't calm themselves again.
When to See Your Doctor About Hyperarousability
Interviewer: So it doesn't sound like it has anything to do with the organs, or if you might have heart disease, or it might lead to something in your brain. Nothing like that, though. Nothing that serious.
Dr. Jones: Not usually, no. Your brain can be hyperstimulated because of medications that you're taking or because of your thyroid. People who have a heart condition where they have a very rapid heartbeat, just having a very rapid heartbeat can make you anxious. And being anxious can trigger a very rapid heartbeat. And when your heart is beating irregularly rapidly, it makes you startle easily. Whether the startle came first or the heartbeat came first is not entirely well known. But people who have a very rapid heart rate, and may actually have a rhythm disturbance, can feel very anxious because their heart is going so fast, and they can startle easily. But we can fix that.
So jumpiness? It could've come from the womb. It could be a trait that you're born with; everybody in your family is kind of jumpy. It could be the mothering style that you were raised with. It could be that your caffeine and your amphetamines are too high, so stop that already. It could be a sign of hyperthyroidism, or it could be a consequence of a traumatic episode that you're not over and might need help with.
Being hyperarousable or hyperirritable is very difficult to live with. Hard for you to live with yourself, and hard for others to live with you. It's worthwhile getting it evaluated and talking to your clinician. There may be a medical reason, but there are very good therapies, such as mindfulness training, to help you be the calm person you really hope to be.
updated: November 21, 2025
originally published: August 6, 2015
More Answers and Resources for Your Women's Health Concerns
![[media-entity-reference:media-alt]](/sites/g/files/zrelqx136/files/styles/landscape_wide/public/media/images/2024/7DOMAINS.png?h=0fc0d179&itok=shSRfF2w)