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  • Genetic Tug of War in the Brain Influences Behavior

    Researchers at the University of Utah School of Medicine report on a version of genetic parental control in mice that is more targeted, and subtle than canonical imprinting. Published in Cell Reports, so-called noncanonical imprinting is particularly prevalent in the brain, and skews the genetic message in subpopulations of cells so that mom, or dad, has a stronger say. The mechanism can influence offspring behavior, and because it is observed more frequently than classic imprinting, appears to be preferred.

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  • Stem Cell Delivery Method Shows Promise for Treating End Stage Heart Failure

    A new clinical trial to test how a high dose of stem cells delivered via a method called “retrograde coronary sinus infusion” affects end stage heart failure patients is showing promising results. The trial, conducted by an international team led by researchers at the University of Utah School of Medicine, Salt Lake City, UT appears in the current issue of STEM CELLS Translational Medicine.

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  • Poor Survival in Multiple Myeloma Patients Linked to Genetic Variation

    Researchers have found that multiple myeloma patients with a genetic variation in the gene FOPNL die on average 1-3 years sooner than patients without it. The finding was identified with a genetic mapping technique, genome wide association studies (GWAS), and verified in patient populations from North America and Europe. Published in Nature Communications, this was the first study to survey the entire human genome for genetic variation influencing survival, and is a first step toward applying precision medicine to multiple myeloma.

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