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John F. Bohnsack, M.D.

Vice-Chair of Clinical Enterprise, Department of Pediatrics

Chief, Division of Pediatric Immunology and Rheumatology

Specialties

Languages

  • English

Clinical Details

Schedule An Appointment Clinical Office Address
(801) 213-3599 PCH Outpatient Services at Riverton
3773 West 12600 South
Riverton, UT 84065
(801) 213-3599 Primary Children's Hospital
100 N Mario Capecchi Drive
Salt Lake City, UT 84113

Bio

John Bohnsack MD graduated from Yale College, and received his medical degree from the University of Virginia. He is board certified in Pediatrics and in Pediatric Rheumatology. He is a Professor of Pediatrics and has been a member of the faculty of the University of Utah School of Medicine for 22 years.

Dr. Bohnsack’s clinical interests include rheumatic disorders, autoimmune and autoinflammatory diseases (including recurrent fever syndromes) and primary immune deficiency disorders of childhood and adolescence.

Dr. Bohnsack's research interests are currently focused on the epidemiology, genetics and treatment of juvenile arthritis.

Board Certification and Academic Information

Academic Departments Pediatrics - Professor
Academic Divisions Pediatric Immunology and Rheumatology
Board Certification American Board of Pediatrics (Pediatrics)

Academic Profile

Board Certification and Academic Information

Academic Departments Pediatrics - Professor
Academic Divisions Pediatric Immunology and Rheumatology
Board Certification American Board of Pediatrics (Pediatrics)

Academic Office Locations

Academic Office Phone Number Academic Office Address
(801) 662-5706 Primary Children's Hospital
Primary Children's Medical Center
100 N Mario Capecchi Drive
Salt Lake City, UT 84113
(801) 587-7416 Williams Building
Pediatric Allergy, Immunology & Rheumatology
295 Chipeta Way
Salt Lake City, UT 84108

Academic Bio

John Bohnsack MD is Professor and Chief of the Division of Allergy, Immunology and Pediatric Rheumatology. He also serves as the Vice Chair of the Department of Pediatrics for the Clinical Enterprise. Dr. Bohnsack graduated from Yale College, and received his medical degree from the University of Virginia. He trained in Pediatrics at the University of Washington, and then did successive fellowships at the University of Washington, the intramural program of the NIH and at Scripps Research Institute. He joined the faculty of the University of Utah in 1988.

Dr. Bohnsack has received NIH funding for his research on neutrophil adhesion molecules, and the pathophysiology of infections caused by Group B streptococci (GBS). His most recent work on GBS helped identify the population structure of GBS using multi-locus sequence typing, and the specific populations that colonize and infected infants in a prospectively collected sample of GBS from women and infants born in six US academic centers. This work was performed in collaboration with Dr. Kimi Lin, an intramural investigator at the National Institute of Child Health and Development, who led the effort that collected the samples and clinical information from this cohort. Dr. Bohnsack’s interest in the population structure of GBS was spurred by his association with Dr. Shinji Takahashi, a Professor at Shinji-Eiyo University in Saitama, Japan, during Dr. Takahashi’s year in Dr. Bohnsack’s lab as a visiting investigator. Dr. Takahashi had earlier identified clones of GBS using analysis of restriction digest profiles. He and Dr. Takashi continue a long-distance collaboration on the role of l-ficollin in the opsonization of GBS.

Most recently, Dr. Bohnsack’s research has shifted towards identifying the genetic basis of childhood rheumatic diseases. He started the Intermountain States Database for Childhood Rheumatic Diseases in 2000, and then worked as a mentor and colleague with Dr. Sampath Prahalad who further developed the Database by collecting DNA and serum samples from over 500 affected children with well-characterized JIA. Dr. Bohnsack was a mentor for Dr. Prahalad’s KO-8 funded research at the University of Utah which identified polymorphisms in selected genes with JIA. The Database continues to expand, and now includes close to 700 samples from affected patients and a larger number of samples from parents. His collaboration continues with Dr. Prahalad, who joined the faculty at Emory University in 2008. They are beginning work on Dr. Prahalad’s NIH RO-1 which will examine segmental chromosome sharing in JIA patients in the Database that are in extended pedigrees identified using the resources of the Utah Population Database. Samples from the Database are also being used in collaborative multi-institutional Genome Wide Association Studies at Cincinnati Children’s Hospital and at the intramural program at the NIH.

Dr. Bohnsack’s clinical interests include the evaluation and treatment of rheumatic disorders, autoimmune and autoinflammatory diseases (including recurrent fever syndromes) and primary immune deficiency disorders of childhood and adolescence. His administrative role in the Department includes oversight of the revenue cycle, Pediatric contracting, implementation of clinical information systems, and redesign of the ambulatory clinics to improve patient and physician satisfaction. He participates in the Primary Childrens’ Medical Center Value Project, a working group that is devising and implementing measures to improve quality while containing cost, and has been an elected member of the University of Utah Medical Group Board since 2005.

Education

Education History

Type School Degree
Research Fellow Scripps Clinic & Research Foundation
Immunology
Research Fellow
Fellowship National Institutes of Health
Immunology
Fellow
Fellowship University of Washington
Immunology
Fellow
Residency University of Washington
Pediatrics
Resident
Internship University of Washington
Pediatrics
Intern
Professional Medical University of Virginia
Medicine
M.D.
Undergraduate Yale University
Molecular Biophysics and Biochemistry
B.A.

Publications

Selected Provider Publications

Journal Article

  1. Prahalad S, Conneely KN, Jiang Y, Sudman M, Wallace CA, Brown MR, Ponder LA, Rohani-Pichavant M, Zwick ME, Cutler DJ, Angeles-Han ST, Vogler LB, Kennedy C, Rouster-Stevens K, Wise CA, Punaro M, Reed AM, Mellins ED, Bohnsack JF, Glass DN, Thompson SD (2013). Susceptibility to childhood onset rheumatoid arthritis: Investigation of a weighted genetic risk score that integrates cumulative effects of variants at five genetic loci.LID - 10.1002/art.37913 [doi]. Arthritis Rheum.
  2. Hinks A, Cobb J, Marion MC, Prahalad S, Sudman M, Bowes J, Martin P, Comeau ME, Sajuthi S, Andrews R, Brown M, Chen WM, Concannon P, Deloukas P, Edkins S, Eyre S, Gaffney PM, Guthery SL, Guthridge JM, Hunt SE, James JA, Keddache M, Moser KL, Nigrovic PA, Onengut-Gumuscu S, Onslow ML, Rose CD, Rich SS, Steel KJ, Wakeland EK, Wallace CA, Wedderburn LR, Woo P, Bohnsack JF, Haas JP, Glass DN, Langefeld CD, Thomson W, Thompson SD (2013). Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis.LID - 10.1038/ng.2614 [doi]. Nat Genet.
  3. Thompson SD, Marion MC, Sudman M, Ryan M, Tsoras M, Howard TD, Barnes MG, Ramos PS, Thomson W, Hinks A, Haas JP, Prahalad S, Bohnsack JF, Wise CA, Punaro M, Rose CD, Pajewski NM, Spigarelli M, Keddache M, Wagner M, Langefeld CD, Glass DN (2012). Genome-wide association analysis of juvenile idiopathic arthritis identifies a new susceptibility locus at chromosomal region 3q13. Arthritis Rheum, 64(8), 2781-91.
  4. Fujieda M, Aoyagi Y, Matsubara K, Takeuchi Y, Fujimaki W, Matsushita M, Bohnsack JF, Takahashi S (2012). L-ficolin and capsular polysaccharide-specific IgG in cord serum contribute synergistically to opsonophagocytic killing of serotype III and V group B streptococci. Infect Immun, 80(6), 2053-60.
  5. Tebo AE, Jaskowski T, Davis KW, Whiting A, Clifford B, Zeft A, McNally B, Hill HR, Bohnsack J, Prahalad S (2012). Profiling anti-cyclic citrullinated peptide antibodies in patients with juvenile idiopathic arthritis. Pediatr Rheumatol Online J, 10(1), 29.
  6. Chattopadhyay D, Carey AJ, Caliot E, Webb RI, Layton JR, Wang Y, Bohnsack JF, Adderson EE, Ulett GC (2011). Phylogenetic lineage and pilus protein Spb1/SAN1518 affect opsonin-independent phagocytosis and intracellular survival of Group B Streptococcus. Microbes Infect, 13(4), 369-82.
  7. Prahalad S, Thompson SD, Conneely KN, Jiang Y, Leong T, Prozonic J, Brown MR, Ponder LA, Angeles-Han ST, Vogler LB, Kennedy C, Wallace CA, Wise CA, Punaro M, Reed A, Park JL, Mellins ED, Zeft AS, Bohnsack JF, Glass AD (2011). Hierarchy of risk of childhood onset rheumatoid arthritis conferred by HLA-DRB1 alleles encoding the shared epitope.LID - 10.1002/art.33376 [doi]. Arthritis Rheum.
  8. Prahalad S, Zeft AS, Pimentel R, Clifford B, McNally B, Mineau GP, Jorde LB, Bohnsack JF (2010). Quantification of the familial contribution to juvenile idiopathic arthritis. Arthritis Rheum, 62(8), 2525-9.
  9. Stringer E, Bohnsack J, Bowyer SL, Griffin TA, Huber AM, Lang B, Lindsley CB, Ota S, Pilkington C, Reed AM, Scuccimarri R, Feldman BM (2010). Treatment approaches to juvenile dermatomyositis (JDM) across North America: The Childhood Arthritis and Rheumatology Research Alliance (CARRA) JDM Treatment Survey. J Rheumatol, 37(9), 1953-61.
  10. Thompson SD, Sudman M, Ramos PS, Marion MC, Ryan M, Tsoras M, Weiler T, Wagner M, Keddache M, Haas JP, Mueller C, Prahalad S, Bohnsack J, Wise CA, Punaro M, Zhang D, Rose CD, Comeau ME, Divers J, Glass DN, Langefeld CD (2010). The susceptibility loci juvenile idiopathic arthritis shares with other autoimmune diseases extend to PTPN2, COG6, and ANGPT1. Arthritis Rheum, 62(11), 3265-76.
  11. Pont-Kingdon G, Bohnsack J, Sumner K, Whiting A, Clifford B, Guthery SS, Jorde LB, Lyon E, Prahalad S (2009). Lack of association between beta 2-adrenergic receptor polymorphisms and juvenile idiopathic arthritis. Scand J Rheumatol, 38(2), 91-5.
  12. Zeft A, Hollister R, LaFleur B, Sampath P, Soep J, McNally B, Kunkel G, Schlesinger M, Bohnsack J (2009). Anakinra for systemic juvenile arthritis: the Rocky Mountain experience. J Clin Rheumatol, 15(4), 161-4.
  13. Evans JJ, Klesius PH, Pasnik DJ, Bohnsack JF (2009). Human Streptococcus agalactiae isolate in Nile tilapia (Oreochromis niloticus). Emerg Infect Dis, 15(5), 774-6.
  14. Prahalad S, Hansen S, Whiting A, Guthery SL, Clifford B, McNally B, Zeft AS, Bohnsack JF, Jorde LB (2009). Variants in TNFAIP3, STAT4, and C12orf30 loci associated with multiple autoimmune diseases are also associated with juvenile idiopathic arthritis. Arthritis Rheum, 60(7), 2124-30.
  15. Zeft AS, Prahalad S, Lefevre S, Clifford B, McNally B, Bohnsack JF, Pope CA 3rd (2009). Juvenile idiopathic arthritis and exposure to fine particulate air pollution. Clin Exp Rheumatol, 27(5), 877-84.
  16. Aoyagi Y, Adderson EE, Rubens CE, Bohnsack JF, Min JG, Matsushita M, Fujita T, Okuwaki Y, Takahashi S (2008). L-Ficolin/mannose-binding lectin-associated serine protease complexes bind to group B streptococci primarily through N-acetylneuraminic acid of capsular polysaccharide and activate the complement pathway. Infect Immun, 76(1), 179-88.
  17. Bohnsack JF, Whiting A, Gottschalk M, Dunn DM, Weiss R, Azimi PH, Philips JB 3rd, Weisman LE, Rhoads GG, Lin FY (2008). Population structure of invasive and colonizing strains of Streptococcus agalactiae from neonates of six U.S. Academic Centers from 1995 to 1999. J Clin Microbiol, 46(4), 1285-91.
  18. Prahalad S, Martins TB, Tebo AE, Whiting A, Clifford B, Zeft AS, McNally B, Bohnsack JF, Hill HR (2008). Elevated serum levels of soluble CD154 in children with juvenile idiopathic arthritis. Pediatr Rheumatol Online J, 6, 8.
  19. Prahalad S, Bohnsack JF, Whiting A, Clifford B, Jorde LB, Guthery SL, Thompson SD, Glass DN, Bamshad MJ (2008). Lack of association of functional CTLA4 polymorphisms with juvenile idiopathic arthritis. Arthritis Rheum, 58(7), 2147-52.
  20. Lovell DJ, Ruperto N, Goodman S, Reiff A, Jung L, Jarosova K, Nemcova D, Mouy R, Sandborg C, Bohnsack J, Elewaut D, Foeldvari I, Gerloni V, Rovensky J, Minden K, Vehe RK, Weiner LW, Horneff G, Huppertz HI, Olson NY, Medich JR, Carcereri-De-Prati R, McIlraith MJ, Giannini EH, Martini A (2008). Adalimumab with or without methotrexate in juvenile rheumatoid arthritis. N Engl J Med, 359(8), 810-20.
  21. Evans JJ, Bohnsack JF, Klesius PH, Whiting AA, Garcia JC, Shoemaker CA, Takahashi S (2008). Phylogenetic relationships among Streptococcus agalactiae isolated from piscine, dolphin, bovine and human sources: a dolphin and piscine lineage associated with a fish epidemic in Kuwait is also associated with human neonatal infections in Japan. J Med Microbiol, 57(Pt 11), 1369-76.
  22. Prahalad S, Bohnsack JF, Jorde LB, Whiting A, Clifford B, Dunn D, Weiss R, Moroldo M, Thompson SD, Glass DN, Bamshad MJ (2006). Association of two functional polymorphisms in the CCR5 gene with juvenile rheumatoid arthritis. Genes Immun, 7(6), 468-75.
  23. Oliveira IC, de Mattos MC, Pinto TA, Ferreira-Carvalho BT, Benchetrit LC, Whiting AA, Bohnsack JF, Figueiredo AM (2006). Genetic relatedness between group B streptococci originating from bovine mastitis and a human group B Streptococcus type V cluster displaying an identical pulsed-field gel electrophoresis pattern. Clin Microbiol Infect, 12(9), 887-93.
  24. Ruperto N, Ravelli A, Castell E, Gerloni V, Haefner R, Malattia C, Kanakoudi-Tsakalidou F, Nielsen S, Bohnsack J, Gibbas D, Rennebohm R, Voygioyka O, Balogh Z, Lepore L, Macejkova E, Wulffraat N, Oliveira S, Russo R, Buoncompagni A, Hilario MO, Alpigiani MG, Passo M, Lovell DJ, Merino R, Martini A, Giannini EH (2006). Cyclosporine A in juvenile idiopathic arthritis. Results of the PRCSG/PRINTO phase IV post marketing surveillance study. Clin Exp Rheumatol, 24(5), 599-605.

Review

  1. Anaya JM, Kim-Howard X, Prahalad S, Chernavsky A, Canas C, Rojas-Villarraga A, Bohnsack J, Jonsson R, Bolstad AI, Brun JG, Cobb B, Moser KL, James JA, Harley JB, Nath SK (2012). Evaluation of genetic association between an ITGAM non-synonymous SNP (rs1143679) and multiple autoimmune diseases. [Review]. Autoimmun Rev, 11(4), 276-80.

Conference Proceedings

  1. Zeft A, Yaish H, Prince J, Bohnsack J, Jackson WD, Coffin CM (2008). A 6-year-old child with Fever of unknown origin, anemia, and abdominal pain. J Pediatr, United States, 153(2), 283-6, 286.e1.

Case Report

  1. Sampert C, Lowichik A, Rollins M, Inman CJ, Bohnsack J, Pohl JF (2011). Sclerosing mesenteritis in a child with celiac disease. J Pediatr Gastroenterol Nutr, 53(6), 688-90.
  2. Deneau M, Wallentine J, Guthery S, OGorman M, Bohnsack J, Fluchel M, Bezzant J, Pohl JF (2010). Natural killer cell lymphoma in a pediatric patient with inflammatory bowel disease. Pediatrics, 126(4), e977-81.

Letter

  1. Zeft A, Bohnsack JF (2007). Cryopyrin-associated autoinflammatory syndrome: a new mutation [Letter to the editor]. Ann Rheum Dis, 66(6), 843-4.

Clinical Trials

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