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Dean Y. Li, M.D., Ph.D.
Interim Co-Chair, Department of Physiology
Bio
Locations
| Schedule An Appointment | Clinical Office Address |
|---|---|
| (801) 584-1235 | Veterans Administration Medical Center 500 S Foothill Blvd Salt Lake City, UT 84149 |
Board Certification and Academic Information
| Academic Departments | Internal Medicine - Professor Human Genetics - Adjunct Professor Oncological Sciences - Adjunct Professor |
| Academic Divisions | Cardiology |
Research Interests
- Vascular Diseases
- Vascular Development
Board Certification and Academic Information
| Academic Departments | Internal Medicine - Professor Human Genetics - Adjunct Professor Oncological Sciences - Adjunct Professor |
| Academic Divisions | Cardiology |
Academic Office Locations
| Academic Office Phone Number | Academic Office Address |
|---|---|
| (801) 587-8294 | George and Dolores Eccles Institute of Human Genetics Molecular Medicine 15 N 2030 E Salt Lake City, UT 84112 |
Academic Bio
Education History
| Type | School | Degree |
|---|---|---|
| Fellowship | University of Utah School of Medicine Cardiology |
Fellow |
| Fellowship | Barnes Hospital Cardiology |
Fellow |
| Residency | Barnes Hospital |
Resident |
| Professional Medical | Washington University |
M.D. |
| Doctoral Training | Washington University |
Ph.D. |
| Undergraduate | University of Chicago |
B.A. |
Selected Provider Publications
- ABCB6 mutations cause ocular coloboma. - American Journal of Human Genetics, 2012
- Blocking Fibroblast Growth Factor Receptor signaling inhibits tumor growth, lymphangiogenesis, and metastasis - PLoS ONE, 2012
- Slit2/Robo4 signaling modulates HIV-1 gp120-Induced lymphatic hyperpermeability. - PLoS Pathogens, 2012
- Small GTPase R-Ras Regulates Integrity and Functionality of Tumor Blood Vessels - Cancer Cell, 2012
- Vascular Leak is a Central Feature in the Pathogenesis of Systemic Sclerosis - Journal of Rheumatology, 2012
- “Cationic PAMAM dendrimers disrupt key platelet functions”. - Molecular Pharmaceutics, 2012
- A luminescent oxygen channeling biosensor that measures small GTPase activation. - Chemical Communications, 2011
- Altered bladder function in elastin-deficient mice at baseline and in response to partial bladder outlet obstruction. - BJU International, 2011
- Genetic Variants at 13q12.12 are associated with high myopia in the Han Chinese population. - American Journal of Human Genetics, 2011
- HADP1, a newly identified pleckstrin homology domain protein, is required for cardiac contractility in zebrafish. - Disease Models and Mechanisms, 2011
- Inhibition of transforming growth factor β worsens elastin degradation in a murine model of Kawasaki disease. - American Journal of Pathology, 2011
- Left ventricular assist device unloading effects on myocardial structure and function: current status of the field and call for action. - Current Opinion in Cardiology, 2011
- Motoneurons are essential for vascular pathfinding. - Development (Cambridge), 2011
- Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice. - Journal of Clinical Investigation, 2011
- Netrin-4 Activates Endothelial Integrin {alpha}6{beta}1. - Circulation Research, 2011
- Novel approach for endothelializing vascular devices: Understanding and exploiting elastin-endothelial interactions. - Annals of Biomedical Engineering, 2011
- Robo4 cooperates with CXCR4 to specify hematopoietic stem cell localization to bone marrow niches. - Cell Stem Cell, 2011
- Robo4-dependent Slit signaling stabilizes the vasculature during pathologic angiogenesis and cytokine storm. - Current Opinion in Hematology, 2011
- Genetic and functional dissection of HTRA1 and LOC387715 in age-related macular degeneration. - PLoS Genetics, 2010
- Slit-robo signaling in ocular angiogenesis. - Advances in Experimental Medicine and Biology, 2010
- Mechanisms of vascular stability and the relationship to human disease. - Current Opinion in Hematology, 2010
- Risk factors predictive of right ventricular failure after left ventricular assist device implantation. - American Journal of Cardiology, The, 2010
- Targeting Robo4-dependent slit signaling to survive the cytokine storm in sepsis and influenza. - Science Translational Medicine, 2010
- Assessing changes in vascular permeability in a hamster model of viral hemorrhagic fever. - Virology Journal, 2010
- Elastin haploinsufficiency results in progressive aortic valve malformation and latent valve disease in a mouse model. - Circulation Research, 2010
- Evaluating strategies for the treatment of cerebral cavernous malformations. - Stroke, 2010
- Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice. - Journal of Clinical Investigation, 2010
- Impact of blood product transfusion-induced tolerance on the incidence of cardiac allograft rejection. - Transplantation Proceedings, 2010
- Impact of mechanical unloading on microvasculature and associated central remodeling features of the failing human heart. - Journal of the American College of Cardiology, 2010
- Netrin-4 induces lymphangiogenesis in vivo. - Blood, 2010
- Recent insights into cerebral cavernous malformations: animal models of CCM and the human phenotype. - The FEBS Journal, 2010
- Vascular Robo-4 restricts proangiogenic VEGF signaling in breast. - Proceedings of the National Academy of Sciences of the United States of America, 2010
- Roundabout 4 is expressed on hematopoietic stem cells and potentially involved in the niche-mediated regulation of the side population phenotype. - Stem Cells, 2009
- Comparison of chromosomal aberrations between primary tumors and their synchronous lymph-node metastases in intestinal-type gastric carcinoma. - Pathology, Research and Practice, 2009
- The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases. - Nature Medicine, 2009
- Endogenous endothelial cell signaling systems maintain vascular stability. - Angiogenesis, 2009
- Evaluation of the mechanical properties of rat bone under simulated microgravity using nanoindentation. - Acta Biomaterialia, 2009
- Distinct function of 2 chromatin remodeling complexes that share a common subunit, Williams syndrome transcription factor (WSTF). - Proceedings of the National Academy of Sciences of the United States of America, 2009
- Three new acylated flavone C-glycosides from the flowers of Trollius chinensis. - Journal of Asian Natural Products Research (electronic), 2009
- Phenomenological simulation of self-organization of microtubule driven by dynein c. - Journal of Chemical Physics, 2009
- Prior human leukocyte antigen-allosensitization and left ventricular assist device type affect degree of post-implantation human leukocyte antigen-allosensitization. - The Journal of Heart and Lung Transplantation, 2009
- Slit2-Robo4 signalling promotes vascular stability by blocking Arf6 activity. - Nature Cell Biology, 2009
- Emerging mechanisms of vascular stabilization - Journal of Thrombosis and Haemostasis, 2009
- Robo4 is expressed on hematopoietic stem cells and potentially involved in the Niche-mediated regulation of the side population phenotype. - Stem Cells, 2009
- Therapeutic Benefits of Chronic Intermittent Inotropic Infusions Combined with Prophylactic Oral Amiodarone in Patients with Decompensated, End-Stage Heart Failure. [Epub ahead of print] - Journal of Cardiovascular Pharmacology, 2009
- Elastin haploinsufficiency induces alternative aging processes in the aorta. - Rejuvenation Research, 2008
- Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability. - Nature Medicine, 2008
- Promoter polymorphism of the erythropoietin gene in severe diabetic eye and kidney complications. - Proceedings of the National Academy of Sciences of the United States of America, 2008
- Genetic structure of Oryza rufipogon Griff. in China. - Heredity (electronic), 2008
- Fiber optic distributed temperature and strain sensing system based on Brillouin light scattering. - Applied Optics, 2008
- HOXA13 is essential for placental vascular patterning and labyrinth endothelial specification. - PLoS Genetics, 2008
- Novel polymer carriers and gene constructs for treatment of myocardial ischemia and infarction. - Journal of Controlled Release, 2008
- Robo4 is expressed on hematopoietic stem cells and potentially involved in the Niche-mediated regulation of the side population phenotype. 2008 Oct 16. [Epub ahead of print] - Stem Cells, 2008
- The netrin receptor, Unc5b, promote angiogenesis in specific vascular beds. - Development (Cambridge), 2008
- Elastin-insufficient mice show normal cardiovascular remodeling in 2K1C hypertension despite higher baseline pressure and unique cardiovascular architecture. - American Journal of Physiology: Heart and Circulatory Physiology, 2007
- Triterpenoid prosapogenols and prosapogenins from the husks of Xanthoceras sorbifolia. - Journal of Asian Natural Products Research, 2007
- [Anterior intercavernous sinuses injured in transsphenoidal surgical for pituitary adenomas] - Zhonghua er bi yan hou tou jing wai ke za zhi, 2007
- Common cues regulate neural and vascular patterning. - Current Opinion in Genetics & Development, 2007
- Pulmonary function at peak exercise in patients with chronic heart failure - International Journal of Cardiology, 2007
- Robo4 signaling inhibits pathologic retinal vascular leak and neovascularization. - Current Opinion in Genetics & Development, 2007
- [Papillary glioneuronal tumor: report of a case] - Zhonghua Binglixue Zazhi, 2006
- Domains 16 and 17 of tropoelastin in elastic fiber formation. - Biochemistry, 2006
- Nitroester drug's effects and their antagonistic effects against morphine on human sphincter of Oddi motility. - World Journal of Gastroenterology, 2005
- Effects of elastin haploinsufficiency on the mechanical behavior of mouse arteries. - American Journal of Physiology: Heart and Circulatory Physiology, 2005
- Identification of new netrin family members in zebrafish: developmental expression of netrin 2 and netrin 4. - Developmental Dynamics, 2005
- Automatic segmentation of echocardiography based on a morphological reconstruction algorithm. - Hangtian Yixue yu Yixue Gongcheng, 2005
- Solid-phase parallel synthesis of 4-beta-D-ribofuranosylpyrazolo[4,3-d]pyrimidine nucleosides. - Nucleosides, Nucleotides and Nucleic Acids, 2005
- A novel role of fibulin-5 as a negative regulator of vascular remodeling. - Proceedings of the National Academy of Sciences of the United States of America, 2005
- Netrins promote developmental and therapeutic angiogenesis - Science, 2005
- Robo4 is essential for angiogenesis in vivo. - Proceedings of the National Academy of Sciences of the United States of America, 2005
- Effects of narcotic analgesic drugs on human Oddi's sphincter motility. - World Journal of Gastroenterology, 2004
- Disrupted arterial morphogenesis in mice lacking Ccm1; implications for the etiology of cavernous malformation. - Development (Cambridge), 2004
- The axonal attractant, netrin-1, is a potent angiogenic factor - Proceedings of the National Academy of Sciences of the United States of America, 2004
- Wiring the vascular circuitry: from growth factors to guidance cues. - Current Topics in Developmental Biology, 2004
- A critical role for elastin signaling in vascular morphogenesis and disease. - Development (Cambridge), 2003
- Loss of distinct arterial and venous boundaries in mice lacking endoglin, a vascular-specific TGFbeta coreceptor. - Developmental Biology, 2003
- Robo4 is a vascular-specific receptor that inhibits endothelial migration. - Developmental Biology, 2003
- Developmental adaptation of the mouse cardiovascular system to elastin haploinsufficiency. - Journal of Clinical Investigation, 2003
- [Application and evaluation of Vitapex Plus Reoko in induction apexification] - Shanghai Journal of Stomatology, 2003
- Elastin hexapeptide activates myofibrillinogenesis in vascular smooth muscle cells - Matrix Biology, 2003
- Elastin in vascular diseases - Trends in Cardiovascular Medicine, 2003
- Extracellular matrix in vascular morphogenesis and disease: structure versus signal. - Trends in Cell Biology, 2003
- The prospective role of tranesophageal echocardiography in the diagnosis and management of patients with suspected infective endocarditis - Echocardiography, 2003
- Oxidized low-density lipoprotein receptor LOX-1 and apoptosis in human atherosclerotic lesions. - Journal of Cardiovascular Pharmacology and Therapeutics, 2002
- Anti-thrombotic effects of atorvastatin--an effect unrelated to lipid lowering. - Journal of Cardiovascular Pharmacology and Therapeutics, 2002
- [The relationship between psychosocial factors and periodontal diseases: a review] - Shanghai Journal of Stomatology, 2002
- Annonaceous acetogenins of the seeds from Annona muricata. - Journal of Asian Natural Products Research, 2001
- Segmentation of medical ultrasonic image using hybrid neural network. - Hangtian Yixue yu Yixue Gongcheng, 2001
- Relation of renin-angiotensin system gene polymorphisms and expressions with the efficacy of antihypertensive drugs. - Di Yi Junyi Daxue Xuebao, 2001
- Diagnostic value of amino acid consumption test on exocrine pancreatic insufficiency. - World Journal of Gastroenterology, 2000
- Arteriovenous malformations in mice lacking activin-like kinase receptor 1. - Nature Genetics, 2000
- Elastin maintains branching morphogenesis in the lung. - American Journal of Respiratory and Critical Care Medicine, 2000
- Outcome of patients with congestive heart failure treated with standard versus high doses of enalapril: a multicenter study. High Enalapril Dose Study Group. Cited at the appendix of the publications -multicenter trials - Journal of the American College of Cardiology, 2000
- Bridge to recovery: understanding the disconnect between clinical and biological outcomes. - Circulation, In Press
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