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Dean Y. Li, M.D., Ph.D.

Chief Scientific Officer for U of U Health Sciences

Associate VP for Research, University of Utah Health Sciences

Director, Molecular Medicine Program

Interim Co-Chair, Department of Physiology

Vice Dean for Research, School of Medicine

Specialties

Languages

  • English

Clinical Details

Locations

Schedule An Appointment Clinical Office Address
(801) 584-1235 Veterans Administration Medical Center
500 S Foothill Blvd
Salt Lake City, UT 84149

Bio

Dr. Li is Associate Vice President for Research and Chief Scientific Officer for University of Utah Health Sciences, and Vice Dean for Research for the School of Medicine. Dr. Li is responsible for oversight of the research enterprise in the health sciences, including development and realization of a strategic plan for research. As Chief Scientific Officer, he is responsible for coordinating and maximizing the University’s health system investment in translational, clinical, and health care research leading to new treatments and health system innovations for patients.

Dr. Li is a distinguished scientist and internationally recognized for his groundbreaking research in vascular development and disease. In addition, Dr. Li practices general cardiology and ICU medicine, diagnosing and treating patients at the Veterans Hospital. He is the HA and Edna Benning Endowed Professor of Internal Medicine and Director of the Molecular Medicine Program and School of Medicine MD/PhD Program. He is also an Adjunct Professor of Human Genetics and Adjunct Professor of Oncological Sciences. Dr. Li received his bachelor’s degree from the University of Chicago and his graduate degrees from Washington University in St. Louis.

Board Certification and Academic Information

Academic Departments Internal Medicine - Professor
Human Genetics - Adjunct Professor
Oncological Sciences - Adjunct Professor
Academic Divisions Cardiovascular Medicine
Cancer Center Programs Cell Response & Regulation

Academic Profile

Research Interests

  • Vascular Diseases
  • Vascular Development

Board Certification and Academic Information

Academic Departments Internal Medicine - Professor
Human Genetics - Adjunct Professor
Oncological Sciences - Adjunct Professor
Academic Divisions Cardiovascular Medicine
Cancer Center Programs Cell Response & Regulation

Academic Office Locations

Academic Office Phone Number Academic Office Address
(801) 587-8294 George and Dolores Eccles Institute of Human Genetics
Molecular Medicine
15 N 2030 E
Salt Lake City, UT 84112

Academic Bio

Dr. Li is Associate Vice President for Research and Chief Scientific Officer for University of Utah Health Sciences, and Vice Dean for Research for the School of Medicine. Dr. Li is responsible for oversight of the research enterprise in the health sciences, including development and realization of a strategic plan for research. As Chief Scientific Officer, he is responsible for coordinating and maximizing the University’s health system investment in translational, clinical, and health care research leading to new treatments and health system innovations for patients. Dr. Li is also Acting Chair of the Physiology Department.

Dr. Li is a distinguished scientist and internationally recognized for his groundbreaking research in vascular development and disease. His work includes studies of angiogenesis, a hallmark of most cancer, and characterization of a metastasis pathway in melanoma. In addition, Dr. Li practices general cardiology and ICU medicine, diagnosing and treating patients at the Veterans Hospital. He is the HA and Edna Benning Endowed Professor of Internal Medicine and Director of the Molecular Medicine Program and School of Medicine MD/PhD Program. He is also an Adjunct Professor of Human Genetics and Adjunct Professor of Oncological Sciences. Dr. Li is the recipient of multiple honors, including the Established Investigator Award from the American Heart Association and the Clinical Scientist Award in Translational Medicine from the Burroughs Wellcome Foundation. Dr. Li has served as a reviewer for the AHA and for several NIH study sections. He is a member of the American Society for Clinical Investigation and the Association of American Physicians. He is the author of multiple manuscripts published in peer-reviewed journals, including Science and Nature. Dr. Li is a current member of the AHA and NAVBO, co-founder of Hydra Biosciences, and founder of Navigen. Dr. Li’s broad experience and expertise in bench science, clinical medicine and biotechnology, combined with his success as a leader and mentor, enable him to have a major impact on the University’s health sciences mission to advance science and translate discoveries into clinical applications and better health care for patients. Dr. Li received his bachelor’s degree from the University of Chicago and his graduate degrees from Washington University in St. Louis.

Education

Education History

Type School Degree
Fellowship University of Utah School of Medicine
Cardiology
Fellow
Fellowship Barnes Hospital
Cardiology
Fellow
Residency Barnes Hospital
Resident
Doctoral Training Washington University
Ph.D.
Professional Medical Washington University
M.D.
Undergraduate University of Chicago
B.A.

Publications

Selected Provider Publications

Journal Article

  1. Wang L, He F, Bu J, Liu X, Du W, Dong J, Cooney JD, Dubey SK, Shi Y, Gong B, Li J, Mc Bride PF, Jia Y, Lu F, Soltis KA, Lin Y, Namburi P, Liang C, Sundaresan P, Paw BH, Li DY, Phillips JD, Yang Z(2012)ABCB6 mutations cause ocular coloboma.  American Journal of Human Genetics, 90(1),40-8
  2. Frédéric Larrieu-Lahargue, Alana L. Welm, Marion Bouchecareilh, Kari Alitalo, Dean Y. Li, Andreas Bikfalvi and Patrick August(2012)Blocking Fibroblast Growth Factor Receptor signaling inhibits tumor growth, lymphangiogenesis, and metastasis  PLoS ONE, 7(6),e39540
  3. Zhang X, Yu J, Kuzontkoski PM, Zhu W, Li DY, Groopman JE(2012)Slit2/Robo4 signaling modulates HIV-1 gp120-Induced lymphatic hyperpermeability.  PLoS Pathogens, (1),
  4. Sawada J, Urakami T, Li F, Urakami A, Zhu W, Fukuda M, Li DY, Ruoslahti E, Komatsu M(2012)Small GTPase R-Ras Regulates Integrity and Functionality of Tumor Blood Vessels  Cancer Cell, 2(22),235-49
  5. Frech TM, Revelo MP, Drakos SG, Murtaugh MA, Markewitz BA, Sawitzke AD, Li DY(2012)Vascular Leak is a Central Feature in the Pathogenesis of Systemic Sclerosis  Journal of Rheumatology, 39(7),1385-91
  6. Jones C, Campbell R, Franks Z, Gibson C, Thiagarajan G, Vieira-de-Abreu A, Sukavaneshvar S, Mohammad S, Li DY, Ghandehari H, Wyrich A, Brooks B, Grainger D(2012)“Cationic PAMAM dendrimers disrupt key platelet functions”.  Molecular Pharmaceutics, 9(6),1599-611
  7. Niebel B, Weiche B, Mueller AL, Li DY, Karnowski N, Famulok M(2011)A luminescent oxygen channeling biosensor that measures small GTPase activation.  Chemical Communications, 47(26),7521-3
  8. Jiang Z, Luttrell I, Li DY, Yang CC, Chitaley K(2011)Altered bladder function in elastin-deficient mice at baseline and in response to partial bladder outlet obstruction.  BJU International, 110(3),413-9
  9. Shi Y, Qu J, Zhang D, Zhao P, Zhang Q, Tam PO, Sun L, Zuo X, Zhou X, Xiao X, Hu J, Li Y, Cai L, Liu X, Lu F, Liao S, Chen B, He F, Gong B, Lin H, Ma S, Cheng J, Zhang J, Chen Y, Zhao F, Yang X, Chen Y, Yang C, Lam DS, Li X, Shi F, Wu Z, Lin Y, Yang J, Li S, Ren Y, Xue A, Fan Y, Li D, Pang CP, Zhang X, Yang Z(2011)Genetic Variants at 13q12.12 are associated with high myopia in the Han Chinese population.  American Journal of Human Genetics, 88(6),805-13
  10. Wythe, JD, Jurynec, MJ, Urness, LD, Jones CA, Sabeh MK, Werdich AA, Sato M, Yose HJ, Grunwald DJ, MacRae CA, Li DY(2011)HADP1, a newly identified pleckstrin homology domain protein, is required for cardiac contractility in zebrafish.  Disease Models and Mechanisms, 4(5),607-21
  11. Alvira CM, Guignabert C, Kim YM, Chen C, Wang L, Duong TT, Yeung RS, Li DY, Rabinovitch M(2011)Inhibition of transforming growth factor ß worsens elastin degradation in a murine model of Kawasaki disease.  American Journal of Pathology, 178(3),1210-20
  12. Drakos SG, Kfoury AG, Selzman CH, Verma DR, Nanas JN, Li DY, Stehlik J(2011)Left ventricular assist device unloading effects on myocardial structure and function: current status of the field and call for action.  Current Opinion in Cardiology, 26(3),245-55
  13. Lim AH, Suli A, Yaniv K, Weinstein B, Li DY*, Chien CB(2011)Motoneurons are essential for vascular pathfinding.  Development (Cambridge), 138(17),3847-57
  14. Chan AC, Drakos SG, Ruiz OE, Smith AC, Gibson CC, Ling J, Passi SF, Stratman AN, Sacharidou A, Revelo MP, Grossmann AH, Diakos NA, Davis GE, Metzstein MM, Whitehead KJ, Li DY(2011)Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice.  Journal of Clinical Investigation, 121(5),1871-81
  15. Larrieu-Lahargue F, Welm AL, Thomas KR, Li DY(2011)Netrin-4 Activates Endothelial Integrin {alpha}6{beta}1.  Circulation Research, 109(7),770-4
  16. Wilson BD, Gibson CC, Sorensen LK, Guilhermier MY, Clinger M, Kelley LL, Shiu YT, Li DY(2011)Novel approach for endothelializing vascular devices: Understanding and exploiting elastin-endothelial interactions.  Annals of Biomedical Engineering, 39(1),337-46
  17. Smith-Berdan S, Nguyen A, Hassanein D, Zimmer M, Ugarte F, Ciriza J, Li D, Garcia-Ojeda ME, Hinck L, Forsberg EC(2011)Robo4 cooperates with CXCR4 to specify hematopoietic stem cell localization to bone marrow niches.  Cell Stem Cell, 8(1),72-83
  18. London NR, Li DY(2011)Robo4-dependent Slit signaling stabilizes the vasculature during pathologic angiogenesis and cytokine storm.  Current Opinion in Hematology, 18(3),186-90
  19. Yang Z, Tong Z, Chen Y, Zeng J, Lu F, Sun X, Zhao C, Wang K, Davey L, Chen H, London N, Muramatsu D, Salasar F, Carmona R, Kasuga D, Wang X, Bedell M, Dixie M, Zhao P, Yang R, Gibbs D, Liu X, Li Y, Li C, Li Y, Campochiaro B, Constantine R, Zack DJ, Campochiaro P, Fu Y, Li DY, Katsanis N, Zhang (2010)Genetic and functional dissection of HTRA1 and LOC387715 in age-related macular degeneration.  PLoS Genetics, 6(2),e1000836
  20. Chen H, Zhang M, Tang S, London NR, Li DY, Zhang (2010)Slit-robo signaling in ocular angiogenesis.  Advances in Experimental Medicine and Biology, 664457-63
  21. Smith MC, Li DY, Whitehead K(2010)Mechanisms of vascular stability and the relationship to human disease.  Current Opinion in Hematology, 17(3),237-44
  22. Drakos SG, Janicki L, Horne BD, Kfoury AG, Reid BB, Clayson S, Horton K, Haddad F, Li DY, Renlund DG, Fisher P(2010)Risk factors predictive of right ventricular failure after left ventricular assist device implantation.  American Journal of Cardiology, The, 105(7),1030-5
  23. London NR, Zhu W, Bozza FA, Smith MC, Greif DM, Sorensen LK, Chen L, Kaminoh Y, Chan AC, Passi SF, Day CW, Barnard DL, Zimmerman GA, Krasnow MA, Li D(2010)Targeting Robo4-dependent slit signaling to survive the cytokine storm in sepsis and influenza.  Science Translational Medicine, 2(23),23ra19
  24. Gowen BB, Julander JG, London NR, Wong MH, Larson D, Morrey JD, Li DY, Bray M(2010)Assessing changes in vascular permeability in a hamster model of viral hemorrhagic fever.  Virology Journal, (7),240
  25. Hinton RB, Adelman-Brown J, Witt S, Krishnamurthy VK, Osinska H, Sakthivel B, James JF, Li DY, Narmoneva DA, Mecham RP, Benson DW(2010)Elastin haploinsufficiency results in progressive aortic valve malformation and latent valve disease in a mouse model.  Circulation Research, 107(4),549-57
  26. Li DY, Whitehead KJ(2010)Evaluating strategies for the treatment of cerebral cavernous malformations.  Stroke, 41(10),S92-4
  27. De Domenico I, Zhang TY, Koening CL, Branch RW, London N, Lo E, Daynes RA, Kushner JP, Li D, Ward DM, Kaplan J(2010)Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice.  Journal of Clinical Investigation, 120(7),2395-405
  28. Kotter JR, Drakos SG, Horne BD, Hammond EH, Stehlik J, Bull DA, Reid BB, Gilbert EM, Everitt M, Alharethi R, Budge D, Verma DR, Li DY, Kfoury AF(2010)Impact of blood product transfusion-induced tolerance on the incidence of cardiac allograft rejection.  Transplantation Proceedings, 42(7),2687-92
  29. 53. Drakos SG, Kfoury AG, Hammond EH, Reid BB, Revelo MP, Rasmusson BY, Whitehead KJ, Salama ME, Selzman CH, Stehlik J, Clayson SE, Bristow MR, Renlund DG, Li DY(2010)Impact of mechanical unloading on microvasculature and associated central remodeling features of the failing human heart.  Journal of the American College of Cardiology, 56(5),382-91
  30. Laarrieu-Lahargue F, Welm AL, Thomas KR, Li DY(2010)Netrin-4 induces lymphangiogenesis in vivo.  Blood, 115(26),5418-26
  31. 48. Chan AC, Li DY, Berg MJ, Whitehead KJ(2010)Recent insights into cerebral cavernous malformations: animal models of CCM and the human phenotype.  The FEBS Journal, 277(5),1076-83
  32. Marlow R, Binnewies M, Sorensen LK, Monica SD, Strickland P, Forsberg EC, Li DY, Hinck L(2010)Vascular Robo-4 restricts proangiogenic VEGF signaling in breast.  Proceedings of the National Academy of Sciences of the United States of America, 107(23),10520-5
  33. Shibata F, Goto-Koshino Y, Morikawa Y, Komori T, Ito M, Fukuchi Y, Houchins JP, Tsang M, Li DY, Kitamura T, Nakajima (2009)Roundabout 4 is expressed on hematopoietic stem cells and potentially involved in the niche-mediated regulation of the side population phenotype.  Stem Cells, 27(1),183-90
  34. Liu XP, Li DY, Liu XL, Xu JD, Furuya T, Kawauchi S, Oga A, Sasaki (2009)Comparison of chromosomal aberrations between primary tumors and their synchronous lymph-node metastases in intestinal-type gastric carcinoma.  Pathology, Research and Practice, 205(2),105-11
  35. Whitehead KJ, Chan AC, Navankasattusas S, Koh W, London NR, Ling J, Mayo AH, Drakos SG, Jones CA, Zhu W, Marchuk DA, Davis GE, Li D(2009)The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases.  Nature Medicine, 15(2),177-84
  36. London NR, Whitehead KJ, Li D(2009)Endogenous endothelial cell signaling systems maintain vascular stability.  Angiogenesis, 12(2),149-58
  37. Sun LW, Fan YB, Li DY, Zhao F, Xie T, Yang X, Gu Z(2009)Evaluation of the mechanical properties of rat bone under simulated microgravity using nanoindentation.  Acta Biomaterialia, 5(9),3506-11
  38. Li ZL, Li DY, Hua HM, Chen XH, Kim C(2009)Three new acylated flavone C-glycosides from the flowers of Trollius chinensis.  Journal of Asian Natural Products Research (electronic), 11(5),426-32
  39. Chen Q, Li DY, Oiwa (2009)Phenomenological simulation of self-organization of microtubule driven by dynein c.  Journal of Chemical Physics, 130(21),214107
  40. Drakos SG, Kfoury AG, Kotter JR, Reid BB, Clayson SE, Selzman CH, Stehlik J, Fisher PW, Merida M 3rd, Eckels DD, Brunisholz K, Horne BD, Stoker S, Li DY, Renlund D(2009)Prior human leukocyte antigen-allosensitization and left ventricular assist device type affect degree of post-implantation human leukocyte antigen-allosensitization.  The Journal of Heart and Lung Transplantation, 28(8),838-42
  41. Jones CA, Nishiya N, London NR, Zhu W, Sorensen LK, Chan AC, Lim CJ, Chen H, Zhang Q, Schultz PG, Hayallah AM, Thomas KR, Famulok M, Zhang K, Ginsberg MH, Li D(2009)Slit2-Robo4 signalling promotes vascular stability by blocking Arf6 activity.  Nature Cell Biology, 11(11),1325-31
  42. 46. London NR, Smith MC, Li DY(2009)Emerging mechanisms of vascular stabilization  Journal of Thrombosis and Haemostasis, 7(1),57-60
  43. 40. Shibata F, Goto-Koshino Y, Morikawa Y, Komori T, Ito M, Fukuchi Y, Houchins JP, Tsang M and Li DY(2009)Robo4 is expressed on hematopoietic stem cells and potentially involved in the Niche-mediated regulation of the side population phenotype.  Stem Cells, 27(1),183-90
  44. Drakos SG, Kanakakis J, Nanas S, Bonios M, Kaldara E, Katsaros F, Pantsios C, Nanas J(2009)Therapeutic Benefits of Chronic Intermittent Inotropic Infusions Combined with Prophylactic Oral Amiodarone in Patients with Decompensated, End-Stage Heart Failure. [Epub ahead of print]  Journal of Cardiovascular Pharmacology,
  45. Pezet M, Jacob MP, Escoubet B, Gheduzzi D, Tillet E, Perret P, Huber P, Quaglino D, Vranckx R, Li DY, Starcher B, Boyle WA, Mecham RP, Faury (2008)Elastin haploinsufficiency induces alternative aging processes in the aorta.  Rejuvenation Research, 11(1),97-112
  46. Jones CA, London NR, Chen H, Park KW, Sauvaget D, Stockton RA, Wythe JD, Suh W, Larrieu-Lahargue F, Mukouyama YS, Lindblom P, Seth P, Frias A, Nishiya N, Ginsberg MH, Gerhardt H, Zhang K, Li D(2008)Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability.  Nature Medicine, 14(4),448-53
  47. Tong Z, Yang Z, Patel S, Chen H, Gibbs D, Yang X, Hau VS, Kaminoh Y, Harmon J, Pearson E, Buehler J, Chen Y, Yu B, Tinkham NH, Zabriskie NA, Zeng J, Luo L, Sun JK, Prakash M, Hamam RN, Tonna S, Constantine R, Ronquillo CC, Sadda S, Avery RL, Brand JM, London N, Anduze AL, King GL, Bernstein PS, Watkins S, Jorde LB, Li DY, Aiello LP, Pollak MR, Zhang (2008)Promoter polymorphism of the erythropoietin gene in severe diabetic eye and kidney complications.  Proceedings of the National Academy of Sciences of the United States of America, 105(19),6998-7003
  48. Wang MX, Zhang HL, Zhang DL, Qi YW, Fan ZL, Li DY, Pan DJ, Cao YS, Qiu ZE, Yu P, Yang QW, Wang XK, Li Z(2008)Genetic structure of Oryza rufipogon Griff. in China.  Heredity (electronic), 101(6),527-35
  49. Chang T, Li DY, Koscica TE, Cui HL, Sui Q, Jia (2008)Fiber optic distributed temperature and strain sensing system based on Brillouin light scattering.  Applied Optics, 47(33),6202-6
  50. Shaut CAE, Keen DR, Sorensen LK, Li D(2008)HOXA13 is essential for placental vascular patterning and labyrinth endothelial specification.  PLoS Genetics, 4(5),e1000073
  51. Yockman JW, Kastenmeier A, Erickson HM, Brumbach JG, Whitten MG, Albanil A, Li DY, Kim SW and Bull DA(2008)Novel polymer carriers and gene constructs for treatment of myocardial ischemia and infarction.  Journal of Controlled Release, 132(3),260-6
  52. Shibata F, Goto-Koshino Y, Morikawa Y, Komori T, Ito M, Fukuchi Y, Houchins JP, Tsang M, Li D(2008)Robo4 is expressed on hematopoietic stem cells and potentially involved in the Niche-mediated regulation of the side population phenotype. 2008 Oct 16. [Epub ahead of print]  Stem Cells,
  53. Navankasattusas S, Whitehead K, Suli A, Sorensen LK, Lim A, Zhao J, Thomas KR, Chien C, Li D(2008)The netrin receptor, Unc5b, promote angiogenesis in specific vascular beds.  Development (Cambridge), 153659-667
  54. Wagenseil JE, Knutsen RH, Li DY, Mecham R(2007)Elastin-insufficient mice show normal cardiovascular remodeling in 2K1C hypertension despite higher baseline pressure and unique cardiovascular architecture.  American Journal of Physiology: Heart and Circulatory Physiology, 293(1),H574-82
  55. Li ZL, Li X, Li DY, Li D, Meng DL, Li W, Sha (2007)Triterpenoid prosapogenols and prosapogenins from the husks of Xanthoceras sorbifolia.  Journal of Asian Natural Products Research, 9(3-5),387-92
  56. Li DY, Zhao XL, Yang Z(2007)[Anterior intercavernous sinuses injured in transsphenoidal surgical for pituitary adenomas]  Zhonghua er bi yan hou tou jing wai ke za zhi, 42(11),865-6
  57. Jones CA, Li D(2007)Common cues regulate neural and vascular patterning.  Current Opinion in Genetics & Development, 17(4),332-6
  58. Papazachou O, Anastasiou-Nana M, Sakellariou D, Tassiou A, Dimopoulos S, Venetsanakos J, Maroulidis G, Drakos SG, Roussos C, Nanas (2007)Pulmonary function at peak exercise in patients with chronic heart failure  International Journal of Cardiology, 118(1),28-35
  59. Jones C, London N, Park K, Chen H, Stockton R, Nishiya N, Ginsberg M, Zhang K, Li D(2007)Robo4 signaling inhibits pathologic retinal vascular leak and neovascularization.  Current Opinion in Genetics & Development, 135659-667
  60. Qi JP, Zhu H, Li DY, Mei H(2006)[Papillary glioneuronal tumor: report of a case]  Zhonghua Binglixue Zazhi, 35(12),764-5
  61. Wachi H, Sato F, Hakazawa J, Nonaka R, Szabo Z, Urban Z, Tasubaga T, Maeda, I, Okamoto K, Starcher, B, Li DY, Mecham R, Seyama Y(2006)Domains 16 and 17 of tropoelastin in elastic fiber formation.  Biochemistry, 402(1),63-70
  62. Wu SD, Zhang ZH, Li DY, Jin JZ, Kong J, Tian Z, Wang W, Wang M(2005)Nitroester drug's effects and their antagonistic effects against morphine on human sphincter of Oddi motility.  World Journal of Gastroenterology, 11(15),2319-23
  63. Wagenseil JE, Nerurkar NL, Knutsen RH, Okamoto RJ, Li DY, Mecham R(2005)Effects of elastin haploinsufficiency on the mechanical behavior of mouse arteries.  American Journal of Physiology: Heart and Circulatory Physiology, 289(3),H1209-17
  64. Park KW, Urness LD, Senchuk MM, Colvin CJ, Wythe JD, Chien CB, Li D(2005)Identification of new netrin family members in zebrafish: developmental expression of netrin 2 and netrin 4.  Developmental Dynamics, 234(3),726-31
  65. Shen XH, Li DY, Lin JL, Wang TF, Wen XH, Zheng CQ, Rao L, Tang (2005)Automatic segmentation of echocardiography based on a morphological reconstruction algorithm.  Hangtian Yixue yu Yixue Gongcheng, 18(4),246-50
  66. Ramasamy KS, Amador RB, Habib Q, Rong F, Han X, Li DY, Huang J, Hong Z, An (2005)Solid-phase parallel synthesis of 4-beta-D-ribofuranosylpyrazolo[4,3-d]pyrimidine nucleosides.  Nucleosides, Nucleotides and Nucleic Acids, 24(10-12),1947-70
  67. SpencerJA, Hacker SL, Davis EC, Mecham RP, Knutsen RH, Li DY, Gerard RD, Richardson RA, Olson EN, Yanisgisawa H(2005) A novel role of fibulin-5 as a negative regulator of vascular remodeling.  Proceedings of the National Academy of Sciences of the United States of America, 102(8)(2946),2951
  68. Wilson, B, Park, KW, Li, M, Suli, A, Koch, GA, Sorensen, L, Urness, L, Chien, CB, Losordo, D, Li, DY(2005)Netrins promote developmental and therapeutic angiogenesis  Science, 313640-4
  69. Bedell V, Yeo,SY, Park,KW, Chung,J, Seth P, Shivalingappa V, Zhao,J, Obara,T, Sukhatme V, Drummond I, Chitnis A, Li DY, Ramchandran R(2005)Robo4 is essential for angiogenesis in vivo.  Proceedings of the National Academy of Sciences of the United States of America, 102(6373),6378
  70. Wu SD, Zhang ZH, Jin JZ, Kong J, Wang W, Zhang Q, Li DY, Wang M(2004)Effects of narcotic analgesic drugs on human Oddi's sphincter motility.  World Journal of Gastroenterology, 10(19),2901-4
  71. 22. Whitehead K, Plummer N, Adams J, Marchuk D and Li DY(2004)Disrupted arterial morphogenesis in mice lacking Ccm1; implications for the etiology of cavernous malformation.  Development (Cambridge), 131(6),1437-48
  72. Park KW, Crouse D, Lee M, Karnik S, Sorenson L, Kuo C, Li D(2004)The axonal attractant, netrin-1, is a potent angiogenic factor  Proceedings of the National Academy of Sciences of the United States of America, 10116210-5
  73. Urness L and Li DY(2004)Wiring the vascular circuitry: from growth factors to guidance cues.  Current Topics in Developmental Biology, 6287-126
  74. Karnik SK, Brooke BS, Bayes-Genis A, Sorensen L, Wythe JD, Schwartz RS, Keating MT, Li D(2003)A critical role for elastin signaling in vascular morphogenesis and disease.  Development (Cambridge), 130(2),411-23
  75. Sorensen LK, Brooke BS, Li DY, Urness L(2003)Loss of distinct arterial and venous boundaries in mice lacking endoglin, a vascular-specific TGFbeta coreceptor.  Developmental Biology, 261(1),235-50
  76. Park KW, Morrison CM, Sorensen LK, Jones CA, Rao Y, Chien CB, Wu JY, Urness LD, Li D(2003)Robo4 is a vascular-specific receptor that inhibits endothelial migration.  Developmental Biology, 261(1),251-67
  77. Faury G, Pezet M, Knutsen RH, Boyle WA, Heximer SP, McLean SE, Minkes RK, Blumer KJ, Kovacs A, Kelly DP, Li DY, Starcher B, Mecham R(2003)Developmental adaptation of the mouse cardiovascular system to elastin haploinsufficiency.  Journal of Clinical Investigation, 112(9),1419-28
  78. Li DY, Wang Y, Qiu J(2003)[Application and evaluation of Vitapex Plus Reoko in induction apexification]  Shanghai Journal of Stomatology, 12(3),239-40
  79. Karnik S, Wythe J, Sorenson L , Li D(2003)Elastin hexapeptide activates myofibrillinogenesis in vascular smooth muscle cells  Matrix Biology, 22 (5)409-425
  80. Brooke B, Bayes-Genis A, Li D(2003)Elastin in vascular diseases  Trends in Cardiovascular Medicine, 13176-81
  81. Brooke BS, Karnik SK and Li DY(2003)Extracellular matrix in vascular morphogenesis and disease: structure versus signal.  Trends in Cell Biology, 13(1),51-6
  82. Harris KM, Li DY, L'Ecuyer P, Moon KET, German M, Fraser V, Barzilai (2003)The prospective role of tranesophageal echocardiography in the diagnosis and management of patients with suspected infective endocarditis  Echocardiography, 20576-62
  83. Li DY, Chen HJ, Staples ED, Ozaki K, Annex B, Singh BK, Vermani R, Mehta J(2002)Oxidized low-density lipoprotein receptor LOX-1 and apoptosis in human atherosclerotic lesions.  Journal of Cardiovascular Pharmacology and Therapeutics, 7(3),147-53
  84. Gaddam V, Li DY, Mehta J(2002)Anti-thrombotic effects of atorvastatin--an effect unrelated to lipid lowering.  Journal of Cardiovascular Pharmacology and Therapeutics, 7(4),247-53
  85. Ge SY, Li D(2002)[The relationship between psychosocial factors and periodontal diseases: a review]  Shanghai Journal of Stomatology, 11(1),71-4
  86. Li DY, Yu JG, Zhu JX, Yu DL, Luo XZ, Sun L, Yang S(2001)Annonaceous acetogenins of the seeds from Annona muricata.  Journal of Asian Natural Products Research, 3(4),267-76
  87. Wang TF, Li DY, Zheng CQ, Zheng (2001)Segmentation of medical ultrasonic image using hybrid neural network.  Hangtian Yixue yu Yixue Gongcheng, 14(2),84-7
  88. Wei XL, Zhao GS, Wang GL, Li DY, Guo J(2001)Relation of renin-angiotensin system gene polymorphisms and expressions with the efficacy of antihypertensive drugs.  Di Yi Junyi Daxue Xuebao, 21(12),898-901
  89. Lei ZM, Li DY, Li J, Wang Q, He K, Zheng SL, Gan Y(2000)Diagnostic value of amino acid consumption test on exocrine pancreatic insufficiency.  World Journal of Gastroenterology, 6(2),290-292
  90. Urness L.D., Sorensen L.K., Li D(2000)Arteriovenous malformations in mice lacking activin-like kinase receptor 1.  Nature Genetics, 26328-331
  91. Wendel D, Taylor D, Keating AK, Li D(2000)Elastin maintains branching morphogenesis in the lung.  American Journal of Respiratory and Critical Care Medicine, 23320-326
  92. Nanas JN, Alexopoulos G, Anastasiou-Nana MI, Karidis K, Tirologos A, Zobolos S, Pirgakis V, Anthopoulos L, Sideris D, Stamatelopoulos SF, Moulopoulos SD, et al, Drakos S(2000)Outcome of patients with congestive heart failure treated with standard versus high doses of enalapril: a multicenter study. High Enalapril Dose Study Group. Cited at the appendix of the publications -multicenter trials  Journal of the American College of Cardiology, 36(7),2090-5

Review

  1. London NR, Smith MC, Li D(2009)Emerging mechanisms of vascular stabilization.  Journal of Thrombosis and Haemostasis, 7 Suppl 157-60

Clinical Trials

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