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John R. Kestle, M.D.

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Clinical Details

Phone Number Clinical Office Address
(801) 662-5340
Primary Children's Hospital
Pediatric Neurosurgery
100 N Mario Capecchi Drive , Suite 1475
Salt Lake City, UT 84113

Bio

John R.W. Kestle, MD specializes in Craniofacial Surgery, Pediatric Neurosurgery, and Brain Tumors. Dr. Kestle is Professor of Neurosurgery and Vice Chair of Clinical Research. His clinical practice has been exclusively in pediatric neurosurgery, with a specific interest in pediatric epilepsy surgery. His research is centered on clinical trials methodology, which he developed a multi-center network for running clinical trials in pediatric neurosurgery. Dr. Kestle is also Chair of the Hydrocephalus Clinical Research Network.

Board Certification and Academic Information

Academic Departments Neurosurgery - Professor
Academic Divisions Pediatric Neurosurgery
Board Certification American Board of Pediatric Neurological Surgery
Royal College of Surgeons of Canada
American Board of Neurological Surgery (Neurosurg)

Academic Profile

Board Certification and Academic Information

Academic Departments Neurosurgery - Professor
Academic Divisions Pediatric Neurosurgery
Board Certification American Board of Pediatric Neurological Surgery
Royal College of Surgeons of Canada
American Board of Neurological Surgery (Neurosurg)

Academic Office Locations

Academic Office Phone Number Academic Office Address
(801) 662-5340 Primary Children's Hospital
Pediatric Neurosurgery
100 N Mario Capecchi Drive
Salt Lake City, UT 84113

Academic Bio

I am currently Professor of Neurosurgery and Vice Chair of Clinical Research at the University of Utah. My research career has always been clinical. I trained at McMaster University in Clinical Epidemiology and Biostatistics. Since the beginning of my career, I have been the Principal Investigator in a number of multicenter clinical trials in pediatric hydrocephalus and have trained 7 Pediatric Neurosurgery residents in clinical epidemiology and biostatistics (MPH training). In 2006, I co-founded the Hydrocephalus Clinical Research Network (HCRN). Although our previous trials had received peer reviewed funding (including the Medical Research Council of Canada when I practiced there), a research goal of mine had been to develop a collaborative network with infrastructure funding. We founded the HCRN in 2006, developed a philanthropic base to get us started, received NIH funding (RC1NS068943-01) in 2009 and currently have 17 investigators, 9 centers and 6 Network protocols running. My role has been development of the Network, recruitment of centers and investigators and mentoring of young investigators. Continued development of clinical research in the neurosciences, especially in hydrocephalus remains my highest academic priority.

Education

Education History

Type School Degree
Fellowship Hospital for Sick Children
Pediatric Neurosurgery
Fellow
Fellowship The Toronto Hospital
Peripheral Nerve Surgery
Fellow
Residency University of Toronto
Neurosurgery
Resident
Graduate Training McMaster University
Biostatistics and Epidemiology
M.S.
Internship St. Michael's Hospital
Surgery
Intern
Professional Medical University of Western Ontario
M.D.
Undergraduate University of Western Ontario
Biology
B.S.

Publications

Selected Provider Publications

Journal Article

  1. Kulkarni AV, Riva-Cambrin J, Holubkov R, Browd SR, Cochrane DD, Drake JM, Limbrick DD, Rozzelle CJ, Simon TD, Tamber MS, Wellons JC 3rd, Whitehead WE, Kestle JR (2016). Endoscopic third ventriculostomy in children: prospective, multicenter results from the Hydrocephalus Clinical Research Network. J Neurosurg Pediatr, 1-7.
  2. Ravindra VM, Bollo RJ, Sivakumar W, Akbari H, Naftel RP, Limbrick DD Jr, Jea A, Gannon S, Shannon C, Birkas Y, Yang GL, Prather CT, Kestle JR, Riva-Cambrin J (2016). Predicting Blunt Cerebrovascular Injury in Pediatric Trauma: Validation of the "Utah Score". (Epub ahead of print) J Neurotrauma.
  3. Kestle JR, Holubkov R, Douglas Cochrane D, Kulkarni AV, Limbrick DD Jr, Luerssen TG, Jerry Oakes W, Riva-Cambrin J, Rozzelle C, Simon TD, Walker ML, Wellons JC 3rd, Browd SR, Drake JM, Shannon CN, Tamber MS, Whitehead WE (2016). A new Hydrocephalus Clinical Research Network protocol to reduce cerebrospinal fluid shunt infection. J Neurosurg Pediatr, 17(4), 391-6.
  4. Riva-Cambrin J, Kestle JR, Holubkov R, Butler J, Kulkarni AV, Drake J, Whitehead WE, Wellons JC 3rd, Shannon CN, Tamber MS, Limbrick DD Jr, Rozzelle C, Browd SR, Simon TD (2016). Risk factors for shunt malfunction in pediatric hydrocephalus: a multicenter prospective cohort study. J Neurosurg Pediatr, 17(4), 382-90.
  5. Steinbok P, Durity F, Kestle J, Cochrane DD (2015). Pediatric neurosurgery at British Columbia's Children's Hospital. Childs Nerv Syst, 31(9), 1419-27.
  6. McAllister JP 2nd, Williams MA, Walker ML, Kestle JR, Relkin NR, Anderson AM, Gross PH, Browd SR (2015). An update on research priorities in hydrocephalus: overview of the third National Institutes of Health-sponsored symposium "Opportunities for Hydrocephalus Research: Pathways to Better Outcomes". J Neurosurg, 123(6), 1427-38.
  7. Bowers C, Taussky P, Kestle JR, Park MS (2015). A Neurosurgical Call to Arms: Lessons from ARUBA, Mr. Clean, and the Hydrocephalus Clinical Research Network. World Neurosurg, 84(2), 202-4.
  8. Johns D, Blagg R, Kestle JR, Riva-Cambrin JK, Siddiqi F, Gociman B (2015). Distraction Osteogenesis Technique for the Treatment of Nonsyndromic Sagittal Synostosis. Plast Reconstr Surg Glob Open, 3(7), e474.
  9. Gopalakrishnan CV, Kestle JR, Connolly MB (2015). The "vagal ansa": a source of complication in vagus nerve stimulation. J Neurosurg Pediatr, 15(5), 535-8.
  10. Spader HS, Hertzler DA, Kestle JR, Riva-Cambrin J (2015). Risk factors for infection and the effect of an institutional shunt protocol on the incidence of ventricular access device infections in preterm infants. J Neurosurg Pediatr, 15(2), 156-60.
  11. Al-Tamimi YZ, Sinha P, Chumas PD, Crimmins D, Drake J, Kestle J, Hayward R, Solanki GA, Thomson S, Thorne J (2014). Ventriculoperitoneal shunt 30-day failure rate: a retrospective international cohort study. Neurosurgery, 74(1), 29-34.
  12. Gociman B, Blagg R, Agko M, Goodwin I, Kestle JR, Siddiqi F (2014). The metopic angle: a novel assessment tool of the trigonocephalic frontal deformity and its correction. J Craniofac Surg, 25(6), 2101-4.
  13. Kulkarni AV, Riva-Cambrin J, Browd SR, Drake JM, Holubkov R, Kestle JR, Limbrick DD, Rozzelle CJ, Simon TD, Tamber MS, Wellons JC 3rd, Whitehead WE (2014). Endoscopic third ventriculostomy and choroid plexus cauterization in infants with hydrocephalus: a retrospective Hydrocephalus Clinical Research Network study. J Neurosurg Pediatr, 14(3), 224-9.
  14. Whitehead WE, Riva-Cambrin J, Wellons JC 3rd, Kulkarni AV, Browd S, Limbrick D, Rozzelle C, Tamber MS, Simon TD, Shannon CN, Holubkov R, Oakes WJ, Luerssen TG, Walker ML, Drake JM, Kestle JR (2014). Factors associated with ventricular catheter movement and inaccurate catheter location: post hoc analysis of the hydrocephalus clinical research network ultrasound-guided shunt placement study. J Neurosurg Pediatr, 14(2), 173-8.
  15. Simon TD, Mayer-Hamblett N, Whitlock KB, Langley M, Kestle JR, Riva-Cambrin J, Rosenfeld M, Thorell EA (2014). Few Patient, Treatment, and Diagnostic or Microbiological Factors, Except Complications and Intermittent Negative Cerebrospinal Fluid (CSF) Cultures During First CSF Shunt Infection, Are Associated With Reinfection. J Pediatric Infect Dis Soc, 3(1), 15-22.
  16. Simon TD, Butler J, Whitlock KB, Browd SR, Holubkov R, Kestle JR, Kulkarni AV, Langley M, Limbrick DD Jr, Mayer-Hamblett N, Tamber M, Wellons JC 3rd, Whitehead WE, Riva-Cambrin J (2014). Risk factors for first cerebrospinal fluid shunt infection: findings from a multi-center prospective cohort study. J Pediatr, 164(6), 1462-8.e2.
  17. Gross P, Reed GT, Engelmann R, Kestle JR (2014). Hydrocephalus research funding from the National Institutes of Health: a 10-year perspective. J Neurosurg Pediatr, 13(2), 145-50.
  18. Guan J, Brock AA, Karsy M, Couldwell WT, Schmidt MH, Kestle J, Jensen RL, Dailey AT, Schmidt RH (In press). Managing concurrent surgery: An analysis of 1053 neurosurgical and spine cases. J Neurosurg.
  19. Simon TD, Kronman MP, Whitlock KB, Gove N, Browd SR, Holubkov R, Kestle J, Kulkarni AV, Langley M, Limbrick DD, Luerssen T, Oakes J, Riva-Cambrin J, Rozzelle C, Shannon C, Tamber M, Wellons J, Whitehead WE, Mayer-Hamblett N, for the Hydrocephalus Clinical Research Network (In Press). Adherence to guidelines in treatment for first cerebrospinal fluid (CSF) shunt infection. Pediatrics.
  20. Walicke P, Abosch A, Asher A, Barker FG II, Harbaugh R, Jehi L, Kestle J, Koroshetz W, Little R, Rubin D, Valadka A, Wisniewski S, Chiocca EA, for the Workshop Participants (In Press). Launching effectiveness research to guide practice in neurosurgery: outcomes from an NINDS workshop report. J Neurosurg.
  21. Wellons JC, Shannon CN, Holubkov R, Riva-Cambrin J, Kulkarni A, Limbrick D, Whitehead W, Browd S, Rozzelle C, Simon T, Tamber M, Oakes WJ, Drake J, Luerssen T, Walker M, Kestle J, for the Hydrocephalus Clinical Research Network (In Press). Shunting outcomes in post-hemorrhagic hydrocephalus (SOPHH): results of an HCRN prospective cohort study. J Neurosurg Pediatr.

Review

  1. Ravindra VM, Kraus KL, Riva-Cambrin JK, Kestle JR (2015). The Need for Cost-Effective Neurosurgical Innovation-A Global Surgery Initiative. [Review]. World Neurosurg, 84(5), 1458-61.

Book Chapter

  1. Sivakumar W, Ravindra VM, Riva-Cambrin J, Kestle JR (2015). Ventricular shunting for hydrocephalus. In Cohen A (Ed.), Pediatric Neurosurgery: Tricks of the Trade (pp. 316-). New York: Thieme.
  2. Garber S, Kestle JRW (2014). Brain stem tumors. In Berger M, Bernstein M (Eds.), Neuro-Oncology: The Essentials (3rd ed, Chapter 27). New York: Thieme.
  3. Kalra RS, Kestle J (2014). Treatment of hydrocephalus with shunts. In Albright A, Pollack I, Adelson D (Eds.), Principles and Practice of Pediatric Neurosurgery (3rd). New York: Thieme Medical Publishers.
  4. Ravindra VM, Sivakumar W, Riva-Cambrin JK, Kestle JR (In Press). Clinical management guidelines: pros and cons. In Good Paper, Successful Career: Guidelines for Biomedical Students, Residents and Researchers.
  5. Ravindra VM, Sivakumar W, Riva-Cambrin JK, Kestle JR (In Press). Clinical management guidelines: definition and development. In Good Paper, Successful Career: Guidelines for Biomedical Students, Residents and Researchers.
  6. Kestle JR (In Press). Hydrocephalus in children: etiology and overall management. In Winn H (Ed.), Youman's Neurological Surgery (7th ed.). Philadelphia: Elsevier.

Editorial

  1. Kestle JR (2016). Editorial: The learning curve in surgical randomized controlled trials. J Neurosurg Pediatr, 18(2), 145.
  2. Kestle JRW (2016). Editorial: The challenges of determining natural history. J Neurosurg Pediatr, 17(2), 121-122.
  3. Kestle JR (2015). Editorial: Measuring resident operative skills. J Neurosurg Pediatr, 1-2.
  4. Kestle JR (2015). Editorial: Bed rest after filum surgery. J Neurosurg Pediatr, 15(5), 459; discussion 460.
  5. Kestle JR (2015). Editorial: Food and Drug Administration Safety Communication on rhBMP-2 use. J Neurosurg Pediatr, 16(1), 1-3.
  6. Kestle JR (2015). Editorial: industry-sponsored research. J Neurosurg, 122(1), 136-8.
  7. Kestle JR (2015). Administrative database research. J Neurosurg, 122(2), 441-2.
  8. Kestle JRW (2014). Counterpoint: Shunts Are Not Going Away So We Need to Do Them Well. AANS Neurosurgeon, 23(1).
  9. Kestle J (In Press). FDA safety communication on rhBMP-2 use. J Neurosurg.

Global Impact

Global Impact

Education History

Type School Degree Country
Fellowship Hospital for Sick Children
Pediatric Neurosurgery
Fellow Canada
Fellowship The Toronto Hospital
Peripheral Nerve Surgery
Fellow Canada
Residency University of Toronto
Neurosurgery
Resident Canada
Graduate Training McMaster University
Biostatistics and Epidemiology
M.S. Canada
Internship St. Michael's Hospital
Surgery
Intern Canada
Professional Medical University of Western Ontario
M.D. Canada
Undergraduate University of Western Ontario
Biology
B.S. Canada

Selected Provider Publications

Journal Article

  1. Wellons JC, Shannon CN, Holubkov R, Riva-Cambrin J, Kulkarni A, Limbrick D, Whitehead W, Browd S, Rozzelle C, Simon T, Tamber M, Oakes WJ, Drake J, Luerssen T, Walker M, Kestle J, for the Hydrocephalus Clinical Research Network (In Press). Shunting outcomes in post-hemorrhagic hydrocephalus (SOPHH): results of an HCRN prospective cohort study. J Neurosurg Pediatr.
    Global Impact: Canada.

Career

Institution Description Country
University of British Columbia Professor and Head, Department of Surgery Canada
University of British Columbia Head, Section of Clinical Epidemiology, Department of Surgery Canada
British Columbia's Children's Hospital Pediatric Neurosurgeon Canada
University of British Columbia Associate Member, Department of Health Care and Epidemiology Canada
University of British Columbia Assistant Professor Canada

Clinical Trials

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