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Siam Oottamasathien, M.D.

Specialties

Languages

  • English
  • Thai

Clinical Details

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Bio

Siam Oottamasathien, MD, FAAP, FACS is a board-certified urologist with subspecialty certification in pediatric urology. He attended the University of Colorado at Boulder studying Molecular Biology and Biochemistry, then obtained his medical degree and completed his urologic residency at the University of Colorado Health Sciences Center. Dr. Oottamasathien pursued a fellowship in pediatric urology at Vanderbilt University, with a special focus on basic science research and inflammatory disorders that affect the bladder. Currently, Dr. Oottamasathien’s practice is dedicated to pediatric urology but he also directs the basic science research efforts for the group. He is a member of multiple medical organizations, including the American Urological Association, Society for Basic Urologic Research, Society for Fetal Urology, and Society for Pediatric Urology. In addition, Dr. Oottamasathien is a Fellow of the American Academy of Pediatrics and Fellow of the American College of Surgeons.

Board Certification and Academic Information

Academic Departments Surgery - Associate Professor
Medicinal Chemistry - Research Assistant Professor
Academic Divisions Urology
Board Certification American Board of Urology
American Board of Urology (Sub: Pediatric Urology)

Academic Profile

Research Interests

  • Pediatric Urology Basic Science
  • Developing Therapeutics to Treat Interstitial Cystitis/Painful Bladder Syndrome
  • Bladder Inflammation and Fibrosis
  • Developing Novel Hyaluronic Acid Based Biomaterials as Anti-Inflammatory Therapeutics
  • Pioneering Animal Models for Investigating Bladder Inflammation

Board Certification and Academic Information

Academic Departments Surgery - Associate Professor
Medicinal Chemistry - Research Assistant Professor
Academic Divisions Urology
Board Certification American Board of Urology
American Board of Urology (Sub: Pediatric Urology)

Academic Office Locations

Academic Office Phone Number Academic Office Address
(801) 662-5555 Primary Children's Hospital
Pediatric Urology
100 N Mario Capecchi Drive
Salt Lake City, UT 84113

Academic Bio

Dr. Oottamasathien launched a pediatric urology basic science research program for the group in 2007. His initial work was in the Department of Human Molecular Biology and Genetics at the University of Utah, investigating the role of T-box proteins in genitourinary development. During that time, he gained invaluable research tools, developed elaborate experimental designs, including the use of germ-line and conditional mutagenesis experiments in mice, and further enhanced his background in genitourinary embryology, molecular biology, and developmental biology. In addition, he was awarded a three year NIH T32 training grant (5T32HL079874-04) under the auspices of Nobel Laureate Dr. Mario Capecchi and received NIH loan repayment program (LRP) funding for pediatric research. After spending a year and a half along this line of research, more clinical translational science was necessary and he partnered with the laboratory of Dr. Glenn Prestwich, a Senior Investigator and Presidential Professor of Medicinal Chemistry at the University of Utah.

Since establishing his collaboration with Dr. Prestwich, his projects have demonstrated great potential in making a significant impact towards treating pediatric urologic disease conditions. The scientific aspects build upon novel hyaluronic acid (HA) – based biomaterials and have been used to investigate and treat bladder inflammatory and fibrotic conditions. Thus far, he has obtained grant funding from the National Kidney Foundation – Utah Chapter, Early Career Development Award from Primary Children’s Medical Center Foundation, NIH K12 Career Development Award (8UL1TR000105) University of Utah Center for Clinical and Translational Science, American Urological Association/Pfizer Award for Investigation in Benign Urologic Disease, Primary Children’s Medical Center Integrated Science Award, and an NIH Phase I SBIR Grant (1R43DK093413-01). Dr. Oottamasathien has also been a three-time recipient (2006, 2010, and 2012) of the prestigious Basic Science Research Award presented by the American Academy of Pediatrics Section on Urology. Overall, his experiences demonstrate the necessity for ongoing rigorous training in research to achieve maximal effectiveness in asking and answering research questions while balancing a clinical career.

Education

Education History

Type School Degree
Fellowship Vanderbilt University
Pediatric Urology
Fellow
Chief Resident University of Colorado at Denver and Health Sciences Center
Urology
Chief Resident
Residency University of Colorado at Denver and Health Sciences Center
Urology
Resident
Residency University of Colorado at Denver and Health Sciences Center
General Surgery
Resident
Internship University of Colorado at Denver and Health Sciences Center
General Surgery
Intern
Professional Medical University of Colorado School of Medicine
Medicine
M.D.
Undergraduate University of Colorado at Boulder
Double Major: Molecular Biology and Biochemistry
B.A.
Undergraduate Illinois Institute of Technology

Publications

Selected Provider Publications

Journal Article

  1. Pediatric urinary stone composition in the United States.Gabrielsen JS, Laciak RJ, Frank EL, McFadden M, Bates CS, Oottamasathien S, Hamilton BD, Wallis MC (2012). Pediatric urinary stone composition in the United States. J Urol, 187(6), 2182-7.
  2. Parameatal urethral cysts in prepubertal males.Willis HL, Snow BW, Cartwright PC, Wallis MC, Oottamasathien S, deVries C (2011). Parameatal urethral cysts in prepubertal males. J Urol, 185(3), 1042-5.
  3. A murine model of inflammatory bladder disease: cathelicidin peptide induced bladder inflammation and treatment with sulfated polysaccharides.Oottamasathien S, Jia W, McCoard L, Slack S, Zhang J, Skardal A, Job K, Kennedy TP, Dull RO, Prestwich GD (2011). A murine model of inflammatory bladder disease: cathelicidin peptide induced bladder inflammation and treatment with sulfated polysaccharides. J Urol, 186(4 Suppl), 1684-92.
  4. Photocrosslinkable hyaluronan-gelatin hydrogels for two-step bioprinting.Skardal A, Zhang J, McCoard L, Xu X, Oottamasathien S, Prestwich GD (2010). Photocrosslinkable hyaluronan-gelatin hydrogels for two-step bioprinting. Tissue Eng Part A, 16(8), 2675-85.
  5. 250 consecutive unilateral extravesical ureteral reimplantations in an outpatient setting.Wicher C, Hadley D, Ludlow D, Oottamasathien S, Wallis MC, Devries C, Snow BW, Cartwright PC (2010). 250 consecutive unilateral extravesical ureteral reimplantations in an outpatient setting. J Urol, 184(1), 311-4.
  6. Dynamically crosslinked gold nanoparticle - hyaluronan hydrogels.Skardal A, Zhang J, McCoard L, Oottamasathien S, Prestwich GD (2010). Dynamically crosslinked gold nanoparticle - hyaluronan hydrogels. Adv Mater, 22(42), 4736-40.
  7. Prostate epithelial cell fate.Matusik RJ, Jin RJ, Sun Q, Wang Y, Yu X, Gupta A, Nandana S, Case TC, Paul M, Mirosevich J, Oottamasathien S, Thomas J (2008). Prostate epithelial cell fate. Differentiation, 76(6), 682-98.
  8. Temporal-spatial protein expression in bladder tissue derived from embryonic stem cells.Thomas JC, Oottamasathien S, Makari JH, Honea L, Sharif-Afshar AR, Wang Y, Adams C, Wills ML, Bhowmick NA, Adams MC, Brock JW 3rd, Hayward SW, Matusik RJ, Pope JC 4th (2008). Temporal-spatial protein expression in bladder tissue derived from embryonic stem cells. J Urol, 180(4 Suppl), 1784-9.
  9. Directed differentiation of embryonic stem cells into bladder tissue.Oottamasathien S, Wang Y, Williams K, Franco OE, Wills ML, Thomas JC, Saba K, Sharif-Afshar AR, Makari JH, Bhowmick NA, DeMarco RT, Hipkens S, Magnuson M, Brock JW 3rd, Hayward SW, Pope JC 4th, Matusik RJ (2007). Directed differentiation of embryonic stem cells into bladder tissue. Dev Biol, 304(2), 556-66.
  10. Testicular tumours in children: a single-institutional experience.Oottamasathien S, Thomas JC, Adams MC, Demarco RT, Brock JW 3rd, Pope JC 4th (2007). Testicular tumours in children: a single-institutional experience. BJU Int.
  11. Testicular tumours in children: a single-institutional experience.Oottamasathien S, Thomas JC, Adams MC, DeMarco RT, Brock JW 3rd, Pope JC 4th (2007). Testicular tumours in children: a single-institutional experience. BJU Int, 99(5), 1123-6.
  12. Urothelial inhibition of transforming growth factor-beta in a bladder tissue recombination model.Oottamasathien S, Williams K, Franco OE, Wills ML, Thomas JC, Sharif-Afshar AR, DeMarco RT, Brock JW 3rd, Bhowmick NA, Hayward SW, Pope JC 4th (2007). Urothelial inhibition of transforming growth factor-beta in a bladder tissue recombination model. J Urol, 178(4 Pt 2), 1643-9.
  13. Gonadoblastoma and Turner syndrome.Brant WO, Rajimwale A, Lovell MA, Travers SH, Furness PD 3rd, Sorensen M, Oottamasathien S, Koyle MA (2006). Gonadoblastoma and Turner syndrome. J Urol, 175(5), 1858-60.
  14. Bladder tissue formation from cultured bladder urothelium.Oottamasathien S, Williams K, Franco OE, Thomas JC, Saba K, Bhowmick NA, Staack A, Demarco RT, Brock JW 3rd, Hayward SW, Pope JC 4th (2006). Bladder tissue formation from cultured bladder urothelium. Dev Dyn, 235(10), 2795-801.

Book Chapter

  1. Oottamasathien S, Snow BW (2011). Office Procedures for Pediatric Urology. In AUA Update Series (Lesson 31, v. 30). American Urologic Association.
  2. Oottamasathien S, Furness PD, Mingin G, Brant WO, Koyle MA (2006). Management of Undescended Testes. Progress in Paediatric Urology Volume 8. New Delhi, London and Washington: Penwel Publishers PLC.

Case Report

  1. Primary extrarenal nephroblastomatosis.Oottamasathien S, Wills ML, Brock JW 3rd, Pope JC 4th (2007). Primary extrarenal nephroblastomatosis. Urology, 69(1), 184.e3-4.

Letter

  1. Metastatic Crohn's disease of the penis in a pediatric patient.Pohl JF, Comstock JM, Oottamasathien S (2011). Metastatic Crohn's disease of the penis in a pediatric patient [Letter to the editor]. Inflamm Bowel Dis, 17(4), 1056.

Abstract

  1. Oottamasathien S, Jia W, Roundy LM, Zhang J, Wang L, Ye X, Hill AC, Savage J, Lee WY, Hannon A, Milner S, Prestwich GD (2012). Physiologic Relevance of LL-37 Induced Bladder Inflammation and Mast Cells [Abstract]. American Academy of Pediatrics National Conference and Exhibition.
  2. Jia WJ, McCoard L, Zhang J, Skardal A, Prestwich GD, Oottamasathien S (2010). Abrogaton of LL-37 Mediated Bladder Inflammation and the Role of the Receptor for Advanced Glycation End-Products (RAGE) Pathway [Abstract]. Western Section American Urologic Association Meeting.
  3. Gabrielsen JS, Laciak RJ, Frank EL, McFadden M, Bates CS, Oottamasathien S, Hamilton BD, Wallis MC (2010). Pediatric Urinary Stone Composition in the United States [Abstract]. Western Section American Urologic Association Meeting.
  4. Wicher CG, Hadley DA, Cartwright PC, Oottamasathien S (2009). Scrotoplasty in Scrotal Agenesis [Abstract]. American Urological Association Video Presentation.
  5. Wicher C, Hadley DA, Cartwright PC, Oottamasathien S (2008). Scrotoplasty in Scrotal Agenesis [Abstract]. WSAUA Video Presentation.
  6. Foot LM, Bates CS, Steadman C, Laciak RJ, Oottamasathien S (2008). Testis Tumors in Children - An Argument for Testis Sparing Surgery [Abstract]. WSAUA Moderated Poster Session.

Poster

  1. Skardal A, Zhang J, McCoard L, Oottamasthien S, Prestwich GD (2010). Reversibly Crosslinked Gold Nanoparticle - Hyaluronan Hydrogels for Vessel Construct Bioprinting. Poster session presented at Society of Biomaterials Annual Meeting, Seattle, WA.

Clinical Trials

Video & News