Patient Rating:

No Rating Available?

Michael E. Engel, M.D., Ph.D., F.A.A.P.

Specialties

Languages

  • English

Clinical Details

Locations

Schedule An Appointment Clinical Office Address
(801) 662-4700 Primary Children's Hospital
100 N Mario Capecchi Drive
Salt Lake City, UT 84113

Bio

Michael Engel, MD, PhD, attended the Vanderbilt University School of Medicine in Nashville, TN. He completed his Pediatric residency training and subspecialty training in Pediatric Hematology/Oncology at the Monroe Carell Jr. Children's Hospital at Vanderbilt. He recently joined the faculty of the University of Utah School of Medicine and Primary Children's Medical Center as Assistant Professor in the Division of Pediatric Hematology/Oncology and as Adjunct Assistant Professor in the Department of Oncological Sciences of the Huntsman Cancer Institute.

Dr. Engel's clinical interests encompass hematologic and oncologic illness in children, adolescents and young adults, with an emphasis on hematologic malignancies including myeloid and lymphoid leukemias.

Dr. Engel's laboratory research interests involve the molecular machinery governing normal hematopoiesis and the molecular pathogenesis of acute leukemias, with a focus on alterations to the signaling machinery that govern cell growth and development. In the clinical domain, Dr. Engel is an active participant in clinical and translational research as a member of the Children's Oncology Group and as a leader within the Center for Children's Cancer Research of the Huntsman Cancer Institute.

As a member of the teaching faculty, Dr. Engel has a long-standing commitment to teaching and mentoring in both the clinical and laboratory domains. His teaching roles have involved learners at the pre- and post-doctoral levels and encompass both didactic and small group settings. He serves as Director of the Pediatric Hematology/Oncology Fellowship Program at the University of Utah and Primary Children's Medical Center.

Dr. Engel is a past recipient of a National Young Investigator award from the American Society of Pediatric Hematology/Oncology, a Ruth Kirschstein fellowship from the National Cancer Institute, a young investigator award from Alex's Lemonade Stand Pediatric Cancer Research Foundation, and served as a Hyundai Hope on Wheels Foundation Scholar. His research is currently supported by a Research Scholar Award from the St. Baldrick's Pediatric Cancer Research Foundation, research grants from CureSearch and Hope Street Kids foundations and a K08 Career Development Award from the National Institutes of Health. In the clinical setting, Dr. Engel is the recipient of a prestigious PRC Top Performer Award for 100th percentile patient satisfaction.

Board Certification and Academic Information

Academic Departments Pediatrics - Assistant Professor
Oncological Sciences - Adjunct Assistant Professor
Academic Divisions Pediatric Hematology/Oncology
Board Certification American Board of Pediatrics (Pediatrics)
American Board of Pediatrics (Sub: Ped Hematology-Oncology)
Cancer Center Programs Nuclear Control of Cell Growth & Differentiation

Academic Profile

Board Certification and Academic Information

Academic Departments Pediatrics - Assistant Professor
Oncological Sciences - Adjunct Assistant Professor
Academic Divisions Pediatric Hematology/Oncology
Board Certification American Board of Pediatrics (Pediatrics)
American Board of Pediatrics (Sub: Ped Hematology-Oncology)
Cancer Center Programs Nuclear Control of Cell Growth & Differentiation

Academic Office Locations

Academic Office Phone Number Academic Office Address
Huntsman Cancer Institute
Laboratory
2000 Circle of Hope
Salt Lake City, UT 84112
(801) 587-3882 Huntsman Cancer Institute
2000 Circle of Hope
Salt Lake City, UT 84112
Primary Children's Hospital
100 N Mario Capecchi Drive
Salt Lake City, UT 84113

Academic Bio

Michael Engel, MD, PhD, attended the Vanderbilt University School of Medicine in Nashville, TN. He completed his Pediatric residency training and subspecialty training in Pediatric Hematology/Oncology at the Monroe Carell Jr. Children's Hospital at Vanderbilt. He recently joined the faculty of the University of Utah School of Medicine and Primary Children's Medical Center as Assistant Professor in the Division of Pediatric Hematology/Oncology and as Adjunct Assistant Professor in the Department of Oncological Sciences of the Huntsman Cancer Institute (HCI). He is an HCI investigator and member of the Nuclear Control of Cell Growth and Differentiation program.

Dr. Engel's clinical interests encompass hematologic and oncologic illness in children, adolescents and young adults, with an emphasis on hematologic malignancies including myeloid and lymphoid leukemias.

Dr. Engel's laboratory research interests involve the molecular determinants of normal and malignant hematopoiesis, with a focus on alterations to the signaling machinery and gene expression programs that govern cell growth and development. In the clinical domain, Dr. Engel is an active participant in clinical and translational research as a member of the Children's Oncology Group.

As a member of the teaching faculty, Dr. Engel has a long-standing commitment to teaching and mentoring in both the clinical and laboratory domains. His teaching roles have involved learners at the pre- and post-doctoral levels and encompass both didactic and small group settings. Dr. Engel serves as the Pediatric hematology/oncology fellowship program director at the University of Utah and Primary Children's Hospital, and trainees supervised by him serve as faculty at academic medical centers throughout the United States. Grounded in his interests in mentoring and development of colleagues, Dr. Engel was selected to represent the University of Utah School of Medicine on the Council of Faculty and Academic Societies of the Association of American Medical Colleges.

Dr. Engel is a past recipient of a National Young Investigator award from the American Society of Pediatric Hematology/Oncology, a Ruth Kirschstein fellowship from the National Cancer Institute, a young investigator award from Alex's Lemonade Stand Pediatric Cancer Research Foundation, and served as a Hyundai Hope on Wheels Foundation Scholar. His research is currently supported by a Research Scholar Award from the St. Baldrick's Pediatric Cancer Research Foundation, research grants from CureSearch and Hope Street Kids foundations and a K08 Career Development Award from the National Institutes of Health. He is a member of the American Society of Hematology, the American Association for Cancer Research and its affiliated Pediatric Cancer Working Group, and the American Society of Pediatric Hematology/Oncology. In the clinical setting, Dr. Engel is the recipient of a prestigious PRC Top Performer Award, which recognizes physicians with patient satisfaction ratings in the 100th percentile nationally. In addition to his research and clinical duties, Dr. Engel is working with colleagues at the University of Utah and the Huntsman Cancer Institute to develop the Center for Children's Cancer Research.

Education

Education History

Type School Degree
Research Fellow Vanderbilt University Medical Center
Department of Biochemistry
Research Fellow
Fellowship Vanderbilt University Medical Center
Pediatric Hematology/Oncology
Clinical Fellow
Residency Vanderbilt University Medical Center
Pediatrics – Special Alternative Pathway Trainee
Resident
Professional Medical Vanderbilt University School of Medicine
Medical Scientist Training Program
M.D.
Doctoral Training Vanderbilt University School of Medicine
Medical Scientist Training Program
Ph.D.
Other Training Vanderbilt University School of Medicine
Medical Scientist Training Program
Undergraduate Purdue University, West Lafayette Campus
Biology
B.S.

Publications

Selected Provider Publications

Journal Article

  1. Mixon BA, Eckrich MJ, Lowas S, Engel M(2013)Vincristine, irinotecan, and temozolomide for treatment of relapsed alveolar rhabdomyosarcoma.  Journal of Pediatric Hematology / Oncology, 35(4),e163-6
  2. Barrett CW, Smith JJ, Lu LC, Markham N, Stengel KR, Short SP, Zhang B, Hunt AA, Fingleton BM, Carnahan RH, Engel ME, Chen X, Beauchamp RD, Wilson KT, Hiebert SW, Reynolds AB, Williams C(2012)Kaiso directs the transcriptional corepressor MTG16 to the Kaiso binding site in target promoters.  PLoS ONE, 7(12),e51205
  3. Fagan E, Slone J, Shoemaker A, Black J, Berlin J, Engel M(2012)Neuroendocrine carcinoma in an adolescent with hypercortisolemia  Journal of Pediatric Hematology / Oncology, 34(3),117-119
  4. Engel ME, Nguyen HN, Mariotti J, Hunt A, Hiebert S(2010)Myeloid translocation gene 16 (MTG16) interacts with Notch transcription complex components to integrate Notch signaling in hematopoietic cell fate specification.  Molecular and Cellular Biology, 30(7),1852-63
  5. Engel ME, Hiebert S(2010)The enemy within: Awakening endogenous retroviruses  Nature Medicine, 16517-518
  6. Chyla BJ, Moreno-Miralles I, Steapleton MA, Thompson MA, Bhaskara S, Engel M, Hiebert S(2008)Deletion of Mtg16, a target of t(16;21), alters hematopoietic progenitor cell proliferation and lineage allocation.  Molecular and Cellular Biology, 28(20),6234-47
  7. Frangoul H, Wills M, Crossno C, Engel M, Domm (2007)Acyclovir-resistant herpes simplex virus pneumonia post-unrelated stem cell transplantation: a word of caution.  Pediatric Transplantation, 11(8),942-4
  8. Engel ME, Hickstein DD, Bauer TR Jr, Calder C, Manes B, Frangoul (2006)Matched unrelated bone marrow transplantation with reduced-intensity conditioning for leukocyte adhesion deficiency.  Bone Marrow Transplantation, 37(7),717-8
  9. Bhowmick NA, Ghiassi M, Bakin A, Aakre M, Lundquist CA, Engel ME, Arteaga CL, Moses H(2001)Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism.  Molecular Biology of the Cell, 12(1),27-36
  10. Engel ME, McDonnell MA, Law BK, Moses H(1999)Interdependent SMAD and JNK signaling in transforming growth factor-beta-mediated transcription.  Journal of Biological Chemistry, 274(52),37413-20
  11. Engel ME, Datta PK, Moses H(1998)RhoB is stabilized by transforming growth factor beta and antagonizes transcriptional activation.  Journal of Biological Chemistry, 273(16),9921-6
  12. Sarkar DK, Pastorcic M, De A, Engel M, Moses H, Ghasemzadeh M(1998)Role of transforming growth factor (TGF)-beta Type I and TGF-beta type II receptors in the TGF-beta1-regulated gene expression in pituitary prolactin-secreting lactotropes.  Endocrinology, 139(8),3620-8
  13. Kawabata M, Imamura T, Miyazono K, Engel ME, Moses H(1995)Interaction of the transforming growth factor-beta type I receptor with farnesyl-protein transferase-alpha.  Journal of Biological Chemistry, 270(50),29628-31
  14. Vedvick T, Buckholz RG, Engel M, Urcan M, Kinney J, Provow S, Siegel RS, Thill G(1991)High-level secretion of biologically active aprotinin from the yeast Pichia pastoris.  Journal of Industrial Microbiology, 7(3),197-201

Review

  1. Engel ME, Datta PK, Moses H(1998)Signal transduction by transforming growth factor-beta: a cooperative paradigm with extensive negative regulation.  Journal of Cellular Biochemistry. Supplement, 30-31111-22

Book Chapter

  1. Engel ME, and Hiebert S(2010)Proleukemic RUNX1 and CBFbeta mutations in the pathogenesis of acute leukemia.  , 145127-147

Abstract

  1. Singer J, Andrade D, Bareyan D, McClellan D, Lucente H, Velinder M, Chandrasekharan M, Theisen E, Liu F, Sharma S and Engel M(2013)Lysine Specific Demethylase-1 inhibition as a therapeutic strategy that leverages the requirement for Growth Factor Indepndence-1 in Notch-driven T-ALL  ,
  2. Singer J, Andrade D, Bareyan D, McClellan D, Lucente H, Velinder M, Chandrasekharan M, Theisen E, Liu F, Sharma S, Maese L and Engel M(2013)Notch alters sumoylation to govern GFI1 protein stability and support its transcriptional repression function  ,
  3. Andrade D, Singe J, Bareyan D, McClellan D, Lucente H, Chandrasekharan M, and Engel M(2013)Notch and PIAS3 differentially regulate sumoylation of GFI1 to modulate transcriptional repression  ,
  4. Andrade D, Maese L, Singer J, Bareyan D, McClellan D, Lucente H, Quinton R, Chandrasekharan M, Liu F, and Engel M(2013)Sumoylation regulates the half-life of Growth Factor Independence (GFI)-1 to modulate transcriptional repression  ,
  5. Andrade DL, Bareyan D, Singer J, Quinton R, Engel M(2012)Regulation of GFI1 proteins by Notch intracellular domains  ,
  6. Mangrum DS, Shams S, Downie J, von Schwelder U, Rodic V, Engel ME, Barnette P, Frazer JK, Trede N, Pei D, Cheng C, Mullighan C, Yang J, Miles R, Schiffman J(2011)Focal 22q11.22 loss combined with IKZF1 alterations predict very poor outcome in childhood acute lymphoblastic leukemia  ,
  7. Mariotti J, Nguyen HN and Engel M(2010)Structure—function relationships between RUNX1-MTG fusion proteins and core components of the Notch transcription complex  ,
  8. Chadalavada N, Nguyen HN, Mariotti J and Engel M(2009)GFI1B interacts with the intracellular domain of Notch1  ,
  9. Engel ME, Nguyen HN, Mariotti J, Hunt A and Hiebert S(2009)Myeloid translocation gene (MTG)-16 binds intracellular domains of Notch receptors to coordinate Notch-dependent cell fate specification  ,
  10. Engel ME, Nguyen HN, Mariotti J, Hunt A, and Hiebert S(2009)Regulation of the canonical Notch transcription complex by Myeloid Translocation Gene-16 in hematopoietic cell fate specification  ,
  11. Williams C, Moore AC, Amann J, Engel ME, Ellis T, Whitehead R, and Hiebert S(2007)A role for MTGR1 in intestinal epithelial migration and repair  ,
  12. Engel ME and Hiebert S(2007)MTG16-mediated transcriptional repression and NCoR interaction are regulated by A-kinase  ,
  13. Engel ME, Hunt A, Ice RJ, and Hiebert S(2006)Phosphorylation-mediated control of gene expression by the myeloid translocation gene protein, MTG16: Implications for hematopoietic stem cell self renewal and leukemogenesis  ,
  14. Engel ME, Ice RJ, Hunt AH, and Hiebert S(2006)Phosphorylation-mediated control of transcriptional repression by the myeloid translocation gene protein, MTG16  ,
  15. Williams C, Engel ME, Ellis T, Martinez A, and Hiebert S(2006)Susceptibility to DSS induced colitis in MTGR1 and MTG16 deficient mice  ,
  16. Engel ME, Ice RJ, Hiebert, S(2005)Post-translational modifications of the Myeloid Translocation Gene protein, Eto2  ,
  17. Engel ME, and Moses H(1998)The Role of Rho Proteins in TGF- ß Signaling  ,
  18. Brierly R, Buckholz R, Engel ME, D’Andrea M, Holtz G, Kinney M, Provow S, Siegel R, Thill G, Vedvick T, Velicelebi G, and Wondrack (1991)High Level Secretion of Recombinant Insulin-Like Growth Factor-1 from the Methylotropic Yeast Pichia pastoris  ,

Other

  1. Engel M(1999)Rho GTP-Binding Proteins and the C-Jun N-Terminal Kinase Cascade. Ph.D. Thesis  ,

Patent

  1. Engel ME, Vedvick T, Urcan M, Buckholz R, and Kinney (1993)Expression System for Bovine Pancreatic Trypsin Inhibitor (BPTI/Aprotinin) Peptides.  American Journal of Hospice and Palliative Medicine,

Poster

  1. Quinton R, Bareyan D, Andrade DL, Singer J, McLellan D, Engel M(2011)Myeloid Translocation Gene (MTG) 16 and the Notch pathway in in vitro erythropoiesis  ,

Clinical Trials

Video & News