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Dementia with Lewy bodies (DLB) is one of the most common types of progressive dementia. The central feature of DLB is progressive cognitive decline combined with three additional defining features:
- Fluctuations in alertness and attention, such as frequent drowsiness, lethargy, lengthy periods of time spent staring into space, or disorganized speech;
- Recurrent visual hallucinations, and
- Parkinsonian motor symptoms, such as rigidity and the loss of spontaneous movement.
People may also suffer from depression. The symptoms of DLB are caused by the build-up of Lewy bodies—accumulated bits of alpha-synuclein protein—inside the nuclei of neurons in areas of the brain that control particular aspects of memory and motor control. Researchers don’t know exactly why alpha-synuclein accumulates into Lewy bodies or how Lewy bodies cause the symptoms of DLB, but they do know that alpha-synuclein accumulation is also linked to Parkinson's disease, multiple system atrophy, and several other disorders, which are referred to as the "synucleinopathies."
The similarity of symptoms between DLB and Parkinson’s disease, and between DLB and Alzheimer’s disease, can often make it difficult for a doctor to make a definitive diagnosis. In addition, Lewy bodies are often also found in the brains of people with Parkinson's and Alzheimer’s diseases. These findings suggest that either DLB is related to these other causes of dementia or that an individual can have both diseases at the same time. DLB usually occurs sporadically in people with no known family history of the disease. However, rare familial cases have occasionally been reported. Read More
Jim’s chief clinical interests are Parkinson's disease rehabilitation, balance training, vestibular rehabilitation and male and female pelvic floor muscle rehabilitation. He is a member of the Deep Brain Stimulation Team at the University Health Sciences Center. In this capacity, he assesses the motor effects of levodopa in individuals with Parki... Read More
Heather Hayes, DPT, NCS, PhD is a Doctor of Physical Therapy (DPT) with advanced certification as a neurologic clinic specialist (NCS). She specializes in the treatment and research of individuals with any neurological disorders, including but not limited to; Stroke, Multiple Sclerosis, Parkinsonsim, ALS, balance and vestibular disorders.... Read More
Dr. House specializes in the surgical treatment of Epilepsy, Movement Disorders,Trigeminal Neuralgia, Brain Tumors, and Traumatic Brain Injury. Paul A. House, MD surgically treats patients who suffer from epilepsy, movement disorders (including tremor, Parkinson’s disease, and dystonia), trigeminal neuralgia and brain tumors. His research interes... Read More
Stefan-M. Pulst, MD, Dr med is Professor and Chair of Neurology. His clinical and research interests focus on inherited diseases of the nervous system with an emphasis on spinocerebellar ataxias and Parkinson´s disease. He received his medical school training at Medizinische Hochschule, Hannover (Germany) and at Harvard Medical School, Boston. Aft... Read More
In 2002, Dr. Renner joined the Department of Neurology faculty, where he currently holds a position as an Associate Professor of Neurology and a diplomate of tropical medicine and infectious disease. Dr. Renner is the course director for medical school neurosciences (Brain and Behavior). Dr. Renner is very active in teaching and mentoring, and ha... Read More
Lauren E. Schrock, MD joined the Department of Neurology in July 2009. Her clinical interests include movement disorders, with particular focus on dystonia and the surgical management of movement disorders. Dr. Schrock has a special interest in the neurophysiology of basal ganglia-thalamocortical circuits and their role in Parkinson’s disease, dyst... Read More
Perla C. Thulin, MD, has special expertise and training in the evaluation and treatment of movement disorders, including Parkinson´s disease, essential tremor, chorea, hemifacial spasm, tics, and dystonia, including torticolllis and blepharospasm, and is an expert in the use of Botox and Myobloc.... Read More
Meghan Zorn, PA-C, is a Physician Assistant, seeing patients with movement disorders. She has expertise in the treatment of Parkinson’s disease, Multiple System Atrophy, Progressive Supranuclear Palsy, Dementia with Lewy Bodies, Essential Tremor and Huntington’s disease. She has extensive experience with Deep Brain Stimulation for the treatment of ... Read More