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Dementia with Lewy bodies (DLB) is one of the most common types of progressive dementia. The central feature of DLB is progressive cognitive decline combined with three additional defining features:
- Fluctuations in alertness and attention, such as frequent drowsiness, lethargy, lengthy periods of time spent staring into space, or disorganized speech;
- Recurrent visual hallucinations, and
- Parkinsonian motor symptoms, such as rigidity and the loss of spontaneous movement.
People may also suffer from depression. The symptoms of DLB are caused by the build-up of Lewy bodies—accumulated bits of alpha-synuclein protein—inside the nuclei of neurons in areas of the brain that control particular aspects of memory and motor control. Researchers don’t know exactly why alpha-synuclein accumulates into Lewy bodies or how Lewy bodies cause the symptoms of DLB, but they do know that alpha-synuclein accumulation is also linked to Parkinson's disease, multiple system atrophy, and several other disorders, which are referred to as the "synucleinopathies."
The similarity of symptoms between DLB and Parkinson’s disease, and between DLB and Alzheimer’s disease, can often make it difficult for a doctor to make a definitive diagnosis. In addition, Lewy bodies are often also found in the brains of people with Parkinson's and Alzheimer’s diseases. These findings suggest that either DLB is related to these other causes of dementia or that an individual can have both diseases at the same time. DLB usually occurs sporadically in people with no known family history of the disease. However, rare familial cases have occasionally been reported. Read More
- Biomarker Study of REM sleep Behavior Disorder
Keywords: Parkinson's Disease, REM Sleep Behavior Disorder, Dream enactment, Neurodegenerative Disease, Dementia with Lewy bodies, RBD
Status: Enrolling by invitation
- Cognitive training and practice effects
Keywords: Memory, Cognitive Training, Mild Cognitive Impairment