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Stephen L. Guthery, M.D., M.S.

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Clinical Details

Schedule An Appointment Clinical Office Address
(801) 213-3599 Eccles Primary Children’s Outpatient Services Building
81 N Mario Capecchi Drive
Salt Lake City, UT 84113
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Bio

Dr. Guthery received his medical degree from the Oregon Health Sciences University and completed his pediatric residency at Cincinnati Children’s Hospital Medical Center. He subsequently completed his fellowship in pediatric gastroenterology at Cincinnati Children’s Hospital Medical Center.

Dr. Guthery is currently Professor of Pediatrics and Adjunct Professor of Human Genetics. Dr. Guthery’s clinical interests include Crohn disease, ulcerative colitis, and liver disease in children and adolescents. His research interests include the epidemiology of rare diseases in children and the genetic basis of childhood intestinal and liver disease. Dr. Guthery is the local principal investigator for several multicenter clinical studies of Crohn disease and ulcerative colitis. He is the principal Investigator for the University of Utah's clinical site for the Childhood Liver Disease Research Network.

Dr. Guthery is board certified in General Pediatrics, Pediatric Gastroenterology, and Pediatric Transplant Hepatology. He has served as a member of the Pediatric Affairs Committee of the Crohn’s and Colitis Foundation of America, and is listed in the Best Doctors in America.

Board Certification and Academic Information

Academic Departments Pediatrics - Professor
Human Genetics - Adjunct Professor
Academic Divisions Pediatric Gastroenterology
Board Certification American Board of Pediatrics (Pediatric Transplant Hepatology)
American Board of Pediatrics (Pediatrics)
American Board of Pediatrics (Sub: Ped Gastroenterology)

Academic Profile

Research Interests

  • Genetic Liver Diseases
  • Sequence Analysis, DNA
  • Biostatistics
  • Human Population Genetics
  • Genetics of Childhood Crohn Disease and Ulcerative Colitis
  • Genomics
  • Epidemiology of Childhood Intestinal and Liver Diseases

Board Certification and Academic Information

Academic Departments Pediatrics - Professor
Human Genetics - Adjunct Professor
Academic Divisions Pediatric Gastroenterology
Board Certification American Board of Pediatrics (Pediatric Transplant Hepatology)
American Board of Pediatrics (Pediatrics)
American Board of Pediatrics (Sub: Ped Gastroenterology)

Academic Office Locations

Academic Office Phone Number Academic Office Address
(801) 213-3599 Eccles Primary Children’s Outpatient Services Building
Pediatric Gastroenterology
81 N Mario Capecchi Drive
Salt Lake City, UT 84113

Academic Bio

Dr. Guthery completed a Clinical Research Fellowship at Cincinnati Children’s Hospital Medical Center in 2002. He obtained a Master’s of Science degree in Epidemiology from the University of Cincinnati, with a focus on biostatistics. In 2002, he came to the University of Utah, and received a Career Development Award from the National Institutes of Health. Dr. Guthery received further research training in human genetics under the mentorship of Drs. Michael Bamshad and subsequently Lynn Jorde. Dr. Guthery is currently a Professor of Pediatrics and Adjunct Professor of Human Genetics.

Dr. Guthery’s research focuses on genome sequencing using novel analytical tools such as VAAST to better understand how genomic variation contributes to liver and GI diseases affecting infants and children. Diseases currently under study include childhood-onset Crohn disease and ulcerative colitis, undiagnosed immune-mediated disease of the GI tract, and undiagnosed liver disease. Dr. Guthery is the local principal investigator for several multicenter clinical studies in Crohn disease and ulcerative colitis. He is the principal Investigator for the University of Utah's clinical site for the Childhood Liver Disease Research Network.

Dr. Guthery is the Associate Director of the Clinical Services Core, a component of the University of Utah’s Center for Clinical and Translational Sciences, a funded CTSA.

Education

Education History

Type School Degree
Graduate Training University of Cincinnati
Epidemiology
M.Sc.
Fellowship Cincinnati Children's Hospital Medical Center
Pediatric Gastroenterology, Hepatology, and Nutrition
Fellow
Residency Cincinnati Children's Hospital Medical Center
Pediatrics
Resident
Professional Medical Oregon Health Sciences University
Medicine
M.D.
Undergraduate Lewis and Clark College
Biology
B.A.

Publications

Selected Provider Publications

Journal Article

  1. Hu H, Roach JC, Coon H, Guthery SL, Voelkerding KV, Margraf RL, Durtschi JD, Tavtigian SV, Shankaracharya, Wu W, Scheet P, Wang S, Xing J, Glusman G, Hubley R, Li H, Garg VAUID- ORCID 0000000237785927, Moore B, Hood L, Galas DJ, Srivastava D, Reese MG, Jorde LB, Yandell M, Huff CD (2014). A unified test of linkage analysis and rare-variant association for analysis of pedigree sequence data. Nat Biotechnol, 32(7), 663-9.
  2. Liu R, Cox K, Guthery SL, Book L, Witt B, Chadwick B, Adler DG (2014). Cholangiocarcinoma and High-Grade Dysplasia in Young Patients with Primary Sclerosing Cholangitis. (Epub ahead of print) Dig Dis Sci.
  3. Singleton MV, Guthery SL, Voelkerding KV, Chen K, Kennedy B, Margraf RL, Durtschi J, Eilbeck K, Reese MG, Jorde LB, Huff CD, Yandell M (2014). Phevor combines multiple biomedical ontologies for accurate identification of disease-causing alleles in single individuals and small nuclear families. Am J Hum Genet, 94(4), 599-610.
  4. Deneau M, Book LS, Guthery SL, Jensen MK (2014). Outcome after Discontinuation of Immunosuppression in Children with Autoimmune Hepatitis: A Population-Based Study.LID - S0022-3476(13)01533-3 [pii]LID - 10.1016/j.jpeds.2013.12.008 [doi]. (Epub ahead of print) J Pediatr.
  5. Walters TD, Kim M, Denson LA, Griffiths AM, Dubinsky M, Markowitz J, Baldassano R, Crandall W, Rosh J, Pfefferkorn M, Otley A, Heyman MB, Leleiko N, Baker S, Guthery SL, Evans J, Ziring D, Kellermayer R, Stephens M, Mack D, Oliva-Hemker M, Patel AS, Kirschner B, Moulton D, Cohen S, Kim S, Liu C, Essers J, Kugathasan S, Hyams JS (2013). Comparative Effectiveness of Early Therapy with Anti-Tumor Necrosis Factor-alpha vs an Immunomodulator in Children With Crohn's Disease.LID - S0016-5085(13)01501-1 [pii]LID - 10.1053/j.gastro.2013.10.027 [doi]. (Epub ahead of print) Gastroenterology.
  6. Deneau M, Jensen MK, Holmen J, Williams MS, Book LS, Guthery SL (2013). Primary sclerosing cholangitis, autoimmune hepatitis, and overlap in utah children: Epidemiology and natural history.LID - 10.1002/hep.26454 [doi]. (Epub ahead of print) Hepatology.
  7. Willson TA, Kuhn BR, Jurickova I, Gerad S, Moon D, Bonkowski E, Carey R, Collins MH, Xu H, Jegga AG, Guthery SL, Denson LA (07/01/2012).

    STAT3 genotypic variation and cellular STAT3 activation and colon leukocyte recruitment in pediatric Crohn disease.

    . J Pediatr Gastroenterol Nutr, 55(1), 32-43.
  8. Huff CD, Witherspoon DJ, Zhang Y, Gatenbee C, Denson LA, Kugathasan S, Hakonarson H, Whiting A, Davis CT, Wu W, Xing J, Watkins WS, Bamshad MJ, Bradfield JP, Bulayeva K, Simonson TS, Jorde LB, Guthery SL (01/01/2012). Crohn's disease and genetic hitchhiking at IBD5. Mol Biol Evol, 29(1), 101-11.
  9. Huff CD, Witherspoon DJ, Simonson TS, Xing J, Watkins WS, Zhang Y, Tuohy TM, Neklason DW, Burt RW, Guthery SL, Woodward SR, Jorde LB (2011). Maximum-likelihood estimation of recent shared ancestry (ERSA). Genome Res, 21(5), 768-74.
  10. Deneau M, Adler DG, Schwartz JJ, Hutson W, Sorensen J, Book L, Lowichik A, Guthery S (2011). Cholangiocarcinoma in a 17-year-old boy with primary sclerosing cholangitis and inflammatory bowel disease. J Pediatr Gastroenterol Nutr, 52(5), 617-20.
  11. Guthery SL, Mineau G, Pimentel R, Williams MS, Kerber RA (2011). Inflammatory bowel disease aggregation in Utah kindreds. Inflamm Bowel Dis, 17(3), 823-30.
  12. Anderson CA, Boucher G, Lees CW, Franke A, DAmato M, Taylor KD, Lee JC, Goyette P, Imielinski M, Latiano A, Lagace C, Scott R, Amininejad L, Bumpstead S, Baidoo L, Baldassano RN, Barclay M, Bayless TM, Brand S, Buning C, Colombel JF, Denson LA, De Vos M, Dubinsky M, Edwards C, Ellinghaus D, Fehrmann RS, Floyd JA, Florin T, Franchimont D, Franke L, Georges M, Glas J, Glazer NL, Guthery SL, Haritunians T, Hayward NK, Hugot JP, Jobin G, Laukens D, Lawrance I, Lemann M, Levine A, Libioulle C, Louis E, McGovern DP, Milla M, Montgomery GW, Morley KI, Mowat C, Ng A, Newman W, Ophoff RA, Papi L, Palmieri O, Peyrin-Biroulet L, Panes J, Phillips A, Prescott NJ, Proctor DD, Roberts R, Russell R, Rutgeerts P, Sanderson J, Sans M, Schumm P, Seibold F, Sharma Y, Simms LA, Seielstad M, Steinhart AH, Targan SR, van den Berg LH, Vatn M, Verspaget H, Walters T, Wijmenga C, Wilson DC, Westra HJ, Xavier RJ, Zhao ZZ, Ponsioen CY, Andersen V, Torkvist L, Gazouli M, Anagnou NP, Karlsen TH, Kupcinskas L, Sventoraityte J, Mansfield JC, Kugathasan S, Silverberg MS, Halfvarson J, Rotter JI, Mathew CG, Griffiths AM, Gearry R, Ahmad T, Brant SR, Chamaillard M, Satsangi J, Cho JH, Schreiber S, Daly MJ, Barrett JC, Parkes M, Annese V, Hakonarson H, Radford-Smith G, Duerr RH, Vermeire S, Weersma RK, Rioux JD (2011). Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet, 43(3), 246-52.
  13. Moore JC, Thompson K, Lafleur B, Book LS, Jackson WD, OGorman MA, Black RE, Downey E Jr, Johnson DG, Matlak ME, Meyers RL, Scaife E, Guthery SL (2011). Clinical variables as prognostic tools in pediatric-onset ulcerative colitis: a retrospective cohort study. Inflamm Bowel Dis, 17(1), 15-21.
  14. Franke A, McGovern DP, Barrett JC, Wang K, Radford-Smith GL, Ahmad T, Lees CW, Balschun T, Lee J, Roberts R, Anderson CA, Bis JC, Bumpstead S, Ellinghaus D, Festen EM, Georges M, Green T, Haritunians T, Jostins L, Latiano A, Mathew CG, Montgomery GW, Prescott NJ, Raychaudhuri S, Rotter JI, Schumm P, Sharma Y, Simms LA, Taylor KD, Whiteman D, Wijmenga C, Baldassano RN, Barclay M, Bayless TM, Brand S, Buning C, Cohen A, Colombel JF, Cottone M, Stronati L, Denson T, De Vos M, DInca R, Dubinsky M, Edwards C, Florin T, Franchimont D, Gearry R, Glas J, Van Gossum A, Guthery SL, Halfvarson J, Verspaget HW, Hugot JP, Karban A, Laukens D, Lawrance I, Lemann M, Levine A, Libioulle C, Louis E, Mowat C, Newman W, Panes J, Phillips A, Proctor DD, Regueiro M, Russell R, Rutgeerts P, Sanderson J, Sans M, Seibold F, Steinhart AH, Stokkers PC, Torkvist L, Kullak-Ublick G, Wilson D, Walters T, Targan SR, Brant SR, Rioux JD, DAmato M, Weersma RK, Kugathasan S, Griffiths AM, Mansfield JC, Vermeire S, Duerr RH, Silverberg MS, Satsangi J, Schreiber S, Cho JH, Annese V, Hakonarson H, Daly MJ, Parkes M (2010). Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet, 42(12), 1118-25.
  15. Imielinski M, Baldassano RN, Griffiths A, Russell RK, Annese V, Dubinsky M, Kugathasan S, Bradfield JP, Walters TD, Sleiman P, Kim CE, Muise A, Wang K, Glessner JT, Saeed S, Zhang H, Frackelton EC, Hou C, Flory JH, Otieno G, Chiavacci RM, Grundmeier R, Castro M, Latiano A, Dallapiccola B, Stempak J, Abrams DJ, Taylor K, McGovern D, Silber G, Wrobel I, Quiros A, Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, Rioux JD, Brant SR, Silverberg MS, Taylor KD, Barmuda MM, Bitton A, Dassopoulos T, Datta LW, Green T, Griffiths AM, Kistner EO, Murtha MT, Regueiro MD, Rotter JI, Schumm LP, Steinhart AH, Targan SR, Xavier RJ, Libioulle C, Sandor C, Lathrop M, Belaiche J, Dewit O, Gut I, Heath S, Laukens D, Mni M, Rutgeerts P, Van Gossum A, Zelenika D, Franchimont D, Hugot JP, de Vos M, Vermeire S, Louis E, Cardon LR, Anderson CA, Drummond H, Nimmo E, Ahmad T, Prescott NJ, Onnie CM, Fisher SA, Marchini J, Ghori J, Bumpstead S, Gwillam R, Tremelling M, Delukas P, Mansfield J, Jewell D, Satsangi J, Mathew CG, Parkes M, Georges M, Daly MJ, Heyman MB, Ferry GD, Kirschner B, Lee J, Essers J, Grand R, Stephens M, Levine A, Piccoli D, Van Limbergen J, Cucchiara S, Monos DS, Guthery SL, Denson L, Wilson DC, Grant SF, Daly M, Silverberg MS, Satsangi J, Hakonarson H (2009). Common variants at five new loci associated with early-onset inflammatory bowel disease. Nat Genet, 41(12), 1335-40.
  16. Xing J, Watkins WS, Witherspoon DJ, Zhang Y, Guthery SL, Thara R, Mowry BJ, Bulayeva K, Weiss RB, Jorde LB (2009). Fine-scaled human genetic structure revealed by SNP microarrays. Genome Res, 19(5), 815-25.
  17. Nair RP, Duffin KC, Helms C, Ding J, Stuart PE, Goldgar D, Gudjonsson JE, Li Y, Tejasvi T, Feng BJ, Ruether A, Schreiber S, Weichenthal M, Gladman D, Rahman P, Schrodi SJ, Prahalad S, Guthery SL, Fischer J, Liao W, Kwok PY, Menter A, Lathrop GM, Wise CA, Begovich AB, Voorhees JJ, Elder JT, Krueger GG, Bowcock AM, Abecasis GR (2009). Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. Nat Genet, 41(2), 199-204.
  18. Kugathasan S, Baldassano RN, Bradfield JP, Sleiman PM, Imielinski M, Guthery SL, Cucchiara S, Kim CE, Frackelton EC, Annaiah K, Glessner JT, Santa E, Willson T, Eckert AW, Bonkowski E, Shaner JL, Smith RM, Otieno FG, Peterson N, Abrams DJ, Chiavacci RM, Grundmeier R, Mamula P, Tomer G, Piccoli DA, Monos DS, Annese V, Denson LA, Grant SF, Hakonarson H (2008). Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease. Nat Genet, 40(10), 1211-5.
  19. Guthery SL, Salisbury BA, Pungliya MS, Stephens JC, Bamshad M (2007). The structure of common genetic variation in United States populations. Am J Hum Genet, 81(6), 1221-31.
  20. Bamshad M, Guthery SL (2007). Race, genetics and medicine: does the color of a leopard's spots matter? Curr Opin Pediatr, 19(6), 613-8.

Letter

  1. Peterson N, Guthery S, Denson L, Lee J, Saeed S, Prahalad S, Biank V, Ehlert R, Tomer G, Grand R, Rudolph C, Kugathasan S (2008). Genetic variants in the autophagy pathway contribute to paediatric Crohn's disease [Letter to the editor]. Gut, 57(9), 1336-7; author reply 1337.

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