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Stephen L. Guthery, M.D., M.S.

Chief, Division of Pediatric Gastroenterology

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Clinical Details

Phone Number Clinical Office Address
(801) 213-3599
Eccles Primary Children’s Outpatient Services Building
81 N Mario Capecchi Drive
Salt Lake City, UT 84113
(801) 213-3599
PCH Outpatient Services at Riverton
3773 West 12600 South
Riverton, UT 84065


Dr. Guthery is the Chief of the Division of Pediatric Gastroenterology, Hepatology, Nutrition. His interests include the care of infants, children and adolescents with Crohn's disease, ulcerative colitis and liver disease. His research involves understanding the genetic basis of and improving treatments for these conditions.

Dr. Guthery is board certified in General Pediatrics, Pediatric Gastroenterology, and Pediatric Transplant Hepatology. Dr. Guthery has served as an expert clinical/scientific consultant for several non-profit agencies and the National Institutes of Health. He is listed among the Best Doctors in America. Dr. Guthery is a native of the Mountain West and has been at the University of Utah and Primary Children’s Hospital for close to 15 years.

Board Certification and Academic Information

Academic Departments Pediatrics - Professor
Human Genetics - Adjunct Professor
Academic Divisions Pediatric Gastroenterology
Board Certification American Board of Pediatrics (Sub: Pediatric Gastroenterology)
American Board of Pediatrics (Pediatrics)
American Board of Pediatrics (Pediatric Transplant Hepatology)

Academic Profile

Research Interests

  • Sequence Analysis, DNA
  • Genetic Liver Diseases
  • Human Population Genetics
  • Epidemiology of Childhood Intestinal and Liver Diseases
  • Genomics
  • Biostatistics
  • Genetics of Childhood Crohn Disease and Ulcerative Colitis

Board Certification and Academic Information

Academic Departments Pediatrics - Professor
Human Genetics - Adjunct Professor
Academic Divisions Pediatric Gastroenterology
Board Certification American Board of Pediatrics (Sub: Pediatric Gastroenterology)
American Board of Pediatrics (Pediatrics)
American Board of Pediatrics (Pediatric Transplant Hepatology)

Academic Office Locations

Academic Office Phone Number Academic Office Address
(801) 213-3599 Eccles Primary Children’s Outpatient Services Building
Pediatric Gastroenterology
81 N Mario Capecchi Drive
Salt Lake City, UT 84113

Academic Bio

Dr. Guthery received his medical degree from the Oregon Health Sciences University and completed his pediatric residency at Cincinnati Children’s Hospital Medical Center. He subsequently completed his fellowship in pediatric gastroenterology at Cincinnati Children’s Hospital Medical Center. He obtained a Master’s of Science degree in Epidemiology from the University of Cincinnati, with a focus on biostatistics. In 2002, he came to the University of Utah, and received a Career Development Award from the National Institutes of Health. Dr. Guthery received further research training in human genetics under the mentorship of Drs. Michael Bamshad and subsequently Lynn Jorde. Dr. Guthery is currently a Professor of Pediatrics and Adjunct Professor of Human Genetics.

Research Statement

Dr. Guthery is the local principal investigator for several multi-center clinical studies to improve the understanding and treatment of Crohn disease and ulcerative colitis ( He is the Principal Investigator for the University of Utah's clinical site for the NIH-funded Childhood Liver Disease Research Network, a network established to find new treatments for liver diseases that affect infants, children, and adolescents (

Dr. Guthery’s research also focuses on genome sequencing using novel analytical tools such as VAAST to better understand how genomic variation contributes to liver and GI diseases affecting infants and children. Diseases currently under study include childhood-onset Crohn disease and ulcerative colitis, undiagnosed immune-mediated disease of the GI tract, and undiagnosed liver disease.


Education History

Type School Degree
Graduate Training University of Cincinnati
Fellowship Cincinnati Children's Hospital Medical Center
Pediatric Gastroenterology, Hepatology, and Nutrition
Residency Cincinnati Children's Hospital Medical Center
Professional Medical Oregon Health Sciences University
Undergraduate Lewis and Clark College


Selected Provider Publications

Journal Article

  1. Lascurain L, Jensen MK, Guthery SL, Holmen J, Deneau M (2016). Inflammatory Bowel Disease Phenotype in Pediatric Primary Sclerosing Cholangitis. Inflamm Bowel Dis, 22(1), 146-50.
  2. Li YR, Zhao SD, Li J, Bradfield JP, Mohebnasab M, Steel L, Kobie J, Abrams DJ, Mentch FD, Glessner JT, Guo Y, Wei Z, Connolly JJ, Cardinale CJ, Bakay M, Li D, Maggadottir SM, Thomas KA, Qui H, Chiavacci RM, Kim CE, Wang F, Snyder J, Flato B, Forre O, Denson LA, Thompson SD, Becker ML, Guthery SL, Latiano A, Perez E, Resnick E, Strisciuglio C, Staiano A, Miele E, Silverberg MS, Lie BA, Punaro M, Russell RK, Wilson DC, Dubinsky MC, Monos DS, Annese V, Munro JE, Wise C, Chapel H, Cunningham-Rundles C, Orange JS, Behrens EM, Sullivan KE, Kugathasan S, Griffiths AM, Satsangi J, Grant SF, Sleiman PM, Finkel TH, Polychronakos C, Baldassano RN, Luning Prak ET, Ellis JA, Li H, Keating BJ, Hakonarson H (2015). Genetic sharing and heritability of paediatric age of onset autoimmune diseases. Nat Commun, 6, 8442.
  3. Hu H, Roach JC, Coon H, Guthery SL, Voelkerding KV, Margraf RL, Durtschi JD, Tavtigian SV, Shankaracharya, Wu W, Scheet P, Wang S, Xing J, Glusman G, Hubley R, Li H, Garg V, Moore B, Hood L, Galas DJ, Srivastava D, Reese MG, Jorde LB, Yandell M, Huff CD (2014). A unified test of linkage analysis and rare-variant association for analysis of pedigree sequence data. Nat Biotechnol, 32(7), 663-9.
  4. Singleton MV, Guthery SL, Voelkerding KV, Chen K, Kennedy B, Margraf RL, Durtschi J, Eilbeck K, Reese MG, Jorde LB, Huff CD, Yandell M (2014). Phevor combines multiple biomedical ontologies for accurate identification of disease-causing alleles in single individuals and small nuclear families. Am J Hum Genet, 94(4), 599-610.
  5. Liu R, Cox K, Guthery SL, Book L, Witt B, Chadwick B, Adler DG (2014). Cholangiocarcinoma and high-grade dysplasia in young patients with primary sclerosing cholangitis. Dig Dis Sci, 59(9), 2320-4.
  6. Deneau M, Book LS, Guthery SL, Jensen MK (2014). Outcome after discontinuation of immunosuppression in children with autoimmune hepatitis: a population-based study. J Pediatr, 164(4), 714-719.e2.
  7. Walters TD, Kim MO, Denson LA, Griffiths AM, Dubinsky M, Markowitz J, Baldassano R, Crandall W, Rosh J, Pfefferkorn M, Otley A, Heyman MB, LeLeiko N, Baker S, Guthery SL, Evans J, Ziring D, Kellermayer R, Stephens M, Mack D, Oliva-Hemker M, Patel AS, Kirschner B, Moulton D, Cohen S, Kim S, Liu C, Essers J, Kugathasan S, Hyams JS (2014). Increased effectiveness of early therapy with anti-tumor necrosis factor-alpha vs an immunomodulator in children with Crohn's disease. Gastroenterology, 146(2), 383-91.
  8. Deneau M, Jensen MK, Holmen J, Williams MS, Book LS, Guthery SL (2013). Primary sclerosing cholangitis, autoimmune hepatitis, and overlap in Utah children: epidemiology and natural history. Hepatology, 58(4), 1392-400.
  9. Huff CD, Witherspoon DJ, Zhang Y, Gatenbee C, Denson LA, Kugathasan S, Hakonarson H, Whiting A, Davis CT, Wu W, Xing J, Watkins WS, Bamshad MJ, Bradfield JP, Bulayeva K, Simonson TS, Jorde LB, Guthery SL (01/01/2012). Crohn's disease and genetic hitchhiking at IBD5. Mol Biol Evol, 29(1), 101-11.
  10. Guthery SL, Mineau G, Pimentel R, Williams MS, Kerber RA (2011). Inflammatory bowel disease aggregation in Utah kindreds. Inflamm Bowel Dis, 17(3), 823-30.
  11. Moore JC, Thompson K, Lafleur B, Book LS, Jackson WD, OGorman MA, Black RE, Downey E Jr, Johnson DG, Matlak ME, Meyers RL, Scaife E, Guthery SL (2011). Clinical variables as prognostic tools in pediatric-onset ulcerative colitis: a retrospective cohort study. Inflamm Bowel Dis, 17(1), 15-21.
  12. Anderson CA, Boucher G, Lees CW, Franke A, DAmato M, Taylor KD, Lee JC, Goyette P, Imielinski M, Latiano A, Lagace C, Scott R, Amininejad L, Bumpstead S, Baidoo L, Baldassano RN, Barclay M, Bayless TM, Brand S, Buning C, Colombel JF, Denson LA, De Vos M, Dubinsky M, Edwards C, Ellinghaus D, Fehrmann RS, Floyd JA, Florin T, Franchimont D, Franke L, Georges M, Glas J, Glazer NL, Guthery SL, Haritunians T, Hayward NK, Hugot JP, Jobin G, Laukens D, Lawrance I, Lemann M, Levine A, Libioulle C, Louis E, McGovern DP, Milla M, Montgomery GW, Morley KI, Mowat C, Ng A, Newman W, Ophoff RA, Papi L, Palmieri O, Peyrin-Biroulet L, Panes J, Phillips A, Prescott NJ, Proctor DD, Roberts R, Russell R, Rutgeerts P, Sanderson J, Sans M, Schumm P, Seibold F, Sharma Y, Simms LA, Seielstad M, Steinhart AH, Targan SR, van den Berg LH, Vatn M, Verspaget H, Walters T, Wijmenga C, Wilson DC, Westra HJ, Xavier RJ, Zhao ZZ, Ponsioen CY, Andersen V, Torkvist L, Gazouli M, Anagnou NP, Karlsen TH, Kupcinskas L, Sventoraityte J, Mansfield JC, Kugathasan S, Silverberg MS, Halfvarson J, Rotter JI, Mathew CG, Griffiths AM, Gearry R, Ahmad T, Brant SR, Chamaillard M, Satsangi J, Cho JH, Schreiber S, Daly MJ, Barrett JC, Parkes M, Annese V, Hakonarson H, Radford-Smith G, Duerr RH, Vermeire S, Weersma RK, Rioux JD (2011). Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet, 43(3), 246-52.
  13. Huff CD, Witherspoon DJ, Simonson TS, Xing J, Watkins WS, Zhang Y, Tuohy TM, Neklason DW, Burt RW, Guthery SL, Woodward SR, Jorde LB (2011). Maximum-likelihood estimation of recent shared ancestry (ERSA). Genome Res, 21(5), 768-74.
  14. Deneau M, Adler DG, Schwartz JJ, Hutson W, Sorensen J, Book L, Lowichik A, Guthery S (2011). Cholangiocarcinoma in a 17-year-old boy with primary sclerosing cholangitis and inflammatory bowel disease. J Pediatr Gastroenterol Nutr, 52(5), 617-20.
  15. Franke A, McGovern DP, Barrett JC, Wang K, Radford-Smith GL, Ahmad T, Lees CW, Balschun T, Lee J, Roberts R, Anderson CA, Bis JC, Bumpstead S, Ellinghaus D, Festen EM, Georges M, Green T, Haritunians T, Jostins L, Latiano A, Mathew CG, Montgomery GW, Prescott NJ, Raychaudhuri S, Rotter JI, Schumm P, Sharma Y, Simms LA, Taylor KD, Whiteman D, Wijmenga C, Baldassano RN, Barclay M, Bayless TM, Brand S, Buning C, Cohen A, Colombel JF, Cottone M, Stronati L, Denson T, De Vos M, DInca R, Dubinsky M, Edwards C, Florin T, Franchimont D, Gearry R, Glas J, Van Gossum A, Guthery SL, Halfvarson J, Verspaget HW, Hugot JP, Karban A, Laukens D, Lawrance I, Lemann M, Levine A, Libioulle C, Louis E, Mowat C, Newman W, Panes J, Phillips A, Proctor DD, Regueiro M, Russell R, Rutgeerts P, Sanderson J, Sans M, Seibold F, Steinhart AH, Stokkers PC, Torkvist L, Kullak-Ublick G, Wilson D, Walters T, Targan SR, Brant SR, Rioux JD, DAmato M, Weersma RK, Kugathasan S, Griffiths AM, Mansfield JC, Vermeire S, Duerr RH, Silverberg MS, Satsangi J, Schreiber S, Cho JH, Annese V, Hakonarson H, Daly MJ, Parkes M (2010). Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet, 42(12), 1118-25.
  16. Nair RP, Duffin KC, Helms C, Ding J, Stuart PE, Goldgar D, Gudjonsson JE, Li Y, Tejasvi T, Feng BJ, Ruether A, Schreiber S, Weichenthal M, Gladman D, Rahman P, Schrodi SJ, Prahalad S, Guthery SL, Fischer J, Liao W, Kwok PY, Menter A, Lathrop GM, Wise CA, Begovich AB, Voorhees JJ, Elder JT, Krueger GG, Bowcock AM, Abecasis GR (2009). Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. Nat Genet, 41(2), 199-204.
  17. Xing J, Watkins WS, Witherspoon DJ, Zhang Y, Guthery SL, Thara R, Mowry BJ, Bulayeva K, Weiss RB, Jorde LB (2009). Fine-scaled human genetic structure revealed by SNP microarrays. Genome Res, 19(5), 815-25.
  18. Imielinski M, Baldassano RN, Griffiths A, Russell RK, Annese V, Dubinsky M, Kugathasan S, Bradfield JP, Walters TD, Sleiman P, Kim CE, Muise A, Wang K, Glessner JT, Saeed S, Zhang H, Frackelton EC, Hou C, Flory JH, Otieno G, Chiavacci RM, Grundmeier R, Castro M, Latiano A, Dallapiccola B, Stempak J, Abrams DJ, Taylor K, McGovern D, Silber G, Wrobel I, Quiros A, Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, Rioux JD, Brant SR, Silverberg MS, Taylor KD, Barmuda MM, Bitton A, Dassopoulos T, Datta LW, Green T, Griffiths AM, Kistner EO, Murtha MT, Regueiro MD, Rotter JI, Schumm LP, Steinhart AH, Targan SR, Xavier RJ, Libioulle C, Sandor C, Lathrop M, Belaiche J, Dewit O, Gut I, Heath S, Laukens D, Mni M, Rutgeerts P, Van Gossum A, Zelenika D, Franchimont D, Hugot JP, de Vos M, Vermeire S, Louis E, Cardon LR, Anderson CA, Drummond H, Nimmo E, Ahmad T, Prescott NJ, Onnie CM, Fisher SA, Marchini J, Ghori J, Bumpstead S, Gwillam R, Tremelling M, Delukas P, Mansfield J, Jewell D, Satsangi J, Mathew CG, Parkes M, Georges M, Daly MJ, Heyman MB, Ferry GD, Kirschner B, Lee J, Essers J, Grand R, Stephens M, Levine A, Piccoli D, Van Limbergen J, Cucchiara S, Monos DS, Guthery SL, Denson L, Wilson DC, Grant SF, Daly M, Silverberg MS, Satsangi J, Hakonarson H (2009). Common variants at five new loci associated with early-onset inflammatory bowel disease. Nat Genet, 41(12), 1335-40.
  19. Kugathasan S, Baldassano RN, Bradfield JP, Sleiman PM, Imielinski M, Guthery SL, Cucchiara S, Kim CE, Frackelton EC, Annaiah K, Glessner JT, Santa E, Willson T, Eckert AW, Bonkowski E, Shaner JL, Smith RM, Otieno FG, Peterson N, Abrams DJ, Chiavacci RM, Grundmeier R, Mamula P, Tomer G, Piccoli DA, Monos DS, Annese V, Denson LA, Grant SF, Hakonarson H (2008). Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease. Nat Genet, 40(10), 1211-5.
  20. Guthery SL, Salisbury BA, Pungliya MS, Stephens JC, Bamshad M (2007). The structure of common genetic variation in United States populations. Am J Hum Genet, 81(6), 1221-31.
  21. Bamshad M, Guthery SL (2007). Race, genetics and medicine: does the color of a leopard's spots matter? Curr Opin Pediatr, 19(6), 613-8.
  22. Guthery SL, Heubi JE, Filipovich A (2004). Enteral metronidazole for the prevention of graft versus host disease in pediatric marrow transplant recipients: results of a pilot study. Bone Marrow Transplant, 33(12), 1235-9.
  23. Guthery SL, Hutchings C, Dean JM, Hoff C (2004). National estimates of hospital utilization by children with gastrointestinal disorders: analysis of the 1997 kids' inpatient database. J Pediatr, 144(5), 589-94.
  24. Guthery SL, Pohl JF, Bucuvalas JC, Alonso MH, Ryckman FC, Balistreri WF, Heubi JE (2003). Bone mineral density in long-term survivors following pediatric liver transplantation. Liver Transpl, 9(4), 365-70.
  25. Guthery SL, Heubi JE, Bucuvalas JC, Gross TG, Ryckman FC, Alonso MH, Balistreri WF, Hornung RW (2003). Determination of risk factors for Epstein-Barr virus-associated posttransplant lymphoproliferative disorder in pediatric liver transplant recipients using objective case ascertainment. Transplantation, 75(7), 987-93.
  26. Guthery SL, Heubi JE (2001). Liver involvement in childhood histiocytic syndromes. Curr Opin Gastroenterol, 17(5), 474-8.


  1. Peterson N, Guthery S, Denson L, Lee J, Saeed S, Prahalad S, Biank V, Ehlert R, Tomer G, Grand R, Rudolph C, Kugathasan S (2008). Genetic variants in the autophagy pathway contribute to paediatric Crohn's disease [Letter to the editor]. Gut, 57(9), 1336-7; author reply 1337.

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