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John J. Ryan, M.D., FACC, FAHA

Specialties

Languages

  • English

Clinical Details

Schedule An Appointment Clinical Office Address
(801) 585-7676 University Hospital
Cardiovascular Center
50 N Medical Dr
Salt Lake City, UT 84132
Map

Bio

John J. Ryan MD, FACC. has an appointment in the Division of Cardiology and is an Assistant Professor in the Department of Internal Medicine. He has been on faculty at the University of Utah since 2013.

Dr. Ryan received his medical degree in University College Cork, Ireland. Dr. Ryan completed Internal Medicine Residency at Boston University Medical Center and served as Chief Medical Resident at Boston University. He completed his Fellowship in Cardiovascular Medicine at the University of Chicago. He also completed advanced training in pulmonary hypertension and research at the University of Chicago. Dr. Ryan’s clinical interests are in pulmonary hypertension, diastolic dysfunction, hypertension, and valvular disease, in particular mitral valve disease. Dr. Ryan is board certified in Internal Medicine and Cardiovascular Disease.

Dr. Ryan is the Director of the new Dyspnea Clinic at the University of Utah Division of Cardiology. This is the first clinic of its kind and currently the only Diastolic Dysfunction clinic in the Mountain West region.

Board Certification and Academic Information

Academic Departments Internal Medicine - Assistant Professor (Clinical)
Radiology - Adjunct Assistant Professor
Academic Divisions Cardiovascular Medicine
Clinical Radiology
Board Certification American Board of Internal Medicine
American Board of Internal Medicine (Sub: Cardiovascular Disease)

Academic Profile

Board Certification and Academic Information

Academic Departments Internal Medicine - Assistant Professor (Clinical)
Radiology - Adjunct Assistant Professor
Academic Divisions Cardiovascular Medicine
Clinical Radiology
Board Certification American Board of Internal Medicine
American Board of Internal Medicine (Sub: Cardiovascular Disease)

Academic Office Locations

Academic Office Phone Number Academic Office Address
(435) 678-3601 Blanding Family Practice
802 South 200 West
Blanding, UT 84511
(801) 585-7676 School of Medicine
Cardiology
30 N Medical Dr
Salt Lake City, UT 84132

Academic Bio

John J. Ryan MD, FACC. is a cardiologist with extensive training and experience in research investigation and clinical patient care. He has a special interest in pulmonary hypertension and diastolic dysfunction and has an appointment in the Division of Cardiology at the University of Utah.

Dr. Ryan is the Director of the new Dyspnea Clinic at the University of Utah Division of Cardiology. This is the first clinic of its kind and currently the only Diastolic Dysfunction clinic in the Mountain West. region.

Dr. Ryan has won more than ten university awards in Ireland, Boston and Chicago. He received Ireland’s prestigious Ceannt Medal, for ranking first in Ireland’s National High School exit exam. He was also an acknowledged scholar at University College Cork and in 2004 received their Blayney Medal for graduating at the top of his class from the University College Cork, School of Medicine. He was also awarded the Stewart Medal from the National University of Ireland in 2004 for being the among the highest ranking medical graduates in Ireland. In 2008, Dr. Ryan became a member of the Royal College of Physicians of Ireland (founded 1654).

After postgraduate training in Internal Medicine and General Surgery at Cork University Hospital in Cork, Ireland, he was moved to Boston University. Between 2005 and 2009 he trained in Boston in Internal Medicine, ultimately being selected as the Chief Resident for Boston University. In Boston, he received awards for humanism from Boston University and the Department of Medicine’s Faculty Teacher of the Year Award.

After Boston, Dr. Ryan moved to Chicago and completed a fellowship in Cardiovascular Medicine at the University of Chicago, where he served as Chief Cardiology Fellow. At the University of Chicago he was awarded Teaching Fellow of the Year from the Department of Medicine and was served on the Illinois-American College of Cardiology Board of Governors. After fellowship, he undertook advanced training in pulmonary hypertension and performed research involving mitochondria and oxygen sensing in pulmonary hypertension. For his work in pulmonary hypertension he was awarded the Cournand and Comroe Young Investigator Award from the American Heart Association in 2012.

Dr. Ryan has published more than 15 original scientific articles in prestigious, peer-reviewed, medical and scientific Journals. He also has published an additional 10 articles that are case reports, reviews or editorials. Dr. Ryan’s work appears in leading Cardio-Pulmonary Journals, including Circulation (impact factor >12), the American Journal of Respiratory Critical Care Medicine (impact factor >11), the International Journal of Cardiology (impact factor >7) and others. These publications relate to his research in Cardiology and Pulmonary Hypertension. Reflective of his reputation in the field of Pulmonary Hypertension, Dr. Ryan is co-organizing a bi-annual Grover meeting on the Pulmonary Circulation and Right Ventricle to be held in Colorado in 2013.

Dr. Ryan is on leadership committee for the American Heart Association’s national council for Functional Genomics and Translational Biology and works on the American College of Cardiology and Journal of the American College of Cardiology Digital Strategy Committee. In addition to his clinical and administrative responsibilities, Dr. Ryan is Associate Editor of the New England Journal of Medicine cardiology website, http://www.CardioExchange.org.

Education

Education History

Type School Degree
Research Fellow University of Chicago Medical Center
Advanced Cardiovascular
Research Fellow
Fellowship University of Chicago Medical Center
Cardiovascular
Fellow
Fellowship University of Chicago
Cardiology
Chief Fellow
Chief Resident Boston Medical Center
Internal Medicine
Chief Medical Resident
Residency Boston Medical Center
Internal Medicine
Resident
Internship Cork University Hospital
Internal Medicine and General Surgery
Intern
Professional Medical University College Cork, Ireland
Medicine
M.D.

Publications

Selected Provider Publications

Journal Article

  1. Harrison A, Wilson BD, Ryan JJ (2014). Exploring the Role of Aldosterone in Right Ventricular Function. Can J Cardiol, 30(2), 155-158.
  2. FOXO1-mediated upregulation of pyruvate dehydrogenase kinase-4 (PDK4) decreases glucose oxidation and impairs right ventricular function in pulmonary hypertension: therapeutic benefits of dichloroacetate.Piao L, Sidhu VK, Fang YH, Ryan JJ, Parikh KS, Hong Z, Toth PT, Morrow E, Kutty S, Lopaschuk GD, Archer SL (2013). FOXO1-mediated upregulation of pyruvate dehydrogenase kinase-4 (PDK4) decreases glucose oxidation and impairs right ventricular function in pulmonary hypertension: therapeutic benefits of dichloroacetate. J Mol Med (Berl), 91(3), 333-46.
  3. Piao L, Fang YH, Parikh K, Ryan JJ, Toth PT, Archer SL (06/06/2013). Cardiac glutaminolysis: a maladaptive cancer metabolism pathway in the right ventricle in pulmonary hypertension. Journal of Molecular Medicine, 91(10), 1185-1197.
  4. Piao L, Fang YH, Parikh K, Ryan JJ, Toth PT, Archer SL (06/06/2013). Cardiac glutaminolysis: a maladaptive cancer metabolism pathway in the right ventricle in pulmonary hypertension. J Mol Med.
  5. Kim GH, Ryan JJ, Archer SL (03/01/2013). Epigenetics in Cardiovascular Medicine (ahead of print). Antioxid Redox Signal.
  6. Ryan JJ, Marsboom G, Fang YH, Toth PT, Morrow E, Luo N, Piao L, Hong Z, Zhang HJ, Haney C, Chen CT, Sharp W, Archer SL (02/28/2013). Mitofusion-2 deficiency promotes smooth muscle cell proliferation and mitofusin-2 gene therapy regresses experimental pulmonary arterial hypertension in females. Am J Respir Crit Care Med.
  7. Hong Z, Kutty S, Toth PT, Marsboom G, Hammel JM, Chamberlain C, Ryan JJ, Zhang HJ, Sharp WW, Morrow E, Trivedi K, Weir EK, Archer SL (03/1/2013). Role of dynamin-related protein 1 (drp1)-mediated mitochondrial fission in oxygen sensing and constriction of the ductus arteriosus. Circ Res, 112(5), 802-15.
  8. Lung (1)(8)F-fluorodeoxyglucose positron emission tomography for diagnosis and monitoring of pulmonary arterial hypertension.Marsboom G, Wietholt C, Haney CR, Toth PT, Ryan JJ, Morrow E, Thenappan T, Bache-Wiig P, Piao L, Paul J, Chen CT, Archer SL (2012). Lung (1)(8)F-fluorodeoxyglucose positron emission tomography for diagnosis and monitoring of pulmonary arterial hypertension. Am J Respir Crit Care Med, 185(6), 670-9.
  9. Stress-only imaging in patients with prior SPECT MPI: a simulation study.Ryan JJ, Mehta R, Thiruvoipati T, Ward RP, Williams KA (2012). Stress-only imaging in patients with prior SPECT MPI: a simulation study. J Nucl Cardiol, 19(2), 311-8.
  10. Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension.Marsboom G, Toth PT, Ryan JJ, Hong Z, Wu X, Fang YH, Thenappan T, Piao L, Zhang HJ, Pogoriler J, Chen Y, Morrow E, Weir EK, Rehman J, Archer SL (2012). Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension. Circ Res, 110(11), 1484-97.
  11. Current practice for determining pulmonary capillary wedge pressure predisposes to serious errors in the classification of patients with pulmonary hypertension.Ryan JJ, Rich JD, Thiruvoipati T, Swamy R, Kim GH, Rich S (2012). Current practice for determining pulmonary capillary wedge pressure predisposes to serious errors in the classification of patients with pulmonary hypertension. Am Heart J, 163(4), 589-94.
  12. The WHO classification of pulmonary hypertension: A case-based imaging compendium.Ryan JJ, Thenappan T, Luo N, Ha T, Patel AR, Rich S, Archer SL (2012). The WHO classification of pulmonary hypertension: A case-based imaging compendium. Pulm Circ, 2(1), 107-21.
  13. Piao L, Fang YH, Parikh KS, Ryan JJ, DSouza KM, Theccanat T, Toth PT, Pogoriler J, Paul J, Blaxall BC, Akhter SA, Archer SL (12/01/2012).

    GRK2-mediated inhibition of adrenergic and dopaminergic signaling in right ventricular hypertrophy: therapeutic implications in pulmonary hypertension.

    . Circulation, 126(24), 2859-69.
  14. Epigenetic mechanisms of pulmonary hypertension.Kim GH, Ryan JJ, Marsboom G, Archer SL (2011). Epigenetic mechanisms of pulmonary hypertension. Pulm Circ, 1(3), 347-56.
  15. G-protein beta3 subunit polymorphism and bleeding in the orbofiban in patients with unstable coronary syndromes-thrombolysis in myocardial infarction 16 trial.Maree AO, Vangjeli C, Jneid H, Ryan J, Cox D, Cannon CP, Shields DC, Fitzgerald DJ (2010). G-protein beta3 subunit polymorphism and bleeding in the orbofiban in patients with unstable coronary syndromes-thrombolysis in myocardial infarction 16 trial. J Thromb Haemost, 8(5), 934-41.
  16. SPECT myocardial perfusion imaging with prone-only acquisitions: correlation with coronary angiography.Shin JH, Pokharna HK, Williams KA, Mehta R, Ward RP (2009). SPECT myocardial perfusion imaging with prone-only acquisitions: correlation with coronary angiography. J Nucl Cardiol, 16(4), 590-6.
  17. Vacuolar leucoencephalopathy and pulvinar sign in association with coeliac disease.LID - bcr08.2008.0650 [pii]Ryan AM, Ryan J, Wan-Ahmed M, Hardiman O, Farrell MA, McNamara B, Sweeney BJ (2009). Vacuolar leucoencephalopathy and pulvinar sign in association with coeliac disease.LID - bcr08.2008.0650 [pii]. BMJ Case Rep, 2009.
  18. Ryan JJ, Ryan A, McGrath E (2004). Is Secondary Care Paediatrics Evidenced Based? An Evaluation in a County Hospital. National Institute of Health Sciences. Research Bulletin, 2/3, 3.

Review

  1. Rodent models of pulmonary hypertension: harmonisation with the world health organisation's categorisation of human PH.Ryan J, Bloch K, Archer SL (2011). Rodent models of pulmonary hypertension: harmonisation with the world health organisation's categorisation of human PH. [Review]. Int J Clin Pract Suppl, (172), 15-34.
  2. The field of tissue injury in the lung and airway.Steiling K, Ryan J, Brody JS, Spira A (2008). The field of tissue injury in the lung and airway. [Review]. Cancer Prev Res (Phila), 1(6), 396-403.

Book Chapter

  1. Ryan JJ, Archer S (2013). Pulmonary Hypertension: Animal Models. In Humbert M, Evgenov OV, Stasch JP (Ed.), Pharmacotherapy of Pulmonary Hypertension (Chapter 5).
  2. Archer SL, Ryan JJ, Rich S, Nathan S, Tsai K, Patel AR, Fang Yh, Piao L (2012). The Right Ventricle: Reemergence of the Forgotten Ventricle. In Joseph A. Hill and Eric N. Olson (Ed.), Muscle: Fundamental Biology and Mechanisms of Disease (CHAPTER 38).
  3. Gomberg-Maitland M, Thenappan T, Ryan J, Cipriani N, Hussain A, Fedson S, Archer SL (2011). Cor Pulmonale. In Yuan JXJ, Garcia JGN , Hales CA, Stuart R, Archer SL, West JB (Ed.), Textbook of Pulmonary Vasular Disease (CHAPTER 97).
  4. Archer SL, Ryan J (2011). Mitochondrial ROS and Redox State in Pulmonary Vascular O2 sensing. In Yuan JXJ, Garcia JGN , Hales CA, Stuart R, Archer SL, West JB (Ed.), Textbook of Pulmonary Vasular Disease (CHAPTER 19).

Case Report

  1. Sudden cardiac death due to large coronary aneurysm successfully treated with a covered stent and ChromaFlo guidance.Ryan JJ, Swamy RS, Shah AP (2011). Sudden cardiac death due to large coronary aneurysm successfully treated with a covered stent and ChromaFlo guidance. J Invasive Cardiol, 23(2), E22-5.
  2. Ryan AM, Ryan JJ, Wan-Ahmed M, Hardiman O, Farrell MA, McNamara B, Sweeney BJ (2007). Vacuolar leucoencephalopathy and pulvinar sign in association with coeliac disease. J Neurol Neurosurg Psychiatry, 78(1), 98-9.

Editorial

  1. Transitioning Between Endothelin Receptor Blockers: Monitoring to Ensure a Smooth Transition.LID - S0828-282X(12)00339-X [pii]LID - 10.1016/j.cjca.2012.07.006 [doi]Luo N, Ryan JJ (2012). Transitioning Between Endothelin Receptor Blockers: Monitoring to Ensure a Smooth Transition.LID - S0828-282X(12)00339-X [pii]LID - 10.1016/j.cjca.2012.07.006 [doi]. Can J Cardiol.
  2. Thenappan T, Ryan JJ, Archer SL (2012). Evolving Epidemiology of Pulmonary Arterial Hypertension. Am. J. Respir. Crit. Care Med, 186, 707-709.
  3. Paracrine proliferative signaling by senescent cells in world health organization group 3 pulmonary hypertension: age corrupting youth?Ryan JJ, Rehman J, Archer SL (2011). Paracrine proliferative signaling by senescent cells in world health organization group 3 pulmonary hypertension: age corrupting youth? Circ Res, 109(5), 476-9.
  4. Pulmonary endarterectomy surgery--a technically demanding cure for WHO Group IV Pulmonary Hypertension: requirements for centres of excellence and availability in Canada.Ryan JJ, Rich S, Archer SL (2011). Pulmonary endarterectomy surgery--a technically demanding cure for WHO Group IV Pulmonary Hypertension: requirements for centres of excellence and availability in Canada. The Canadian Journal of Cardiology, 27(6), 671-4.

Letter

  1. A KCNE1 missense variant (V47I) causing exercise-induced long QT syndrome (Romano Ward).Ryan JJ, Kalscheur M, Dellefave L, McNally E, Archer SL (2012). A KCNE1 missense variant (V47I) causing exercise-induced long QT syndrome (Romano Ward) [Letter to the editor]. Int J Cardiol, 156(2), e33-5.
  2. Vacuolar leucoencephalopathy and pulvinar sign in association with coeliac disease.Ryan AM, Ryan J, Wan-Ahmed M, Hardiman O, Farrell MA, McNamara B, Sweeney BJ (2007). Vacuolar leucoencephalopathy and pulvinar sign in association with coeliac disease [Letter to the editor]. J Neurol Neurosurg Psychiatry, 78(1), 98-9.

Other

  1. Ryan JJ (2004). Author of several hundred columns for the 'weekly column' of Ireland's leading medical newspapers. Medicine Weekly and Irish Medical Times.

Video/Film/CD/Web/Podcast

  1. Ryan JJ (2012). Digital Business Strategy [Web]. American College of Cardiology.
  2. Ryan JJ (2012). Usability Project, Fellows-In-Training representative [Web]. CardioSource.

Clinical Trials

Clinical Trials

  • PITCH-HF
    Keywords: Heart Failure, Left Ventricular Dysfunction, Pulmonary Hypertension, Tadalafil, Phosphodiesterase Type 5 Inhibition
    Status: Not yet recruiting Principal Investigator: Jose Nativi-Nicolau
  • NEAT HFpEF
    Keywords: Heart Failure, Preserved Ejection Fraction, HFpEF, Nitrates, Activity Tolerance
    Status: Not yet recruiting Principal Investigator: Jose Nativi-Nicolau

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