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Kevin B. Jones, M.D.

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Clinical Details

Phone Number Clinical Office Address
(801) 585-0262
Huntsman Cancer Institute
Clinic 2E, Sarcoma
2000 Circle of Hope
Salt Lake City, UT 84112
Map
(801) 285-1440
PCH Outpatient Services at Riverton
3773 West 12600 South
Riverton, UT 84065
(801) 662-5600
Primary Children's Hospital
Pediatric Orthopaedics
100 N Mario Capecchi Drive , Suite 4550
Salt Lake City, UT 84113

Bio

Specializing in the evaluation, diagnosis, and surgical management of sarcomas, tumors arising in bone and soft-tissue, Dr. Jones sees both pediatric and adult patients. His practice also includes surgery for benign bone tumors such as giant cell tumor of bone, chondromyxoid fibroma, osteochondromas, and others as well as stabilization of the bones with metastatic disease from other cancers causing pathologic fractures or impending fractures. Children and adults in need of resection and reconstruction, (often termed limb-salvage surgery) for osteosarcoma, Ewing's sarcoma, chondrosarcoma, synovial sarcoma, liposarcoma, and leiomyosarcoma of the extremities and pelvis come from all across the mountain west to see Dr. Jones and the multidisciplinary team approach used by Sarcoma Services at the Huntsman Cancer Institute. Weekly meetings bring together surgeons, chemotherapy specialists, radiation oncologists, pathologists, radiologists, and other providers to discuss every new case of sarcoma. Dr. Jones emphasizes clear communication and educates and empowers patients to make wise choices with regard to their cancer care. He studied English literature at Harvard and received his medical degree from Johns Hopkins University. After orthopaedic residency training at the University of Iowa, he specialized in musculoskeletal oncology through fellowship training at the University of Toronto, Mount Sinai and Princess Margaret Hospitals.

Board Certification and Academic Information

Academic Departments Orthopaedics - Associate Professor
Oncological Sciences - Adjunct Associate Professor
Board Certification American Board of Orthopedic Surgery
Cancer Center Programs Nuclear Control of Cell Growth & Differentiation

Academic Profile

Research Interests

  • Sarcoma, Synovial
  • Osteosarcoma
  • Sarcoma
  • Soft Tissue Sarcomas
  • Sarcoma, Clear Cell
  • Mouse Models
  • Chondrosarcoma
  • Ewing's Sarcoma

Board Certification and Academic Information

Academic Departments Orthopaedics - Associate Professor
Oncological Sciences - Adjunct Associate Professor
Board Certification American Board of Orthopedic Surgery
Cancer Center Programs Nuclear Control of Cell Growth & Differentiation

Academic Office Locations

Academic Office Phone Number Academic Office Address
(801) 585-0300 Huntsman Cancer Institute
Sarcoma Services
2000 Circle of Hope
Salt Lake City, UT 84112

Academic Bio

Supported by a K08 award from the National Cancer Institute, I studied mouse genetic modeling under the mentorship of Mario R. Capecchi, PhD, during my first 5 years at the University of Utah. My laboratory's move to independent space in the Huntsman Cancer Institute took place in July 2013. I continue to study cancer biology with a focus on sarcomagenesis, or the initiating steps of connective tissue malignancies. This work focuses on conditional activation of translocation-associated fusion oncogenes as well as conditional inactivation of a variety of tumor suppressors. We utilize transposon-mediated insertional mutagenesis to identify critical pathways with somatic forward genetic screens. Specifically in my growing independent program, we focus on the epigenetics of sarcomagenesis, impacted by fusion oncogenes. Current models under investigation in the laboratory include synovial sarcoma, Ewing’s sarcoma, osteosarcoma, chondrosarcoma, clear cell sarcoma, and alveolar soft-part sarcoma. Identification of therapeutic targets is a central goal in each project.

Research Statement

With 80 percent protected time for academic pursuits, and an independent laboratory at the Huntsman Cancer Institute, I focus most of my research on dissecting the genetic and epigenetic underpinnings of sarcoma initiation. Although sarcomas are rare cancers, the tissues which give rise to sarcomas when they become cancerous are the predominant tissues in the human body, the muscles, tendons, bones, vessels, fat, etc. These tissues derive from mesenchyme or mesoderm. While many organ-based cancer cells gain some characteristics of mesenchyme or mesoderm as they become malignant, turning mesenchyme itself into cancer is much more difficult. The intrinsic resistance to transformation (the process of becoming cancerous) in mesenchyme has brought particular focus to any factor capable of overcoming that resistance and forming cancers from connective tissues.Thus, sarcomas--not only in spite of, but actually because of their low frequency in the general population--have played a central role in the fundamental discoveries of cancer biology. For example, radium dial painters developing osteosarcomas led to the discovery that radiation causes cancer. Oncogenes, the tumor causing genes, were discovered by study of a virus that caused sarcomas in birds. Tumor suppressor genes, the genes that when turned off lead to cancer, were discovered because families had too many sarcomas (Even two is way too common in any one family!) We therefore pursue sarcoma biology vigorously not only because we need to generate better treatment strategies for this horrible group of cancers that impacts young people disproportionately, but also because sarcoma will likely yet teach us much more about cancer biology in general, especially its beginnings.

Education

Education History

Type School Degree
Other Training Mario Capecchi Laboratory, University of Utah
Mentored Scientific Training-Mouse Genetic Modeling of Sarcoma
Fellowship Mount Sinai Hospital
Musculoskeletal Oncology
Fellow
Residency University of Iowa Hospitals and Clinics
Orthopaedic Surgery
Resident
Professional Medical Johns Hopkins University
Medicine
M.D.
Undergraduate Harvard University
English and American Literature and Language
A.B.

Publications

Selected Provider Publications

Journal Article

  1. Jones KB, Barrott JJ, Xie M, Haldar M, Jin H, Zhu JF, Monument MJ, Mosbruger TL, Langer EM, Randall RL, Wilson RK, Cairns BR, Ding L, Capecchi MR (2016). The impact of chromosomal translocation locus and fusion oncogene coding sequence in synovial sarcomagenesis.LID - 10.1038/onc.2016.38 [doi]. (Epub ahead of print) Oncogene.
  2. Barrott JJ, Illum BE, Jin H, Zhu JF, Mosbruger T, Monument MJ, Smith-Fry K, Cable MG, Wang Y, Grossmann AH, Capecchi MR, Jones KB (2015). beta-catenin stabilization enhances SS18-SSX2-driven synovial sarcomagenesis and blocks the mesenchymal to epithelial transition. Oncotarget, 6(26), 22758-66.
  3. de Andrea CE, Zhu JF, Jin H, Bovee JV, Jones KB (2015). Cell cycle deregulation and mosaic loss of Ext1 drive peripheral chondrosarcomagenesis in the mouse and reveal an intrinsic cilia deficiency. J Pathol, 236(2), 210-8.
  4. Jones KB (2015). Transposon mutagenesis disentangles osteosarcoma genetic drivers. Nat Genet, 47(6), 564-5.
  5. Quist T, Jin H, Zhu JF, Smith-Fry K, Capecchi MR, Jones KB (2015). The impact of osteoblastic differentiation on osteosarcomagenesis in the mouse. Oncogene, 34(32), 4278-84.
  6. Monument MJ, Bernthal NM, Bowles AJ, Jones KB, Randall RL (2015). What are the 5-year survivorship outcomes of compressive endoprosthetic osseointegration fixation of the femur? Clin Orthop Relat Res, 473(3), 883-90.
  7. Goodwin ML, Jin H, Straessler K, Smith-Fry K, Zhu JF, Monument MJ, Grossmann A, Randall RL, Capecchi MR, Jones KB (2014). Modeling alveolar soft part sarcomagenesis in the mouse: a role for lactate in the tumor microenvironment. Cancer Cell, 26(6), 851-62.
  8. Jones KB, Datar M, Ravichandran S, Jin H, Jurrus E, Whitaker R, Capecchi MR (2013). Toward an understanding of the short bone phenotype associated with multiple osteochondromas. J Orthop Res, 31(4), 651-7.
  9. Straessler KM, Jones KB, Hu H, Jin H, van de Rijn M, Capecchi MR (2013). Modeling clear cell sarcomagenesis in the mouse: cell of origin differentiation state impacts tumor characteristics. Cancer Cell, 23(2), 215-27.
  10. Jones KB, Su L, Jin H, Lenz C, Randall RL, Underhill TM, Nielsen TO, Sharma S, Capecchi MR (2013). SS18-SSX2 and the mitochondrial apoptosis pathway in mouse and human synovial sarcomas. Oncogene, 32(18), 2365-71, 2375.e1-5.
  11. Jones KB, Salah Z, Del Mare S, Galasso M, Gaudio E, Nuovo GJ, Lovat F, LeBlanc K, Palatini J, Randall RL, Volinia S, Stein GS, Croce CM, Lian JB, Ageilan RI (04/01/2012). miRNA signatures associate with pathogenesis and progression of osteosarcoma. Cancer Res, 72(7), 1865-77.
  12. Jones KB, Ferguson PC, Lam B, Biau DJ, Hopyan S, Deheshi B, Griffin AM, White LM, Wunder JS (2012). Effects of neoadjuvant chemotherapy on image-directed planning of surgical resection for distal femoral osteosarcoma. J Bone Joint Surg Am, 94(15), 1399-405.
  13. Su L, Sampaio AV, Jones KB, Pacheco M, Goytain A, Lin S, Poulin N, Yi L, Rossi FM, Kast J, Capecchi MR, Underhill TM, Nielsen TO (2012). Deconstruction of the SS18-SSX fusion oncoprotein complex: insights into disease etiology and therapeutics. Cancer Cell, 21(3), 333-47.
  14. Israelsen RB, Ilium BE, Crabtree S, Randall RL, Jones KB (2011). Extremity sarcoma surgery in younger children: ten years of patients ten years and under. Iowa Orthop J, 31, 145-53.
  15. Jones KB, Schiffman JD, Kohlmann W, Randall RL, Lessnick SL, Cannon-Albright LA (2011). Complex genotype sarcomas display familial inheritance independent of known cancer predisposition syndromes. Cancer Epidemiol Biomarkers Prev, 20(5), 751-7.
  16. Jones KB, Piombo V, Searby C, Kurriger G, Yang B, Grabellus F, Roughley PJ, Morcuende JA, Buckwalter JA, Capecchi MR, Vortkamp A, Sheffield VC (2010). A mouse model of osteochondromagenesis from clonal inactivation of Ext1 in chondrocytes. Proc Natl Acad Sci U S A, 107(5), 2054-9.
  17. Jones KB (2007). Reliability of histopathologic and radiologic grading of cartilaginous neoplasms in long bones [Skeletal Lesion Interobserver Correlation among Expert Diagnosticians (SLICED) Study Group ]. J Bone Joint Surg Am, 89(10), 2113-2123.

Global Impact

Global Impact

Education History

Type School Degree Country
Fellowship Mount Sinai Hospital
Musculoskeletal Oncology
Fellow Canada

Career

Institution Description Country
Mount Sinai and Princess Margaret Hospitals Musculoskeletal Oncology Fellow Canada

Clinical Trials

Video & News

Video