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Kevin B. Jones, M.D.

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Clinical Details

Schedule An Appointment Clinical Office Address
(801) 585-0262 Huntsman Cancer Institute
Clinic 2E, Sarcoma
2000 Circle of Hope
Salt Lake City, UT 84112
Map
(801) 285-1440 PCH Outpatient Services at Riverton
3773 West 12600 South
Riverton, UT 84065
(801) 662-5600 Primary Children's Hospital
Pediatric Orthopaedics
100 N Mario Capecchi Drive , Suite 4550
Salt Lake City, UT 84113

Bio

Specializing in the evaluation, diagnosis, and surgical management of sarcomas, tumors arising in bone and soft-tissue, Dr. Jones sees both pediatric and adult patients. His practice also includes surgery for benign bone tumors such as giant cell tumor of bone, chondromyxoid fibroma, osteochondromas, and others as well as stabilization of the bones with metastatic disease from other cancers causing pathologic fractures or impending fractures. Children and adults in need of resection and reconstruction for osteosarcoma, Ewing's sarcoma, chondrosarcoma, synovial sarcoma, liposarcoma, and leiomyosarcoma of the extremities and pelvis come from all across the mountain west to see Dr. Jones and the multidisciplinary team approach used by Sarcoma Services at the Huntsman Cancer Institute. Weekly meetings bring together surgeons, chemotherapy specialists, radiation oncologists, pathologists, radiologists, and other providers to discuss every new case of sarcoma. Dr. Jones emphasizes clear communication and educates and empowers patients to make wise choices with regard to their cancer care. He studied English literature at Harvard and received his medical degree from Johns Hopkins University. After orthopaedic residency training at the University of Iowa, he specialized in musculoskeletal oncology through fellowship training at the University of Toronto, Mount Sinai and Princess Margaret Hospitals.

Board Certification and Academic Information

Academic Departments Orthopaedics - Assistant Professor
Board Certification American Board of Orthopedic Surgery
Cancer Center Programs Nuclear Control of Cell Growth & Differentiation

Academic Profile

Research Interests

  • Mouse Models
  • Sarcoma, Clear Cell
  • Soft Tissue Sarcomas
  • Sarcoma, Synovial
  • Ewing's Sarcoma
  • Sarcoma
  • Chondrosarcoma
  • Osteosarcoma

Board Certification and Academic Information

Academic Departments Orthopaedics - Assistant Professor
Board Certification American Board of Orthopedic Surgery
Cancer Center Programs Nuclear Control of Cell Growth & Differentiation

Academic Office Locations

Academic Office Phone Number Academic Office Address
(801) 585-0300 Huntsman Cancer Institute
Sarcoma Services
2000 Circle of Hope
Salt Lake City, UT 84112

Academic Bio

Supported by a K08 award, I have been a surgeon-scientist under the mentorship of Mario R. Capecchi, PhD. My laboratory's move to independent space in the Huntsman Cancer Institute took place in July 2013. As a junior faculty member embedded with the Capecchi Genetics Laboratory for a training period of 5 years, I directed the sarcoma-related efforts underway with a variety of mouse genetic models. Investigation for each of these continues under my now independent research program. This work focuses on conditional activation of translocation-associated fusion oncogenes as well as conditional inactivation of a variety of tumor suppressors. We utilize transposon-mediated insertional mutagenesis to identify critical pathways with somatic forward genetic screens. Specifically in my growing independent program, we focus on the epigenetics of sarcomagenesis, impacted by fusion oncogenes. Current models under investigation in the laboratory include synovial sarcoma, Ewing’s sarcoma, osteosarcoma, chondrosarcoma, clear cell sarcoma, and alveolar soft-part sarcoma. Identification of therapeutic targets is a central goal in each project.

Education

Education History

Type School Degree
Fellowship Mount Sinai Hospital
Musculoskeletal Oncology
Fellow
Residency University of Iowa Hospitals and Clinics
Orthopaedic Surgery
Resident
Professional Medical Johns Hopkins University
Medicine
M.D.
Undergraduate Harvard University
English and American Literature and Language
A.B.

Publications

Selected Provider Publications

Journal Article

  1. Monument MJ, Jones KB (2014). Molecular characterization of bone tumors and implications for treatment and prognosis. J Natl Compr Canc Netw, 12(2), 214-20.
  2. Kafchinski LA, Jones KB (2014). MicroRNAs in Osteosarcomagenesis. Adv Exp Med Biol, 804, 119-27.
  3. Monument MJ, Bernthal NM, Bowles AJ, Jones KB, Randall RL (2014). What Are the 5-year Survivorship Outcomes of Compressive Endoprosthetic Osseointegration Fixation of the Femur? Clin Orthop Relat Res.
  4. Jones KB, Su L, Jin H, Lenz C, Randall RL, Underhill TM, Nielsen TO, Sharma S, Capecchi MR (2013). SS18-SSX2 and the mitochondrial apoptosis pathway in mouse and human synovial sarcomas. Oncogene, 32(18), 2365-71, 2375.e1-5.
  5. Jones KB, Datar M, Ravichandran S, Jin H, Jurrus E, Whitaker R, Capecchi MR (2013). Toward an understanding of the short bone phenotype associated with multiple osteochondromas. J Orthop Res, 31(4), 651-7.
  6. Straessler KM, Jones KB, Hu H, Jin H, van de Rijn M, Capecchi MR (2013). Modeling clear cell sarcomagenesis in the mouse: cell of origin differentiation state impacts tumor characteristics. Cancer Cell, 23(2), 215-27.
  7. Price SL, Farukhi MA, Jones KB, Aoki SK, Randall RL (2013). Complications of cemented long-stem hip arthroplasty in metastatic bone disease revisited. Clin Orthop Relat Res, 471(10), 3303-7.
  8. Su L, Sampaio AV, Jones KB, Pacheco M, Goytain A, Lin S, Poulin N, Yi L, Rossi FM, Kast J, Capecchi MR, Underhill TM, Nielsen TO (2012). Deconstruction of the SS18-SSX fusion oncoprotein complex: insights into disease etiology and therapeutics. Cancer Cell, 21(3), 333-47.
  9. de Andrea CE, Kroon HM, Wolterbeek R, Romeo S, Rosenberg AE, De Young BR, Liegl B, Inwards CY, Hauben E, McCarthy EF, Idoate M, Athanasou NA, Jones KB, Hogendoorn PC, Bovee JV (2012). Interobserver reliability in the histopathological diagnosis of cartilaginous tumors in patients with multiple osteochondromas. Mod Pathol, 25(9), 1275-83.
  10. Jones KB, Ferguson PC, Lam B, Biau DJ, Hopyan S, Deheshi B, Griffin AM, White LM, Wunder JS (2012). Effects of neoadjuvant chemotherapy on image-directed planning of surgical resection for distal femoral osteosarcoma. J Bone Joint Surg Am, 94(15), 1399-405.
  11. Jahromi MS, Putnam AR, Druzgal C, Wright J, Spraker-Perlman H, Kinsey M, Zhou H, Boucher KM, Randall RL, Jones KB, Lucas D, Rosenberg A, Thomas D, Lessnick SL, Schiffman JD (2012). Molecular inversion probe analysis detects novel copy number alterations in Ewing sarcoma. Cancer Genet, 205(7-8), 391-404.
  12. Jones KB, Salah Z, Del Mare S, Galasso M, Gaudio E, Nuovo GJ, Lovat F, LeBlanc K, Palatini J, Randall RL, Volinia S, Stein GS, Croce CM, Lian JB, Ageilan RI (04/01/2012). miRNA signatures associate with pathogenesis and progression of osteosarcoma. Cancer Res, 72(7), 1865-77.
  13. Jones KB, Schiffman JD, Kohlmann W, Randall RL, Lessnick SL, Cannon-Albright LA (2011). Complex genotype sarcomas display familial inheritance independent of known cancer predisposition syndromes. Cancer Epidemiol Biomarkers Prev, 20(5), 751-7.
  14. Jones KB, Griffin AM, Chandrasekar CR, Biau D, Babinet A, Deheshi B, Bell RS, Grimer RJ, Wunder JS, Ferguson PC (2011). Patient-oriented functional results of total femoral endoprosthetic reconstruction following oncologic resection. J Surg Oncol, 104(6), 561-5.
  15. Israelsen RB, Ilium BE, Crabtree S, Randall RL, Jones KB (2011). Extremity sarcoma surgery in younger children: ten years of patients ten years and under. Iowa Orthop J, 31, 145-53.
  16. Joyner DE, Jones KB, Lessnick SL, Schiffman JD, Randall RL (2011). Potential for modulation of the fas apoptotic pathway by epidermal growth factor in sarcomas. Sarcoma, 2011, 847409.
  17. Jones KB, Ferguson PC, Deheshi B, Riad S, Griffin A, Bell RS, Wunder JS (2010). Complete femoral nerve resection with soft tissue sarcoma: functional outcomes. Ann Surg Oncol, 17(2), 401-6.
  18. Jones KB, Piombo V, Searby C, Kurriger G, Yang B, Grabellus F, Roughley PJ, Morcuende JA, Buckwalter JA, Capecchi MR, Vortkamp A, Sheffield VC (2010). A mouse model of osteochondromagenesis from clonal inactivation of Ext1 in chondrocytes. Proc Natl Acad Sci U S A, 107(5), 2054-9.
  19. Cummings J, Villanueva E, Cearley D, Jones KB, Randall RL (2010). Stringent patient selection in bulk allograft reconstructions. Orthopedics, 33(2), 86-92.
  20. Kurek KC, Del Mare S, Salah Z, Abdeen S, Sadiq H, Lee SH, Gaudio E, Zanesi N, Jones KB, DeYoung B, Amir G, Gebhardt M, Warman M, Stein GS, Stein JL, Lian JB, Aqeilan RI (2010). Frequent attenuation of the WWOX tumor suppressor in osteosarcoma is associated with increased tumorigenicity and aberrant RUNX2 expression. Cancer Res, 70(13), 5577-86.

Review

  1. Jones KB, Pacifici M, Hilton MJ (2014). Multiple hereditary exostoses (MHE): elucidating the pathogenesis of a rare skeletal disorder through interdisciplinary research. [Review]. Connect Tissue Res, 55(2), 80-8.
  2. Bernthal NM, Jones KB, Monument MJ, Liu T, Viskochil D, Randall RL (2013). Lost in translation: ambiguity in nerve sheath tumor nomenclature and its resultant treatment effect. [Review]. Cancers, 5(2), 519-28.
  3. Calvert GT, Randall RL, Jones KB, Cannon-Albright L, Lessnick S, Schiffman JD (2012). At-risk populations for osteosarcoma: the syndromes and beyond. [Review]. Sarcoma, 2012, 152382.
  4. Spraker HL, Price SL, Chaturvedi A, Schiffman JD, Jones KB, Lessnick SL, Beckerle M, Randall RL (2012). The clone wars - revenge of the metastatic rogue state: the sarcoma paradigm. [Review]. Frontiers in Oncology, 2, 2.
  5. Calvert GT, Monument MJ, Burt RW, Jones KB, Randall RL (2012). Extra-abdominal desmoid tumors associated with familial adenomatous polyposis. [Review]. Sarcoma, 2012, 726537.
  6. Jones KB (2011). Osteosarcomagenesis: modeling cancer initiation in the mouse. [Review]. Sarcoma, 2011, 694136.
  7. Jahromi MS, Jones KB, Schiffman JD (2011). Copy Number Alterations and Methylation in Ewing's Sarcoma. [Review]. Sarcoma, 2011, 362173.
  8. Jones KB, Haldar M, Schiffman JD, Cannon-Albright L, Lessnick SL, Sharma S, Capecchi MR, Randall RL (2011). Of mice and men: opportunities to use genetically engineered mouse models of synovial sarcoma for preclinical cancer therapeutic evaluation. [Review]. Cancer Control, 18(3), 196-203.
  9. Gouw LG, Jones KB, Sharma S, Randall RL (2011). Sarcoma immunotherapy. [Review]. Cancers, 3(4), 4139-50.
  10. Randall RL, Lessnick SL, Jones KB, Gouw LG, Cummings JE, Cannon-Albright L, Schiffman JD (2010). Is There a Predisposition Gene for Ewing's Sarcoma? [Review]. Journal of Oncology, 2010, 397632.
  11. Ferguson PC, Kulidjian AA, Jones KB, Deheshi BM, Wunder JS (2009). Peripheral nerve considerations in the management of extremity soft tissue sarcomas. [Review]. Recent Results in Cancer Research, 179, 243-56.
  12. Jones KB, Ferguson PC, Kandel R, Wunder JS (2009). Determination of Chromosomal Translocations in Soft Tissue Sarcomas: A Worthwhile Undertaking. [Review]. Pathology Case Reviews, 13(2), 57-64.

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