This mini symposium highlights the integration of metabolic and oncogenic signaling. Cancer cells co-opt metabolic routes to drive energy production, cell growth, division, and invasion in different environments. Common themes, like how metabolic pathways integrate mechanical signals from the environment to influence cell behavior, will be covered. This includes integration with the mitogenic EGFR/RAS/ERK-MAPK pathway and mechanisms of therapeutic resistance. Trainee talks will highlight the contributions to the field by Huntsman Cancer Institute’s Cell Response and Regulation Program.
Questions? Contact Kat Haymond.
Topic: The Intersection of Migration and Metabolism: Fueling the invasion of metastatic cells
Bruce Edgar, PhD
Topic: EGFR signaling activates intestinal stem cells by promoting mitochondrial biogenesis and β-oxidation
Topic: Metabolic changes induced by nutrient availability alters the protrusive state of migrating cells
Topic: Combined inhibition of ULK-mediated autophagy and KRASG12C controls tumor growth in preclinical models of lung cancer
|10:35–10:50 am||Light refreshment break|
Jessie Yanxiang Guo, PhD
Topic: The role of autophagy in KRAS-driven lung cancer
Topic: Transcriptional regulation of glycolysis
|11:45 am–12:05 pm||
Topic: Lean adipocytes potently inhibit breast cancer growth through lipid signaling