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Sankar Swaminathan, M.D.

Division Chief, Division of Infectious Diseases

Specialties

Languages

  • English

Clinical Details

Schedule An Appointment Clinical Office Address
(801) 585-2031 University Hospital
Infectious Diseases, Clinic 1A
50 N Medical Dr
Salt Lake City, UT 84132
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Bio

Sankar Swaminathan, MD has specialized expertise in the treatment of infectious diseases. He is board certified in Internal Medicine and Infectious Diseases. His main clinical focus is in the diagnosis and treatment of infections in immunocompromised patients, including cancer patients and transplant recipients. He has integrated a research program funded by the National Cancer institute on the role of viruses in cancers into his clinical practice.

Board Certification and Academic Information

Academic Departments Internal Medicine - Professor
Pathology - Adjunct Professor
Academic Divisions Infectious Diseases
Microbiology and Immunology
Board Certification American Board of Internal Medicine
American Board of Internal Medicine (Sub: Infec Disease)
Cancer Center Programs Nuclear Control of Cell Growth & Differentiation

Academic Profile

Research Interests

  • Epstein-Barr Virus Infections
  • Herpesvirus 1, Human

Board Certification and Academic Information

Academic Departments Internal Medicine - Professor
Pathology - Adjunct Professor
Academic Divisions Infectious Diseases
Microbiology and Immunology
Board Certification American Board of Internal Medicine
American Board of Internal Medicine (Sub: Infec Disease)
Cancer Center Programs Nuclear Control of Cell Growth & Differentiation

Academic Office Locations

Academic Office Phone Number Academic Office Address
(801) 587-7216 School of Medicine
Infectious Disease
30 N Medical Dr
Salt Lake City, UT 84132
University Hospital
50 N Medical Dr
Salt Lake City, UT 84132

Academic Bio

Dr. Sankar Swaminathan comes from the University of Florida, where he was professor of internal medicine in infectious diseases and director of that university’s Tumor Virology Program. In his new role as Chief of Infectious Diseases at the University of Utah, he plans to make both basic-science and clinical research priorities in his division. This will include expanding the collaborative virology research between the infectious diseases division and other departments and divisions at the medical school as well as promoting more clinical research in HIV, infections in immunocompromised patients, and travel medicine.

Dr. Swaminathan did his medical residency at the University of Chicago Medical Center followed by Infectious Diseases fellowship and research training at Harvard Medical School.

Dr. Swaminathan is a Huntsman Cancer Institute investigator and a member of the Nuclear Control of Cell Growth and Differentiation program. Dr. Swaminathan's research focuses on the regulation of gene expression in two viruses associated with lymphoma and other cancers: Epstein-Barr virus (EBV) and Kaposi’s sarcoma-associated herpes virus. He has been funded by the National Institute of Health for over 20 years. Dissecting the innate immune response and understanding the mechanisms that control these viruses’ replication is a major aspect of Swaminathan’s research.

In addition to his clinical and research duties, Dr. Swaminathan is a member of the editorial board of the Journal of Virology, works on NIH study sections, and serves as treasurer of the International Association for Research on EBV and Associated Diseases, among numerous other activities.

Education

Education History

Type School Degree
Research Fellow Harvard Medical School
Microbiology and Molecular Genetics
Research Fellow
Research Fellow Beth Israel Hospital, Brigham & Women's Hospital, Dana Farber Cancer Institute
Infectious Disease
Research Fellow
Fellowship Harvard Medical School
Medicine
Clinical Fellow
Fellowship Beth Israel Hospital, Brigham & Women's Hospital, Dana Farber Cancer Institute
Infectious Disease
Clinical Fellow
Residency University of Chicago Medical Center
Internal Medicine
Resident
Internship University of Chicago Medical Center
Internal Medicine
Intern
Professional Medical Emory University School of Medicine
Medicine
M.D.
Graduate Training Emory University School of Medicine
Microbiology and Immunology
M.S.
Undergraduate Harvard College
Biochemistry and Molecular Biology, magna cum laude
A.B.

Publications

Selected Provider Publications

Journal Article

  1. Li DJ, Verma D, Mosbruger T, Swaminathan S (01/2014). CTCF and Rad21 Act as Host Cell Restriction Factors for Kaposi's Sarcoma-Associated Herpesvirus (KSHV) Lytic Replication by Modulating Viral Gene Transcription. PLoS Pathog, 10(1371).
  2. Cell-based screening assay for antiviral compounds targeting the ability of herpesvirus posttranscriptional regulatory proteins to stabilize viral mRNAs.Verma D, Kim EA, Swaminathan S (2013). Cell-based screening assay for antiviral compounds targeting the ability of herpesvirus posttranscriptional regulatory proteins to stabilize viral mRNAs. J Virol, 87(19), 10742-51.
  3. Li DJ, Verma D, Swaminathan S (2012). Binding of cellular export factor REF/Aly by Kaposi's sarcoma-associated herpesvirus (KSHV) ORF57 protein is not required for efficient KSHV lytic replication. J Virol.
  4. Baden LR, Bensinger W, Angarone M, Casper C, Dubberke ER, Freifeld AG, Garzon R, Greene JN, Greer JP, Ito JI, Karp JE, Kaul DR, King E, Mackler E, Marr KA, Montoya JG, Morris-Engemann A, Pappas PG, Rolston K, Segal B, Seo SK, Swaminathan S, Naganuma M, Shead DA (10/2012). Prevention and treatment of cancer-related infections. J Natl Compr Canc Netw, 1412(45).
  5. Epstein-Barr Virus SM protein utilizes cellular splicing factor SRp20 to mediate alternative splicing.Verma D, Bais S, Gaillard M, Swaminathan S (2010). Epstein-Barr Virus SM protein utilizes cellular splicing factor SRp20 to mediate alternative splicing. J Virol, 84(22), 11781-9.
  6. Negative autoregulation of Epstein-Barr virus (EBV) replicative gene expression by EBV SM protein.Verma D, Ling C, Johannsen E, Nagaraja T, Swaminathan S (2009). Negative autoregulation of Epstein-Barr virus (EBV) replicative gene expression by EBV SM protein. J Virol, 83(16), 8041-50.
  7. General and target-specific RNA binding properties of Epstein-Barr virus SM posttranscriptional regulatory protein.Han Z, Verma D, Hilscher C, Dittmer DP, Swaminathan S (2009). General and target-specific RNA binding properties of Epstein-Barr virus SM posttranscriptional regulatory protein. J Virol, 83(22), 11635-44.
  8. Epstein-Barr virus SM protein functions as an alternative splicing factor.Verma D, Swaminathan S (2008). Epstein-Barr virus SM protein functions as an alternative splicing factor. J Virol, 82(14), 7180-8.
  9. Multiple roles of Epstein-Barr virus SM protein in lytic replication.Han Z, Marendy E, Wang YD, Yuan J, Sample JT, Swaminathan S (2007). Multiple roles of Epstein-Barr virus SM protein in lytic replication. J Virol, 81(8), 4058-69.
  10. Kaposi's sarcoma-associated herpesvirus ORF57 protein enhances mRNA accumulation independently of effects on nuclear RNA export.Nekorchuk M, Han Z, Hsieh TT, Swaminathan S (2007). Kaposi's sarcoma-associated herpesvirus ORF57 protein enhances mRNA accumulation independently of effects on nuclear RNA export. J Virol, 81(18), 9990-8.
  11. Kaposi's sarcoma-associated herpesvirus lytic gene ORF57 is essential for infectious virion production.Han Z, Swaminathan S (2006). Kaposi's sarcoma-associated herpesvirus lytic gene ORF57 is essential for infectious virion production. J Virol, 80(11), 5251-60.

Review

  1. Swaminathan S (2009). Gamma-secretase inhibitors - Do they have a role in the treatment of B cell lymphoma? [Review]. Cancer Biology & Therapy, 8(22), 2126-43.
  2. Swaminathan S (2008). Oncogenic herpesvirus noncoding RNAs. [Review]. Journal of Cellular Physiology, 216(2), 321-6.
  3. Post-transcriptional gene regulation by gamma herpesviruses.Swaminathan S (2005). Post-transcriptional gene regulation by gamma herpesviruses. [Review]. J Cell Biochem, 95(4), 698-711.

Book Chapter

  1. Swaminathan S (2010). The role of noncoding RNAs in EBV-induced cell growth and transformation. In Robertson ES (Ed.), Epstein-Barr Virus Latency and Transformation. Caister Academic Press.
  2. Swaminathan S, Kenney S (2009). Lytic EBV DNA Replication. In Damania B, Pipas J (Ed.), DNA Tumor Viruses. Springer Science.
  3. Swaminathan S (2008). Unusual Infections. In Layon A, Gabrielli A, Yu M (Ed.), Civetta, Taylor, & Kirby’s Critical Care (4th). Lippincott Williams & Wilkins.
  4. Swaminathan S (2007). Serious viral infections in adults. In Southwick F (Ed.), Infectious Diseases in thirty days (2nd). McGraw Hill.
  5. Swaminathan S (2005). Post-transcriptional Gene Regulation by EBV SM Protein. In Robertson E (Ed.), Infection, Pathogenesis, Molecular Biology and Control of Epstein - Barr virus. Horizon Press.

Clinical Trials

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