Wade S. Samowitz,
MD
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Languages Spoken: English, Italian
Dr. Samowitz is the medical director for numerous molecular tests in gastrointestinal cancer and other tumors, including microsatellite instability by IHC and PCR, mutational testing for BRAF, PIK3CA, and NRAS, evaluation for molar pregnancy, and specimen identification.
Specialties
Board Certification and Academic Information
| Academic Departments | Pathology
-
Professor |
| Academic Divisions | Anatomic Pathology |
| Board Certification | American Board of Pathology (Sub: Anatomic Path) |
Dr. Samowitz is the medical director for numerous molecular tests in gastrointestinal cancer and other tumors, including microsatellite instability by IHC and PCR, mutational testing for BRAF, PIK3CA, and NRAS, evaluation for molar pregnancy, and specimen identification.
Academic Locations
Board Certification and Academic Information
| Academic Departments | Pathology
-
Professor |
| Academic Divisions | Anatomic Pathology |
| Board Certification | American Board of Pathology (Sub: Anatomic Path) |
Research Interests
- Colorectal Cancer Genetics
Education History
| Fellowship | Johns Hopkins University Pathology Fellow, 1987 |
| Residency | University of Chicago Hospital Pathology Resident, 1985 |
| Fellowship | University of Texas Health Science Center Cardiovascular Pathology Fellow, 1982 |
| Internship | University of Texas Southwestern Medical School Internal Medicine Intern, 1982 |
| Professional Medical | SUNY at Brooklyn Medicine M.D., 1981 |
| Undergraduate | Cornell University College of Arts and Sciences B.A., 1977 |
Selected Publications - Journal Articles
Journal Article
- Samadder NJ, Neklason D, Snow A, Samowitz W, Cessna MH, Rowe K, Sandhu I, Boucher K, Pappas L, Smith KR, Wong J, Curtin K, Provenzale D, Burt RW (2019). Clinical and Molecular Features of Post-Colonoscopy Colorectal Cancers. Clin Gastroenterol Hepatol, 17(13), 2731-2739.e2.
- Sample DC, Samadder NJ, Pappas LM, Boucher KM, Samowitz WS, Berry T, Westover M, Nathan D, Kanth P, Byrne KR, Burt RW, Neklason DW (2018). Variables affecting penetrance of gastric and duodenal phenotype in familial adenomatous polyposis patients. BMC Gastroenterol, 18(1), 115.
- Pellatt AJ, Mullany LE, Herrick JS, Sakoda LC, Wolff RK, Samowitz WS, Slattery ML (2018). The TGFβ-signaling pathway and colorectal cancer: associations between dysregulated genes and miRNAs. J Transl Med, 16(1), 191.
- Wolff RK, Hoffman MD, Wolff EC, Herrick JS, Sakoda LC, Samowitz WS, Slattery ML (2018). Mutation analysis of adenomas and carcinomas of the colon: Early and late drivers. Genes Chromosomes Cancer, 57(7), 366-376.
- Slattery ML, Mullany LE, Wolff RK, Sakoda LC, Samowitz WS, Herrick JS (2018). The p53-signaling pathway and colorectal cancer: Interactions between downstream p53 target genes and miRNAs. Genomics.
- Samadder NJ, Kuwada SK, Boucher KM, Byrne K, Kanth P, Samowitz W, Jones D, Tavtigian SV, Westover M, Berry T, Jasperson K, Pappas L, Smith L, Sample D, Burt RW, Neklason DW (2018). Association of Sulindac and Erlotinib vs Placebo With Colorectal Neoplasia in Familial Adenomatous Polyposis: Secondary Analysis of a Randomized Clinical Trial. JAMA Oncol, 4(5), 671-677.
- Mullany LE, Herrick JS, Sakoda LC, Samowitz W, Stevens JR, Wolff RK, Slattery ML (2019). MicroRNA-messenger RNA interactions involving JAK-STAT signaling genes in colorectal cancer. Genes Cancer, 9(5-6), 232-246.
- Mullany LE, Herrick JS, Wolff RK, Stevens JR, Samowitz W, Slattery ML (2017). MicroRNA-transcription factor interactions and their combined effect on target gene expression in colon cancer cases. Genes Chromosomes Cancer, 57(4), 192-202.
- Slattery ML, Mullany LE, Sakoda LC, Wolff RK, Samowitz WS, Herrick JS (2018). Dysregulated genes and miRNAs in the apoptosis pathway in colorectal cancer patients. Apoptosis, 23(3-4), 237-250.
- Dehghanizadeh S, Khoddami V, Mosbruger TL, Hammoud SS, Edes K, Berry TS, Done M, Samowitz WS, DiSario JA, Luba DG, Burt RW, Jones DA (2018). Active BRAF-V600E is the key player in generation of a sessile serrated polyp-specific DNA methylation profile. PLoS One, 13(3), e0192499.
- Slattery ML, Mullany LE, Sakoda LC, Wolff RK, Samowitz WS, Herrick JS (2018). The MAPK-Signaling Pathway in Colorectal Cancer: Dysregulated Genes and Their Association With MicroRNAs. Cancer Inform, 17, 1176935118766522.
- Slattery ML, Mullany LE, Sakoda L, Samowitz WS, Wolff RK, Stevens JR, Herrick JS (2017). The NF-κB signalling pathway in colorectal cancer: associations between dysregulated gene and miRNA expression. J Cancer Res Clin Oncol, 144(2), 269-283.
- Mullany LE, Herrick JS, Sakoda LC, Samowitz W, Stevens JR, Wolff RK, Slattery ML (2018). miRNA involvement in cell cycle regulation in colorectal cancer cases. Genes Cancer, 9(1-2), 53-65.
- Slattery ML, Mullany LE, Sakoda LC, Samowitz WS, Wolff RK, Stevens JR, Herrick JS (2017). Expression of Wnt-signaling pathway genes and their associations with miRNAs in colorectal cancer. Oncotarget, 9(5), 6075-6085.