Adam Barker
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Adam Barker, PhD

Languages spoken: English

Dr. Barker is interested in mycobacterial pathogenesis and improving early diagnosis of emerging pathogens in this area. He wants to lead the field in mass spectrometry in the clinical microbiology laboratory. In particular, rapid identification and classification of difficult pathogens for a fraction of the cost.

Dr. Barker's lab researches Mycobacterium abscessus and Pseudomonas aeruginosa pathogenesis. He is interested in identifying unknown, unclassified virulence factors that contribute to pathogenesis. He also is interested in the biochemistry of gamma interferon inducible lysosomal thiol reductase (GILT) in collaboration Dr. Peter Jensen.

Specialties

  • Pathology, Clinical

Board Certification

American Board of Medical Microbiology

Dr. Barker is interested in mycobacterial pathogenesis and improving early diagnosis of emerging pathogens in this area. He wants to lead the field in mass spectrometry in the clinical microbiology laboratory. In particular, rapid identification and classification of difficult pathogens for a fraction of the cost.

Dr. Barker's lab researches Mycobacterium abscessus and Pseudomonas aeruginosa pathogenesis. He is interested in identifying unknown, unclassified virulence factors that contribute to pathogenesis. He also is interested in the biochemistry of gamma interferon inducible lysosomal thiol reductase (GILT) in collaboration Dr. Peter Jensen.

Board Certification and Academic Information

Academic Departments Pathology -Professor (Clinical)
Board Certification
American Board of Medical Microbiology

Education history

Undergraduate Colorado State University, Department of Microbiology B.S.
Doctoral Training University of Colorado Health Sciences Center, Microbiology and Immunology Department Ph.D.
Fellowship Harvard Medical School, Department of Microbiology and Molecular Genetics Fellow
Fellowship Medical Microbiology - University of Utah, Pathology Department Fellow

Selected Publications

Journal Article

  1. Reyes-Vargas E, Barker AP, Zhou Z, He X, Jensen P (2020). HLA-DM catalytically enhances peptide dissociation by sensing peptide-MHC class II interactions throughout the peptide-binding cleft. The Journal of biological chemistry, 295(10), 2959-2973.
  2. Okoye NC, Barker AP, Curtis K, Orlandi RR, Snavely EA, Wright C, Hanson KE, Pearson L (2021). Performance Characteristics of BinaxNOW COVID-19 Antigen Card for Screening Asymptomatic Individuals in a University Setting. Journal of clinical microbiology, 59(4),
  3. Hanson KE, Barker AP, Hillyard DR, Gilmore N, Barrett JW, Orlandi RR, Shakir S (2020). Self-Collected Anterior Nasal and Saliva Specimens versus Health Care Worker-Collected Nasopharyngeal Swabs for the Molecular Detection of SARS-CoV-2. Journal of clinical microbiology, 58(11),
  4. Ravkov EV, Charlton CM, Barker AP, Hill H, Peterson LK, Slev P, Tebo A, Voelkerding KV, Wittwer CT, Heikal N, Delgado JC, Lázár-Molnár E, Kumánovics (2019). Evaluation of Mass Cytometry in the Clinical Laboratory. Cytometry. Part B, Clinical cytometry, 96(4), 266-274.
  5. Sobczyk J, Pyne MT, Barker A, Mayer J, Hanson KE, Samore MH, Noriega (2021). Efficient and effective single-step screening of individual samples for SARS-CoV-2 RNA using multi-dimensional pooling and Bayesian inference. Journal of the Royal Society, Interface, 18(179), 20210155.
  6. Forde BM, Roberts LW, Phan MD, Peters KM, Fleming BA, Russell CW, Lenherr SM, Myers JB, Barker AP, Fisher MA, Chong TM, Yin WF, Chan KG, Schembri MA, Mulvey MA, Beatson S (2019). Population dynamics of an Escherichia coli ST131 lineage during recurrent urinary tract infection. Nature communications, 10(1), 3643.
  7. Amol O. Bajaj1*, Suraj Saraswat1¿, Juha E. A. Knuuttila2, Joanna Freeke3,4, J. Benjamin Stielow3,4 and Adam P. Barker1 (2021). Accurate Identification of Closely Related Mycobacterium tuberculosisComplex Species by High Resolution Tandem Mass Spectrometry. Frontiers in cellular and infection microbiology,
  8. Rasmussen NN, Barker A, Strathmann F (2018). Lowering the Bar for Mass Spectrometry: A Comparison between Immunoassay and Rapid Time-of-Flight for Presumptive Screening of Drugs in Urine. The journal of applied laboratory medicine, 2(4), 535-542.
  9. Pyne MT, Simmon KE, Mallory MA, Hymas WC, Stevenson J, Barker AP, Hillyard D (2022). HIV-1 Drug Resistance Assay Using Ion Torrent Next Generation Sequencing and On-Instrument End-to-End Analysis Software. Journal of clinical microbiology, 60(7), e0025322.
  10. Bajaj AO, Slechta ES, Barker A (2022). Rapid and Accurate Differentiation of Mycobacteroides abscessus Complex Species by Liquid Chromatography-Ultra-High-Resolution Orbitrap¿ Mass Spectrometry. Frontiers in cellular and infection microbiology, 12, 809348.
  11. Yang T, Beach KE, Zhu C, Gan M, Wang W, Zhou H, Peng L, Wang S, Cai L, Li W, Davis JB, Cicchetti N, Slechta ES, Barker A, Shakir SM, Carey AF, Liu (2024). Genomic analysis of global Mycobacterium abscessus isolates reveals ongoing evolution of drug-resistance-associated genes. The Journal of infectious diseases,

Letter

  1. Shakir SM, Barker AP, Hillyard DR, Gilmore N, Barrett JW, Orlandi RR, Hanson K (2020). Combined Self-Collected Anterior Nasal and Oropharyngeal Specimens versus Provider-Collected Nasopharyngeal Swabs for the Detection of SARS-CoV-2. Journal of clinical microbiology, 59(1),

Abstract

  1. Hansen J, Barker AP, Johnson S, Case K, Slechta ES, Meary B, Bauman S, Hanson K (2012). Evaluation of a newly developed lateral flow and enzyme-linked immunoassay (EIA) for detection of cryptococcal antigen.
  2. Barker AP, Siady SH, Slechta ES, Cohen S, Hanson K (2012). Differentiation of the Species in the Mycobacterium tuberculosis complex using Matrix Assisted Laser Desorption lonization Time of Flight.
  3. Barker AP, Nguyen AP, Smith GL, Cohen S, Hanson K (2012). Differentiation of M. Chelonae from M. abscessus using Matrix Assisted Laser Desorption Ionization Time of Flight.
  4. Tardiff KD, Barker AP (2013). Identification of Rapidily Growing Mycobacteria by MALDI-TOF Mass Spectrometry.
  5. Hamula CLA, Slechta ES, Barker AP, Hanson K (2012). Development of a novel high-resolution melt PCR assay for detection of inducible macrolide resistance in bacteria from the Mycobacterium chelonae-abscessus complex.
  6. Slechta ES, Hamula C, Barker AP, Hanson KE (2012). Differentiation of Mycobacterium abscessus group isolates by sequence analysis of the Inducible Macrolide Resistance Gene erm.