J. Robinson Singleton, MD

Journal Article

1. Stewart SL, Thomas S, Hke E, Simpson D, Singleton JR, Hke A (2021). Vitamin B6 levels do not correlate with severity of neuropathy in chronic idiopathic axonal polyneuropathy. J Peripher Nerv Syst. (Read full article)
2. Smith AG, Singleton JR (2021). Dietary management of obesity-associated neuropathy: Implications for clinical practice and trial design. Obesity (Silver Spring), 29(12), 1990-1991. (Read full article)
3. Singleton JR, Foster-Palmer S, Marcus RL (2021). Exercise as Treatment for Neuropathy in the Setting of Diabetes and Pre-diabetic Metabolic Syndrome: a Review of Animal Models and Human Trials. Curr Diabetes Rev. (Read full article)
4. Bailey RR, Singleton JR, Majersik JJ (2020). Association of obesity and diabetes with physical activity and fruit and vegetable consumption in stroke survivors. Fam Pract, 38(1), 56-61. (Read full article)
5. Freeman R, Gewandter JS, Faber CG, Gibbons C, Haroutounian S, Lauria G, Levine T, Malik RA, Singleton JR, Smith AG, Bell J, Dworkin RH, Feldman E, Herrmann DN, Hoke A, Kolb N, Mansikka H, Oaklander AL, Peltier A, Polydefkis M, Ritt E, Russell JW, Sainati S, Steiner D, Treister R, eyler N (2020). Idiopathic distal sensory polyneuropathy: ACTTION diagnostic criteria. Neurology, 95(22), 1005-1014. (Read full article)
6. Brownstein MJ, Simon NG, Long JD, Yankey J, Maibach HT, Cudkowicz M, Coffey C, Conwit RA, Lungu C, Anderson KE, Hersch SM, Ecklund DJ, Damiano EM, Itzkowitz DE, Lu S, Chase MK, Shefner JM, McGarry A, Thornell B, Gladden C, Costigan M, OSuilleabhain P, Marshall FJ, Chesire AM, Deritis P, Adams JL, Hedera P, Lowen K, Rosas HD, Hiller AL, Quinn J, Keith K, Duker AP, Gruenwald C, Molloy A, Jacob C, Factor S, Sperin E, Bega D, Brown ZR, Seeberger LC, Sung VW, Benge M, Kostyk SK, Daley AM, Perlman S, Suski V, Conlon P, Barrett MJ, Lowenhaupt S, Quigg M, Perlmutter JS, Wright BA, Most E, Schwartz GJ, Lamb J, Chuang RS, Singer C, Marder K, Moran JA, Singleton JR, Zorn M, Wall PV, Dubinsky RM, Gray C, Drazinic C (2020). Safety and Tolerability of SRX246, a Vasopressin 1a Antagonist, in Irritable Huntington's Disease Patients-A Randomized Phase 2 Clinical Trial. J Clin Med, 9(11). (Read full article)
7. Cudkowicz M, Chase MK, Coffey CS, Ecklund DJ, Thornell BJ, Lungu C, Mahoney K, Gutmann L, Shefner JM, Staley KJ, Bosch M, Foster E, Long JD, Bayman EO, Torner J, Yankey J, Peters R, Huff T, Conwit RA, NeuroNEXT Clinical Study Sites, Shinnar S, Patch D, Darras BT, Ellis A, Packer RJ, Marder KS, Chiriboga CA, Henchcliffe C, Moran JA, Nikolov B, Factor SA, Seeley C, Greenberg SM, Amato AA, DeGregorio S, Simuni T, Ward T, Kissel JT, Kolb SJ, Bartlett A, Quinn JF, Keith K, Levine SR, Gilles N, Coyle PK, Lamb J, Wolfe GI, Crumlish A, Mejico L, Iqbal MM, Bowen JD, Tongco C, Nabors LB, Bashir K, Benge M, McDonald CM, Henricson EK, Oskarsson B, Dobkin BH, Canamar C, Glauser TA, Woo D, Molloy A, Clark P, Vollmer TL, Stein AJ, Barohn RJ, Dimachkie MM, Le Pichon JB, Benatar MG, Steele J, Wechsler L, Clemens PR, Amity C, Holloway RG, Annis C, Goldberg MP, Andersen M, Iannaccone ST, Smith AG, Singleton JR, Doudova M, Haley EC, Quigg MS, Lowenhaupt S, Malow BA, Adkins K, Clifford DB, Teshome MA, Connolly N (2020). Seven-Year Experience From the National Institute of Neurological Disorders and Stroke-Supported Network for Excellence in Neuroscience Clinical Trials. JAMA Neurol, 77(6), 755-763. (Read full article)
8. Thomas S, Ajroud-Driss S, Dimachkie MM, Gibbons C, Freeman R, Simpson DM, Singleton JR, Smith AG, PNRR Study Group, Hke A (2019). Peripheral Neuropathy Research Registry: A prospective cohort. J Peripher Nerv Syst, 24(1), 39-47. (Read full article)
9. Kolb NA, Smith AG, Singleton JR, Beck SL, Howard D, Dittus K, Karafiath S, Mooney K (2017). Chemotherapy-related neuropathic symptom management: a randomized trial of an automated symptom-monitoring system paired with nurse practitioner follow-up. Support Care Cancer, 26(5), 1607-1615. (Read full article)
10. Kluding PM, Singleton JR, Pasnoor M, Dimachkie MM, Barohn RJ, Smith AG, Marcus RL (2016). Activity for Diabetic Polyneuropathy (ADAPT): Study Design and Protocol for a 2-Site Randomized Controlled Trial. Phys Ther, 97(1), 20-31. (Read full article)
11. Kolb NA, Smith AG, Singleton JR, Beck SL, Stoddard GJ, Brown S, Mooney K (2016). The Association of Chemotherapy-Induced Peripheral Neuropathy Symptoms and the Risk of Falling. JAMA Neurol, 73(7), 860-6. (Read full article)
12. Vinik AI, Smith AG, Singleton JR, Callaghan B, Freedman BI, Tuomilehto J, Bordier L, Bauduceau B, Roche F (2016). Normative Values for Electrochemical Skin Conductances and Impact of Ethnicity on Quantitative Assessment of Sudomotor Function. Diabetes Technol Ther, 18(6), 391-8. (Read full article)
13. Singleton JR, Smith AG, Marcus RL (2015). Exercise as Therapy for Diabetic and Prediabetic Neuropathy. Curr Diab Rep, 15(12), 120. (Read full article)
14. Tavakoli M, Ferdousi M, Petropoulos IN, Morris J, Pritchard N, Zhivov A, Ziegler D, Pacaud D, Romanchuk K, Perkins BA, Lovblom LE, Bril V, Singleton JR, Smith G, Boulton AJ, Efron N, Malik RA (2015). Normative values for corneal nerve morphology assessed using corneal confocal microscopy: a multinational normative data set. Diabetes Care, 38(5), 838-43. (Read full article)
15. Kinard KI, Smith AG, Singleton JR, Lessard MK, Katz BJ, Warner JE, Crum AV, Mifflin MD, Brennan KC, Digre KB (2015). Chronic migraine is associated with reduced corneal nerve fiber density and symptoms of dry eye. Headache, 55(4), 543-9. (Read full article)
16. Singleton JR, Marcus RL, Lessard MK, Jackson JE, Smith AG (2014). Supervised exercise improves cutaneous reinnervation capacity in metabolic syndrome patients. Ann Neurol, 77(1), 146-53. (Read full article)
17. Hamid HS, Mervak CM, Mnch AE, Robell NJ, Hayes JM, Porzio MT, Singleton JR, Smith AG, Feldman EL, Lentz SI (2014). Hyperglycemia- and neuropathy-induced changes in mitochondria within sensory nerves. Ann Clin Transl Neurol, 1(10), 799-812. (Read full article)
18. Singleton JR, Marcus RL, Jackson JE, K Lessard M, Graham TE, Smith AG (2014). Exercise increases cutaneous nerve density in diabetic patients without neuropathy. Ann Clin Transl Neurol, 1(10), 844-9. (Read full article)
19. Smith AG, Lessard M, Reyna S, Doudova M, Singleton JR (2014). The diagnostic utility of Sudoscan for distal symmetric peripheral neuropathy. J Diabetes Complications, 28(4), 511-6. (Read full article)
20. Cortez M, Singleton JR, Smith AG (2014). Glucose intolerance, metabolic syndrome, and neuropathy. Handb Clin Neurol, 126, 109-22. (Read full article)
21. Smith AG, Kim G, Porzio M, Allen B, Koach M, Mifflin M, Digre K, Keung BM, Singleton JR (2013). Corneal confocal microscopy is efficient, well-tolerated, and reproducible. J Peripher Nerv Syst, 18(1), 54-8. (Read full article)
22. Smith AG, Singleton JR (2008). Impaired glucose tolerance and neuropathy. Neurologist, 14(1), 23-9. (Read full article)
23. Singleton JR (2005). Evaluation and treatment of painful peripheral polyneuropathy. Semin Neurol, 25(2), 185-95. (Read full article)
24. Singleton JR, Smith AG, Russell JW, Feldman EL (2003). Microvascular complications of impaired glucose tolerance. Diabetes, 52(12), 2867-73. (Read full article)
25. Singleton JR, Feldman EL (2001). Insulin-like growth factor-I in muscle metabolism and myotherapies. Neurobiol Dis, 8(4), 541-54. (Read full article)
26. Ahnen DJ, Singleton JR, Hoops TC, Kloppel TM (1986). Posttranslational processing of secretory component in the rat jejunum by a brush border metalloprotease. J Clin Invest, 77(6), 1841-8. (Read full article)

Editorial

1. Callaghan BC, Singleton JR (2021). Causes and Implications of Isolated Small Fiber Neuropathy. Neurology, 97(22), 1015-1016. (Read full article)
2. Burns TM, Smith GA, Allen JA, Amato AA, Arnold WD, Barohn R, Benatar M, Bird SJ, Bromberg M, Chahin N, Ciafaloni E, Cohen JA, Corse A, Crum BA, David WS, Dimberg E, Sousa EA, Donofrio PD, Dyck PJ, Engel AG, Ensrud ER, Ferrante M, Freimer M, Gable KL, Gibson S, Gilchrist JM, Goldstein JM, Gooch CL, Goodman BP, Gorelov D, Gospe SM Jr, Goyal NA, Guidon AC, Guptill JT, Gutmann L, Gutmann L, Gwathmey K, Harati Y, Harper CM Jr, Hehir MK, Hobson-Webb LD, Howard JF Jr, Jackson CE, Johnson N, Jones SM, Juel VC, Kaminski HJ, Karam C, Kennelly KD, Khella S, Khoury J, Kincaid JC, Kissel JT, Kolb N, Lacomis D, Ladha S, Larriviere D, Lewis RA, Li Y, Litchy WJ, Logigian E, Lou JS, MacGowen DJ, Maselli R, Massey JM, Mauermann ML, Mathews KD, Meriggioli MN, Miller RG, Moon JS, Mozaffar T, Nations SP, Nowak RJ, Ostrow LW, Pascuzzi RM, Peltier A, Ruzhansky K, Richman DP, Ross MA, Rubin DI, Russell JA, Sachs GM, Salajegheh MK, Saperstein DS, Scelsa S, Selcen D, Shaibani A, Shieh PB, Silvestri NJ, Singleton JR, Smith BE, So YT, Solorzano G, Sorenson EJ, Srinivasen J, Tavee J, Tawil R, Thaisetthawatkul P, Thornton C, Trivedi J, Vernino S, Wang AK, Webb TA, Weiss MD, Windebank AJ, Wolfe GI (2015). Editorial by concerned physicians: Unintended effect of the orphan drug act on the potential cost of 3,4-diaminopyridine. Muscle Nerve, 53(2), 165-8. (Read full article)

Other

1. Shoham S, Bloch EM, Casadevall A, Hanley D, Lau B, Gebo K, Cachay E, Kassaye SG, Paxton JH, Gerber J, Levine AC, Currier J, Patel B, Allen ES, Anjan S, Appel L, Baksh S, Blair PW, Bowen A, Broderick P, Caputo CA, Cluzet V, Cordisco ME, Cruser D, Ehrhardt S, Forthal D, Fukuta Y, Gawad AL, Gniadek T, Hammel J, Huaman MA, Jabs DA, Jedlicka A, Karlen N, Klein S, Laeyendecker O, Lane K, McBee N, Meisenberg B, Merlo C, Mosnaim G, Park HS, Pekosz A, Petrini J, Rausch W, Shade DM, Shapiro JR, Singleton JR, Sutcliffe C, Thomas DL, Yarava A, Zand M, Zenilman JM, Tobian AAR, Sullivan D (2021). Randomized controlled trial transfusing convalescent plasma as post-exposure prophylaxis against SARS-CoV-2 infection. United States. (Read full article)

• Convalescent Plasma to Stem Coronavirus: A Randomized Controlled Double Blinded Phase 2 Study Comparing the Efficacy and Safety of Human Coronavirus Immune Plasma (HCIP) vs. control (SARS-CoV-2 non-immune plasma) among Adults Exposed to COVID-19