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Nicholas Alonzo Frost
( out of 169 reviews )

Nicholas Alonzo Frost, MD, PhD

Languages spoken: English

Dr. Frost is a board certified neurologist who sees patients with disorders of memory and cognition. His clinical and research interests focus on understanding mechanisms that contribute to disorders of cognition. His research focuses on how information relevant to complex behaviors including social interactions are encoded within the prefrontal cortex and disrupted in disease. His laboratory utilizes imaging and transcriptomic approaches to understand how heterogeneous populations of neurons function in concert to encode different types of behavioral information.

Dr. Frost received his medical degree and graduate research training from the University of Maryland School of Medicine. There his research focused on developing super-resolution microscopy to image biological processes in living neurons. He then moved to San Francisco for further clinical training including an internship in internal medicine and residency in adult neurology at the University of California, San Francisco. Following residency he completed a research fellowship at UCSF focused on characterizing circuit-level endophenotypes underlying abnormal behavior in preclinical models of neurodevelopmental disorders.

Board Certification

American Board of Psychiatry & Neurology (Neurology)

Patient Rating

Patients consistently describe Dr. Frost as knowledgeable, thorough, and caring, noting that he listens attentively and explains diagnoses and treatment options in clear, understandable terms. Reviewers emphasize his patience, empathy, and professionalism, which help them feel supported and confident in their care. Many also praise his practical, thoughtful treatment plans and the clarity of his communication.

Generated via Patient Reviews

4.9 /5
( out of 169 reviews )

The patient rating score is an average of all responses on our patient experience survey. The rating averages scores for all questions about care from our providers. The scale on which responses are measured is 1 to 5 with 5 being the best score.


May 31, 2026
CLINICAL NEUROSCIENCES CENTER

Took the necessary time with me to learn and sort out my issues.

May 20, 2026
CLINICAL NEUROSCIENCES CENTER

Very personable. Felt like he really cared.

May 17, 2026
CLINICAL NEUROSCIENCES CENTER

He's a great doctor. I'm glad he's in my life so that he can help me.

May 04, 2026
CLINICAL NEUROSCIENCES CENTER

Dr. Frost has a very good handle on my health history. We appreciate his common sense approach to a tough diagnosis. He is kind and caring

May 03, 2026
CLINICAL NEUROSCIENCES CENTER

Excellent

May 03, 2026
CLINICAL NEUROSCIENCES CENTER

I felt like I was in very good hands with Dr. Frost. He explained things well and I felt very confident that I have made a good choice for my care.

May 02, 2026
CLINICAL NEUROSCIENCES CENTER

Wonderful caring provider.

May 01, 2026
CLINICAL NEUROSCIENCES CENTER

Very knowledgeable

Apr 29, 2026
CLINICAL NEUROSCIENCES CENTER

He has been a great physician for me during me new diagnosis of Alzheimer's Disease

Apr 20, 2026
CLINICAL NEUROSCIENCES CENTER

Our visit with Dr Nicholas Frost was very informative and most welcome. We find Dr Frost to be extremely knowledgeable in Neuroscience and both extremely informative and supportive. We appreciated his manner and additionally his extreme ease of manner accompanied by a welcomed release of both compassion and humor punctuated with hope.

Apr 16, 2026
CLINICAL NEUROSCIENCES CENTER

Dr. Frost is always genuinely interested in my wellbeing. He understands my fears and concerns as I continue down the unknown road of Alzheimer's. I appreciate his encouragement for doing my part as my illness progresses.

Apr 14, 2026
CLINICAL NEUROSCIENCES CENTER

honest and forthright

Apr 09, 2026
CLINICAL NEUROSCIENCES CENTER

Great doctor and medical care.

Apr 08, 2026
CLINICAL NEUROSCIENCES CENTER

Excellent care from Dr. FROST AND HIS ENTIRE STAFF.

Apr 06, 2026
CLINICAL NEUROSCIENCES CENTER

He is very good i n diagnosis

Mar 26, 2026
CLINICAL NEUROSCIENCES CENTER

He is a well knowledgeable doct

Mar 15, 2026
CLINICAL NEUROSCIENCES CENTER

Dr. Frost is an extremely knowledgeable and caring physician. He really listens and explains complicated issues in an understandable way.

Feb 22, 2026
CLINICAL NEUROSCIENCES CENTER

This was our first meeting with Dr. Frost. He was thorough and helpful, provided clear information and instructions. We are looking forward to working with him.

Feb 21, 2026
CLINICAL NEUROSCIENCES CENTER

Dr. Frost is Thoughtful and KIND. I am VERY Grateful for his caring and support!

Feb 20, 2026
CLINICAL NEUROSCIENCES CENTER

Great, thoughtful caregiver

Feb 14, 2026
CLINICAL NEUROSCIENCES CENTER

Very kind and patient, explained things thoroughly

Feb 14, 2026
CLINICAL NEUROSCIENCES CENTER

Dr. Frost is a caring doctor. His concern shows in everything he says and does.

Feb 04, 2026
CLINICAL NEUROSCIENCES CENTER

As a patient, Dr Frost told me everything I needed to know, and omitted information I did not need to know. He is a clear communicator, going into further detail when I needed more explanation. He is direct and straightforward, he doesn't beat around the bush. I'm so glad my Primary Physician referred me to Dr Frost.

Jan 18, 2026
CLINICAL NEUROSCIENCES CENTER

Dr. Frost was a pleasure to work with. He is obviously highly knowledgeable and has a very pleasant style. He is also a talented communicator who explains things clearly. I trust him implicitly with my care.

Jan 17, 2026
CLINICAL NEUROSCIENCES CENTER

practical and thoughtful

Jan 15, 2026
CLINICAL NEUROSCIENCES CENTER

Dr Nicholas Frost is one of the most caring and compassionate Doctors. He has been so kind to my husband who has dementia. I highly recommend him to anyone that is seeking care

Jan 15, 2026
CLINICAL NEUROSCIENCES CENTER

Very helpful

Jan 14, 2026
CLINICAL NEUROSCIENCES CENTER

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Jan 03, 2026
CLINICAL NEUROSCIENCES CENTER

Dr. Frost was very patient and understanding. He was thorough and explained things well.

Jan 01, 2026
CLINICAL NEUROSCIENCES CENTER

Dr. Frost has always taken the time to answer all of my questions. I believe he really does care about his patients and their well being. He was extremely thorough and did all the tests available that was needed to determine my diagnosis. Thank you Dr. Frost for taking such good care of me as your patient.

Dec 19, 2025
CLINICAL NEUROSCIENCES CENTER

Excellent care.

Dec 11, 2025
CLINICAL NEUROSCIENCES CENTER

Dr. Frost talks to me and my daughters every time we meet. He keeps all the balls in the air and we know we are being heard. Very clear directives!

Dec 10, 2025
CLINICAL NEUROSCIENCES CENTER

Brilliant physician. Very compassionate.

Nov 27, 2025
CLINICAL NEUROSCIENCES CENTER

Great doctor! Would recommend him to anyone. He explains everything!

Nov 26, 2025
CLINICAL NEUROSCIENCES CENTER

He is excellent!

Nov 07, 2025
CLINICAL NEUROSCIENCES CENTER

A good guy, a good neurologist. His expertise saved us from much frustration and confusion arising from prior information and testing. I drove 5 hours each way to see him 2 times. Was he worth it? Heck yes.

Nov 06, 2025
CLINICAL NEUROSCIENCES CENTER

Dr. Frost has become one of my favorites at the U.

Nov 04, 2025
CLINICAL NEUROSCIENCES CENTER

Was very impressed with him and his knowledge of the treatment that he was suggesting.

Nov 02, 2025
CLINICAL NEUROSCIENCES CENTER

Dr. Frost is genuinely a wonderful doctor who is honest with patients, kind, and thorough. I know that I am in good hands with him and with those work work with him

Nov 01, 2025
CLINICAL NEUROSCIENCES CENTER

Dr. Frost was great at explaining the Ct, PET and other information available to him. He was very thorough and I believe he actually cares about the patient and getting the correct diagnosis.

Oct 31, 2025
CLINICAL NEUROSCIENCES CENTER

Very very helpful

Oct 24, 2025
CLINICAL NEUROSCIENCES CENTER

Dr. Frost was very kind and informative. He pulled up the MRI pictures and explained things in detail. Gave us a plan for follow-up testing and care.

Oct 16, 2025
CLINICAL NEUROSCIENCES CENTER

Dr Frist is a very caring snd knowledgeable man who I trust with my brain. Thanks Doc

Oct 11, 2025
CLINICAL NEUROSCIENCES CENTER

Dr. Frost has the time to paint a full picture and answer questions-as if he has all of the time we need

Oct 10, 2025
CLINICAL NEUROSCIENCES CENTER

Extremely caring and easy to talk with.

Oct 09, 2025
CLINICAL NEUROSCIENCES CENTER

The time spent on the tele Visit was useful

Oct 08, 2025
CLINICAL NEUROSCIENCES CENTER

Excellent care!

Sep 29, 2025
CLINICAL NEUROSCIENCES CENTER

Dr. Frost is the best for me. He never pulled a red marker out stating ¿lost cause!¿ He talked me through the whole process. (Wanted a little more help with the questions) but I really feel protected and that he is doing everything possible to give the best outcome for me. He gives me hope! Thank you, Dr. Frost!

Sep 11, 2025
CLINICAL NEUROSCIENCES CENTER

Dr Frost is very competent. He explains things well and cares about his patients.

Sep 10, 2025
CLINICAL NEUROSCIENCES CENTER

Dr. Nicholas Frost is WONDERFUL!!! I would Highly Recommend Him to everyone I know!!!

Sep 03, 2025
CLINICAL NEUROSCIENCES CENTER

Excellent care

Aug 23, 2025
CLINICAL NEUROSCIENCES CENTER

Extremely knowledgeable and professional!

Aug 17, 2025
CLINICAL NEUROSCIENCES CENTER

Dr. Frost was very knowledgeable and helped both myself and my wife about what I will have in the future.

Aug 12, 2025
CLINICAL NEUROSCIENCES CENTER

He answered my questions well.

Jul 18, 2025
CLINICAL NEUROSCIENCES CENTER

Very professional

Jun 16, 2025
CLINICAL NEUROSCIENCES CENTER

I'm very thankful for his help & devotion to my issue.

May 29, 2025
CLINICAL NEUROSCIENCES CENTER

Dr. Frost is very knowledgeable. He listens and gives honest feedback. He shares information so you can make our own decision for what is best for you. His staff is very helpful and professional-also they really care.

May 25, 2025
CLINICAL NEUROSCIENCES CENTER

Dr. Frost has a great way of while being professional he explains thing well so less educated in his area of specialty can understand. He's empathetic and wants to make sure my husband is getting all care available to him.

May 18, 2025
CLINICAL NEUROSCIENCES CENTER

He is very good but hard to see, booking apps 6 months out

May 04, 2025
CLINICAL NEUROSCIENCES CENTER

Great doctor

Apr 24, 2025
CLINICAL NEUROSCIENCES CENTER

I'm very happy with Dr Frost. He and his staff are very good.

Apr 11, 2025
CLINICAL NEUROSCIENCES CENTER

I totally respect Dr. Frost and his team. He explains things so that I understand what he is going to do and what is going to happen next in my treatment plan. I am so happy that I chose to go with the U of U for my treatment plan.

Mar 23, 2025
CLINICAL NEUROSCIENCES CENTER

Great doctor! I would recommend him to anyone that needs to see a Neurologist. He explains everything he is going to do.

Feb 15, 2025
CLINICAL NEUROSCIENCES CENTER

Dr. Frost is very thorough, professional, kind & good with good with his explanations.

Jan 25, 2025
CLINICAL NEUROSCIENCES CENTER

Dr. Frost is great he has helped me a lot

Jan 23, 2025
CLINICAL NEUROSCIENCES CENTER

Dr. Frost is an excellent Doctor!

Jan 16, 2025
CLINICAL NEUROSCIENCES CENTER

Dr. Frost is an exceptionally talented Neurologist. His level of expertise in understanding the complexity of Alzheimer's disease and his ability to navigate the possible treatments to delay the progress of this disease gave me great confidence and hope. I have past experience on Boards of Health systems and can say that U Health, Dr. Frost, and his team are exceptional.

Jan 16, 2025
CLINICAL NEUROSCIENCES CENTER

See previous comments. Gave me what I needed but had to wait too long between test and consultation.

Dec 26, 2024
CLINICAL NEUROSCIENCES CENTER 1

One of the nicest and most caring physicians we've ever met

Dec 22, 2024
CLINICAL NEUROSCIENCES CENTER 1

Great

Dec 22, 2024
CLINICAL NEUROSCIENCES CENTER 1

Dr. Frost is very good at helping me I just wish it didn't take so long

Dec 09, 2024
CLINICAL NEUROSCIENCES CENTER 1

Dr Nicholas Frost addressed my condition or concern for Mild Cognitive Impairment. After studies with procedures and specialist appointments, it was said that diagnostically that I met criteria for diagnosis for Mild Cognitive Impairment. Etiogically, cognitive decline was seen since my last Neuropsych Evaluation and continued neurologic work up was warranted. Dr Frost's impression and plan showed consolidation was preserved making AD or LATE unlikely but LP would show more insight. Dr Frost presented professional and skilled characteristics to determine my future diagnosis. He expressed excellent knowledge to determine my issues and he was very thorough with testing and counseling. I WILL RESPECT HIS PROFESSIONAL INSIGHT WITH HOW I SHOULD MOVE FORWARD AND I AM LOOKING FORWARD TO HIS RECOMMENDATIONS.

Nov 10, 2024
CLINICAL NEUROSCIENCES CENTER

I'm very lucky to have Dr. Frost as a provider and to live so close to U of U Medical Center.

Nov 09, 2024
CLINICAL NEUROSCIENCES CENTER

Amazing doctor who answered our questions and concerns in a manner that helped us to understand dementia and the available treatments and the expectations for each choice.

Nov 03, 2024
CLINICAL NEUROSCIENCES CENTER

Dr Frost listens to our experiences and concerns and gives us choices regarding procedures and studies.

Oct 13, 2024
CLINICAL NEUROSCIENCES CENTER

Kind, upfront about my condition, knowledgable, concerned about me & wanting to take care of me ASAP. ,

Oct 11, 2024
CLINICAL NEUROSCIENCES CENTER

This was our most positive visit. Dr Frost was totally prepared for the virtual visit. He explained things in detail. [NAME REMOVED] got a diagnosis and suggested treatment going forward, allowing him to make his own decision. Best meeting yet!

Oct 10, 2024
CLINICAL NEUROSCIENCES CENTER

Dr Frost is competent, caring, and thorough in his treatment procedures. He explains things clearly, and seeks out any questions I may have. He's able to inquire in a way that helps to identify and treat my health problems. He seems genuinely interested in my responses.

Oct 06, 2024
CLINICAL NEUROSCIENCES CENTER

Such a consummate professional

Oct 05, 2024
CLINICAL NEUROSCIENCES CENTER

Wonderful and compassionate

Sep 15, 2024
CLINICAL NEUROSCIENCES CENTER

Dr. Frost is very knowledgeable. He presents factual information. He spends time to listen to patients concerns and is very supporting helping to set and make an achievable plan to have the best possible results for the patient. I highly recommend Dr Frost and his excellent nurses and people in his team.

Sep 14, 2024
CLINICAL NEUROSCIENCES CENTER

Dr. FROST IS THE Best Dr. FROST IS THE BEST!

Sep 13, 2024
CLINICAL NEUROSCIENCES CENTER

Great dr. I am lucky to have him

Jul 28, 2024
CLINICAL NEUROSCIENCES CENTER

U of U is very lucky to have Dr Frost in their program!. I'm so happy to be his patient.

Jul 13, 2024
CLINICAL NEUROSCIENCES CENTER

I know he is brilliant and cares about his work and patients.

Jul 01, 2024
CLINICAL NEUROSCIENCES CENTER

Very professional, knowledgeable and caring

Jun 29, 2024
CLINICAL NEUROSCIENCES CENTER

Dr Frost is a true professional who also displays an unusual compassion for this patient and his family.

Jun 29, 2024
CLINICAL NEUROSCIENCES CENTER

He is very professional, kind, understanding and excellent in examining things.

Jun 28, 2024
CLINICAL NEUROSCIENCES CENTER

Dr. FROST is the absolute best Dr. I have ever met.

Jun 22, 2024
CLINICAL NEUROSCIENCES CENTER

He knows his stuff doesn't job to a conclusion even if it's what you want. Patience and kindness he has along with great humor. We are blessed he is in our corner.

Jun 15, 2024
CLINICAL NEUROSCIENCES CENTER

A very thorough approach!

Jun 10, 2024
CLINICAL NEUROSCIENCES CENTER

We really appreciate his willingness to help and give us counsel for the challenge we are going through. His willingness to try to help find help and support help. Thank You

Jun 06, 2024
CLINICAL NEUROSCIENCES CENTER

Dr. Nicholas A Frost, MD is a fine person. He makes us smile by his easy demeanor. He listened when I complained that I thought they dropped the ball on getting us back in line for the next appointment in April, after we saw him. He went to make sure that it didn't happen again and explained that a bit of a rest in between all the infusions was not a bad thing, that it lets the body get used to the meds that are being administered. I would recommend him to anyone needing care.

May 30, 2024
CLINICAL NEUROSCIENCES CENTER

Excellent Doctor, would recommend to anyone!

May 27, 2024
CLINICAL NEUROSCIENCES CENTER

Knowledgeable, efficient, kind.

May 25, 2024
CLINICAL NEUROSCIENCES CENTER

Very skilled and quite caring

May 25, 2024
CLINICAL NEUROSCIENCES CENTER

Provided exceptional communication and care for my needs. Knowledgeable, competent, caring.

May 10, 2024
CLINICAL NEUROSCIENCES CENTER

He is the best!! My wife and I are very impressed with him!

May 10, 2024
CLINICAL NEUROSCIENCES CENTER

As busy as this department is at present , Dr Frost genuinely focused on areas of concern and best practices moving forward.

May 06, 2024
CLINICAL NEUROSCIENCES CENTER

Dr Frost is a very kind and knowledgeable doctor. We appreciate his dedication to our needs.

May 05, 2024
CLINICAL NEUROSCIENCES CENTER

Love him he was interested me me and is trying to help

Apr 26, 2024
CLINICAL NEUROSCIENCES CENTER

Dr. Frost is an exceptional medical professional, second y none!

Apr 18, 2024
CLINICAL NEUROSCIENCES CENTER

Such a thoughtful, thorough doctor. I really liked his approach

Apr 14, 2024
CLINICAL NEUROSCIENCES CENTER

We liked Dr Frost and how he went about getting the base line history of a new patient and trying to figure the best approach to figure out cognitive decline.

Apr 06, 2024
CLINICAL NEUROSCIENCES CENTER

We knew he understood our concerns and said he would try to help us in any way that he could.

Mar 31, 2024
CLINICAL NEUROSCIENCES CENTER

Very kind, personal & professional.

Mar 30, 2024
CLINICAL NEUROSCIENCES CENTER

Friendly, knowledgeable, and caring physician who asked the right questions in order to formulate a treatment plan that's going to help me get better. He took his time to probe my situation, tested me in necessary areas, and even recommended a great lunch place in the facility.

Mar 24, 2024
CLINICAL NEUROSCIENCES CENTER

Dr.Frost is extremely professional and is equally knowledgeable, he is the best!

Mar 11, 2024
CLINICAL NEUROSCIENCES CENTER

It was encouraging to meet with Dr. Frost and have a serious discussion and investigation into that which was bugging me physically! I am very anxious that the results will be delightful.

Feb 25, 2024
CLINICAL NEUROSCIENCES CENTER

I found Dr. Frost is very knowledgeable and thorough on his evaluation of my wife

Feb 19, 2024
CLINICAL NEUROSCIENCES CENTER

Very knowledgeable. Including information on latest treatments, positive and possible negative impacts. We appreciated Dr. Frost taking the time to explain options with the diagnosis. He also offered to speak with us further if needed. We would definitely recommend him to others.

Feb 17, 2024
CLINICAL NEUROSCIENCES CENTER

Knowledgeable & curious

Feb 14, 2024
CLINICAL NEUROSCIENCES CENTER

Dr. Frost is a rare gem of a physician who listens, explains, and genuinely cares for my wellbeing. I feel absolutely confident in his management of my medical needs.

Feb 09, 2024
CLINICAL NEUROSCIENCES CENTER

I feel confident in following the advice of Dr. Frost, based on our first visit. He seemed to be quite personable, and a quick but thorough analyst of my health needs. I am looking forward to having him help me along this path!

Jan 06, 2024
CLINICAL NEUROSCIENCES CENTER

I feel I am in excellent hands with dr. Frost. He provided a great deal of information and left me feeling quite hopeful.

Jan 06, 2024
CLINICAL NEUROSCIENCES CENTER

Dr Frost is the guy to go to

Dec 31, 2023
CLINICAL NEUROSCIENCES CENTER

He needed to elaborate more with his diagnosis and reasoning behind doing his tests. I didn't really receive answers to my questions.

Dec 26, 2023
CLINICAL NEUROSCIENCES CENTER

We are so great full to have a kind provider with the expertise of Dr. Frost here in SLC

Dec 22, 2023
CLINICAL NEUROSCIENCES CENTER

Dr Frost and his staff have been excellent. We very much appreciate them.

Dec 21, 2023
CLINICAL NEUROSCIENCES CENTER

Dr. Frost genuinely cares about his patients. I appreciate that he wanted to help me and validated my concerns. He explained my diagnosis thoroughly in terms I could easily understand. I understand now the cause of my symptoms.

Dec 11, 2023
CLINICAL NEUROSCIENCES CENTER

Dr. Frost is superb and meticulous.

Nov 22, 2023
CLINICAL NEUROSCIENCES CENTER

Dr. Frost is personable, knowlegable and an excellent Dr. During the intake appointment, Dr. Frost was Informative, sincere, caring, insightful and very patient. I felt that we dug in & identified issues and made productive plans for going forward.

Nov 18, 2023
CLINICAL NEUROSCIENCES CENTER

Kind and considerate. Listens and cares about my well being.

Nov 06, 2023
CLINICAL NEUROSCIENCES CENTER

He explained why he thought my cognitive issues were not related to my hyperintensities. Cool.

Nov 05, 2023
CLINICAL NEUROSCIENCES CENTER

Efficient, professional, but compassionate with a sense of humor

Oct 30, 2023
CLINICAL NEUROSCIENCES CENTER

Very caring and knowledgeable.

Oct 28, 2023
CLINICAL NEUROSCIENCES CENTER

Dr. Frost is very caring and patient. He helped me understand my mental condition in a clear and concise manner that I could easily comprehend. When he prescribed my medication I understood very easily how it is going to help me. I commend him for explaining things clearly. He is not pretentious like the previous neurologist I had dealt with. Thus the reason for seeking a second opinion on my first diagnosis. I can live with my condition and accept it as one of life's challenges.

Oct 27, 2023
CLINICAL NEUROSCIENCES CENTER

He explained what we needed to do and did what he could to move it forward. We did not receive the medication or a Rx for it. It should be sent to Bountiful Drug!

Oct 21, 2023
CLINICAL NEUROSCIENCES CENTER

Attentive and informative

Oct 04, 2023
CLINICAL NEUROSCIENCES CENTER

I met with Dr. Frost, to get a second opinion on a diagnosis from another provider. Dr. Frost acknowledged my request. He is an excellent listener and his explainations are very easy to understand. He is genuinely interested in helping me, and in recommending additional tests. I am confident that his final diagnosis will be more accurate than the previous neurological provider

Sep 30, 2023
CLINICAL NEUROSCIENCES CENTER

Dr. Frost, tested me then explained all the things that could happen, then he carefully took his time to talk about the results that could come. He gave me answers that I really needed to be able to continue.

Aug 12, 2023
CLINICAL NEUROSCIENCES CENTER

I liked him very much. My nurse practitioner had sent me to him for a different reason than I thought she had. He explained the reasoning behind it in a nice way. So I agreed it was probably good to check me for that reason.

Jul 17, 2023
CLINICAL NEUROSCIENCES CENTER

Competent and knowledgeable.

Jul 17, 2023
CLINICAL NEUROSCIENCES CENTER

We really appreciate his willingness to explain to us what is happening to [NAME REMOVED].

Apr 22, 2023
CLINICAL NEUROSCIENCES CENTER

Great experience.

Apr 16, 2023
CLINICAL NEUROSCIENCES CENTER

He did a very good job and was very helpful

Feb 26, 2023
CLINICAL NEUROSCIENCES CENTER

Gentle and kind when giving bad news.

Feb 25, 2023
CLINICAL NEUROSCIENCES CENTER

I am extremely please with my visit with Dr. Frost

Feb 06, 2023
CLINICAL NEUROSCIENCES CENTER

We are so pleased to have Neil in his care.

Jan 15, 2023
CLINICAL NEUROSCIENCES CENTER

Dr. Frost was kind and caring. Everything I did not understand, he rephrased so I could understand completely. He was empathetic and his questions were so thorough. I felt at ease and I am grateful I am under his care.


Patient comments are gathered from our patient experience survey and displayed in their entirety. For the convenience of our visitors, some patient comments have been translated from their original language into English while preserving their original meaning as accurately as possible. Patients are de-identified for confidentiality and patient privacy.

Dr. Frost is a board certified neurologist who sees patients with disorders of memory and cognition. His clinical and research interests focus on understanding mechanisms that contribute to disorders of cognition. His research focuses on how information relevant to complex behaviors including social interactions are encoded within the prefrontal cortex and disrupted in disease. His laboratory utilizes imaging and transcriptomic approaches to understand how heterogeneous populations of neurons function in concert to encode different types of behavioral information.

Dr. Frost received his medical degree and graduate research training from the University of Maryland School of Medicine. There his research focused on developing super-resolution microscopy to image biological processes in living neurons. He then moved to San Francisco for further clinical training including an internship in internal medicine and residency in adult neurology at the University of California, San Francisco. Following residency he completed a research fellowship at UCSF focused on characterizing circuit-level endophenotypes underlying abnormal behavior in preclinical models of neurodevelopmental disorders.

Board Certification and Academic Information

Academic Departments Neurology -Assistant Professor
Neurobiology -Adjunct Assistant Professor
Board Certification
American Board of Psychiatry & Neurology (Neurology)

Education history

Undergraduate Biochemistry, Spanish - Florida State University B.S., B.A.
Professional Medical Neuroscience - University of Maryland School of Medicine M.D., Ph.D.
Internship Internal Medicine - University of California, San Francisco Intern
Residency Neurology - University of California, San Francisco Resident
Research Fellow R25 Research Fellowship in circuit disorders underlying abnormal behavior - University of California, San Francisco Postdoctoral Fellow

Selected Publications

Journal Article

  1. Ngam PI, Anzai Y, Cliatt Brown CJ, Frost NA, Keown Sorweid M, Thientunyakit T, Minoshima S, Alzheimer's Disease Neuroimaging Initiativ (2026). Copathologies of Limbic-Predominant Age-Related TDP-43 Encephalopathy and Alzheimer Disease: [(18)F]FDG PET Statistical Mapping and Quantitative MRI Volumetry. Journal of nuclear medicine, 67(4), 621-628.
  2. Curd BC, Zubrick C, Brown CJC, Sorweid MK, Dehoney SB, Anzai Y, Minoshima S, Parks AL, Frost N (2026). Real-world experience with lecanemab therapy for Alzheimer's disease in the Intermountain West. Alzheimer's & dementia (Amsterdam, Netherlands), 18(1), e70251.
  3. Ni C, Hou X, HashemizadehKolowri S, Kim SE, Wen Q, Frost NA, McNally JS, Yuan C, Ma (2026). Simultaneous Assessment of Intracranial Artery and Paravascular CSF Pulsation Using 3D Whole-Brain Diffusion-Prepared Cine bSSFP (DECAF) MRI. Magnetic resonance in medicine,
  4. Canales CP, Lozano SA, Frost NA, Cichewicz K, Amaral W, Seban N, Fenton E, Wade A, Chu N, Smith E, Ardekani C, Frank S, Bennett J, Lavenex P, Kopley-Smith A, Rahbarian D, Corea M, Perla D, Davis L, Zhu J, Ortiz R, Beauregard P, Morse S, Baker J, Sun J, Ma B, Lu J, Sohal VS, Amaral DG, Zuo Y, Nord A (2025). Persistent cortical excitatory neuron dysregulation in adult Chd8 haploinsufficient mice. Research square,
  5. Walker H, Kwak D, Devaraju P, Curd BC, Chikuni AM, Frost N (2025). Impaired Spatiotemporal Encoding of Social Behavior and Anxiety in the Prefrontal Cortex of Mice Lacking ASD-Risk Gene Shank3. bioRxiv,
  6. Frost NA, Donohue KC, Kwak D, Sohal V (2025). Context-invariant socioemotional encoding by prefrontal ensembles. Nature communications, 16(1), 5455.
  7. Gatlin RE, Gagon J, Kwak D, Park S, Walker H, Kronheim L, Everett T, Covington A, Fluck MM, Zickmund T, Frost NA, Zelikowsky (2025). Co-release of opposing signaling molecules controls the escalation and release of aggression. bioRxiv,
  8. Shin D, Kim CN, Ross J, Hennick KM, Wu SR, Paranjape N, Leonard R, Wang JC, Keefe MG, Pavlovic BJ, Donohue KC, Moreau C, Wigdor EM, Larson HH, Allen DE, Cadwell CR, Bhaduri A, Popova G, Bearden CE, Pollen AA, Jacquemont S, Sanders SJ, Haussler D, Wiita AP, Frost NA, Sohal VS, Nowakowski TJ (2024). Thalamocortical organoids enable in vitro modeling of 22q11.2 microdeletion associated with neuropsychiatric disorders. Cell Stem Cell, 31(3), 421-432.e8.
  9. Walker H, Frost N (2024). Distinct transcriptional programs define a heterogeneous neuronal ensemble for social interaction. iScience, 27(7), 110355.
  10. Walker H, Frost N (2024). Protocol for the generation of single-nuclei RNA-seq libraries and quantification of heterogeneous cell types activated during social interaction. STAR protocols, 5(4), 103395.
  11. Frost NA, Donohue KC, Sohal V (2023). Context-invariant socioemotional encoding by prefrontal ensembles. bioRxiv.
  12. Frost NA, Haggart A, Sohal VS (2021). Dynamic patterns of correlated activity in the prefrontal cortex encode information about social behavior. PLoS Biol, May 3;19(5), e3001235.
  13. MacGillavry HD, Kerr JM, Kassner J, Frost NA, Blanpied TA (2016). Shank-cortactin interactions control actin dynamics to maintain flexibility of neuronal spines and synapses. Eur J Neurosci, 43(2), 179-93.
  14. Jensen CS, Watanabe S, Rasmussen HB, Schmitt N, Olesen SP, Frost NA, Blanpied TA, Misonou H (2014). Specific sorting and post-Golgi trafficking of dendritic potassium channels in living neurons. J Biol Chem, 289(15), 10566-81.
  15. Lu HE, MacGillavry HD, Frost NA, Blanpied TA (2014). Multiple spatial and kinetic subpopulations of CaMKII in spines and dendrites as resolved by single-molecule tracking PALM. J Neurosci, 34(22), 7600-10.
  16. Parikh RV, Frost NA, Green A, Dandu M (2014). A Leathery Lining. J Gen Intern Med, 29(1), 243.
  17. Lieberman JA, Frost NA, Hoppert M, Fernandes PJ, Vogt SL, Raivio TL, Blanpied TA, Donnenberg MS (2012). Outer membrane targeting, ultrastructure, and single molecule localization of the enteropathogenic Escherichia coli type IV pilus secretin BfpB. J Bacteriol, 194(7), 1646-58.
  18. Frost NA, Lu HE, Blanpied TA (2012). Optimization of cell morphology measurement via single-molecule tracking PALM. PLoS One, 7(5), e36751.
  19. Frost NA, Shroff H, Kong H, Betzig E, Blanpied TA (2010). Single-molecule discrimination of discrete perisynaptic and distributed sites of actin filament assembly within dendritic spines. Neuron, 67(1), 86-99.
  20. Frost NA, Kerr JM, Lu HE, Blanpied TA (2010). A network of networks: cytoskeletal control of compartmentalized function within dendritic spines. Curr Opin Neurobiol, 20(5), 578-87.
  21. Weinman EJ, Steplock D, Cha B, Kovbasnjuk O, Frost NA, Cunningham R, Shenolikar S, Blanpied TA, Donowitz M (2009). PTH transiently increases the percent mobile fraction of Npt2a in OK cells as determined by FRAP. Am J Physiol Renal Physiol, 297(6), F1560-5.
  22. Gerdes MJ, Myakishev M, Frost NA, Rishi V, Moitra J, Acharya A, Levy MR, Park SW, Glick A, Yuspa SH, Vinson C (2006). Activator protein-1 activity regulates epithelial tumor cell identity. Cancer Res, 66(15), 7578-88.

Book Chapter

  1. Frost NA, MacGillavry HD, Lu HE, Blanpied TA (2014). Live-cell PALM of intracellular proteins in neurons. In Nägerl U, Triller A (Eds.), Nanoscale Imaging of Synapses. Neuromethods (84, pp. 93-123). New York, NY: Humana Press.