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Moran Clinical Trials

4D MT Choroideremia

Description: The study will evaluate patients over time in order to study the rate of progression of choroideremia (as measured by several visual function tests and anatomical biomarkers) and determine the usefulness of specific measures for future clinical trials. ...

Keywords: Retinal eye disease, Genetics, Disease progression
Principal Investigator: Paul Bernstein

 
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4D-125-XLRP

Description: To evaluate the safety and tolerability of gene therapy with 4D-125 for the treatment of X-linked retinitis pigmentosa caused by mutations in the RPGR gene ...
Keywords: Inherited retinal disease, Gene therapy, Clinical research trial
Principal Investigator: Paul Bernstein

 
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Carotenoid Supplementation During Pregnancy

Description: The purpose of this study is to characterize the effects of prenatal supplementation with the carotenoids lutein and zeaxanthin both in the mothers and their newborn infants. No OTC prenatal vitamins currently available contain these nutrients, however they are commonly recommended for older adults at risk for developing age-related macular degeneration. ...
Keywords: prenatal vitamins, vision health
Principal Investigator: Paul Bernstein

 

 

 
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CIRB: Adjust

Description: To develop evidence for the safety and utility of stopping adalimumab treatment in JIA-associated uveitis patients ...
Keywords: JIA, Uveitis / ocular inflammation, Medical treatment
Principal Investigator: Albert Vitale

 
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Clinical Phenotypes of Inherited Retinal Disease

Description: To collect thorough, ocular-related data from patients with rare genetic eye diseases in order to establish complete clinical characterizations of the disorders. ...
Keywords: Inherited eye disease, Bardet-Biedl Syndrome, X-linked retinitis pigmentosa (RP), Incontinentia pigmenta, Familial exudative vitreoretinopathy (FEVR)
Principal Investigator: Marielle Young

 
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Clinical Study of the ARTISAN® Aphakia Lens for the Correction of Aphakia in Adults

Description: To determine the effectiveness of the ARTISAN Aphakia Lens in individuals whose eye condition requires an anterior chamber lens to provide the focusing power previously accomplished by their natural lens. ...
Keywords: Aphakia, Intraocular lens
Principal Investigator: Craig Chaya

 
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Effect of Purified Amniotic Fluid on Re-epithelialization after PRK

Description: The study will assess the safety of processed amniotic fluid eyedrops used for 7 days post-operatively by patients undergoing PRK, and evaluate their effects on healing and pain during the post-op period. ...
Keywords: refractive surgery, PRK
Principal Investigator: Mark Mifflin

 
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EyeGene Creation of Repository for Inherited Ophthalmic Diseases

Description: The overall goals of eyeGENE are: • To provide a repository of DNA coupled to anonymous phenotypic information for researchers • To provide molecular diagnosis to patients with inherited eye diseases • To establish genotype-phenotype correlations for rare eye diseases • To enhance recruitment for clinical trials and investigations in inherited eye diseases This initial protocol (Stage 1-- Creation ...
Keywords: EyeGene, genetic testing, genotyping
Principal Investigator: Paul Bernstein

 
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ISEE2008

Description: To evaluate the safety and efficacy of intravitreal administration of Zimura in patients with dry age-related macular degeneration as measured by rate of change in the area of geographic atrophy ...
Keywords: age related eye disease, macular degeneration, intravitreal injection
Principal Investigator: Paul Bernstein

 
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MacTel NTMT-03

Description: To determine if the Renexus intraocular implant benefits visual function in patients with Macular Telangiectasia type 2 ...
Keywords: Eye disease, Retina, Treatment trial
Principal Investigator: Paul Bernstein

 
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MacTel Registry Study

Description: Study Purposes and Objectives:The objectives should be stated in such a way that the reader can determine the appropriateness of the study design. If appropriate, state the specific hypotheses being tested and/or study aims. Use lay language. The purpose of this study is to identify persons with MacTel Type 2, and their affected family members to create a Registry of persons with MacTel Type 2. Th ...
Keywords: MacTel
Principal Investigator: Paul Bernstein

 

 

 
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MOPD measures in eye and other tissues

Description: The purpose of this study is to understand the role of nutrition and its effects on the eye and other tissues. We will study this by validating and correlating various non-invasive measurement methods of carotenoid concentrations in the human eye and skin tissue.A secondary objective is to correlate blood levels of carotenoids on a sub-set of participants. ...
Keywords: macular pigments, nutrition 
Principal Investigator: Paul Bernstein

 
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OAKS

Description: To evaluate the safety and effectiveness of the study drug in slowing the progression of dry age-related macular degeneration ...
Keywords: Retinal disease, Age-related macular degeneration, Treatment trial
Principal Investigator: Paul Bernstein

 
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OPH2005

Description: To evaluate the safety and efficacy of the study drug in patients with Stargardt Disease ...
Keywords: Eye disease of retina, Genetic eye disease, Drug therapy
Principal Investigator: Paul Bernstein

 
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Pseudoexfoliation and Co-Morbidities

Description: To clinically characterize individuals and family members with a diagnosis of pseudoexfoliative syndrome (XFS) or glaucoma (XFG), and perform DNA and RNA analyses (through donated blood samples and, when available, eye lens capsule tissue removed during standard care cataract surgery) to identify genetic associations with this disease. ...
Keywords: Glaucoma, Exfoliation syndrome, Family study
Principal Investigator: Barbara Wirostko

 
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PVD OCT

Description: To increase understanding of the process of formation of posterior vitreous detachment over time ...
Keywords: eye conditions, biomedical research
Principal Investigator: Eileen Hwang

 
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RHONE-X

Description: To evaluate the long-term use of faricimab in treating diabetic macular edema ...
Keywords: diabetic eye disese
Principal Investigator: Rachael Jacoby

 
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ROP1

Description: Determine the lowest effective dose of the intravitreally administered, anti-VEGF drug, bevacizumab (Avastin), for the treatment of Retinopathy of Prematurity (ROP). Treatment success is defined in the protocol as improvement, by day 4 following bevacizumab injection, and no recurrence of type 1 ROP/severe neovascularization. ...
Keywords: Prematurity, Eye diseases, Treatments for ROP
Principal Investigator: Mary Elizabeth Hartnett

 
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RUSH2A

Description: To describe the natural history of Usher Syndrome type 2A, characterize clinical and genetic sub-populations of patients, and identify possible structural and functional outcome measures that could be used in future treatment trials ...
Keywords: Usher Syndrome type 2A, Genetic disorder, Natural history study
Principal Investigator: Paul Bernstein

 

 
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SeaSTAR

Description: To determine if the study drug, emixustat hydrochloride (emixustat), reduces the rate of progression of macular atrophy (MA) compared to placebo in subjects with Stargardt disease (STGD). ...
Keywords: Retinal disease
Principal Investigator: Paul Bernstein

 

 
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Utah Center for MacTel Genetics

Description: Characterize the genetic and clinical associations of MacTel Type 2 ...
Keywords: Macular Telangiectasia Type 2, Retinal eye disease, Genetics
Principal Investigator: Paul Bernstein

 

 
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XOLARIS

Description: To gain better understanding of disease progression over time in patients with X-linked retinitis pigmentosa (XLRP) ...
Keywords: Genetic eye disease, Retinal disease, Natural history study
Principal Investigator: Paul Bernstein

 

 
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YOSEMITE

Description: To determine the safety and effectiveness of the study compound in treating patients with macular edema secondary to diabetic retinopathy ...
Keywords: Diabetic eye disease, Treatment trial
Principal Investigator: Rachael Jacoby

 

 
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Zoster Eye Disease Study (ZEDS)

Description: To evaluate whether or not prolonged suppressive oral antiviral treatment with valacyclovir reduces complications of HZO, including new or worsening dendriform epithelial keratitis, stromal keratitis, endothelial keratitis, and/or iritis and/or postherpetic neuralgia, compared to placebo. ...
Keywords: Eye disease, Herpes Zoster, Long-term therapy
Principal Investigator: Amy Lin

 

 
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